EA201390712A1 - Производные пиридазина, композиции и способы лечения когнитивного нарушения - Google Patents

Производные пиридазина, композиции и способы лечения когнитивного нарушения

Info

Publication number
EA201390712A1
EA201390712A1 EA201390712A EA201390712A EA201390712A1 EA 201390712 A1 EA201390712 A1 EA 201390712A1 EA 201390712 A EA201390712 A EA 201390712A EA 201390712 A EA201390712 A EA 201390712A EA 201390712 A1 EA201390712 A1 EA 201390712A1
Authority
EA
Eurasian Patent Office
Prior art keywords
derivatives
compositions
cognitive impairment
methods
pyridazin
Prior art date
Application number
EA201390712A
Other languages
English (en)
Other versions
EA027840B1 (ru
Inventor
Джон А. Лоу III
Original Assignee
Эйджинбайо, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эйджинбайо, Инк. filed Critical Эйджинбайо, Инк.
Publication of EA201390712A1 publication Critical patent/EA201390712A1/ru
Publication of EA027840B1 publication Critical patent/EA027840B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Настоящее изобретение относится к производным пиридазина, композициям, содержащим терапевтически эффективные количества данных производных пиридазина, и способам применения данных производных или композиций при лечении нарушений центральной нервной системы (ЦНС) с когнитивным нарушением, которые реагируют на агонисты содержащего α5 субъединицу ГАМКрецептора, напримервозрастное когнитивное нарушение, умеренное когнитивное нарушение (УКН), деменция, болезнь Альцгеймера (БА), продромальная фаза БА, посттравматическое стрессовое расстройство (ПТСР), шизофрения и связанное с терапией рака когнитивное нарушение.
EA201390712A 2010-11-15 2011-11-15 Производные пиридазина, композиции и способы лечения когнитивного нарушения EA027840B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41397110P 2010-11-15 2010-11-15
PCT/US2011/060854 WO2012068161A1 (en) 2010-11-15 2011-11-15 Pyridazine derivatives, compositions and methods for treating cognitive impairment

Publications (2)

Publication Number Publication Date
EA201390712A1 true EA201390712A1 (ru) 2013-11-29
EA027840B1 EA027840B1 (ru) 2017-09-29

Family

ID=46084380

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201390712A EA027840B1 (ru) 2010-11-15 2011-11-15 Производные пиридазина, композиции и способы лечения когнитивного нарушения

Country Status (12)

Country Link
US (2) US9145372B2 (ru)
EP (2) EP2640391B1 (ru)
JP (1) JP5916746B2 (ru)
CN (1) CN103313712B (ru)
AU (1) AU2011328993B2 (ru)
BR (1) BR112013012062B1 (ru)
CA (1) CA2818025A1 (ru)
DK (2) DK2640391T3 (ru)
EA (1) EA027840B1 (ru)
MX (1) MX346185B (ru)
NO (1) NO3034079T3 (ru)
WO (1) WO2012068161A1 (ru)

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EA036844B1 (ru) 2015-06-19 2020-12-28 Эйджинбайо, Инк. Производные бензодиазепина, композиции и способы для лечения когнитивного нарушения
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Publication number Publication date
JP5916746B2 (ja) 2016-05-11
BR112013012062B1 (pt) 2020-06-02
US9145372B2 (en) 2015-09-29
EP3034079B1 (en) 2018-01-10
AU2011328993A1 (en) 2013-06-06
US9801879B2 (en) 2017-10-31
US20160008357A1 (en) 2016-01-14
MX2013005442A (es) 2013-10-03
EP3034079A1 (en) 2016-06-22
EP2640391A1 (en) 2013-09-25
DK3034079T3 (en) 2018-02-05
MX346185B (es) 2017-03-10
NO3034079T3 (ru) 2018-06-09
JP2013542267A (ja) 2013-11-21
EP2640391B1 (en) 2015-11-11
CN103313712A (zh) 2013-09-18
CA2818025A1 (en) 2012-05-24
WO2012068161A1 (en) 2012-05-24
AU2011328993B2 (en) 2017-03-02
EA027840B1 (ru) 2017-09-29
US20130237545A1 (en) 2013-09-12
DK2640391T3 (da) 2016-02-15
EP2640391A4 (en) 2014-05-07
BR112013012062A2 (pt) 2016-08-16
CN103313712B (zh) 2016-10-26

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