ATE306264T1 - Verwendung von acetylcholinesterase inhibitoren zur modulierung der hypothalamus-hypophysen- gonadenachse - Google Patents
Verwendung von acetylcholinesterase inhibitoren zur modulierung der hypothalamus-hypophysen- gonadenachseInfo
- Publication number
- ATE306264T1 ATE306264T1 AT99967223T AT99967223T ATE306264T1 AT E306264 T1 ATE306264 T1 AT E306264T1 AT 99967223 T AT99967223 T AT 99967223T AT 99967223 T AT99967223 T AT 99967223T AT E306264 T1 ATE306264 T1 AT E306264T1
- Authority
- AT
- Austria
- Prior art keywords
- acetylcholinesterase inhibitors
- pitophysis
- hypothalamus
- modulate
- gonad axis
- Prior art date
Links
- 239000000544 cholinesterase inhibitor Substances 0.000 title abstract 3
- ASUTZQLVASHGKV-JDFRZJQESA-N galanthamine Chemical compound O1C(=C23)C(OC)=CC=C2CN(C)CC[C@]23[C@@H]1C[C@@H](O)C=C2 ASUTZQLVASHGKV-JDFRZJQESA-N 0.000 abstract 2
- IYVSXSLYJLAZAT-NOLJZWGESA-N lycoramine Natural products CN1CC[C@@]23CC[C@H](O)C[C@@H]2Oc4cccc(C1)c34 IYVSXSLYJLAZAT-NOLJZWGESA-N 0.000 abstract 2
- GJRMHIXYLGOZSE-JDFRZJQESA-N 1,2-Dihydrogalanthamine Chemical compound O1C(=C23)C(OC)=CC=C2CN(C)CC[C@]23[C@@H]1C[C@@H](O)CC2 GJRMHIXYLGOZSE-JDFRZJQESA-N 0.000 abstract 1
- HPOIPOPJGBKXIR-UHFFFAOYSA-N 3,6-dimethoxy-10-methyl-galantham-1-ene Natural products O1C(C(=CC=2)OC)=C3C=2CN(C)CCC23C1CC(OC)C=C2 HPOIPOPJGBKXIR-UHFFFAOYSA-N 0.000 abstract 1
- LPCKPBWOSNVCEL-UHFFFAOYSA-N Chlidanthine Natural products O1C(C(=CC=2)O)=C3C=2CN(C)CCC23C1CC(OC)C=C2 LPCKPBWOSNVCEL-UHFFFAOYSA-N 0.000 abstract 1
- XSVMFMHYUFZWBK-NSHDSACASA-N Rivastigmine Chemical compound CCN(C)C(=O)OC1=CC=CC([C@H](C)N(C)C)=C1 XSVMFMHYUFZWBK-NSHDSACASA-N 0.000 abstract 1
- 206010059594 Secondary hypogonadism Diseases 0.000 abstract 1
- 206010003883 azoospermia Diseases 0.000 abstract 1
- 230000003111 delayed effect Effects 0.000 abstract 1
- 229960003980 galantamine Drugs 0.000 abstract 1
- BGLNUNCBNALFOZ-WMLDXEAASA-N galanthamine Natural products COc1ccc2CCCC[C@@]34C=CCC[C@@H]3Oc1c24 BGLNUNCBNALFOZ-WMLDXEAASA-N 0.000 abstract 1
- ASUTZQLVASHGKV-UHFFFAOYSA-N galanthamine hydrochloride Natural products O1C(=C23)C(OC)=CC=C2CN(C)CCC23C1CC(O)C=C2 ASUTZQLVASHGKV-UHFFFAOYSA-N 0.000 abstract 1
- 230000004185 hypothalamic-pituitary-gonadal axis Effects 0.000 abstract 1
- 208000000509 infertility Diseases 0.000 abstract 1
- 231100000535 infertility Toxicity 0.000 abstract 1
- 230000036512 infertility Effects 0.000 abstract 1
- 231100000545 luteal phase defect Toxicity 0.000 abstract 1
- 208000008634 oligospermia Diseases 0.000 abstract 1
- 230000016087 ovulation Effects 0.000 abstract 1
- 229960004136 rivastigmine Drugs 0.000 abstract 1
- 230000000638 stimulation Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Enzymes And Modification Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11191398P | 1998-12-11 | 1998-12-11 | |
| PCT/US1999/028972 WO2000033840A1 (en) | 1998-12-11 | 1999-12-08 | Use of acetylcholinesterase inhibitors on the modulation of the hypothalamic-pituitary-gonadal axis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE306264T1 true ATE306264T1 (de) | 2005-10-15 |
Family
ID=22341099
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99967223T ATE306264T1 (de) | 1998-12-11 | 1999-12-08 | Verwendung von acetylcholinesterase inhibitoren zur modulierung der hypothalamus-hypophysen- gonadenachse |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP1137414B1 (de) |
| JP (1) | JP2002531502A (de) |
| AT (1) | ATE306264T1 (de) |
| AU (1) | AU2354400A (de) |
| CA (1) | CA2354035A1 (de) |
| DE (1) | DE69927705T2 (de) |
| WO (1) | WO2000033840A1 (de) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1777222A1 (de) * | 2005-09-22 | 2007-04-25 | Galantos Pharma GmbH | Cholinesterase Inhibitoren mit erhöter Blut Hirn Schranke Permeabilität zur Behandlung von kognitiven Störungen |
| US20090253654A1 (en) | 2005-09-22 | 2009-10-08 | Galantos Pharma Gmbh | Cholinergic enhancers with improved blood-brain barrier permeability for the treatment of diseases accompanied by cognitive impairment |
| JP5379692B2 (ja) | 2006-11-09 | 2013-12-25 | プロビオドルグ エージー | 潰瘍、癌及び他の疾患の治療のためのグルタミニルシクラーゼの阻害薬としての３−ヒドロキシ−１，５−ジヒドロ−ピロール−２−オン誘導体 |
| SI2091948T1 (sl) | 2006-11-30 | 2012-07-31 | Probiodrug Ag | Novi inhibitorji glutaminil ciklaze |
| CN101668525A (zh) | 2007-03-01 | 2010-03-10 | 前体生物药物股份公司 | 谷氨酰胺酰环化酶抑制剂的新用途 |
| EP2142514B1 (de) | 2007-04-18 | 2014-12-24 | Probiodrug AG | Thioharnstoffderivate als glutaminylcyclaseinhibitoren |
| EP2533645B1 (de) | 2010-02-09 | 2016-07-27 | The Johns Hopkins University | Verfahren und zusammensetzungen zur verbesserung von kognitiven funktionen |
| WO2011107530A2 (en) | 2010-03-03 | 2011-09-09 | Probiodrug Ag | Novel inhibitors |
| KR101790806B1 (ko) | 2010-03-10 | 2017-11-20 | 프로비오드룩 아게 | 글루타미닐 사이클라제(ｑｃ, ｅｃ 2.3.2.5)의 헤테로사이클릭 억제제 |
| WO2011131748A2 (en) | 2010-04-21 | 2011-10-27 | Probiodrug Ag | Novel inhibitors |
| WO2012123563A1 (en) | 2011-03-16 | 2012-09-20 | Probiodrug Ag | Benz imidazole derivatives as inhibitors of glutaminyl cyclase |
| EP2919788A4 (de) | 2012-11-14 | 2016-05-25 | Univ Johns Hopkins | Verfahren und zusammensetzungen zur behandlung von schizophrenie |
| WO2014144801A1 (en) | 2013-03-15 | 2014-09-18 | Agenebio Inc. | Methods and compositions for improving cognitive function |
| EP3827820A1 (de) | 2013-03-15 | 2021-06-02 | The Johns Hopkins University | Brivaracetam zur verbesserung der kognitiven funktion |
| CN112843005B (zh) | 2015-05-22 | 2023-02-21 | 艾吉因生物股份有限公司 | 左乙拉西坦的延时释放药物组合物 |
| DK3461819T3 (da) | 2017-09-29 | 2020-08-10 | Probiodrug Ag | Inhibitorer af glutaminylcyklase |
| CN112121049B (zh) * | 2020-08-28 | 2022-02-01 | 嘉兴市第一医院 | 顺式阿曲库铵在制备治疗男性性腺功能减退症的药物中的应用 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU201906B (en) * | 1987-03-04 | 1991-01-28 | Sandoz Ag | Process for producing phenyl-carbamate derivative and acid additional salts and pharmaceutical compositions containing them |
-
1999
- 1999-12-08 EP EP99967223A patent/EP1137414B1/de not_active Expired - Lifetime
- 1999-12-08 AT AT99967223T patent/ATE306264T1/de not_active IP Right Cessation
- 1999-12-08 DE DE69927705T patent/DE69927705T2/de not_active Expired - Lifetime
- 1999-12-08 CA CA002354035A patent/CA2354035A1/en not_active Abandoned
- 1999-12-08 JP JP2000586332A patent/JP2002531502A/ja active Pending
- 1999-12-08 AU AU23544/00A patent/AU2354400A/en not_active Abandoned
- 1999-12-08 WO PCT/US1999/028972 patent/WO2000033840A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP1137414B1 (de) | 2005-10-12 |
| WO2000033840A1 (en) | 2000-06-15 |
| EP1137414A4 (de) | 2002-07-31 |
| EP1137414A1 (de) | 2001-10-04 |
| AU2354400A (en) | 2000-06-26 |
| DE69927705D1 (de) | 2006-02-23 |
| JP2002531502A (ja) | 2002-09-24 |
| CA2354035A1 (en) | 2000-06-15 |
| DE69927705T2 (de) | 2006-07-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |