WO1998018935A3 - P70-S6K or related kinase with constitutive activity - Google Patents

P70-S6K or related kinase with constitutive activity Download PDF

Info

Publication number
WO1998018935A3
WO1998018935A3 PCT/EP1997/005979 EP9705979W WO9818935A3 WO 1998018935 A3 WO1998018935 A3 WO 1998018935A3 EP 9705979 W EP9705979 W EP 9705979W WO 9818935 A3 WO9818935 A3 WO 9818935A3
Authority
WO
WIPO (PCT)
Prior art keywords
constitutive activity
related kinase
kinase
p70s6k
serine
Prior art date
Application number
PCT/EP1997/005979
Other languages
French (fr)
Other versions
WO1998018935A2 (en
Inventor
George Thomas
Sara Kozma
Original Assignee
Novartis Ag
George Thomas
Sara Kozma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag, George Thomas, Sara Kozma filed Critical Novartis Ag
Priority to EP97950043A priority Critical patent/EP0942990A2/en
Priority to AU53145/98A priority patent/AU5314598A/en
Publication of WO1998018935A2 publication Critical patent/WO1998018935A2/en
Publication of WO1998018935A3 publication Critical patent/WO1998018935A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

A protein kinase having a structure related to that of a kinase enzyme of the p70S6K signalling pathway is described, wherein a serine or threonine residue homologous to T¿389? in p70?S6K¿ is replaced with an acidic amino acid residue in order to confer constitutive activity.
PCT/EP1997/005979 1996-10-31 1997-10-29 P70-s6k or related kinase with constitutive activity WO1998018935A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP97950043A EP0942990A2 (en) 1996-10-31 1997-10-29 P70-s6k or related kinase with constitutive activity
AU53145/98A AU5314598A (en) 1996-10-31 1997-10-29 P70-s6k or related kinase with constitutive activity

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3026296P 1996-10-31 1996-10-31
US60/030,262 1996-10-31

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US09297404 A-371-Of-International 1999-04-29
US10/317,550 Continuation US20030166034A1 (en) 1996-10-31 2002-12-12 P70-S6K or related kinase with constitutive activity

Publications (2)

Publication Number Publication Date
WO1998018935A2 WO1998018935A2 (en) 1998-05-07
WO1998018935A3 true WO1998018935A3 (en) 1998-07-30

Family

ID=21853348

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1997/005979 WO1998018935A2 (en) 1996-10-31 1997-10-29 P70-s6k or related kinase with constitutive activity

Country Status (3)

Country Link
EP (1) EP0942990A2 (en)
AU (1) AU5314598A (en)
WO (1) WO1998018935A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6830909B1 (en) 1998-08-04 2004-12-14 Ludwig Institute For Cancer Research Identification and functional characterization of a novel ribosomal S6 protein kinase
JP4472179B2 (en) * 1998-08-04 2010-06-02 ルドヴィク インスティテュート フォー キャンサー リサーチ Identification and functional characterization of a novel ribosomal S6 protein kinase

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993019752A1 (en) * 1992-04-07 1993-10-14 Dana-Farber Cancer Institute, Inc. Inhibition of p70 s6 kinase

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993019752A1 (en) * 1992-04-07 1993-10-14 Dana-Farber Cancer Institute, Inc. Inhibition of p70 s6 kinase

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
DENNIS P. B. ET AL.: "The principal rapamycin-sensitive p70-S6K phosphorylation sites, T-229 and T-389, are differentially regulated by rapamycin-insensitive kinase kinases.", MOLECULAR AND CELLULAR BIOLOGY, vol. 16, no. 11, November 1996 (1996-11-01), pages 6242 - 6251, XP002057559 *
FERRARI S. ET AL.: "The immunosuppressant rapamycin induces inactivation of p70-S6K through dephosphorylation of a novel set of sites.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 268, no. 22, 1993, pages 16091 - 16094, XP002057558 *
HAN J.W. ET AL.: "Rapamycin, Wortmannin, and the methylxanthine SQ200006 inactivate p70-S6K by inducing dephosphorylation of the same subset of sites.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 270, no. 36, 1995, pages 21396 - 21403, XP002057557 *
PEARSON R B ET AL: "THE PRINCIPAL TARGET OF RAPAMYCIN-INDUCED P70S6K INACTIVATION IS A NOVEL PHOSPHORYLATION SITE WITHIN A CONSERVED HYDROPHOBIC DOMAIN", EMBO JOURNAL, vol. 14, no. 21, 1 November 1995 (1995-11-01), pages 5279 - 5287, XP000561164 *
PROUD C. G.: "p70 S6 kinase: an enigma with variations.", TRENDS IN BIOCHEMICAL SCIENCES, vol. 21, no. 5, May 1996 (1996-05-01), pages 181 - 185, XP002057556 *

Also Published As

Publication number Publication date
AU5314598A (en) 1998-05-22
WO1998018935A2 (en) 1998-05-07
EP0942990A2 (en) 1999-09-22

Similar Documents

Publication Publication Date Title
CA2270289A1 (en) Proteins with enhanced levels of essential amino acids
AU6676894A (en) An enzyme exhibiting mannanase activity
CY2561B1 (en) Protein kinase C inhibitors
WO2001079463A3 (en) Nucleic acids encoding polypeptides having haloperoxidase activity
DE69907240D1 (en) FIXED PHYTASE COMPOSITIONS
IL112088A0 (en) Novel stem cell factor formulations and methods
AR244544A1 (en) Amino acid beta-lyase enzyme inhibitors as deodorants
CA2186423A1 (en) Protein which induces interferon-gamma production by immunocompetent cell
AU4388296A (en) Nuclear protein serine/threonine kinases
EP0614970A3 (en) Hydroxyphenylpyruvate-dioxygenase inhibitors and assay for the identification of the enzyme.
WO1998018935A3 (en) P70-S6K or related kinase with constitutive activity
AU2587499A (en) Suppression of alpha-amylase and protease expression using serine/threonine protein kinase
WO2002024941A3 (en) Protein kinase regulation
ATE362768T1 (en) PRB2/P130 PEPTIDE INHIBITORS OF CDK2 KINASE ACTIVITY
AU4450489A (en) The use of ethylenediaminetetraacetic acid as inhibitor of calcium/calmodulin-dependent protein kinase ii or of protein kinase c
ZA949611B (en) Protein kinase C inhibitors
GB9027268D0 (en) Lipolytic enzyme inhibitors
WO1998024934A3 (en) Methods for identifying herbicidal agents that inhibit d1 protease
AU7851387A (en) Protein kinase c enzymes
NZ326769A (en) High-content famciclovir tablets
AU4203789A (en) 1,4-dihydrothionapthoquinone and heterocyclic congeners which inhibit lipoxygenase enzymes
IL87327A0 (en) Aqueous enzyme compositions comprising proteolytic inhibitors as stabilizers
AU7624201A (en) A novel polypeptide, a human atp dependent-uncoiling enzyme protein 10 and the polynucleotide encoding the polypeptide
AU1436292A (en) Transglutaminase enzyme inhibitors
AU4116796A (en) Assay for the measurement of multilineage stem cells and methods of use thereof

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GE GH HU ID IL IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZW AM AZ BY KG KZ MD RU TJ TM

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH KE LS MW SD SZ UG ZW AT BE CH DE DK ES FI FR GB GR IE IT LU MC

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 1997950043

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 09297404

Country of ref document: US

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWP Wipo information: published in national office

Ref document number: 1997950043

Country of ref document: EP

NENP Non-entry into the national phase

Ref country code: CA

WWW Wipo information: withdrawn in national office

Ref document number: 1997950043

Country of ref document: EP