EA201290764A1 - Способы и композиции для улучшения когнитивной функции - Google Patents

Способы и композиции для улучшения когнитивной функции

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Publication number
EA201290764A1
EA201290764A1 EA201290764A EA201290764A EA201290764A1 EA 201290764 A1 EA201290764 A1 EA 201290764A1 EA 201290764 A EA201290764 A EA 201290764A EA 201290764 A EA201290764 A EA 201290764A EA 201290764 A1 EA201290764 A1 EA 201290764A1
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EA
Eurasian Patent Office
Prior art keywords
inhibitor
compositions
cognitive impairment
methods
achei
Prior art date
Application number
EA201290764A
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English (en)
Other versions
EA037187B1 (ru
Inventor
Михела Галлахер
Ребекка Хаберман
Мин Тен Кох
Original Assignee
Дзе Джонс Хопкинс Юниверсити
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Application filed by Дзе Джонс Хопкинс Юниверсити filed Critical Дзе Джонс Хопкинс Юниверсити
Publication of EA201290764A1 publication Critical patent/EA201290764A1/ru
Publication of EA037187B1 publication Critical patent/EA037187B1/ru

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Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N57/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Изобретение относится к способам и композициям, улучшающим когнитивную функцию посредством использования сочетания ингибитора синаптического везикулярного белка 2А (SV2A) и ингибитора ацетохолинэстеразы (AChEI) или их фармацевтически приемлемых солей, гидратов, сольватов, полиморфов. В частности, оно относится к использованию сочетания ингибитора SV2A и AChEI для лечения нарушения центральной нервной системы с когнитивным расстройством у субъекта, нуждающегося в этом или подверженного риску заболевания, включая без ограничения субъектов, страдающих или подверженных риску заболевания возрастным когнитивным расстройством, умеренным когнитивным расстройством (MCI), деменцией, болезнью Альцгеймера (AD), продромальной AD, посттравматическим стрессовым расстройством (PTSD), шизофренией, боковым амиотрофическим склерозом (ALS) и связанным с лечением рака когнитивным расстройством.
EA201290764A 2010-02-09 2011-02-09 Способ и композиция для лечения когнитивного расстройства EA037187B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30276010P 2010-02-09 2010-02-09
PCT/US2011/024256 WO2011100373A1 (en) 2010-02-09 2011-02-09 Methods and compositions for improving cognitive function

Publications (2)

Publication Number Publication Date
EA201290764A1 true EA201290764A1 (ru) 2014-01-30
EA037187B1 EA037187B1 (ru) 2021-02-17

Family

ID=44368107

Family Applications (2)

Application Number Title Priority Date Filing Date
EA201290764A EA037187B1 (ru) 2010-02-09 2011-02-09 Способ и композиция для лечения когнитивного расстройства
EA202092673A EA202092673A3 (ru) 2010-02-09 2011-02-09 Способы и композиции для улучшения когнитивной функции

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EA202092673A EA202092673A3 (ru) 2010-02-09 2011-02-09 Способы и композиции для улучшения когнитивной функции

Country Status (9)

Country Link
US (3) US20110212928A1 (ru)
EP (1) EP2533645B1 (ru)
JP (6) JP6082250B2 (ru)
CN (2) CN109662964A (ru)
AU (1) AU2011215870B2 (ru)
BR (1) BR112012019923A2 (ru)
CA (1) CA2789014C (ru)
EA (2) EA037187B1 (ru)
WO (1) WO2011100373A1 (ru)

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WO2014078568A1 (en) 2012-11-14 2014-05-22 The Johns Hopkins University Methods and compositions for treating schizophrenia
AU2018208662B2 (en) * 2012-11-14 2020-07-23 The Johns Hopkins University Methods and Compositions for Treating Schizophrenia
WO2014144546A1 (en) * 2013-03-15 2014-09-18 The Johns Hopkins University Methods and compositons for improving cognitive function
EP3827820A1 (en) * 2013-03-15 2021-06-02 The Johns Hopkins University Brivaracetam for improving cognitive function
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EA034167B8 (ru) 2015-05-22 2021-04-27 Эйджинбайо, Инк. Фармацевтические композиции леветирацетама пролонгированного высвобождения
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