PT866870E - Proteinas de fusao factor tecidual-dominio de kunitz como inibidores do factor viia - Google Patents

Proteinas de fusao factor tecidual-dominio de kunitz como inibidores do factor viia

Info

Publication number
PT866870E
PT866870E PT96940592T PT96940592T PT866870E PT 866870 E PT866870 E PT 866870E PT 96940592 T PT96940592 T PT 96940592T PT 96940592 T PT96940592 T PT 96940592T PT 866870 E PT866870 E PT 866870E
Authority
PT
Portugal
Prior art keywords
factor
domain
kunitz
fusion proteins
viia inhibitors
Prior art date
Application number
PT96940592T
Other languages
English (en)
Inventor
Robert A Lazarus
Robert F Kelley
Geoffrey F Lee
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/566,800 external-priority patent/US5736364A/en
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of PT866870E publication Critical patent/PT866870E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8114—Kunitz type inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PT96940592T 1995-12-01 1996-11-22 Proteinas de fusao factor tecidual-dominio de kunitz como inibidores do factor viia PT866870E (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US56645995A 1995-12-01 1995-12-01
US08/566,800 US5736364A (en) 1995-12-04 1995-12-04 Factor viia inhibitors

Publications (1)

Publication Number Publication Date
PT866870E true PT866870E (pt) 2003-08-29

Family

ID=27074189

Family Applications (1)

Application Number Title Priority Date Filing Date
PT96940592T PT866870E (pt) 1995-12-01 1996-11-22 Proteinas de fusao factor tecidual-dominio de kunitz como inibidores do factor viia

Country Status (8)

Country Link
EP (1) EP0866870B1 (pt)
AT (1) ATE234359T1 (pt)
AU (1) AU1023497A (pt)
DE (1) DE69626671T2 (pt)
DK (1) DK0866870T3 (pt)
ES (1) ES2195025T3 (pt)
PT (1) PT866870E (pt)
WO (1) WO1997020939A1 (pt)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6214333B1 (en) * 1997-07-08 2001-04-10 Texas Heart Institute Vasoprotective recombinant adenovirus vector containing a human TFPI gene
WO2000004148A1 (en) 1998-07-15 2000-01-27 Genentech, Inc. Tissue factor protein variants with increased affinity for coagulation factor fvii/fviia
AU781618C (en) 1999-07-02 2006-03-16 Genentech Inc. FVIIa antagonists
CA2380633A1 (en) * 1999-08-06 2001-02-15 Genentech, Inc. Peptide antagonists of factor viia
US6905683B2 (en) 2000-05-03 2005-06-14 Novo Nordisk Healthcare A/G Human coagulation factor VII variants
US7176288B2 (en) 2000-09-13 2007-02-13 Novo Nordisk Healthcare A/G Human coagulation factor VII variants
AU2002218029A1 (en) 2000-11-09 2002-05-21 The Scripps Research Institute Modified factor viia
US7052868B2 (en) 2001-09-27 2006-05-30 Novo Nordisk Healthcare A/G Human coagulation factor VII polypeptides
US6960657B2 (en) 2001-11-02 2005-11-01 Novo Nordisk Healthcare A/G Human coagulation factor VII polypeptides
US7164002B2 (en) 2002-02-06 2007-01-16 Genentech, Inc. FVIIa antagonists
US6911323B2 (en) 2002-09-25 2005-06-28 Novo Nordisk Healthcare A/G Human coagulation factor VII polypeptides
CN101870729A (zh) 2003-09-09 2010-10-27 诺和诺德医疗保健公司 凝固因子ⅶ多肽
WO2007115953A1 (en) * 2006-04-07 2007-10-18 Novo Nordisk Health Care Ag Covalent factor vii-tissue factor complex
KR20230104617A (ko) * 2020-10-07 2023-07-10 드렌 바이오, 인크. 항-덱틴-1 항체 및 이의 사용 방법
US20240108688A1 (en) 2020-11-20 2024-04-04 Universitätsmedizin Der Johannes Gutenberg-Universität Mainz Inhibitors of the tissue factor-protease activated receptor 2 (TF-PAR2) signaling pathway for use in the treatment or prevention of heart failure (HF) and associated or resulting diseases

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0439442B1 (en) * 1990-01-25 1996-03-06 Washington University Factor x-laci hybrid protein
US5346991A (en) * 1991-06-13 1994-09-13 Genentech, Inc. Tissue factor mutants useful for the treatment of myocardial infarction and coagulopathic disorders
AU7050994A (en) * 1993-06-01 1994-12-20 Scripps Research Institute, The Human mutant tissue factor compositions useful as tissue factor antagonists
US5795954A (en) * 1994-03-04 1998-08-18 Genentech, Inc. Factor VIIa inhibitors from Kunitz domain proteins

Also Published As

Publication number Publication date
EP0866870B1 (en) 2003-03-12
AU1023497A (en) 1997-06-27
DE69626671T2 (de) 2004-03-18
ATE234359T1 (de) 2003-03-15
DK0866870T3 (da) 2003-06-23
WO1997020939A1 (en) 1997-06-12
ES2195025T3 (es) 2003-12-01
DE69626671D1 (de) 2003-04-17
EP0866870A1 (en) 1998-09-30

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