ES2162068T3 - Peptidos que ligan el factor ix, derivados del factor viii y su utilizacion como inhibidores de la coagulacion de la sangre. - Google Patents

Peptidos que ligan el factor ix, derivados del factor viii y su utilizacion como inhibidores de la coagulacion de la sangre.

Info

Publication number
ES2162068T3
ES2162068T3 ES96917727T ES96917727T ES2162068T3 ES 2162068 T3 ES2162068 T3 ES 2162068T3 ES 96917727 T ES96917727 T ES 96917727T ES 96917727 T ES96917727 T ES 96917727T ES 2162068 T3 ES2162068 T3 ES 2162068T3
Authority
ES
Spain
Prior art keywords
factor
peptides
blood coagulation
viii
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96917727T
Other languages
English (en)
Inventor
Koenraad Mertens
Petrus Johannes Lenting
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Stichting Sanquin Bloedvoorziening
Original Assignee
Stichting Sanquin Bloedvoorziening
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stichting Sanquin Bloedvoorziening filed Critical Stichting Sanquin Bloedvoorziening
Application granted granted Critical
Publication of ES2162068T3 publication Critical patent/ES2162068T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/829—Blood
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/829—Blood
    • Y10S530/83—Plasma; serum

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

ESTA INVENCION ESTA RELACIONADA CON PEPTIDOS BIOLOGICAMENTE ACTIVOS QUE INHIBEN ESPECIFICAMENTE LA VIA DE COAGULACION SANGUINEA DEPENDIENTE DEL FACTOR IX. ESTOS PEPTIDOS ESTAN BASADOS EN UN TEMA ESPECIFICO QUE REPRESENTA UNA SECUENCIA DEL FACTOR VIII (AMINOACIDO 1811-1818) QUE INTERVIENE EN LA FIJACION DEL FACTOR IX ACTIVADO ASI COMO DEL CIMOGENO DEL FACTOR IX INTACTO. LA FIJACION DE LOS PEPTIDOS CITADOS AL FACTOR IX O A DERIVADOS SIMILARES ACTIVADOS, INHIBE EFICAZMENTE LA UNION COMPLEJA CON EL FACTOR VIII. POR CONSIGUIENTE, ESTOS PEPTIDOS INTERFIEREN ESPECIFICAMENTE LA VIA DE FORMACION DE TROMBINA DEPENDIENTE DEL FACTOR IX, SIN AFECTAR A OTRAS VIAS HEMOSTATICAS. EN VIRTUD DE ESTA ESPECIFICIDAD UNICA, LOS PEPTIDOS DE ESTA INVENCION SON PARTICULARMENTE UTILES EN NUEVAS COMPOSICIONES FARMACEUTICAS PARA EL TRATAMIENTO DE ENFERMEDADES TROMBOTICAS.
ES96917727T 1995-06-12 1996-06-12 Peptidos que ligan el factor ix, derivados del factor viii y su utilizacion como inhibidores de la coagulacion de la sangre. Expired - Lifetime ES2162068T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP95201554 1995-06-12

Publications (1)

Publication Number Publication Date
ES2162068T3 true ES2162068T3 (es) 2001-12-16

Family

ID=8220373

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96917727T Expired - Lifetime ES2162068T3 (es) 1995-06-12 1996-06-12 Peptidos que ligan el factor ix, derivados del factor viii y su utilizacion como inhibidores de la coagulacion de la sangre.

Country Status (11)

Country Link
US (1) US6284871B1 (es)
EP (1) EP0833848B1 (es)
JP (1) JPH11507664A (es)
AT (1) ATE205506T1 (es)
AU (1) AU713303B2 (es)
CA (1) CA2221567A1 (es)
DE (1) DE69615185T2 (es)
DK (1) DK0833848T3 (es)
ES (1) ES2162068T3 (es)
PT (1) PT833848E (es)
WO (1) WO1996041816A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2484155C (en) * 2002-04-29 2015-10-13 Baxter International Inc. Antagonists of factor viii interaction with low-density lipoprotein receptor-related protein
US7122580B2 (en) * 2002-08-09 2006-10-17 Transtech Pharma, Inc. Aryl and heteroaryl compounds and methods to modulate coagulation
US7208601B2 (en) * 2003-08-08 2007-04-24 Mjalli Adnan M M Aryl and heteroaryl compounds, compositions, and methods of use
WO2005014533A2 (en) * 2003-08-08 2005-02-17 Transtech Pharma, Inc. Aryl and heteroaryl compounds, compositions, and methods of use
WO2005014534A1 (en) 2003-08-08 2005-02-17 Transtech Pharma, Inc. Aryl and heteroaryl compounds, compositions, and methods of use
US8101379B2 (en) * 2006-12-15 2012-01-24 Institute of Radiation Medicine Academy of Military Medical Science Preparation of low bleeding anticoagulant fusion protein and its use
EP3283108B1 (en) 2015-04-13 2020-10-14 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for treatment of haemorrhagic diseases
JP6595247B2 (ja) * 2015-07-30 2019-10-23 シスメックス株式会社 凝固時間の測定方法およびその装置、凝固時間測定用試薬ならびに試薬キット

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA877535B (en) * 1986-10-09 1988-04-11 F. Hoffmann-La Roche & Co. Aktiengesellschaft Factor ix-peptides
WO1990015615A1 (en) 1989-06-20 1990-12-27 Scripps Clinic And Research Foundation The phospholipid binding domain of factor viii
US5187155A (en) * 1989-06-23 1993-02-16 Board Of Regents, The University Of Texas System Anticoagulant peptides
BE1008491A3 (fr) 1994-07-14 1996-05-07 Croix Rouge De Belgique Depart Sequence polypeptidique antigenique du facteur viii, fragments et/ou epitopes de celle-ci.
DE69740154D1 (de) * 1996-04-24 2011-05-05 Univ Michigan Gegen Inaktivierung resistenter Faktor VIII

Also Published As

Publication number Publication date
EP0833848B1 (en) 2001-09-12
WO1996041816A1 (en) 1996-12-27
AU6017796A (en) 1997-01-09
AU713303B2 (en) 1999-11-25
PT833848E (pt) 2002-01-30
DK0833848T3 (da) 2001-11-05
JPH11507664A (ja) 1999-07-06
ATE205506T1 (de) 2001-09-15
EP0833848A1 (en) 1998-04-08
US6284871B1 (en) 2001-09-04
CA2221567A1 (en) 1996-12-27
DE69615185T2 (de) 2002-06-13
DE69615185D1 (de) 2001-10-18

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