DE69626671D1 - Fusionsproteine bestehend aus gewebefaktor-kunitzdomäne als inhibitoren des faktors viia - Google Patents

Fusionsproteine bestehend aus gewebefaktor-kunitzdomäne als inhibitoren des faktors viia

Info

Publication number
DE69626671D1
DE69626671D1 DE69626671T DE69626671T DE69626671D1 DE 69626671 D1 DE69626671 D1 DE 69626671D1 DE 69626671 T DE69626671 T DE 69626671T DE 69626671 T DE69626671 T DE 69626671T DE 69626671 D1 DE69626671 D1 DE 69626671D1
Authority
DE
Germany
Prior art keywords
factor
inhibitors
fusion proteins
fabric
kunitz domain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69626671T
Other languages
English (en)
Other versions
DE69626671T2 (de
Inventor
F Kelley
A Lazarus
F Lee
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/566,800 external-priority patent/US5736364A/en
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of DE69626671D1 publication Critical patent/DE69626671D1/de
Application granted granted Critical
Publication of DE69626671T2 publication Critical patent/DE69626671T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8114—Kunitz type inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE69626671T 1995-12-01 1996-11-22 Fusionsproteine bestehend aus gewebefaktor-kunitzdomäne als inhibitoren des faktors viia Expired - Fee Related DE69626671T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US566800 1983-12-29
US56645995A 1995-12-01 1995-12-01
US566459 1995-12-01
US08/566,800 US5736364A (en) 1995-12-04 1995-12-04 Factor viia inhibitors
PCT/US1996/018756 WO1997020939A1 (en) 1995-12-01 1996-11-22 TISSUE FACTOR - KUNITZ DOMAIN FUSION PROTEINS AS FACTOR VIIa INHIBITORS

Publications (2)

Publication Number Publication Date
DE69626671D1 true DE69626671D1 (de) 2003-04-17
DE69626671T2 DE69626671T2 (de) 2004-03-18

Family

ID=27074189

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69626671T Expired - Fee Related DE69626671T2 (de) 1995-12-01 1996-11-22 Fusionsproteine bestehend aus gewebefaktor-kunitzdomäne als inhibitoren des faktors viia

Country Status (8)

Country Link
EP (1) EP0866870B1 (de)
AT (1) ATE234359T1 (de)
AU (1) AU1023497A (de)
DE (1) DE69626671T2 (de)
DK (1) DK0866870T3 (de)
ES (1) ES2195025T3 (de)
PT (1) PT866870E (de)
WO (1) WO1997020939A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6214333B1 (en) * 1997-07-08 2001-04-10 Texas Heart Institute Vasoprotective recombinant adenovirus vector containing a human TFPI gene
WO2000004148A1 (en) 1998-07-15 2000-01-27 Genentech, Inc. Tissue factor protein variants with increased affinity for coagulation factor fvii/fviia
AU781618C (en) 1999-07-02 2006-03-16 Genentech Inc. FVIIa antagonists
CA2380633A1 (en) * 1999-08-06 2001-02-15 Genentech, Inc. Peptide antagonists of factor viia
US6905683B2 (en) 2000-05-03 2005-06-14 Novo Nordisk Healthcare A/G Human coagulation factor VII variants
CN101486761A (zh) 2000-09-13 2009-07-22 诺沃挪第克健康护理股份公司 人凝血因子vii变体
WO2002038162A1 (en) 2000-11-09 2002-05-16 The Scripps Research Institute MODIFIED FACTOR VIIa
US7052868B2 (en) 2001-09-27 2006-05-30 Novo Nordisk Healthcare A/G Human coagulation factor VII polypeptides
US6960657B2 (en) 2001-11-02 2005-11-01 Novo Nordisk Healthcare A/G Human coagulation factor VII polypeptides
US7164002B2 (en) 2002-02-06 2007-01-16 Genentech, Inc. FVIIa antagonists
US6911323B2 (en) 2002-09-25 2005-06-28 Novo Nordisk Healthcare A/G Human coagulation factor VII polypeptides
CN1863908B (zh) 2003-09-09 2010-08-04 诺和诺德医疗保健公司 凝固因子ⅶ多肽
JP5759102B2 (ja) * 2006-04-07 2015-08-05 ノボ ノルディスク ヘルス ケア アーゲー Ｖｉｉ因子・組織因子共有結合複合体
EP4225373A1 (de) * 2020-10-07 2023-08-16 Dren Bio, Inc. Anti-dectin-1-antikörper und verfahren zur verwendung davon
WO2022106648A1 (en) 2020-11-20 2022-05-27 Universitätsmedizin Der Johannes Gutenberg-Universität Mainz Inhibitors of the tissue factor-protease activated receptor 2 (tf-par2) signaling pathway for use in the treatment or prevention of heart failure (hf) and associated or resulting diseases

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2086521T3 (es) * 1990-01-25 1996-07-01 Univ Washington Proteina hibrida laci-factor x.
US5346991A (en) * 1991-06-13 1994-09-13 Genentech, Inc. Tissue factor mutants useful for the treatment of myocardial infarction and coagulopathic disorders
WO1994028017A1 (en) * 1993-06-01 1994-12-08 The Scripps Research Institute Human mutant tissue factor compositions useful as tissue factor antagonists
US5795954A (en) * 1994-03-04 1998-08-18 Genentech, Inc. Factor VIIa inhibitors from Kunitz domain proteins

Also Published As

Publication number Publication date
DK0866870T3 (da) 2003-06-23
ES2195025T3 (es) 2003-12-01
ATE234359T1 (de) 2003-03-15
EP0866870A1 (de) 1998-09-30
AU1023497A (en) 1997-06-27
DE69626671T2 (de) 2004-03-18
EP0866870B1 (de) 2003-03-12
PT866870E (pt) 2003-08-29
WO1997020939A1 (en) 1997-06-12

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee