BR112012019923A2 - métodos e composições para melhorar a função cognitiva - Google Patents

métodos e composições para melhorar a função cognitiva

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Publication number
BR112012019923A2
BR112012019923A2 BR112012019923A BR112012019923A BR112012019923A2 BR 112012019923 A2 BR112012019923 A2 BR 112012019923A2 BR 112012019923 A BR112012019923 A BR 112012019923A BR 112012019923 A BR112012019923 A BR 112012019923A BR 112012019923 A2 BR112012019923 A2 BR 112012019923A2
Authority
BR
Brazil
Prior art keywords
compositions
methods
cognitive impairment
cognitive function
inhibitor
Prior art date
Application number
BR112012019923A
Other languages
English (en)
Inventor
Michela Gallagher
Ming Teng Koh
Rebecca Haberman
Original Assignee
Univ Johns Hopkins
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Johns Hopkins filed Critical Univ Johns Hopkins
Publication of BR112012019923A2 publication Critical patent/BR112012019923A2/pt

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Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N57/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

métodos e composições para função cognitiva melhorada. a presente invenção refere-se aos métodos e às composições para função cognitiva melhorada por meio do uso de uma combinação de uma inibidor da proteína 2a da vesícula sináptica (sv2a) e um inibidor acetilcolinesterase (achei) ou seus sais, hidratos, solvatos e polimorfos farmaceuticamente aceitáveis dos mesmos. em particular, a presente invenção refere-se ao uso de uma combinação de um inibidor sv2a e achei no tratamento d e um distúrbio no sistema nervoso central, com dano cognitivo em um sujeito em necessidade ou em risco de dano cognitivo relacionado à idade, dano cognitivo leve (mci), demência, doença de alzheimer (ad), ad prodromal, distúrbio de estresse pós-traumático (ptsd), esquizofrenia, esclerose lateral amiotrópica (als), e dano cognitivo relacionado à terapia de cancêr.
BR112012019923A 2010-02-09 2011-02-09 métodos e composições para melhorar a função cognitiva BR112012019923A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30276010P 2010-02-09 2010-02-09
PCT/US2011/024256 WO2011100373A1 (en) 2010-02-09 2011-02-09 Methods and compositions for improving cognitive function

Publications (1)

Publication Number Publication Date
BR112012019923A2 true BR112012019923A2 (pt) 2016-08-09

Family

ID=44368107

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012019923A BR112012019923A2 (pt) 2010-02-09 2011-02-09 métodos e composições para melhorar a função cognitiva

Country Status (9)

Country Link
US (3) US20110212928A1 (pt)
EP (1) EP2533645B1 (pt)
JP (6) JP6082250B2 (pt)
CN (2) CN102905532A (pt)
AU (1) AU2011215870B2 (pt)
BR (1) BR112012019923A2 (pt)
CA (1) CA2789014C (pt)
EA (2) EA037187B1 (pt)
WO (1) WO2011100373A1 (pt)

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US10154988B2 (en) * 2012-11-14 2018-12-18 The Johns Hopkins University Methods and compositions for treating schizophrenia
AU2018208662B2 (en) * 2012-11-14 2020-07-23 The Johns Hopkins University Methods and Compositions for Treating Schizophrenia
US11160785B2 (en) * 2013-03-15 2021-11-02 Agenebio Inc. Methods and compositions for improving cognitive function
EP2968257A4 (en) * 2013-03-15 2016-08-31 Univ Johns Hopkins METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION
EP2968237A4 (en) 2013-03-15 2016-08-31 Univ Johns Hopkins METHOD AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION
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