ES2178157T3 - Tratamiento de arritmias mediante la inhibicion de una proteina quinasa multifuncional dependiente de calcio/calmodulina. - Google Patents

Tratamiento de arritmias mediante la inhibicion de una proteina quinasa multifuncional dependiente de calcio/calmodulina.

Info

Publication number
ES2178157T3
ES2178157T3 ES98904783T ES98904783T ES2178157T3 ES 2178157 T3 ES2178157 T3 ES 2178157T3 ES 98904783 T ES98904783 T ES 98904783T ES 98904783 T ES98904783 T ES 98904783T ES 2178157 T3 ES2178157 T3 ES 2178157T3
Authority
ES
Spain
Prior art keywords
calmodulin
calcium
treatment
arritmias
inhibition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98904783T
Other languages
English (en)
Inventor
Mark E Anderson
Andrew P Braun
Howard Schulman
Ruey J Sung
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Leland Stanford Junior University
Original Assignee
Leland Stanford Junior University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leland Stanford Junior University filed Critical Leland Stanford Junior University
Application granted granted Critical
Publication of ES2178157T3 publication Critical patent/ES2178157T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Abstract

LA INVENCION SUMINISTRA UN PROCEDIMIENTO PARA TRATAR O PREVENIR LAS ARRITMIAS EN UN SUJETO HUMANO QUE COMPRENDE LA ADMINISTRACION DE UNA CANTIDAD EFECTIVA DE UN INHIBIDOR DE LA QUINASA DE LA PROTEINA DEPENDIENTE DEL CALCIO/CALMODULINA. TAMBIEN SE SUMINISTRAN COMPOSICIONES FARMACEUTICAS QUE COMPRENDEN EL INHIBIDOR DE LA QUINASA DE LA PROTEINA DEPENDIENTES DEL CALCIO/LA CALMODULINA Y UN EXCIPIENTE FARMACOLOGICAMENTE ACEPTABLE Y PROCEDIMIENTOS PARA IDENTIFICAR AGENTES UTILES PARA EL TRATAMIENTO DE LAS ARRITMIAS.
ES98904783T 1997-01-31 1998-01-30 Tratamiento de arritmias mediante la inhibicion de una proteina quinasa multifuncional dependiente de calcio/calmodulina. Expired - Lifetime ES2178157T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US3683397P 1997-01-31 1997-01-31

Publications (1)

Publication Number Publication Date
ES2178157T3 true ES2178157T3 (es) 2002-12-16

Family

ID=21890905

Family Applications (1)

Application Number Title Priority Date Filing Date
ES98904783T Expired - Lifetime ES2178157T3 (es) 1997-01-31 1998-01-30 Tratamiento de arritmias mediante la inhibicion de una proteina quinasa multifuncional dependiente de calcio/calmodulina.

Country Status (8)

Country Link
US (2) US6518245B1 (es)
EP (1) EP0966274B1 (es)
JP (1) JP2001509808A (es)
AT (1) ATE218854T1 (es)
AU (1) AU6257798A (es)
DE (1) DE69805973T2 (es)
ES (1) ES2178157T3 (es)
WO (1) WO1998033491A2 (es)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004506442A (ja) * 2000-08-25 2004-03-04 メルク　パテント　ゲゼルシャフト　ミット　ベシュレンクテル　ハフトング ＣａＭ−キナーゼＩＩ阻害剤の同定
US7369890B2 (en) * 2000-11-02 2008-05-06 Cardiac Pacemakers, Inc. Technique for discriminating between coordinated and uncoordinated cardiac rhythms
US6689117B2 (en) * 2000-12-18 2004-02-10 Cardiac Pacemakers, Inc. Drug delivery system for implantable medical device
DE10126405A1 (de) * 2001-05-22 2003-02-27 Trommsdorff Gmbh & Co Physiologisch verträgliche Kalium- und Magnesiumsalze enthaltendes pharmazeutisches Präparat sowie dessen Verwendung zur Prophylaxe und/oder Therapie von QT-Zeitverlängerungen
US7493162B2 (en) * 2001-06-15 2009-02-17 Cardiac Pacemakers, Inc. Pulmonary vein stent for treating atrial fibrillation
US7209783B2 (en) * 2001-06-15 2007-04-24 Cardiac Pacemakers, Inc. Ablation stent for treating atrial fibrillation
US7340303B2 (en) * 2001-09-25 2008-03-04 Cardiac Pacemakers, Inc. Evoked response sensing for ischemia detection
MXPA04003040A (es) * 2001-10-01 2004-07-15 Vanderbil University Uso de inhibidores de calmodulin quinasa ii para tratar la disfuncion miocardica en la enfermedad de corazon estructural.
US20030153951A1 (en) * 2002-02-08 2003-08-14 Ideker Raymond E. Methods and devices for treating arrhythmias using defibrillation shocks
WO2003088978A1 (en) * 2002-04-18 2003-10-30 Cv Therapeutics, Inc. Method of treating arrhythmias comprising administration of an a1 adenosine agonist with a beta blocker, calcium channel blocker or a cardiac glycoside
US7072711B2 (en) * 2002-11-12 2006-07-04 Cardiac Pacemakers, Inc. Implantable device for delivering cardiac drug therapy
US20040158289A1 (en) * 2002-11-30 2004-08-12 Girouard Steven D. Method and apparatus for cell and electrical therapy of living tissue
US7627373B2 (en) * 2002-11-30 2009-12-01 Cardiac Pacemakers, Inc. Method and apparatus for cell and electrical therapy of living tissue
US20100113563A1 (en) * 2004-01-30 2010-05-06 Zaijie Wang Method for Treating Pain with a Calmodulin Inhibitor
US7256200B2 (en) * 2003-02-10 2007-08-14 The Board Of Trustees Of The University Of Illinois, A Body Corporate And Politic Of The State Of Illinois Method and composition for potentiating an oplate analgesic
US7320675B2 (en) 2003-08-21 2008-01-22 Cardiac Pacemakers, Inc. Method and apparatus for modulating cellular metabolism during post-ischemia or heart failure
US20050137626A1 (en) * 2003-12-19 2005-06-23 Pastore Joseph M. Drug delivery system and method employing external drug delivery device in conjunction with computer network
US7840263B2 (en) * 2004-02-27 2010-11-23 Cardiac Pacemakers, Inc. Method and apparatus for device controlled gene expression
US20050245972A1 (en) * 2004-04-29 2005-11-03 Medtronic, Inc. Apparatus and methods for treating arrhythmia and lowering defibrillation threshold
US7764995B2 (en) 2004-06-07 2010-07-27 Cardiac Pacemakers, Inc. Method and apparatus to modulate cellular regeneration post myocardial infarct
US20060079445A1 (en) * 2004-06-16 2006-04-13 Pitt Geoffrey S CaMKII/calcium channel binding-related compositions and methods
WO2006007422A2 (en) * 2004-06-16 2006-01-19 The Trustees Fo Columbia University In The City Of New York CaMKII/CALCIUM CHANNEL PHOSPHORYLATION-RELATED COMPOSITIONS AND METHODS
US7828711B2 (en) * 2004-08-16 2010-11-09 Cardiac Pacemakers, Inc. Method and apparatus for modulating cellular growth and regeneration using ventricular assist device
US7567841B2 (en) * 2004-08-20 2009-07-28 Cardiac Pacemakers, Inc. Method and apparatus for delivering combined electrical and drug therapies
US7981065B2 (en) 2004-12-20 2011-07-19 Cardiac Pacemakers, Inc. Lead electrode incorporating extracellular matrix
US8060219B2 (en) * 2004-12-20 2011-11-15 Cardiac Pacemakers, Inc. Epicardial patch including isolated extracellular matrix with pacing electrodes
US7499748B2 (en) * 2005-04-11 2009-03-03 Cardiac Pacemakers, Inc. Transvascular neural stimulation device
US7617003B2 (en) * 2005-05-16 2009-11-10 Cardiac Pacemakers, Inc. System for selective activation of a nerve trunk using a transvascular reshaping lead
US7616990B2 (en) * 2005-10-24 2009-11-10 Cardiac Pacemakers, Inc. Implantable and rechargeable neural stimulator
US8841423B2 (en) 2008-04-28 2014-09-23 University Of Iowa Research Foundation Monoclonal antibodies specific for oxidized calcium/calmodulin dependent protein kinase II
EP2699152B1 (en) 2011-04-22 2015-11-04 Topera, Inc. Basket style cardiac mapping catheter having an atraumatic basket tip for detection of cardiac rhythm disorders
AU2014225889B2 (en) 2013-03-06 2018-12-06 The Johns Hopkins University CaMKII inhibitors and uses thereof
CN107074856A (zh) 2014-09-05 2017-08-18 阿略斯泰罗斯医疗公司 CaMKII抑制剂及其用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5089526A (en) * 1983-05-23 1992-02-18 Bristol-Myers Company Antiarrhythmic class III process
CA1290813C (en) * 1985-08-12 1991-10-15 Michael B. Sweeney Pacemaker for detecting and terminating a tachycardia
US4860749A (en) * 1988-01-06 1989-08-29 Wayne State University Tachycardia detection for automatic implantable cardioverter/defibrillator with atrial and ventricular sensing capability
IT1225572B (it) 1988-11-07 1990-11-22 Giocondo Baggio Procedimento di palissonatura per pelli e macchina atta a realizzare tale procedimento.
JPH0753505A (ja) * 1992-10-01 1995-02-28 Hokuriku Seiyaku Co Ltd ベンゼンスルホンアミド誘導体及びその用途

