MX346185B - Derivados de piridazina, composiciones y metodos para tratar deterioro cognitivo. - Google Patents

Derivados de piridazina, composiciones y metodos para tratar deterioro cognitivo.

Info

Publication number
MX346185B
MX346185B MX2013005442A MX2013005442A MX346185B MX 346185 B MX346185 B MX 346185B MX 2013005442 A MX2013005442 A MX 2013005442A MX 2013005442 A MX2013005442 A MX 2013005442A MX 346185 B MX346185 B MX 346185B
Authority
MX
Mexico
Prior art keywords
cognitive impairment
compositions
methods
pyridazine derivatives
derivatives
Prior art date
Application number
MX2013005442A
Other languages
English (en)
Other versions
MX2013005442A (es
Inventor
A Lowe John Iii
Original Assignee
Agenebio Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agenebio Inc filed Critical Agenebio Inc
Publication of MX2013005442A publication Critical patent/MX2013005442A/es
Publication of MX346185B publication Critical patent/MX346185B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invención se refiere a los derivados de piridazina, a las composiciones que comprenden cantidades terapéuticamente efectivas de esos derivados de piridazina y los métodos de uso de esos derivados o las composiciones en el tratamiento de trastornos del sistema nervioso central (SNC) con deterioro cognitivo, que responden a los agonistas del receptor de GABAA que contiene la subunidad por ejemplo, el deterioro cognitivo relacionado a la edad, Deterioro Cognitivo Leve (MCI), demencia, Enfermedad de Alzheimer (AD), AD prodrómica, trastorno de estrés post traumático (PTSD), esquizofrenia y deterioro cognitivo relacionado a la terapia contra el cáncer.
MX2013005442A 2010-11-15 2011-11-15 Derivados de piridazina, composiciones y metodos para tratar deterioro cognitivo. MX346185B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41397110P 2010-11-15 2010-11-15
PCT/US2011/060854 WO2012068161A1 (en) 2010-11-15 2011-11-15 Pyridazine derivatives, compositions and methods for treating cognitive impairment

Publications (2)

Publication Number Publication Date
MX2013005442A MX2013005442A (es) 2013-10-03
MX346185B true MX346185B (es) 2017-03-10

Family

ID=46084380

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013005442A MX346185B (es) 2010-11-15 2011-11-15 Derivados de piridazina, composiciones y metodos para tratar deterioro cognitivo.

Country Status (12)

Country Link
US (2) US9145372B2 (es)
EP (2) EP3034079B1 (es)
JP (1) JP5916746B2 (es)
CN (1) CN103313712B (es)
AU (1) AU2011328993B2 (es)
BR (1) BR112013012062B1 (es)
CA (1) CA2818025A1 (es)
DK (2) DK3034079T3 (es)
EA (1) EA027840B1 (es)
MX (1) MX346185B (es)
NO (1) NO3034079T3 (es)
WO (1) WO2012068161A1 (es)

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WO2014078377A1 (en) * 2012-11-14 2014-05-22 Agenebio, Inc. Methods and compositions for treating schizophrenia
EP3083569B1 (en) 2013-12-20 2022-01-26 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
CA2990004C (en) 2015-06-19 2024-04-23 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
TWI697485B (zh) * 2015-07-21 2020-07-01 日商捷恩智股份有限公司 含唑啉環的化合物、含有其的電子輸送/注入層用材料、使用其的有機電致發光元件、顯示裝置及照明裝置
US11505555B2 (en) 2016-12-19 2022-11-22 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
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Also Published As

Publication number Publication date
US20160008357A1 (en) 2016-01-14
US20130237545A1 (en) 2013-09-12
BR112013012062B1 (pt) 2020-06-02
EP3034079B1 (en) 2018-01-10
US9145372B2 (en) 2015-09-29
JP2013542267A (ja) 2013-11-21
WO2012068161A1 (en) 2012-05-24
CN103313712A (zh) 2013-09-18
MX2013005442A (es) 2013-10-03
EP3034079A1 (en) 2016-06-22
US9801879B2 (en) 2017-10-31
EP2640391B1 (en) 2015-11-11
EA027840B1 (ru) 2017-09-29
EA201390712A1 (ru) 2013-11-29
BR112013012062A2 (pt) 2016-08-16
EP2640391A4 (en) 2014-05-07
DK2640391T3 (da) 2016-02-15
AU2011328993A1 (en) 2013-06-06
JP5916746B2 (ja) 2016-05-11
AU2011328993B2 (en) 2017-03-02
EP2640391A1 (en) 2013-09-25
NO3034079T3 (es) 2018-06-09
DK3034079T3 (en) 2018-02-05
CA2818025A1 (en) 2012-05-24
CN103313712B (zh) 2016-10-26

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