ATE313802T1 - Bestimmung von adrenomedullin-bindenden proteinen - Google Patents
Bestimmung von adrenomedullin-bindenden proteinenInfo
- Publication number
- ATE313802T1 ATE313802T1 AT00961705T AT00961705T ATE313802T1 AT E313802 T1 ATE313802 T1 AT E313802T1 AT 00961705 T AT00961705 T AT 00961705T AT 00961705 T AT00961705 T AT 00961705T AT E313802 T1 ATE313802 T1 AT E313802T1
- Authority
- AT
- Austria
- Prior art keywords
- methods
- complexes
- factor
- binding proteins
- provides
- Prior art date
Links
- 102000034273 adrenomedullin binding proteins Human genes 0.000 title 1
- 108091000485 adrenomedullin binding proteins Proteins 0.000 title 1
- ULCUCJFASIJEOE-NPECTJMMSA-N adrenomedullin Chemical compound C([C@@H](C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)NCC(=O)N[C@@H]1C(N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CSSC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(N)=O)[C@@H](C)O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](N)CC=1C=CC(O)=CC=1)C1=CC=CC=C1 ULCUCJFASIJEOE-NPECTJMMSA-N 0.000 abstract 13
- 102000004379 Adrenomedullin Human genes 0.000 abstract 11
- 101800004616 Adrenomedullin Proteins 0.000 abstract 11
- 238000000034 method Methods 0.000 abstract 6
- 102000023732 binding proteins Human genes 0.000 abstract 4
- 108091008324 binding proteins Proteins 0.000 abstract 4
- 102000016550 Complement Factor H Human genes 0.000 abstract 3
- 108010053085 Complement Factor H Proteins 0.000 abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 239000005557 antagonist Substances 0.000 abstract 2
- 201000011510 cancer Diseases 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 206010012601 diabetes mellitus Diseases 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- -1 AM/FH complexes Chemical class 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Pathology (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Zoology (AREA)
- Analytical Chemistry (AREA)
- Marine Sciences & Fisheries (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15339799P | 1999-09-10 | 1999-09-10 | |
| PCT/US2000/024722 WO2001018550A2 (en) | 1999-09-10 | 2000-09-08 | Determination of adrenomedullin-binding proteins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE313802T1 true ATE313802T1 (de) | 2006-01-15 |
Family
ID=22547062
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00961705T ATE313802T1 (de) | 1999-09-10 | 2000-09-08 | Bestimmung von adrenomedullin-bindenden proteinen |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US20070025915A1 (de) |
| EP (1) | EP1214600B1 (de) |
| AT (1) | ATE313802T1 (de) |
| AU (1) | AU774725B2 (de) |
| CA (1) | CA2383419A1 (de) |
| DE (1) | DE60025008T2 (de) |
| ES (1) | ES2254220T3 (de) |
| PT (1) | PT1214600E (de) |
| WO (1) | WO2001018550A2 (de) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7430081B2 (en) | 2002-02-28 | 2008-09-30 | Emcore Corporation | Sub-micron adjustable mount for supporting a component and method |
| CA2481399A1 (en) * | 2002-03-19 | 2003-09-25 | Oncorex, Inc. | Peptides and pharmaceutical compositions comprising said peptides for treating cancer |
| US7364719B2 (en) | 2002-10-04 | 2008-04-29 | The United States Of America As Represented By The Department Of Health And Human Services | Vasoregulating compounds and methods of their use |
| US7462593B2 (en) | 2002-11-07 | 2008-12-09 | Us Gov Health & Human Serv | Compositions and methods for promoting angiogenesis |
| WO2004097423A1 (en) * | 2003-04-25 | 2004-11-11 | Genova Ltd. | Secreted polypeptide species reduced cardiovascular disorders |
| CA2788502A1 (en) * | 2003-09-08 | 2005-03-24 | The Government Of The United States Of America, As Represented By The Se Cretary, Department Of Health And Human Services | Non-peptide agonists and antagonists of adrenomedullin and gastric releasing peptide |
| US8703693B2 (en) * | 2004-03-31 | 2014-04-22 | The Feinstein Institute For Medical Research | Adrenomedullin and adrenomedullin binding protein for ischemia/reperfusion treatment |
| CA2562957C (en) | 2004-03-31 | 2013-05-21 | The Feinstein Institute For Medical Research | Adrenomedullin and adrenomedullin binding protein for ischemia/reperfusion treatment |
| US20070280886A1 (en) * | 2004-09-09 | 2007-12-06 | Bayer Healthcare Ag | Diagnostics and Therapeutics for Diseases Associated with Adrenomedullin Receptor (Amdr) |
| US8906857B2 (en) * | 2005-12-01 | 2014-12-09 | B.R.A.H.M.S. Gmbh | Methods for the diagnosis and treatment of critically ill patients with endothelin, endothelin agonists and adrenomedullin antagonists |