Also Published As

Publication number Publication date
ATE218854T1 (de) 2002-06-15
WO1998033491A3 (en) 1999-02-18
EP0966274A2 (en) 1999-12-29
US6518245B1 (en) 2003-02-11
US7251525B2 (en) 2007-07-31
DE69805973D1 (de) 2002-07-18
AU6257798A (en) 1998-08-25
WO1998033491A2 (en) 1998-08-06
DE69805973T2 (de) 2002-12-19
EP0966274B1 (en) 2002-06-12
US20030134777A1 (en) 2003-07-17
JP2001509808A (ja) 2001-07-24

Similar Documents

Publication Publication Date Title
ES2178157T3 (es) Tratamiento de arritmias mediante la inhibicion de una proteina quinasa multifuncional dependiente de calcio/calmodulina.
EA200100572A1 (ru) Способ применения ингибитора циклооксигеназы-2 и одного или нескольких противоопухолевых лекарственных средств в качестве комбинированного способа лечебного воздействия при лечении неоплазии
EP1045636A4 (en) PHARMACEUTICAL COMPOSITIONS AND METHOD OF USING THE SAME FOR TREATING FAILURE MYOCARDIAL TISSUES
IL125735A (en) Pharmaceutical compositions for the treatment of glaucoma comprising an inhibitor of serine-threonine kinase, tyrosine kinase or protein tyrosine phosphatase or an actin-disrupting compound
ATE235481T1 (de) Substituierte benzopyranderivate zur behandlung von entzündungen
ATE334668T1 (de) Pharmazeutische zusammensetzung zur behandlung von neurologischen und neuropsychiatrischen erkrankungen
ATE265857T1 (de) Pharmazeutische oder diätetische zusammensetzung zur prävention oder behandlung von hyperoxalurie
DE69835011D1 (de) Unterschiedliche behandlung von prothesenteilen
NO985652D0 (no) Anvendelse av naaladaseinhibitorer ved behandling av kreft
DE60001735D1 (de) 1-aminotriazolo 4,3-a chinazolin-5-one und/oder -thione inhibitoren von phosphodiesterasen iv
DE69806801T2 (de) Galenische präparation zur prävention und behandlung von hepatokarzinomen
NO20004419D0 (no) Ny anvendelse
ES2189252T3 (es) Composiciones analgesicas que comprenden un antagonista de la colecistoquinina y un opioide.
ID18382A (id) Komposisi sediaan farmasi dan metoda pengobatan gangguan kompulsif dengan menggunakan inhibitor naaladase
EE9800203A (et) ACE-inhibiitorite uus meditsiiniline kasutamine düspeptiliste sümptomite raviks
DE69721484D1 (de) Nukleosidderivative in kombinationspräparaten zur behandlung von hsv krankheiten
IL139144A0 (en) Mycobacterial inhibitors
ATE346840T1 (de) Aminoalkylphenol-derivate zur behandlung von depression und gedächtnis-funktionsstörung
ES2190581T3 (es) 2-aminotetralina opticamente activa, procedimiento para su preparacion y composiciones farmaceuticas que la contienen, activa en la prevencion y tratamiento de shock septico.
NO984196D0 (no) Fremgangsmåte for behandling av stoffmisbruk
MY140504A (en) Statin-mmp inhibitor combinations
NO984198L (no) FremgangsmÕte for behandling av aggresjon
PT1313500E (pt) Associacoes de dalfopristina/quinupristina com o cefpirome
BR1101180A (pt) formulação para tratamento de sintomas e doenças.
DE69822628D1 (de) Zur vorbeugung oder behandlung von östrogenabhängigen krankheiten nützliche pyrrolo[2.1.5-cd]indolizin-derivate