JP2015501833A5 - - Google Patents
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- Publication number
- JP2015501833A5 JP2015501833A5 JP2014546692A JP2014546692A JP2015501833A5 JP 2015501833 A5 JP2015501833 A5 JP 2015501833A5 JP 2014546692 A JP2014546692 A JP 2014546692A JP 2014546692 A JP2014546692 A JP 2014546692A JP 2015501833 A5 JP2015501833 A5 JP 2015501833A5
- Authority
- JP
- Japan
- Prior art keywords
- independently
- pharmaceutically acceptable
- acceptable salt
- optionally substituted
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 17
- 150000003839 salts Chemical class 0.000 claims 17
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 8
- 125000001424 substituent group Chemical group 0.000 claims 8
- 125000003545 alkoxy group Chemical group 0.000 claims 7
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 7
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 6
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 6
- 125000001072 heteroaryl group Chemical group 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 125000004076 pyridyl group Chemical group 0.000 claims 4
- VHPXWPAGHGHDCK-UHFFFAOYSA-N 5-chloro-4-[(3,4-dichlorophenoxy)methyl]-2-fluoro-n-methylsulfonylbenzamide Chemical compound C1=C(F)C(C(=O)NS(=O)(=O)C)=CC(Cl)=C1COC1=CC=C(Cl)C(Cl)=C1 VHPXWPAGHGHDCK-UHFFFAOYSA-N 0.000 claims 3
- 229940124777 Nav1.7 inhibitor Drugs 0.000 claims 3
- 229910052799 carbon Inorganic materials 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 208000035475 disorder Diseases 0.000 claims 3
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 2
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 claims 2
- 150000001721 carbon Chemical group 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 125000006526 (C1-C2) alkyl group Chemical group 0.000 claims 1
- 125000006555 (C3-C5) cycloalkyl group Chemical group 0.000 claims 1
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 1
- 125000006625 (C3-C8) cycloalkyloxy group Chemical group 0.000 claims 1
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 206010065390 Inflammatory pain Diseases 0.000 claims 1
- 208000001294 Nociceptive Pain Diseases 0.000 claims 1
- 208000002193 Pain Diseases 0.000 claims 1
- 125000002947 alkylene group Chemical group 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 1
- 125000001624 naphthyl group Chemical group 0.000 claims 1
- 208000004296 neuralgia Diseases 0.000 claims 1
- 230000002981 neuropathic effect Effects 0.000 claims 1
- 208000021722 neuropathic pain Diseases 0.000 claims 1
- 230000003040 nociceptive effect Effects 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 229920006395 saturated elastomer Polymers 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161576005P | 2011-12-15 | 2011-12-15 | |
| US61/576,005 | 2011-12-15 | ||
| PCT/IB2012/057035 WO2013088315A1 (en) | 2011-12-15 | 2012-12-06 | Sulfonamide derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015501833A JP2015501833A (ja) | 2015-01-19 |
| JP2015501833A5 true JP2015501833A5 (enExample) | 2016-01-21 |
| JP6058023B2 JP6058023B2 (ja) | 2017-01-11 |
Family
ID=47557422
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014546692A Expired - Fee Related JP6058023B2 (ja) | 2011-12-15 | 2012-12-06 | スルホンアミド誘導体 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US9085517B2 (enExample) |
| EP (1) | EP2791108B1 (enExample) |
| JP (1) | JP6058023B2 (enExample) |
| CA (1) | CA2857603C (enExample) |
| ES (1) | ES2593533T3 (enExample) |
| WO (1) | WO2013088315A1 (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2014005297A (es) | 2011-10-31 | 2014-09-11 | Xenon Pharmaceuticals Inc | Compuestos de bencenosulfonamida y su uso como agentes terapeuticos. |
| WO2013064984A1 (en) | 2011-10-31 | 2013-05-10 | Xenon Pharmaceuticals Inc. | Biaryl ether sulfonamides and their use as therapeutic agents |
| JP6067031B2 (ja) * | 2012-01-04 | 2017-01-25 | ファイザー・リミテッドＰｆｉｚｅｒ Ｌｉｍｉｔｅｄ | Ｎ−アミノスルホニルベンズアミド |
| HK1209100A1 (en) | 2012-05-22 | 2016-03-24 | 基因泰克有限公司 | N-substituted benzamides and their use in the treatment of pain |
| WO2014008458A2 (en) | 2012-07-06 | 2014-01-09 | Genentech, Inc. | N-substituted benzamides and methods of use thereof |
| MX2015011436A (es) | 2013-03-14 | 2016-06-06 | Genentech Inc | Triazolopiridinas sustituidas y metodos para usarlas. |
| US9493429B2 (en) | 2013-03-15 | 2016-11-15 | Genentech, Inc. | Substituted benzoxazoles and methods of use thereof |
| EP3450428A1 (en) | 2013-11-27 | 2019-03-06 | Genentech, Inc. | Substituted benzamides and methods of use thereof |
| WO2016007534A1 (en) | 2014-07-07 | 2016-01-14 | Genentech, Inc. | Therapeutic compounds and methods of use thereof |
| HK1252567A1 (zh) | 2015-05-22 | 2019-05-31 | 基因泰克公司 | 被取代的苯甲酰胺和其使用方法 |
| EP3341353A1 (en) | 2015-08-27 | 2018-07-04 | Genentech, Inc. | Therapeutic compounds and methods of use thereof |
| AU2016330503B2 (en) | 2015-09-28 | 2021-04-08 | Genentech, Inc. | Therapeutic compounds and methods of use thereof |
| PL3375782T3 (pl) | 2015-11-13 | 2021-02-22 | iN Therapeutics Co., Ltd. | Bloker kanału sodowego |
| WO2017091592A1 (en) | 2015-11-25 | 2017-06-01 | Genentech, Inc. | Substituted benzamides useful as sodium channel blockers |
| CN109071426A (zh) | 2016-03-30 | 2018-12-21 | 基因泰克公司 | 取代的苯甲酰胺及其使用方法 |
| BR112019007763A2 (pt) | 2016-10-17 | 2019-07-02 | Genentech Inc | composto de fórmula, composição farmacêutica, métodos para tratar uma doença ou condição, para tratar dores, para diminuir o fluxo de íons e para tratar prurido, uso de um composto e invenção |
| US10793550B2 (en) | 2017-03-24 | 2020-10-06 | Genentech, Inc. | 4-piperidin-n-(pyrimidin-4-yl)chroman-7-sulfonamide derivatives as sodium channel inhibitors |
| EP3676248A4 (en) | 2017-08-31 | 2021-04-14 | RaQualia Pharma Inc. | BIARYLOXY DERIVATIVES AS TTX-S BLOCKERS |
| JP2021514980A (ja) | 2018-02-26 | 2021-06-17 | ジェネンテック， インコーポレイテッド | 疼痛及び関連病態に対するピリジン−スルホンアミド化合物及びその使用 |
| LT3762368T (lt) | 2018-03-08 | 2022-06-10 | Incyte Corporation | Aminopirazindiolio junginiai, kaip pi3k-γ inhibitoriai |
| CN111936494A (zh) | 2018-03-30 | 2020-11-13 | 豪夫迈·罗氏有限公司 | 作为钠通道抑制剂的取代的氢-吡啶并-吖嗪 |
| TW202003490A (zh) | 2018-05-22 | 2020-01-16 | 瑞士商赫孚孟拉羅股份公司 | 治療性化合物及其使用方法 |
| US11046658B2 (en) | 2018-07-02 | 2021-06-29 | Incyte Corporation | Aminopyrazine derivatives as PI3K-γ inhibitors |
| MX2021007425A (es) | 2018-12-26 | 2021-08-05 | Raqualia Pharma Inc | Derivados heterociclicos como bloqueadores de nav1.7 y nav1.8. |
| WO2021132577A1 (ja) * | 2019-12-27 | 2021-07-01 | 日本たばこ産業株式会社 | アシルスルファミド化合物及びその医薬用途 |
| CN113200956B (zh) * | 2021-05-18 | 2022-04-22 | 潍坊医学院 | 一种磺胺苯甲酰胺类衍生物及其制备方法和应用 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR0166088B1 (ko) | 1990-01-23 | 1999-01-15 | . | 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도 |
| US5376645A (en) | 1990-01-23 | 1994-12-27 | University Of Kansas | Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof |
| JPH05289262A (ja) | 1992-04-10 | 1993-11-05 | Fuji Photo Film Co Ltd | ハロゲン化銀カラー写真感光材料 |
| PT617001E (pt) | 1993-03-19 | 2000-06-30 | Merck & Co Inc | Derivados do acido fenoxifenilacetico |
| CA2195758A1 (en) | 1994-08-08 | 1996-02-22 | Scott W. Bagley | Phenoxyphenylacetic acid derivatives |
| WO1996009818A1 (en) | 1994-09-27 | 1996-04-04 | Merck & Co., Inc. | Endothelin receptor antagonists for the treatment of emesis |
| GB9518953D0 (en) | 1995-09-15 | 1995-11-15 | Pfizer Ltd | Pharmaceutical formulations |
| WO2000035296A1 (en) | 1996-11-27 | 2000-06-22 | Wm. Wrigley Jr. Company | Improved release of medicament active agents from a chewing gum coating |
| GB9711643D0 (en) | 1997-06-05 | 1997-07-30 | Janssen Pharmaceutica Nv | Glass thermoplastic systems |
| GB9828442D0 (en) | 1998-12-24 | 1999-02-17 | Karobio Ab | Novel thyroid receptor ligands and method II |
| JP4181408B2 (ja) | 2001-01-30 | 2008-11-12 | メルク エンド カムパニー インコーポレーテッド | 肥満、糖尿病及び脂質異常を治療するためのアシルスルファミド類 |
| AR045238A1 (es) * | 2003-08-08 | 2005-10-19 | Vertex Pharma | Compuestos utiles como inhibidores de canales ionicos regulados por voltaje |
| EP1663204B1 (en) | 2003-08-29 | 2014-05-07 | Exelixis, Inc. | C-kit modulators and methods of use |
| GB0423554D0 (en) | 2004-10-22 | 2004-11-24 | Cancer Rec Tech Ltd | Therapeutic compounds |
| WO2008008234A1 (en) | 2006-07-07 | 2008-01-17 | Targegen, Inc. | 2-amino-5-substituted pyrimidine inhibitors |
| RS20090154A (sr) | 2006-10-18 | 2010-10-31 | Pfizer Products Inc. | Jedinjenja biaril etra uree |
| DE602008000809D1 (de) | 2007-03-23 | 2010-04-29 | Icagen Inc | Ionenkanal-Hemmer |
| BRPI0810202A2 (pt) | 2007-05-03 | 2014-10-21 | Pfizer Ltd | Derivados de piridina |
| EP2173743A2 (en) | 2007-07-13 | 2010-04-14 | Icagen, Inc. | Sodium channel inhibitors |
| GB0725214D0 (en) | 2007-12-24 | 2008-02-06 | Karobio Ab | Pharmaceutical compounds |
| CA2724294A1 (en) | 2008-05-16 | 2009-11-19 | Schering Corporation | Glucagon receptor antagonists, compositions, and methods for their use |
| RU2609021C2 (ru) * | 2009-09-25 | 2017-01-30 | Астеллас Фарма Инк. | Замещенные соединения амида |
| JP5289262B2 (ja) | 2009-09-30 | 2013-09-11 | 京セラドキュメントソリューションズ株式会社 | シート搬送装置とこれを備えた画像読取装置及び画像形成装置 |
| AR079438A1 (es) | 2009-12-09 | 2012-01-25 | Panacea Biotec Ltd | Derivados de azucar, composiciones farmaceuticas y sus usos |
| KR20130029368A (ko) | 2010-02-11 | 2013-03-22 | 벤더르빌트 유니버시티 | Ｍｇｌｕｒ4 알로스테릭 강화제로서 피라졸로피리딘, 피라졸로피라진, 피라졸로피리미딘, 피라졸로티오펜 및 피라졸로티아졸 화합물, 조성물, 및 신경 기능이상을 치료하는 방법 |
| MX2012009377A (es) | 2010-02-11 | 2012-09-12 | Univ Vanderbilt | Benzotiazoles y azabenzotiazoles como potenciadores alostericos mglur4, composiciones y metodos para tratar la disfuncion neurologica. |
| TW201204735A (en) | 2010-04-16 | 2012-02-01 | Methylgene Inc | Inhibitors of protein tyrosine kinase activity |
| ES2526981T3 (es) * | 2010-07-12 | 2015-01-19 | Pfizer Limited | N-sulfonilbenzamidas como inhibidores de canales de sodio dependientes de voltaje |
| EP2593428B1 (en) * | 2010-07-12 | 2014-11-19 | Pfizer Limited | N-sulfonylbenzamides as inhibitors of voltage-gated sodium channels |
| WO2014008458A2 (en) * | 2012-07-06 | 2014-01-09 | Genentech, Inc. | N-substituted benzamides and methods of use thereof |
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2012
- 2012-12-06 JP JP2014546692A patent/JP6058023B2/ja not_active Expired - Fee Related
- 2012-12-06 CA CA2857603A patent/CA2857603C/en not_active Expired - Fee Related
- 2012-12-06 EP EP12813989.6A patent/EP2791108B1/en not_active Not-in-force
- 2012-12-06 US US14/358,494 patent/US9085517B2/en not_active Expired - Fee Related
- 2012-12-06 WO PCT/IB2012/057035 patent/WO2013088315A1/en not_active Ceased
- 2012-12-06 ES ES12813989.6T patent/ES2593533T3/es active Active