JP2020519606A5 - - Google Patents
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- Publication number
- JP2020519606A5 JP2020519606A5 JP2019561849A JP2019561849A JP2020519606A5 JP 2020519606 A5 JP2020519606 A5 JP 2020519606A5 JP 2019561849 A JP2019561849 A JP 2019561849A JP 2019561849 A JP2019561849 A JP 2019561849A JP 2020519606 A5 JP2020519606 A5 JP 2020519606A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- pharmaceutically acceptable
- acceptable salt
- alkyl
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- SAPIPDRRWHANJP-UHFFFAOYSA-N CC(C)N(CCCc1cc(N)ncc1)C#N Chemical compound CC(C)N(CCCc1cc(N)ncc1)C#N SAPIPDRRWHANJP-UHFFFAOYSA-N 0.000 description 2
- SJFDYVZPAXIUNB-UHFFFAOYSA-N CC(C)N(CCc1cc(N)ncc1)C#N Chemical compound CC(C)N(CCc1cc(N)ncc1)C#N SJFDYVZPAXIUNB-UHFFFAOYSA-N 0.000 description 2
- ONPMLTBDCPUFNI-UFFNRZRYSA-N Nc1nccc(/C=C/[C@H](CCC2)N2C#N)c1 Chemical compound Nc1nccc(/C=C/[C@H](CCC2)N2C#N)c1 ONPMLTBDCPUFNI-UFFNRZRYSA-N 0.000 description 2
- REJAELATJINCLZ-VUWPPUDQSA-N Nc1nccc(CC([C@H](CCC2)N2C#N)O)c1 Chemical compound Nc1nccc(CC([C@H](CCC2)N2C#N)O)c1 REJAELATJINCLZ-VUWPPUDQSA-N 0.000 description 2
- SSXWUBDALDDEKI-UHFFFAOYSA-N Nc1nccc(CCC(CCC2)N2C#N)c1 Chemical compound Nc1nccc(CCC(CCC2)N2C#N)c1 SSXWUBDALDDEKI-UHFFFAOYSA-N 0.000 description 2
- UWRPVIIGPAYFNZ-UHFFFAOYSA-N CC(C)(C(NC(Cc(cc1)cnc1N)C(COc(c(F)c(cc1)F)c1F)=O)=O)OC Chemical compound CC(C)(C(NC(Cc(cc1)cnc1N)C(COc(c(F)c(cc1)F)c1F)=O)=O)OC UWRPVIIGPAYFNZ-UHFFFAOYSA-N 0.000 description 1
- PCMPYMTVHQTEEU-UHFFFAOYSA-N CC(C)(C(NC(Cc(cc1)cnc1N)C(COc(c(F)cc(COC(C)(C)C(NC(Cc1ccc(N)nc1)C(COc(c(F)c(cc1F)F)c1F)=O)=O)c1)c1F)=O)=O)OC Chemical compound CC(C)(C(NC(Cc(cc1)cnc1N)C(COc(c(F)cc(COC(C)(C)C(NC(Cc1ccc(N)nc1)C(COc(c(F)c(cc1F)F)c1F)=O)=O)c1)c1F)=O)=O)OC PCMPYMTVHQTEEU-UHFFFAOYSA-N 0.000 description 1
- MBKALDCXUZPRQO-UHFFFAOYSA-N CC(C)(C(NC(Cc1cc(N)ncc1)C(COc1n[o]cc1)=O)=O)OC Chemical compound CC(C)(C(NC(Cc1cc(N)ncc1)C(COc1n[o]cc1)=O)=O)OC MBKALDCXUZPRQO-UHFFFAOYSA-N 0.000 description 1
- WAZSPOKNSKZTKF-UHFFFAOYSA-N CC(C)(C(NC(Cc1ccnc(N)c1)C(COc(c(F)c(cc1)F)c1F)=O)=O)OC Chemical compound CC(C)(C(NC(Cc1ccnc(N)c1)C(COc(c(F)c(cc1)F)c1F)=O)=O)OC WAZSPOKNSKZTKF-UHFFFAOYSA-N 0.000 description 1
- NHHSBFGBWHVSHV-UHFFFAOYSA-N CC(C)(C(NC(Cc1ccnc(N)c1)C(COc(c(F)c(cc1F)F)c1F)=O)=O)OC Chemical compound CC(C)(C(NC(Cc1ccnc(N)c1)C(COc(c(F)c(cc1F)F)c1F)=O)=O)OC NHHSBFGBWHVSHV-UHFFFAOYSA-N 0.000 description 1
- JAXPOCGCWXNTES-UHFFFAOYSA-N CC(C)(C(NC(Cc1ccnc(N)c1)C(COc(c(F)ccc1)c1F)=O)=O)OC Chemical compound CC(C)(C(NC(Cc1ccnc(N)c1)C(COc(c(F)ccc1)c1F)=O)=O)OC JAXPOCGCWXNTES-UHFFFAOYSA-N 0.000 description 1
- PPSISFLMAGKAGL-UHFFFAOYSA-N Nc1ccc(CC(C(COc2n[o]cc2)=O)NC(C2CCCC2)=O)cn1 Chemical compound Nc1ccc(CC(C(COc2n[o]cc2)=O)NC(C2CCCC2)=O)cn1 PPSISFLMAGKAGL-UHFFFAOYSA-N 0.000 description 1
- IKTBLPPQOOUMNH-UHFFFAOYSA-N Nc1ncc(CC(C(COc(c(F)c(cc2)F)c2F)=O)NC(C2CCCC2)=O)cc1 Chemical compound Nc1ncc(CC(C(COc(c(F)c(cc2)F)c2F)=O)NC(C2CCCC2)=O)cc1 IKTBLPPQOOUMNH-UHFFFAOYSA-N 0.000 description 1
- WBABMBJNOHOXGF-UHFFFAOYSA-N Nc1nccc(CC(C(COc2n[o]cc2)=O)NC(C2CCCC2)=O)c1 Chemical compound Nc1nccc(CC(C(COc2n[o]cc2)=O)NC(C2CCCC2)=O)c1 WBABMBJNOHOXGF-UHFFFAOYSA-N 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022083544A JP2022110138A (ja) | 2017-05-10 | 2022-05-23 | アミノピリジン化合物ならびにその調製および使用のための方法 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762504480P | 2017-05-10 | 2017-05-10 | |
| US201762504442P | 2017-05-10 | 2017-05-10 | |
| US62/504,442 | 2017-05-10 | ||
| US62/504,480 | 2017-05-10 | ||
| PCT/US2018/032139 WO2018209132A1 (en) | 2017-05-10 | 2018-05-10 | Aminopyridine compounds and methods for the preparation and use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022083544A Division JP2022110138A (ja) | 2017-05-10 | 2022-05-23 | アミノピリジン化合物ならびにその調製および使用のための方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020519606A JP2020519606A (ja) | 2020-07-02 |
| JP2020519606A5 true JP2020519606A5 (enExample) | 2021-07-26 |
| JP7079794B2 JP7079794B2 (ja) | 2022-06-02 |
Family
ID=64104973
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019561849A Expired - Fee Related JP7079794B2 (ja) | 2017-05-10 | 2018-05-10 | アミノピリジン化合物ならびにその調製および使用のための方法 |
| JP2022083544A Withdrawn JP2022110138A (ja) | 2017-05-10 | 2022-05-23 | アミノピリジン化合物ならびにその調製および使用のための方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022083544A Withdrawn JP2022110138A (ja) | 2017-05-10 | 2022-05-23 | アミノピリジン化合物ならびにその調製および使用のための方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US11059786B2 (enExample) |
| EP (1) | EP3621613A4 (enExample) |
| JP (2) | JP7079794B2 (enExample) |
| CN (1) | CN110944637A (enExample) |
| AU (1) | AU2018265397A1 (enExample) |
| CA (1) | CA3062855A1 (enExample) |
| WO (1) | WO2018209132A1 (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12257272B2 (en) | 2015-12-24 | 2025-03-25 | Seed Health, Inc. | Method and system for reducing the likelihood of developing depression in an individual |
| US11951140B2 (en) | 2011-02-04 | 2024-04-09 | Seed Health, Inc. | Modulation of an individual's gut microbiome to address osteoporosis and bone disease |
| US12279989B2 (en) | 2011-02-04 | 2025-04-22 | Seed Health, Inc. | Method and system for increasing beneficial bacteria and decreasing pathogenic bacteria in the oral cavity |
| US11844720B2 (en) | 2011-02-04 | 2023-12-19 | Seed Health, Inc. | Method and system to reduce the likelihood of dental caries and halitosis |
| US12533312B2 (en) | 2011-02-04 | 2026-01-27 | Seed Health, Inc. | Method and system for preventing sore throat in humans |
| US11998479B2 (en) | 2011-02-04 | 2024-06-04 | Seed Health, Inc. | Method and system for addressing adverse effects on the oral microbiome and restoring gingival health caused by sodium lauryl sulphate exposure |
| US11951139B2 (en) | 2015-11-30 | 2024-04-09 | Seed Health, Inc. | Method and system for reducing the likelihood of osteoporosis |
| US11833177B2 (en) | 2013-12-20 | 2023-12-05 | Seed Health, Inc. | Probiotic to enhance an individual's skin microbiome |
| US12318377B2 (en) | 2013-12-20 | 2025-06-03 | Seed Health, Inc. | Method and system for reducing the likelihood of a porphyromonas gingivalis infection in a human being |
| US12005085B2 (en) | 2013-12-20 | 2024-06-11 | Seed Health, Inc. | Probiotic method and composition for maintaining a healthy vaginal microbiome |
| US12246043B2 (en) | 2013-12-20 | 2025-03-11 | Seed Health, Inc. | Topical application to treat acne vulgaris |
| US11839632B2 (en) | 2013-12-20 | 2023-12-12 | Seed Health, Inc. | Topical application of CRISPR-modified bacteria to treat acne vulgaris |
| US11642382B2 (en) | 2013-12-20 | 2023-05-09 | Seed Health, Inc. | Method for treating an individual suffering from bladder cancer |
| US11969445B2 (en) | 2013-12-20 | 2024-04-30 | Seed Health, Inc. | Probiotic composition and method for controlling excess weight, obesity, NAFLD and NASH |
| US12329783B2 (en) | 2013-12-20 | 2025-06-17 | Seed Health, Inc. | Method and system to improve the health of a person's skin microbiome |
| US11980643B2 (en) | 2013-12-20 | 2024-05-14 | Seed Health, Inc. | Method and system to modify an individual's gut-brain axis to provide neurocognitive protection |
| US11998574B2 (en) | 2013-12-20 | 2024-06-04 | Seed Health, Inc. | Method and system for modulating an individual's skin microbiome |
| US11826388B2 (en) | 2013-12-20 | 2023-11-28 | Seed Health, Inc. | Topical application of Lactobacillus crispatus to ameliorate barrier damage and inflammation |
| US11529379B2 (en) | 2013-12-20 | 2022-12-20 | Seed Health, Inc. | Method and system for reducing the likelihood of developing colorectal cancer in an individual human being |
| US11672835B2 (en) | 2013-12-20 | 2023-06-13 | Seed Health, Inc. | Method for treating individuals having cancer and who are receiving cancer immunotherapy |
| MX2019003087A (es) | 2016-09-16 | 2019-08-12 | Cortexyme Inc | Inhibidores cetónicos de gingipain de lisina. |
| CN110944637A (zh) | 2017-05-10 | 2020-03-31 | 库特克希米公司 | 氨基吡啶化合物及其制备方法和使用方法 |
| CN115850094B (zh) * | 2022-09-07 | 2025-02-11 | 北华航天工业学院 | 一种利用1,2-环氧丁烷合成β-氨基醇的方法 |
| CN120752237A (zh) * | 2022-12-22 | 2025-10-03 | 普罗泰克特治疗有限公司 | 吡咯并吡啶和吡咯并哒嗪类化合物及其作为pkr抑制剂的用途 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU3208500A (en) * | 1999-01-27 | 2000-08-18 | Ortho-Mcneil Pharmaceutical, Inc. | Peptidyl heterocyclic ketones useful as tryptase inhibitors |
| WO2000053172A1 (en) * | 1999-03-08 | 2000-09-14 | Smithkline Beecham Corporation | Ccr-3 receptor antagonists |
| CN105579432A (zh) | 2013-05-01 | 2016-05-11 | 尼奥酷里私人有限公司 | 治疗感染的化合物和方法 |
| US10654807B2 (en) * | 2013-12-20 | 2020-05-19 | The University Of Kansas | Toll-like receptor 8 agonists |
| US20170014468A1 (en) * | 2014-04-29 | 2017-01-19 | Cortexyme, Inc. | Methods of use for therapeutics targeting the pathogen porphyromonas gingivalis |
| GB201416754D0 (en) * | 2014-09-23 | 2014-11-05 | Mission Therapeutics Ltd | Novel compounds |
| SG11201702797RA (en) * | 2014-10-06 | 2017-05-30 | Cortexyme Inc | Inhibitors of lysine gingipain |
| CA3004095A1 (en) | 2015-11-09 | 2017-05-18 | Cortexyme, Inc. | Inhibitors of arginine gingipain |
| MX2019003087A (es) | 2016-09-16 | 2019-08-12 | Cortexyme Inc | Inhibidores cetónicos de gingipain de lisina. |
| CN110944637A (zh) | 2017-05-10 | 2020-03-31 | 库特克希米公司 | 氨基吡啶化合物及其制备方法和使用方法 |
-
2018
- 2018-05-10 CN CN201880046454.9A patent/CN110944637A/zh active Pending
- 2018-05-10 CA CA3062855A patent/CA3062855A1/en active Pending
- 2018-05-10 JP JP2019561849A patent/JP7079794B2/ja not_active Expired - Fee Related
- 2018-05-10 WO PCT/US2018/032139 patent/WO2018209132A1/en not_active Ceased
- 2018-05-10 AU AU2018265397A patent/AU2018265397A1/en not_active Abandoned
- 2018-05-10 EP EP18798781.3A patent/EP3621613A4/en not_active Withdrawn
-
2019
- 2019-11-08 US US16/678,700 patent/US11059786B2/en active Active
-
2021
- 2021-07-08 US US17/370,884 patent/US20210340105A1/en not_active Abandoned
-
2022
- 2022-05-23 JP JP2022083544A patent/JP2022110138A/ja not_active Withdrawn
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