| WO2007062676A1 (en) * | 2005-12-01 | 2007-06-07 | B.R.A.H.M.S. Aktiengesellschaft | Methods for the diagnosis and treatment of critically ill patients with endothelin, endothelin agonists and adrenomedullin antagonists |
| DE102006052916A1 (de) * | 2006-11-08 | 2008-05-15 | Brahms Aktiengesellschaft | Diagnose und Risikostratifizierung von Diabetes mellitus mittels MR-proADM |
| US8088715B2 (en) * | 2007-11-13 | 2012-01-03 | Ikonisys, Inc. | Detection of circulating tumor cells in peripheral blood with an automated scanning fluorescence microscope |
| ITMI20080357A1 (it) * | 2008-03-04 | 2009-09-05 | Sarm Allergeni Srl | Proteina da haliotis midae e suo uso come agente immunoterapico |
| EP2211182A1 (de) * | 2009-01-16 | 2010-07-28 | Roche Diagnostics GmbH | Verfahren zur Bewertung des Schweregrades einer Leberzirrhose |
| SG11201402354YA (en) | 2011-11-16 | 2014-06-27 | Adrenomed Ag | Anti-adrenomedullin (adm) antibody or anti-adm antibody fragment or anti-adm non-ig scaffold for regulating the fluid balance in a patient having a chronic or acute disease |
| HRP20170427T1 (hr) | 2011-11-16 | 2017-06-16 | Sphingotec Gmbh | Testovi na adrenomedulin i postupci određivanja zrelog adrenomedulina |
| FI3553084T3 (fi) | 2011-11-16 | 2023-03-03 | Adrenomed Ag | Anti-adrenomedulliinivasta-aine (ADM) tai anti-ADM-vasta-ainefragmentti tai anti-ADM-non-Ig-skaffoldi elimen toimintahäiriön tai elimen vajaatoiminnan ehkäisemiseksi tai pienentämiseksi kroonisen tai akuutin taudin tai akuutin tilan omaavassa potilaassa |
| JP6224608B2 (ja) | 2011-11-16 | 2017-11-01 | アドレノメト アクチェンゲゼルシャフト | 血液循環を安定化させるための、患者の急性疾患又は急性病態の治療法における使用に向けた、抗アドレノメデュリン（ＡＤＭ）抗体、抗ＡＤＭ抗体フラグメント又は抗ＡＤＭ非Ｉｇ足場 |
| EP2594588B1 (de) * | 2011-11-16 | 2014-05-21 | AdrenoMed AG | Anti-Adrenomedullin-Antikörper (ADM) oder Anti-ADM-Antikörperfragment oder Anti-ADM-non-Ig Proteingerüst zur Verwendung bei der Behandlung |
| US20150093331A1 (en) * | 2013-10-01 | 2015-04-02 | OncoLock Co., Ltd. | Biomarkers for breast cancer |
| WO2017100413A1 (en) * | 2015-12-08 | 2017-06-15 | The University Of North Carolina At Chapel Hill | Adrenomedullin therapy to improve fetal implantation |
| EP3438668A1 (de) * | 2017-08-04 | 2019-02-06 | B.R.A.H.M.S GmbH | Diagnose und risikostratifizierung von pilzinfektionen |
| JP2021500548A (ja) * | 2017-10-18 | 2021-01-07 | アドレノメト アクチェンゲゼルシャフト | 抗アドレノメデュリン（ａｄｍ）結合剤での処置下での治療モニタリング |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4444879A (en) * | 1981-01-29 | 1984-04-24 | Science Research Center, Inc. | Immunoassay with article having support film and immunological counterpart of analyte |
| JPH0742235B2 (ja) * | 1985-11-08 | 1995-05-10 | 三共株式会社 | 自己免疫性疾病の予防・治療剤 |
| US4774323A (en) * | 1987-06-29 | 1988-09-27 | Rorer Pharmaceutical Corporation | Purification of von Willebrand Factor solutions using gel permeation chromatography |
| US5641685A (en) * | 1995-04-24 | 1997-06-24 | Smithkline Beecham Corporation | Method carboxy terminal protein or peptide sequencing |
| DE69602756T2 (de) * | 1995-08-18 | 2000-02-10 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, Rockville | Funktionelle rolle von adrenomedullin(am) und dem gen-verwandten produkt(pamp) in der menschlichen pathologie und physiologie |
-
2000
- 2000-09-08 ES ES00961705T patent/ES2254220T3/es not_active Expired - Lifetime
- 2000-09-08 CA CA002383419A patent/CA2383419A1/en not_active Abandoned
- 2000-09-08 WO PCT/US2000/024722 patent/WO2001018550A2/en not_active Ceased
- 2000-09-08 AU AU73622/00A patent/AU774725B2/en not_active Ceased
- 2000-09-08 AT AT00961705T patent/ATE313802T1/de not_active IP Right Cessation
- 2000-09-08 DE DE60025008T patent/DE60025008T2/de not_active Expired - Lifetime
- 2000-09-08 PT PT00961705T patent/PT1214600E/pt unknown
- 2000-09-08 EP EP00961705A patent/EP1214600B1/de not_active Expired - Lifetime
-
2006
- 2006-09-08 US US11/530,411 patent/US20070025915A1/en not_active Abandoned
-
2008
- 2008-09-23 US US12/236,418 patent/US7659081B2/en not_active Expired - Fee Related
-
2009
- 2009-12-15 US US12/638,747 patent/US7993857B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU774725B2 (en) | 2004-07-08 |
| EP1214600B1 (de) | 2005-12-21 |
| CA2383419A1 (en) | 2001-03-15 |
| AU7362200A (en) | 2001-04-10 |
| US20100098703A1 (en) | 2010-04-22 |
| US7993857B2 (en) | 2011-08-09 |
| US7659081B2 (en) | 2010-02-09 |
| ES2254220T3 (es) | 2006-06-16 |
| DE60025008T2 (de) | 2006-09-14 |
| EP1214600A2 (de) | 2002-06-19 |
| WO2001018550A9 (en) | 2002-09-26 |
| US20070025915A1 (en) | 2007-02-01 |
| US20090053734A1 (en) | 2009-02-26 |
| PT1214600E (pt) | 2006-05-31 |
| WO2001018550A2 (en) | 2001-03-15 |
| DE60025008D1 (de) | 2006-01-26 |
| WO2001018550A3 (en) | 2001-08-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |