ATE362768T1 - Prb2/p130 peptidinhibitoren der cdk2 kinaseaktivität - Google Patents

Prb2/p130 peptidinhibitoren der cdk2 kinaseaktivität

Info

Publication number
ATE362768T1
ATE362768T1 AT98939257T AT98939257T ATE362768T1 AT E362768 T1 ATE362768 T1 AT E362768T1 AT 98939257 T AT98939257 T AT 98939257T AT 98939257 T AT98939257 T AT 98939257T AT E362768 T1 ATE362768 T1 AT E362768T1
Authority
AT
Austria
Prior art keywords
kinase activity
prb2
cdk2 kinase
peptide inhibitors
cdk2
Prior art date
Application number
AT98939257T
Other languages
English (en)
Inventor
Antonio Giordano
Original Assignee
Univ Jefferson
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Jefferson filed Critical Univ Jefferson
Application granted granted Critical
Publication of ATE362768T1 publication Critical patent/ATE362768T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
AT98939257T 1997-08-21 1998-08-06 Prb2/p130 peptidinhibitoren der cdk2 kinaseaktivität ATE362768T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US5620797P 1997-08-21 1997-08-21

Publications (1)

Publication Number Publication Date
ATE362768T1 true ATE362768T1 (de) 2007-06-15

Family

ID=22002895

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98939257T ATE362768T1 (de) 1997-08-21 1998-08-06 Prb2/p130 peptidinhibitoren der cdk2 kinaseaktivität

Country Status (7)

Country Link
US (1) US6297357B1 (de)
EP (1) EP1015015B1 (de)
JP (1) JP4323716B2 (de)
AT (1) ATE362768T1 (de)
CA (1) CA2301333C (de)
DE (1) DE69837808T2 (de)
WO (1) WO1999008700A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003287622A1 (en) * 2002-11-06 2004-06-03 Fraunhofer Usa Expression of foreign sequences in plants using trans-activation system
US7491509B2 (en) 2003-02-03 2009-02-17 Fraunhofer Usa, Inc. System for expression of genes in plants
US7683238B2 (en) * 2002-11-12 2010-03-23 iBio, Inc. and Fraunhofer USA, Inc. Production of pharmaceutically active proteins in sprouted seedlings
US7692063B2 (en) * 2002-11-12 2010-04-06 Ibio, Inc. Production of foreign nucleic acids and polypeptides in sprout systems
CA2555230A1 (en) * 2004-02-20 2005-09-09 Fraunhofer Usa Inc. Systems and methods for clonal expression in plants
US7470670B2 (en) * 2006-10-17 2008-12-30 Sbarro Health Research Organization, Inc. Peptide inhibitors of cyclin-dependent kinase activity and uses thereof
US20090054333A1 (en) * 2006-10-17 2009-02-26 Antonio Giordano Peptide inhibitors of cyclin-dependent kinase activity and uses thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5596079A (en) 1991-12-16 1997-01-21 Smith; James R. Mimetics of senescent cell derived inhibitors of DNA synthesis
US5496731A (en) 1993-03-25 1996-03-05 Xu; Hong-Ji Broad-spectrum tumor suppressor genes, gene products and methods for tumor suppressor gene therapy
US5457049A (en) * 1993-08-12 1995-10-10 Temple University - Of The Commonwealth System Of Higher Education Tumor suppressor protein pRb2, related gene products, and DNA encoding therefor
US5688665A (en) * 1994-01-07 1997-11-18 Fred Hutchinson Cancer Research Center Isolated nucleic acid molecules encoding the p27 KIP-1 protein
US5625031A (en) * 1994-02-08 1997-04-29 Bristol-Myers Squibb Company Peptide inhibitors of the p33cdk2 and p34cdc2 cell cycle regulatory kinases and human papillomavirus E7 oncoprotein
US5672508A (en) * 1996-01-23 1997-09-30 Mitotix, Inc. Inhibitors of cell-cycle progression, and uses related thereto

Also Published As

Publication number Publication date
EP1015015A4 (de) 2004-12-08
JP2002500160A (ja) 2002-01-08
CA2301333C (en) 2011-12-06
EP1015015B1 (de) 2007-05-23
WO1999008700A1 (en) 1999-02-25
US6297357B1 (en) 2001-10-02
DE69837808T2 (de) 2008-02-07
DE69837808D1 (de) 2007-07-05
CA2301333A1 (en) 1999-02-25
JP4323716B2 (ja) 2009-09-02
EP1015015A1 (de) 2000-07-05

Similar Documents

Publication Publication Date Title
DE69731226D1 (de) Verwendung von substrat-subtraktionsbibliotheken zur unterscheidung von enzymspezifitäten
DK0873340T3 (da) Heterocyklisk substituerede cyclopentanforbindelser
WO1998020133A3 (en) Proteins with enhanced levels of essential amino acids
ZA987491B (en) Naphthyridinones for inhibiting protein tyrosine kinase and cell cycle kinase mediated cellular proliferation
WO1997033996A3 (en) Human bikunin
ATE320488T1 (de) Mutanten des lag-3 proteins, ihre expression und verwendung
PT81624A (en) Recombinant methods for production of serine protease inhibitors and method for isolation of same
WO1999025843A3 (en) Human checkpoint kinase, hcds1, compositions and methods
DK0495918T3 (da) Aminosyre-beta-lyaseenzyminhibitorer som deodoranter
WO2004069200A3 (en) Specific inhibitors of nfat activation by calcineurin and their use in treating immune-related diseases
ES2141249T3 (es) Procedimiento para la identificacion de celulas humanas y animales que presentan la capacidad para una proliferacion ilimitada o para una formacion de tumores.
ATE362768T1 (de) Prb2/p130 peptidinhibitoren der cdk2 kinaseaktivität
WO1999049038A3 (en) Human calcium-binding proteins
NO20006026L (no) Fremgangsmåter og blandinger for modulering av angiogenese ved bruk av tyrosin kinase SRC
IL149416A0 (en) Human enzymes of the metalloprotease family
NO972063L (no) Isolert BMP-reseptorkinaseprotein, DNA-sekvens, rekombinant ekspresjonsvektor samt vertscelle
ES2172682T3 (es) Preparaciones desodorantes con contenido en quitosano, clorohidrato de aluminio e inhibidores de esterasa.
WO1999001567A3 (en) Methods and compositions for a deubiquitinating enzyme and variants thereof
WO1999031225A3 (en) Human phosphatases
ES2122912A1 (es) Inhibidores de metalocarboxipeptidasas y moleculas derivadas como agentes antitumorales.
SE9604439D0 (sv) New receptor
MXPA03004436A (es) Proteinas bcl-2 mutantes y sus usos.
NO910981L (no) Peptidforbindelser.
DE69828986D1 (de) Men1, mit typ 1 multipler endokriner neoplasie assoziiertes gen, meninpolypeptide und deren verwendungen
NO996209L (no) Peptider og forbindelser som bindes til IL-5 reseptoren

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties