NL7605526A - Nieuwe tetracyclische derivaten. - Google Patents

Nieuwe tetracyclische derivaten.

Info

Publication number
NL7605526A
NL7605526A NL7605526A NL7605526A NL7605526A NL 7605526 A NL7605526 A NL 7605526A NL 7605526 A NL7605526 A NL 7605526A NL 7605526 A NL7605526 A NL 7605526A NL 7605526 A NL7605526 A NL 7605526A
Authority
NL
Netherlands
Prior art keywords
tetracyclical
derivatives
new
tetracyclical derivatives
new tetracyclical
Prior art date
Application number
NL7605526A
Other languages
English (en)
Original Assignee
Akzo Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nv filed Critical Akzo Nv
Priority to NL7605526A priority Critical patent/NL7605526A/nl
Priority to ZA00772752A priority patent/ZA772752B/xx
Priority to GB20275/77A priority patent/GB1567862A/en
Priority to IE1013/77A priority patent/IE45419B1/en
Priority to FR7715413A priority patent/FR2352800A1/fr
Priority to US05/798,222 priority patent/US4145434A/en
Priority to CH626477A priority patent/CH633536A5/de
Priority to SE7705957A priority patent/SE436202B/xx
Priority to AU25331/77A priority patent/AU509073B2/en
Priority to JP5929577A priority patent/JPS532465A/ja
Priority to ES459024A priority patent/ES459024A1/es
Priority to HU77AO447A priority patent/HU173795B/hu
Priority to BE177807A priority patent/BE854915A/xx
Priority to FI771635A priority patent/FI65238C/fi
Priority to DE2760372A priority patent/DE2760372C2/de
Priority to LU77387A priority patent/LU77387A1/xx
Priority to DE19772723209 priority patent/DE2723209A1/de
Priority to CA279,010A priority patent/CA1122976A/en
Priority to DK227477A priority patent/DK157868C/da
Publication of NL7605526A publication Critical patent/NL7605526A/nl
Priority to ES470408A priority patent/ES470408A1/es
Priority to ES470407A priority patent/ES470407A1/es
Priority to US05/918,217 priority patent/US4154836A/en
Priority to US05/918,219 priority patent/US4158059A/en
Priority to US05/918,883 priority patent/US4177275A/en
Priority to US05/918,981 priority patent/US4271177A/en
Priority to US05/919,196 priority patent/US4271178A/en
Priority to US05/919,110 priority patent/US4158058A/en
Priority to US05/923,606 priority patent/US4271179A/en
Priority to CH351282A priority patent/CH637382A5/de
Priority to FI832085A priority patent/FI67701C/fi
Priority to JP61007790A priority patent/JPS61178965A/ja

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/70—[b]- or [c]-condensed containing carbocyclic rings other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/18—Ring systems of four or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
NL7605526A 1976-05-24 1976-05-24 Nieuwe tetracyclische derivaten. NL7605526A (nl)

Priority Applications (31)

Application Number Priority Date Filing Date Title
NL7605526A NL7605526A (nl) 1976-05-24 1976-05-24 Nieuwe tetracyclische derivaten.
ZA00772752A ZA772752B (en) 1976-05-24 1977-05-09 Novel tetracyclic derivatives
GB20275/77A GB1567862A (en) 1976-05-24 1977-05-13 Tetracyclic derivatives
IE1013/77A IE45419B1 (en) 1976-05-24 1977-05-17 Novel tetracylic derivatives
FR7715413A FR2352800A1 (fr) 1976-05-24 1977-05-18 Nouveaux composes tetracycliques utiles comme depresseurs
US05/798,222 US4145434A (en) 1976-05-24 1977-05-18 Tetracyclic derivatives and pharmaceutical compositions of matter
CH626477A CH633536A5 (de) 1976-05-24 1977-05-20 Verfahren zur herstellung neuer tetracyclischer piperidin- oder pyrrolidinderivate.
SE7705957A SE436202B (sv) 1976-05-24 1977-05-20 Analogiforfarande for framstellning av tetracykliska derivat
AU25331/77A AU509073B2 (en) 1976-05-24 1977-05-20 Novel tetracyclic derivatives
JP5929577A JPS532465A (en) 1976-05-24 1977-05-20 Novel tetracyclic derivative* its preparation and formulations containing same
ES459024A ES459024A1 (es) 1976-05-24 1977-05-21 Procedimiento para la preparacion de un compuesto tetraci- clico.
LU77387A LU77387A1 (nl) 1976-05-24 1977-05-23
BE177807A BE854915A (fr) 1976-05-24 1977-05-23 Nouveaux composes tetracycliques utiles comme depresseurs
FI771635A FI65238C (fi) 1976-05-24 1977-05-23 Foerfarande foer framstaellning av terapeutiskt anvaendbara teracykliska foereningar
DE2760372A DE2760372C2 (nl) 1976-05-24 1977-05-23
HU77AO447A HU173795B (hu) 1976-05-24 1977-05-23 Sposob poluchenija novykh tetraciklicheskikh soedinenij
DE19772723209 DE2723209A1 (de) 1976-05-24 1977-05-23 Tetracyclische pyridin- oder pyrrolderivate
CA279,010A CA1122976A (en) 1976-05-24 1977-05-24 Tetracyclic compounds
DK227477A DK157868C (da) 1976-05-24 1977-05-24 Analogifremgangsmaade til fremstilling af tetracykliske forbindelser
ES470408A ES470408A1 (es) 1976-05-24 1978-06-01 Procedimiento para la preparacion de un compuesto tetraci- clico
ES470407A ES470407A1 (es) 1976-05-24 1978-06-01 Procedimiento para la preparacion de un compuesto tetraci- clico
US05/918,219 US4158059A (en) 1976-05-24 1978-06-23 Tension reducing 2,3,4,4a,9,136-hexahydro-dibenz[1,2;5,6]cyclohepta[3,4-c]py
US05/918,217 US4154836A (en) 1976-05-24 1978-06-23 Tension reducing 1,2,3,4,4a,13b-hexahydro-dibenz[2,3;6,7]oxepino[4,5-c]pyridines
US05/918,883 US4177275A (en) 1976-05-24 1978-06-26 Tension reducing 2,3,4,4a,9,13b-hexahydro-1H-dibenzo[b,f]pyrido[3,4-d]azepine derivatives
US05/918,981 US4271177A (en) 1976-05-24 1978-06-26 2,3,3a,12b-Tetrahydro-1H-dibenzo[2,3;6,7]thiepino[4,5-c]pyrroles and pharmaceutical use thereof
US05/919,196 US4271178A (en) 1976-05-24 1978-06-26 1,2,3,3a,8,12b-Hexahydro-dibenzo[b,f]pyrrolo[3,4-d]azepines and pharmaceutical use thereof
US05/919,110 US4158058A (en) 1976-05-24 1978-06-26 Tension reducing 1,2,3,4,4a,13b-hexahydro-dibenzo[2,3;6,7]thiepino[4,5-c]pyridines
US05/923,606 US4271179A (en) 1976-05-24 1978-06-26 1,2,3,3a,8,12b-Hexahydro-dibenzo[1,2;5,6]cyclohepta[3,4-C]pyrroles and pharmaceutical use thereof
CH351282A CH637382A5 (de) 1976-05-24 1982-06-07 Verfahren zur herstellung neuer tetracyclischer pyridin- oder pyrrolderivate.
FI832085A FI67701C (fi) 1976-05-24 1983-06-09 Foerfarande foer framstaellning av nya terapeutiskt anvaendbara tetracykliska foereningar
JP61007790A JPS61178965A (ja) 1976-05-24 1986-01-17 新規な四環式誘導体

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL7605526A NL7605526A (nl) 1976-05-24 1976-05-24 Nieuwe tetracyclische derivaten.

Publications (1)

Publication Number Publication Date
NL7605526A true NL7605526A (nl) 1977-11-28

Family

ID=19826245

Family Applications (1)

Application Number Title Priority Date Filing Date
NL7605526A NL7605526A (nl) 1976-05-24 1976-05-24 Nieuwe tetracyclische derivaten.

Country Status (18)

Country Link
US (1) US4145434A (nl)
JP (2) JPS532465A (nl)
AU (1) AU509073B2 (nl)
BE (1) BE854915A (nl)
CA (1) CA1122976A (nl)
CH (2) CH633536A5 (nl)
DE (2) DE2723209A1 (nl)
DK (1) DK157868C (nl)
ES (3) ES459024A1 (nl)
FI (1) FI65238C (nl)
FR (1) FR2352800A1 (nl)
GB (1) GB1567862A (nl)
HU (1) HU173795B (nl)
IE (1) IE45419B1 (nl)
LU (1) LU77387A1 (nl)
NL (1) NL7605526A (nl)
SE (1) SE436202B (nl)
ZA (1) ZA772752B (nl)

Families Citing this family (86)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0007450A1 (de) * 1978-07-07 1980-02-06 Ciba-Geigy Ag Azatetracyclische Carbonitrile, ihre Herstellung, pharmazeutische Präparate, die diese enthalten und deren Verwendung
DE3069086D1 (de) * 1979-12-10 1984-10-04 Ciba Geigy Ag Azatetracyclic carbonitriles
FR2504140A1 (fr) * 1981-04-16 1982-10-22 Centre Nat Rech Scient Nouveaux derives tetracycliques de la dibenzazepine, leur procede de preparation et les compositions pharmaceutiques en renfermant
NZ204242A (en) * 1982-05-18 1986-08-08 Hoffmann La Roche 8-halo-6-phenyl-2,3-dihydro-1h,4h-pyrrolo(3,4-d)(2)benzazepine-(1-or 3-ones or 1,3-diones)
JPS62101941U (nl) * 1985-12-16 1987-06-29
IE62754B1 (en) * 1988-08-26 1995-02-22 Akzo Nv Tetracyclic antidepressants
EP0569096A1 (en) * 1992-05-08 1993-11-10 Akzo Nobel N.V. Depot preparation
EP0690863B1 (en) * 1993-04-06 2003-03-05 Abbott Laboratories Tetracyclic compounds as dopamine agonists
CN1079670C (zh) * 1994-03-02 2002-02-27 阿克佐诺贝尔公司 舌下或颊给药的药物组合物
JP3274579B2 (ja) * 1995-01-12 2002-04-15 住友製薬株式会社 脳血管障害に伴う精神症候治療剤
NZ329953A (en) * 1996-04-12 1999-06-29 Janssen Pharmaceutica Nv Substituted tetracyclic n-oxide tetrahydrofuran derivatives, salts and stereoisomeric forms thereof for the treatment of cns cardiovascular or gastrointestinal disorders
HUP0002106A3 (en) * 1997-05-26 2001-11-28 Akzo Nobel Nv Aromatic sulfonates of trans-5-chloro-2,3,3a,12b-tetrahydro-2-methyl-1h-dibenz-[2,3:6,7]oxepino[4,5-c]pyrrole and pharmaceutical compositions containing it
HRP20020305A8 (en) * 2002-04-10 2009-03-31 GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. 2-thia-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof
HRP20020441A2 (en) * 2002-05-21 2003-12-31 Pliva D D 1-oxa-dibenzoazulen as inhibitor of production of tumor necrosis factors and intermediate for preparation thereof
HRP20030160A2 (en) * 2003-03-06 2005-04-30 Pliva-Istra�iva�ki institut d.o.o. 1-thiadibenzoazulene derivatives and biological action thereof
MXPA05012317A (es) * 2003-05-16 2006-01-30 Pfizer Prod Inc Combinaciones terapeuticas de agentes antipsicoticos atipicos con agentes moduladores del gaba anticonvulsivos o benzodiazepinas.
HRP20030885A2 (en) * 2003-11-03 2005-08-31 Pliva-Istra�iva�ki institut d.o.o. USE OF 2-THIA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYYTEM DISEASES AND DISORDERS
HRP20030958A2 (en) * 2003-11-21 2005-08-31 Pliva-Istra�iva�ki institut d.o.o. USE OF 1,3-DIAZA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS
HRP20030955A2 (en) * 2003-11-21 2005-08-31 Pliva-Istra�iva�ki institut d.o.o. USE OF 1-OXADIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS
HRP20030957A2 (en) * 2003-11-21 2005-08-31 Pliva-Istra�iva�ki institut d.o.o. USE OF 1-THIA-3-AZA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS
HRP20030959A2 (nl) * 2003-11-21 2005-10-31 Pliva-Istra�iva�ki institut d.o.o.
HRP20030956A2 (en) * 2003-11-21 2005-08-31 Pliva-Istra�iva�ki institut d.o.o. USE OF 1,2-DIAZA-DIBENZO[e,h]AZULENES FOR THE MANU
HRP20030954A2 (en) * 2003-11-21 2005-08-31 Pliva D.D. USE OF 1-AZA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS
HRP20030953A2 (en) * 2003-11-21 2005-10-31 Pliva-Istra�iva�ki institut d.o.o. PREPARATION OF 1-AZA-2-OXA-DIBENZO[e,h]AZULENES AND THEIR USE FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS
HRP20040104A2 (en) * 2004-01-30 2005-10-31 Pliva-Istra�iva�ki institut d.o.o. Use of benzonaphthoazulenes for the manufacture of pharmaceutical formulations for the treatment and prevention of central nervous system diseases and disorders
BRPI0507609A (pt) * 2004-02-13 2007-07-03 Pfizer Prod Inc combinações terapêuticas de anti-psicóticos atìpicos com antagonistas de fator de liberação de corticotropina
JP2007537232A (ja) * 2004-05-11 2007-12-20 ファイザー・プロダクツ・インク 非定型抗精神病薬と５−ｈｔ１ｂ受容体拮抗薬の組合せ
RU2403039C2 (ru) * 2004-10-15 2010-11-10 H.B.Opганон Лечение биполярных расстройств и сопутствующих симптомов
US7872147B2 (en) 2005-04-07 2011-01-18 N. V. Organon Intermediate compounds for the preparation of trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole
EP2154134B1 (en) * 2005-04-07 2012-10-24 MSD Oss B.V. Process for the preparation of trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1h-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole.
SI1917267T1 (sl) * 2005-04-07 2009-04-30 Organon Nv Kristalna oblika asenapin maleata
US7741358B2 (en) * 2005-04-14 2010-06-22 N.V. Organon Crystal form of asenapine maleate
WO2007046554A1 (ja) * 2005-10-21 2007-04-26 Sumitomo Chemical Company, Limited ジベンゾオキセピノピロール化合物の製造方法、その中間体及び該中間体の製造方法
US7750167B2 (en) * 2006-07-05 2010-07-06 N.V. Organon Process for the preparation of asenapine and intermediate products used in said process
TW200817414A (en) * 2006-07-05 2008-04-16 Organon Nv Process for the preparation of asenapine and intermediate products used in said process
US20080090892A1 (en) * 2006-10-06 2008-04-17 N.V. Organon Amorphous asenapine and processes for preparing same
US7875729B2 (en) * 2007-01-05 2011-01-25 Synthon Bv Process for making asenapine
WO2008148515A1 (en) * 2007-06-05 2008-12-11 Synthon B.V. Intranasal administration of asenapine and pharmaceutical compositions therefor
JP5245428B2 (ja) * 2007-07-06 2013-07-24 住友化学株式会社 トランス−ジベンゾオキセノピロール化合物の製造方法およびその中間体
CN101918411A (zh) * 2008-01-04 2010-12-15 欧加农股份有限公司 一种制备阿塞那平的方法以及该方法中应用的中间体产物
EP2254420A4 (en) 2008-02-20 2012-02-15 Targia Pharmaceuticals CNS PHARMACEUTICALS AND METHOD FOR THEIR USE
CA2727573A1 (en) * 2008-06-25 2009-12-30 Pfizer Inc. Diaryl compounds and uses thereof
CA2766291C (en) * 2009-06-24 2016-06-21 Msd Oss B.V. Injectable formulations containing asenapine and method of treatment using same
AR077429A1 (es) 2009-07-29 2011-08-24 Organon Nv Compuestos hidroxiasenapina sus derivados y composiciones farmaceuticas que comprenden los mismos
CA2802990A1 (en) 2010-06-18 2011-12-22 Dr. Reddy's Laboratories Ltd. Asenapine maleate
JP5815702B2 (ja) 2010-07-29 2015-11-17 ラボラトリオス レスヴィ，エス．エル． アセナピンの新規な製造方法
EP2640391B1 (en) 2010-11-15 2015-11-11 Agenebio, Inc. Pyridazine derivatives, compositions and methods for treating cognitive impairment
WO2012066565A2 (en) 2010-11-16 2012-05-24 Cadila Healthcare Limited Asenapine maleate amorphous and crystalline form and process for preparation thereof
EP2468750A1 (en) 2010-12-13 2012-06-27 Chemo Ibérica, S.A. Polymorphic forms of asenapine maleate and processes for their preparation
ES2575544T3 (es) 2010-12-24 2016-06-29 Medichem, S.A. Procedimientos para la preparación de 5-cloro-2-metil-2,3,3a,12b-tetrahidro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pirrol
WO2012123325A1 (en) 2011-03-11 2012-09-20 Medichem S.A. NEW CRYSTAL FORMS OF THE SALT OF TRANS-5-CHLORO-2-METHYL-2,3,3A,12b-TETRAHYDRO-1H-DIBENZO[2,3:6,7]OXEPINO[4,5-c]PYRROLE WITH MALEIC ACID
ITMI20110734A1 (it) 2011-05-02 2012-11-03 Olon Spa Sali cristallini di asenapina
EP2524921A1 (en) * 2011-05-17 2012-11-21 Sandoz AG Novel Crystalline Salts of Asenapine
EP2524919A1 (en) * 2011-05-17 2012-11-21 Sandoz AG Novel crystalline salts of Asenapine with organic Di-acids and Tri-acids
US9505771B2 (en) 2011-05-18 2016-11-29 Laboratories Lesvi S.L. Stable micronised monoclin form of asenapine maleate and its synthesis
WO2012156676A1 (en) 2011-05-18 2012-11-22 Laboratorios Lesvi S.L. Monoclinic crystalline form of asenapine maleate with a specific particle size distribution
WO2013024492A2 (en) 2011-07-01 2013-02-21 Megafine Pharma (P) Ltd. A process for the preparation of asenapine and novel salts thereof
US9145421B2 (en) 2011-07-20 2015-09-29 Ranbaxy Laboratories Limited Process for the preparation of asenapine maleate
WO2013035109A1 (en) 2011-09-08 2013-03-14 Mylan Laboratories Ltd Improved process for the preparation of asenapine maleate
WO2013041604A1 (en) 2011-09-21 2013-03-28 Sandoz Ag Crystal form of asenapine maleate
EP2572703A1 (en) 2011-09-21 2013-03-27 Hexal AG Compressed oral dosage form for asenapine maleate
EP2785718A1 (en) 2011-11-28 2014-10-08 Ranbaxy Laboratories Limited Process for the preparation of asenapine intermediate
CN103254201B (zh) * 2012-02-21 2016-04-13 四川科伦药物研究有限公司 一种阿塞那平的制备方法
WO2013190481A1 (en) * 2012-06-21 2013-12-27 Alembic Pharmaceuticals Limited Process for preparing asenapine and salts of intermediates thereof
ITMI20121810A1 (it) 2012-10-24 2014-04-25 Chemo Iberica Sa Poliformi di maleato di asenapina e processo per la loro preparazione
US10154988B2 (en) 2012-11-14 2018-12-18 The Johns Hopkins University Methods and compositions for treating schizophrenia
WO2014127786A1 (en) 2013-02-22 2014-08-28 Zentiva, K.S. Orally disintegrating pharmaceutical composition comprising asenapine
CN103113379A (zh) * 2013-03-12 2013-05-22 盛世泰科生物医药技术(苏州)有限公司 阿塞那平马来酸盐的合成工艺
CN103351393B (zh) * 2013-07-03 2016-04-06 华裕(无锡)制药有限公司 用于制备阿森那平之还原剂及阿森那平之制备方法
CA3123897C (en) 2013-12-20 2024-02-06 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
CN103772401A (zh) * 2014-01-07 2014-05-07 万特制药(海南)有限公司 11-氯-2,3,3a,12b-四氢-2-甲基-1H-二苯并[2,3:6,7]氧杂卓并[4,5-c]吡咯-1-酮的一种新精制方法
CN103772400A (zh) * 2014-01-07 2014-05-07 万特制药(海南)有限公司 反式-5-氯-2,3,3a,12b-四氢-1H-二苯并[2,3:6,7]氧杂卓并[4,5-c]吡咯的制备方法
CA2987081C (en) 2015-06-11 2022-08-30 Alrise Biosystems Gmbh Process for the preparation of drug loaded microparticles
WO2016205739A1 (en) 2015-06-19 2016-12-22 Belew Mekonnen Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
US20180170941A1 (en) 2016-12-19 2018-06-21 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
BR112019012821A2 (pt) 2016-12-19 2019-11-26 Agenebio Inc derivados de benzodiazepina, composições e métodos para o tratamento do comprometimento cognitivo
EP3338768B1 (en) 2016-12-20 2019-10-30 LTS Lohmann Therapie-Systeme AG Transdermal therapeutic system containing asenapine
EP3558276A1 (en) 2016-12-20 2019-10-30 LTS Lohmann Therapie-Systeme AG Transdermal therapeutic system containing asenapine and polysiloxane or polyisobutylene
CA3067938A1 (en) 2017-06-26 2019-01-03 Lts Lohmann Therapie-Systeme Ag Transdermal therapeutic system containing asenapine and silicone acrylic hybrid polymer
CN112601749B (zh) 2018-06-19 2024-03-26 艾吉因生物股份有限公司 用于治疗认知损害的苯并二氮杂环庚三烯衍生物，组合物和方法
KR20210022656A (ko) 2018-06-20 2021-03-03 에르테에스 로만 테라피-시스테메 아게 아세나핀을 함유하는 경피 치료 시스템
CN110183457A (zh) * 2019-06-27 2019-08-30 浙江天顺药业有限公司 一种阿塞那平及其制备方法
CN112830931A (zh) 2019-08-13 2021-05-25 浙江奥翔药业股份有限公司 制备阿塞那平的方法
US11679407B2 (en) * 2020-06-26 2023-06-20 Intel Corporation Liquid metal thermal interface material application
WO2023006954A1 (en) 2021-07-30 2023-02-02 Fundació Institut D'investigació Biomèdica De Bellvitge (Idibell) Asenapine for use in cancer
WO2024039886A1 (en) 2022-08-19 2024-02-22 Agenebio, Inc. Benzazepine derivatives, compositions, and methods for treating cognitive impairment

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH501007A (de) * 1968-11-27 1970-12-31 Ciba Geigy Ag Verfahren zur Herstellung von neuen Thiepin- und Oxepinderivaten
NL178593C (nl) * 1974-01-31 1986-04-16 Akzo Nv Werkwijze ter bereiding van een farmaceutisch preparaat op basis van een tetracyclische verbinding en werkwijze voor de bereiding van de daarbij te gebruiken tetracyclische verbindingen.
AU469026B2 (en) * 1974-11-07 1976-01-29 Ciba-Geigy Ag New azepine derivatives and process forthe production thereof

Also Published As

Publication number Publication date
AU509073B2 (en) 1980-04-17
BE854915A (fr) 1977-11-23
IE45419B1 (en) 1982-08-25
FI771635A (nl) 1977-11-25
FI65238C (fi) 1984-04-10
DK227477A (da) 1977-11-25
FI65238B (fi) 1983-12-30
JPS532465A (en) 1978-01-11
SE436202B (sv) 1984-11-19
DK157868B (da) 1990-02-26
DE2723209A1 (de) 1977-12-15
US4145434A (en) 1979-03-20
JPS6238348B2 (nl) 1987-08-17
FR2352800B1 (nl) 1980-02-01
ZA772752B (en) 1978-04-26
SE7705957L (sv) 1977-11-25
FR2352800A1 (fr) 1977-12-23
ES459024A1 (es) 1978-11-01
ES470408A1 (es) 1979-01-01
CH637382A5 (de) 1983-07-29
CH633536A5 (de) 1982-12-15
HU173795B (hu) 1979-08-28
GB1567862A (en) 1980-05-21
LU77387A1 (nl) 1977-08-29
CA1122976A (en) 1982-05-04
JPS6134426B2 (nl) 1986-08-07
DK157868C (da) 1990-07-30
ES470407A1 (es) 1979-01-01
IE45419L (en) 1977-11-24
DE2760372C2 (nl) 1991-05-29
AU2533177A (en) 1978-11-23
JPS61178965A (ja) 1986-08-11

Similar Documents

Publication Publication Date Title
NL7605526A (nl) Nieuwe tetracyclische derivaten.
NL7711539A (nl) Nieuwe psoraleenderivaten.
NL7806016A (nl) Nieuwe fthalazinederivaten.
DK65077A (da) 2-piperazinyl-6,7-dimethoxyquinazoliner
NL7804159A (nl) Nieuwe guanidine-derivaten.
NL7711901A (nl) Benzamidederivaten.
NO137297C (no) Prosjektil.
NL7711788A (nl) Nieuwe gibberellinezouten.
NL7810864A (nl) Nieuwe ftalazine derivaten.
NL7702614A (nl) Nieuwe polyesteramiden.
NL7809075A (nl) Nieuwe 2-gesubstitueerde 5-hydroxy-1h-imidazool-4-car- boxamidederivaten.
NL7705037A (nl) M-fenoxybenzamide-derivaten.
NL7709808A (nl) Nieuwe uracilderivaten.
NL7711332A (nl) Nieuwe 8-azapurin-6-onen.
NL7800717A (nl) Nieuwe aminoalkoxyfenyl-derivaten.
NL7602370A (nl) Nieuwe butyrofenonderivaten.
NL7707949A (nl) Nieuwe fenoxyhydroxypropylamine derivaten.
NL7708452A (nl) Nieuwe gehinderde fosfieten.
NL7713339A (nl) Gesubstitueerde heterofulvalenen.
IT1113573B (it) L,3-diidro-eteroarilspiro isobenzo-furani
NL7707558A (nl) Fenothiazinederivaten.
NL7800450A (nl) Nieuwe fenylazacycloalkanen.
NL7701872A (nl) Nieuwe d-homosteroiden.
NL7708845A (nl) 1-aryloxy-3-aminopropan-2-ol derivaten.
NL7804839A (nl) Nieuwe fenylglycinederivaten.

Legal Events

Date Code Title Description
BC A request for examination has been filed
A85 Still pending on 85-01-01
BV The patent application has lapsed