AU2002218029A1 - Modified factor viia - Google Patents

Modified factor viia

Info

Publication number
AU2002218029A1
AU2002218029A1 AU2002218029A AU1802902A AU2002218029A1 AU 2002218029 A1 AU2002218029 A1 AU 2002218029A1 AU 2002218029 A AU2002218029 A AU 2002218029A AU 1802902 A AU1802902 A AU 1802902A AU 2002218029 A1 AU2002218029 A1 AU 2002218029A1
Authority
AU
Australia
Prior art keywords
factor viia
modified factor
modified
viia
factor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2002218029A
Inventor
Ramona J. Petrovan
Wolfram Ruf
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Scripps Research Institute
Original Assignee
Scripps Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scripps Research Institute filed Critical Scripps Research Institute
Publication of AU2002218029A1 publication Critical patent/AU2002218029A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6437—Coagulation factor VIIa (3.4.21.21)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21021—Coagulation factor VIIa (3.4.21.21)
AU2002218029A 2000-11-09 2001-11-09 Modified factor viia Abandoned AU2002218029A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US24758900P 2000-11-09 2000-11-09
US60247589 2000-11-09
PCT/US2001/047329 WO2002038162A1 (en) 2000-11-09 2001-11-09 MODIFIED FACTOR VIIa

Publications (1)

Publication Number Publication Date
AU2002218029A1 true AU2002218029A1 (en) 2002-05-21

Family

ID=22935495

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2002218029A Abandoned AU2002218029A1 (en) 2000-11-09 2001-11-09 Modified factor viia

Country Status (3)

Country Link
US (1) US7173000B2 (en)
AU (1) AU2002218029A1 (en)
WO (1) WO2002038162A1 (en)

