DE69615185D1 - Faktor ix bindende peptide abgeleitet von faktor vii und ihre verwendung als inhibitoren der blutgerinnung - Google Patents

Faktor ix bindende peptide abgeleitet von faktor vii und ihre verwendung als inhibitoren der blutgerinnung

Info

Publication number
DE69615185D1
DE69615185D1 DE69615185T DE69615185T DE69615185D1 DE 69615185 D1 DE69615185 D1 DE 69615185D1 DE 69615185 T DE69615185 T DE 69615185T DE 69615185 T DE69615185 T DE 69615185T DE 69615185 D1 DE69615185 D1 DE 69615185D1
Authority
DE
Germany
Prior art keywords
factor
peptides
blood coagulation
inhibitors
binding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69615185T
Other languages
English (en)
Other versions
DE69615185T2 (de
Inventor
Koenraad Mertens
Petrus Johannes Lenting
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Stichting Sanquin Bloedvoorziening
Original Assignee
Stichting Sanquin Bloedvoorziening
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stichting Sanquin Bloedvoorziening filed Critical Stichting Sanquin Bloedvoorziening
Publication of DE69615185D1 publication Critical patent/DE69615185D1/de
Application granted granted Critical
Publication of DE69615185T2 publication Critical patent/DE69615185T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/829—Blood
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/829—Blood
    • Y10S530/83—Plasma; serum

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE69615185T 1995-06-12 1996-06-12 Faktor ix bindende peptide abgeleitet von faktor vii und ihre verwendung als inhibitoren der blutgerinnung Expired - Fee Related DE69615185T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP95201554 1995-06-12
PCT/NL1996/000236 WO1996041816A1 (en) 1995-06-12 1996-06-12 Factor ix binding peptides, derived from factor viii and their use as inhibitors of blood coagulation

Publications (2)

Publication Number Publication Date
DE69615185D1 true DE69615185D1 (de) 2001-10-18
DE69615185T2 DE69615185T2 (de) 2002-06-13

Family

ID=8220373

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69615185T Expired - Fee Related DE69615185T2 (de) 1995-06-12 1996-06-12 Faktor ix bindende peptide abgeleitet von faktor vii und ihre verwendung als inhibitoren der blutgerinnung

Country Status (11)

Country Link
US (1) US6284871B1 (de)
EP (1) EP0833848B1 (de)
JP (1) JPH11507664A (de)
AT (1) ATE205506T1 (de)
AU (1) AU713303B2 (de)
CA (1) CA2221567A1 (de)
DE (1) DE69615185T2 (de)
DK (1) DK0833848T3 (de)
ES (1) ES2162068T3 (de)
PT (1) PT833848E (de)
WO (1) WO1996041816A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005535588A (ja) * 2002-04-29 2005-11-24 バクスター・インターナショナル・インコーポレイテッド 第ｖｉｉｉ因子と低密度リポタンパク質レセプター関連タンパク質との相互作用のアンタゴニスト
WO2004014844A2 (en) * 2002-08-09 2004-02-19 Transtech Pharma, Inc. Aryl and heteroaryl compounds and methods to modulate coagulation
US7459472B2 (en) * 2003-08-08 2008-12-02 Transtech Pharma, Inc. Aryl and heteroaryl compounds, compositions, and methods of use
US7208601B2 (en) * 2003-08-08 2007-04-24 Mjalli Adnan M M Aryl and heteroaryl compounds, compositions, and methods of use
CA2531796A1 (en) * 2003-08-08 2005-02-17 Transtech Pharma, Inc. Aryl and heteroaryl compounds, compositions, and methods of use
EP2103630B1 (de) * 2006-12-15 2011-11-16 Institute Of Radiation Medicine Academy Of Military Medical Sciences, PLA Herstellung von mit geringen blutungen assoziiertem gerinnungshemmendem fusionsprotein und dessen verwendung
WO2016166110A1 (en) 2015-04-13 2016-10-20 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for treatment of haemorrhagic diseases
JP6595247B2 (ja) * 2015-07-30 2019-10-23 シスメックス株式会社 凝固時間の測定方法およびその装置、凝固時間測定用試薬ならびに試薬キット

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA877535B (en) * 1986-10-09 1988-04-11 F. Hoffmann-La Roche & Co. Aktiengesellschaft Factor ix-peptides
AU5930890A (en) 1989-06-20 1991-01-08 Scripps Clinic And Research Foundation The phospholipid binding domain of factor viii
US5187155A (en) * 1989-06-23 1993-02-16 Board Of Regents, The University Of Texas System Anticoagulant peptides
BE1008491A3 (fr) * 1994-07-14 1996-05-07 Croix Rouge De Belgique Depart Sequence polypeptidique antigenique du facteur viii, fragments et/ou epitopes de celle-ci.
DE69740154D1 (de) * 1996-04-24 2011-05-05 Univ Michigan Gegen Inaktivierung resistenter Faktor VIII

Also Published As

Publication number Publication date
AU713303B2 (en) 1999-11-25
US6284871B1 (en) 2001-09-04
CA2221567A1 (en) 1996-12-27
DK0833848T3 (da) 2001-11-05
AU6017796A (en) 1997-01-09
WO1996041816A1 (en) 1996-12-27
EP0833848A1 (de) 1998-04-08
ES2162068T3 (es) 2001-12-16
ATE205506T1 (de) 2001-09-15
EP0833848B1 (de) 2001-09-12
DE69615185T2 (de) 2002-06-13
JPH11507664A (ja) 1999-07-06
PT833848E (pt) 2002-01-30

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee