CN110944637A - 氨基吡啶化合物及其制备方法和使用方法 - Google Patents

氨基吡啶化合物及其制备方法和使用方法 Download PDF

Info

Publication number
CN110944637A
CN110944637A CN201880046454.9A CN201880046454A CN110944637A CN 110944637 A CN110944637 A CN 110944637A CN 201880046454 A CN201880046454 A CN 201880046454A CN 110944637 A CN110944637 A CN 110944637A
Authority
CN
China
Prior art keywords
compound
pharmaceutically acceptable
acceptable salt
group
mixture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201880046454.9A
Other languages
English (en)
Chinese (zh)
Inventor
安德列·康纳迪
小罗伯特·A·加利莫
凯西·C·林奇
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Quince Therapeutics Inc
Original Assignee
Cortexyme Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cortexyme Inc filed Critical Cortexyme Inc
Publication of CN110944637A publication Critical patent/CN110944637A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Psychiatry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
CN201880046454.9A 2017-05-10 2018-05-10 氨基吡啶化合物及其制备方法和使用方法 Pending CN110944637A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762504480P 2017-05-10 2017-05-10
US201762504442P 2017-05-10 2017-05-10
US62/504,442 2017-05-10
US62/504,480 2017-05-10
PCT/US2018/032139 WO2018209132A1 (en) 2017-05-10 2018-05-10 Aminopyridine compounds and methods for the preparation and use thereof

Publications (1)

Publication Number Publication Date
CN110944637A true CN110944637A (zh) 2020-03-31

Family

ID=64104973

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201880046454.9A Pending CN110944637A (zh) 2017-05-10 2018-05-10 氨基吡啶化合物及其制备方法和使用方法

Country Status (7)

Country Link
US (2) US11059786B2 (enExample)
EP (1) EP3621613A4 (enExample)
JP (2) JP7079794B2 (enExample)
CN (1) CN110944637A (enExample)
AU (1) AU2018265397A1 (enExample)
CA (1) CA3062855A1 (enExample)
WO (1) WO2018209132A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115850094A (zh) * 2022-09-07 2023-03-28 北华航天工业学院 一种利用1,2-环氧丁烷合成β-氨基醇的方法

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11844720B2 (en) 2011-02-04 2023-12-19 Seed Health, Inc. Method and system to reduce the likelihood of dental caries and halitosis
US11951140B2 (en) 2011-02-04 2024-04-09 Seed Health, Inc. Modulation of an individual's gut microbiome to address osteoporosis and bone disease
US11998479B2 (en) 2011-02-04 2024-06-04 Seed Health, Inc. Method and system for addressing adverse effects on the oral microbiome and restoring gingival health caused by sodium lauryl sulphate exposure
US11951139B2 (en) 2015-11-30 2024-04-09 Seed Health, Inc. Method and system for reducing the likelihood of osteoporosis
US12257272B2 (en) 2015-12-24 2025-03-25 Seed Health, Inc. Method and system for reducing the likelihood of developing depression in an individual
US12279989B2 (en) 2011-02-04 2025-04-22 Seed Health, Inc. Method and system for increasing beneficial bacteria and decreasing pathogenic bacteria in the oral cavity
US11642382B2 (en) 2013-12-20 2023-05-09 Seed Health, Inc. Method for treating an individual suffering from bladder cancer
US12318377B2 (en) 2013-12-20 2025-06-03 Seed Health, Inc. Method and system for reducing the likelihood of a porphyromonas gingivalis infection in a human being
US11969445B2 (en) 2013-12-20 2024-04-30 Seed Health, Inc. Probiotic composition and method for controlling excess weight, obesity, NAFLD and NASH
US11529379B2 (en) 2013-12-20 2022-12-20 Seed Health, Inc. Method and system for reducing the likelihood of developing colorectal cancer in an individual human being
US12329783B2 (en) 2013-12-20 2025-06-17 Seed Health, Inc. Method and system to improve the health of a person's skin microbiome
US11839632B2 (en) 2013-12-20 2023-12-12 Seed Health, Inc. Topical application of CRISPR-modified bacteria to treat acne vulgaris
US11980643B2 (en) 2013-12-20 2024-05-14 Seed Health, Inc. Method and system to modify an individual's gut-brain axis to provide neurocognitive protection
US11833177B2 (en) 2013-12-20 2023-12-05 Seed Health, Inc. Probiotic to enhance an individual's skin microbiome
US11672835B2 (en) 2013-12-20 2023-06-13 Seed Health, Inc. Method for treating individuals having cancer and who are receiving cancer immunotherapy
US12005085B2 (en) 2013-12-20 2024-06-11 Seed Health, Inc. Probiotic method and composition for maintaining a healthy vaginal microbiome
US11826388B2 (en) 2013-12-20 2023-11-28 Seed Health, Inc. Topical application of Lactobacillus crispatus to ameliorate barrier damage and inflammation
US11998574B2 (en) 2013-12-20 2024-06-04 Seed Health, Inc. Method and system for modulating an individual's skin microbiome
US12246043B2 (en) 2013-12-20 2025-03-11 Seed Health, Inc. Topical application to treat acne vulgaris
CN109983012B (zh) 2016-09-16 2023-12-01 莱特豪斯制药公司 赖氨酸牙龈蛋白酶的酮抑制剂
JP7079794B2 (ja) * 2017-05-10 2022-06-02 コーテクシーミー， インコーポレイテッド アミノピリジン化合物ならびにその調製および使用のための方法
IL321581A (en) * 2022-12-22 2025-08-01 Protekt Therapeutics Ltd Pyrrolopyridine and pyrrolopyridazine based compounds and use thereof as pkr inhibitors

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000053172A1 (en) * 1999-03-08 2000-09-14 Smithkline Beecham Corporation Ccr-3 receptor antagonists
CN1353701A (zh) * 1999-01-27 2002-06-12 奥索-麦克尼尔药品公司 用作类胰蛋白酶抑制剂的肽基杂环酮类化合物
WO2016046530A1 (en) * 2014-09-23 2016-03-31 Mission Therapeutics Ltd Novel compounds
US20160096830A1 (en) * 2014-10-06 2016-04-07 Cortexyme, Inc. Inhibitors of lysine gingipain
US20160347715A1 (en) * 2013-12-20 2016-12-01 Sunil Abraham David Toll-Like Receptor 8 Agonists

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ751197A (en) 2013-05-01 2020-07-31 Neoculi Pty Ltd Compounds and methods of treating infections
US20170014468A1 (en) * 2014-04-29 2017-01-19 Cortexyme, Inc. Methods of use for therapeutics targeting the pathogen porphyromonas gingivalis
CA3004095A1 (en) 2015-11-09 2017-05-18 Cortexyme, Inc. Inhibitors of arginine gingipain
CN109983012B (zh) 2016-09-16 2023-12-01 莱特豪斯制药公司 赖氨酸牙龈蛋白酶的酮抑制剂
JP7079794B2 (ja) 2017-05-10 2022-06-02 コーテクシーミー， インコーポレイテッド アミノピリジン化合物ならびにその調製および使用のための方法

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1353701A (zh) * 1999-01-27 2002-06-12 奥索-麦克尼尔药品公司 用作类胰蛋白酶抑制剂的肽基杂环酮类化合物
WO2000053172A1 (en) * 1999-03-08 2000-09-14 Smithkline Beecham Corporation Ccr-3 receptor antagonists
US20160347715A1 (en) * 2013-12-20 2016-12-01 Sunil Abraham David Toll-Like Receptor 8 Agonists
WO2016046530A1 (en) * 2014-09-23 2016-03-31 Mission Therapeutics Ltd Novel compounds
US20160096830A1 (en) * 2014-10-06 2016-04-07 Cortexyme, Inc. Inhibitors of lysine gingipain

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BIALAS ET AL.: "Exploring the Sn Binding Pockets in Gingipains by Newly Developed Inhibitors: Structure-Based Design, Chemistry, and Activity", 《JOURNAL OF MEDICINAL CHEMISTRY》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115850094A (zh) * 2022-09-07 2023-03-28 北华航天工业学院 一种利用1,2-环氧丁烷合成β-氨基醇的方法

Also Published As

Publication number Publication date
US11059786B2 (en) 2021-07-13
JP7079794B2 (ja) 2022-06-02
EP3621613A4 (en) 2020-12-02
US20210340105A1 (en) 2021-11-04
EP3621613A1 (en) 2020-03-18
CA3062855A1 (en) 2018-11-15
JP2020519606A (ja) 2020-07-02
US20200148642A1 (en) 2020-05-14
WO2018209132A1 (en) 2018-11-15
JP2022110138A (ja) 2022-07-28
AU2018265397A1 (en) 2019-11-28

Similar Documents

Publication Publication Date Title
CN110944637A (zh) 氨基吡啶化合物及其制备方法和使用方法
CN101305011B (zh) 吡啶衍生物及其在治疗精神障碍中的用途
TW202043217A (zh) Ｂｃｌ－２抑制劑
CN116635393A (zh) 中环或大环苄基取代的杂环衍生物及其作为食欲素-2受体激动剂的用途
CN109956898B (zh) 免疫调节剂及其制法与医药上的用途
CN109790146B (zh) 药物化合物
CN103153063A (zh) 喹啉衍生物及含有其的melk抑制剂
CN112312910A (zh) 人整合素α4β7拮抗剂
CN104039787A (zh) 激酶抑制剂
TW202400606A (zh) 中環或大環之經苄基取代之雜環衍生物及相關用途
KR102281284B1 (ko) 피페라진 유도체 및 약제로서의 이의 용도
CN119212978A (zh) 用于抑制nlrp3的氧代吲哚啉基酰胺衍生物及其用途
EP4448105A1 (en) Heterocycle derivatives for the treatment of disease
ES2991287T3 (es) Compuestos derivados del 1,3,4-oxadiazol como inhibidor de la histona 6 desacetilasa, y la composición farmacéutica que comprende los mismos
CN109983012B (zh) 赖氨酸牙龈蛋白酶的酮抑制剂
WO2024153240A1 (zh) 一种杂环化合物及其制备方法和应用
CN110049985B (zh) 作为RORγ调节剂的杂环砜类
CN114222739A (zh) 磺酰脲衍生物及其用途
CN114761383A (zh) 磺酰胺衍生物及其用途
WO1998002431A1 (fr) DERIVES D'AMINOCYCLOPROPANE cis-SUBSTITUES
CN110278711A (zh) 作为RORγ调节剂的三环砜
CN113825542A (zh) 精氨酸牙龈蛋白酶抑制剂
CN119948015A (zh) 新型磺胺及其作为神经保护剂和/或神经修复剂的用途
TW202329938A (zh) Ｂｃｌ－２抑制劑
CN115052478A (zh) Trpv4受体配体

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
WD01 Invention patent application deemed withdrawn after publication
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20200331