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US6747003B1 (en) 1997-10-23 2004-06-08 Regents Of The University Of Minnesota Modified vitamin K-dependent polypeptides
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US7812132B2 (en) 2000-04-28 2010-10-12 Regents Of The University Of Minnesota Modified vitamin K-dependent polypeptides
US7220837B1 (en) 2000-04-28 2007-05-22 Regents Of The University Of Minnesota Modified vitamin K-dependent polypeptides
US6905683B2 (en) * 2000-05-03 2005-06-14 Novo Nordisk Healthcare A/G Human coagulation factor VII variants
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US7052868B2 (en) 2001-09-27 2006-05-30 Novo Nordisk Healthcare A/G Human coagulation factor VII polypeptides
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US6960657B2 (en) 2001-11-02 2005-11-01 Novo Nordisk Healthcare A/G Human coagulation factor VII polypeptides
IL162239A0 (en) 2001-12-21 2005-11-20 Novo Nordisk Healthcare Ag Liquid composition of factor vii polypeptides
KR20040065278A (en) * 2001-12-21 2004-07-21 노보 노르디스크 에이/에스 Liquid composition of modified factor vii polypeptides
DK1499719T3 (en) 2002-04-30 2011-02-28 Bayer Healthcare Llc Factor VII or VIIa polypeptide variants
US20040009918A1 (en) * 2002-05-03 2004-01-15 Hanne Nedergaard Stabilised solid compositions of modified factor VII
KR101212025B1 (en) * 2002-06-21 2013-01-09 노보 노르디스크 헬스 케어 악티엔게젤샤프트 Stabilised solid compositions of factor ⅶ polypeptides
US6911323B2 (en) 2002-09-25 2005-06-28 Novo Nordisk Healthcare A/G Human coagulation factor VII polypeptides
AU2003266931B2 (en) * 2002-09-30 2010-01-21 Bayer Healthcare Llc FVII or FVIIa variants having increased clotting activity
CN1761747A (en) 2003-03-18 2006-04-19 诺和诺德医疗保健公司 Method for the production of GLA-residue containing serine proteases
AU2004222625A1 (en) * 2003-03-18 2004-09-30 Novo Nordisk Health Care Ag Liquid, aqueous, pharmaceutical compositions of factor VII polypeptides
EP2085470B1 (en) 2003-03-20 2012-05-16 Bayer HealthCare LLC FVII or FVIIa variants
US7897734B2 (en) * 2003-03-26 2011-03-01 Novo Nordisk Healthcare Ag Method for the production of proteins
ATE454900T1 (en) * 2003-05-23 2010-01-15 Novo Nordisk Healthcare Ag STABILIZATION OF PROTEINS IN SOLUTION
BRPI0411650A (en) 2003-06-19 2006-08-08 Maxygen Holdings Ltd polypeptide variant of factor vii (fvii) or factor viia (fviia), nucleotide sequence, expression vector, host cell, composition, use of a variant, and method for treating a mammal having a disease or disorder in which clot formation is desirable
DE602004023848D1 (en) * 2003-07-01 2009-12-10 Novo Nordisk Healthcare Ag OF FACTOR VII POLYPEPTIDES
CN102872451A (en) * 2003-08-14 2013-01-16 诺和诺德医疗保健公司 Liquid composition of factor vii polypeptides
EP2392655A3 (en) * 2003-09-09 2012-02-29 Novo Nordisk Health Care AG Coagulation factor VII polypeptides
EP1664291B1 (en) * 2003-09-09 2012-02-29 Novo Nordisk Health Care AG Coagulation factor vii polypeptides
DK1711513T3 (en) 2003-12-01 2014-09-15 Novo Nordisk Healthcare Ag Nanofiltration of factor VII solutions to remove virus
KR20130026498A (en) 2003-12-19 2013-03-13 노보 노르디스크 헬스 케어 악티엔게젤샤프트 Stabilised compositions of factor vii polypeptides
CA2552043A1 (en) 2004-01-21 2005-08-04 Novo Nordisk A/S Transglutaminase mediated conjugation of peptides
ATE469216T1 (en) 2004-08-17 2010-06-15 Csl Behring Gmbh MODIFIED VITAMIN K DEPENDENT POLYPEPTIDES
BRPI0519626A2 (en) 2004-12-23 2009-02-25 Novo Nordisk Healthcare Ag Methods for reducing the content of one or more contaminants, the protein content in a composition, the content of one or more protein contaminants in a cell culture supernatant, the protein content in a cell culture supernatant. , composition comprising a vitamin k-dependent protein of interest
EP1893632B1 (en) 2005-06-17 2015-08-12 Novo Nordisk Health Care AG Selective reduction and derivatization of engineered factor vii proteins comprising at least one non-native cysteine
US7696318B2 (en) 2005-07-13 2010-04-13 Novo Nordisk Health Care Ag Host cell protein knock-out cells for production of therapeutic proteins
US8127396B2 (en) * 2005-07-20 2012-03-06 Optimus Services Ag Robotic floor cleaning with sterile, disposable cartridges
ES2515915T3 (en) 2005-09-01 2014-10-30 Novo Nordisk Health Care Ag Purification of Factor VII polypeptides by hydrophobic interaction chromatography
EP1926817A2 (en) 2005-09-14 2008-06-04 Novo Nordisk Health Care AG Human coagulation factor vii polypeptides
EP1929005A1 (en) * 2005-09-21 2008-06-11 Novo Nordisk Health Care AG Human coagulation factor vii polypeptides
WO2008009634A2 (en) * 2006-07-17 2008-01-24 Novo Nordisk Health Care Ag Factor viia analogues with increased activity for treating thrombocytopenia
ES2531934T3 (en) 2006-09-01 2015-03-20 Novo Nordisk Health Care Ag Modified glycoproteins
KR20150067772A (en) 2007-04-13 2015-06-18 카탈리스트 바이오사이언시즈, 인코포레이티드 Modified factor VII polypeptides and uses thereof
FR2917414B1 (en) * 2007-06-15 2012-07-13 Lab Francais Du Fractionnement MODIFIED HUMAN FACTOR VII / VIIA AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME
PL2574677T3 (en) 2007-12-27 2017-12-29 Baxalta GmbH Cell culture processes
TWI538916B (en) * 2008-04-11 2016-06-21 介控生化科技公司 Factor vii polypeptides that are modified and uses thereof
KR102210133B1 (en) 2009-06-09 2021-02-01 프로롱 파마슈티컬스, 엘엘씨 Hemoglobin compositions
JP2013533871A (en) 2010-06-30 2013-08-29 ノヴォ ノルディスク アー／エス Antibodies capable of specific binding to tissue factor pathway inhibitors
RU2013142015A (en) 2011-03-02 2015-04-10 Ново Нордиск А/С TARGETING THE BLOOD COAGING FACTORS TO THE TLT-1 RECEPTOR ON THE SURFACE OF ACTIVATED Platelets
WO2012170969A2 (en) 2011-06-10 2012-12-13 Biogen Idec Ma Inc. Pro-coagulant compounds and methods of use thereof
JP2015534573A (en) 2012-10-10 2015-12-03 ノヴォ・ノルディスク・ヘルス・ケア・アーゲー Liquid pharmaceutical composition of factor VII polypeptide
US20210069306A1 (en) 2019-08-15 2021-03-11 Catalyst Biosciences, Inc. Modified factor vii polypeptides for subcutaneous administration and on-demand treatment

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JP3330932B2 (en) * 1990-01-29 2002-10-07 ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト Anticoagulant protein
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WO1994007515A1 (en) 1992-10-06 1994-04-14 The Scripps Research Institute Mutant tissue factor lacking factor vii activation activity
ATE210458T1 (en) 1993-05-21 2001-12-15 Zymogenetics Inc MODIFIED FACTOR VII TO INHIBIT VASCULAR RESTENOSIS AND THROMBOCYTE DEPOSITION
US5736364A (en) * 1995-12-04 1998-04-07 Genentech, Inc. Factor viia inhibitors
DE69626671T2 (en) 1995-12-01 2004-03-18 Genentech, Inc., South San Francisco FUSION PROTEINS CONSISTING OF FABRIC FACTOR KUNITZ DOMAIN AS INHIBITORS OF FACTOR VIIA
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US5994296A (en) * 1998-03-05 1999-11-30 The Scripps Research Institute Human mutant tissue factor compositions useful as tissue factor antagonists
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RU2278123C2 (en) * 2000-02-11 2006-06-20 Максиджен Холдингз Лтд. Molecules similar to factor vii or viia
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US6960657B2 (en) * 2001-11-02 2005-11-01 Novo Nordisk Healthcare A/G Human coagulation factor VII polypeptides

Also Published As

Publication number Publication date
US7173000B2 (en) 2007-02-06
WO2002038162A1 (en) 2002-05-16
US20040033566A1 (en) 2004-02-19

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