JP2021501756A5 - - Google Patents
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- Publication number
- JP2021501756A5 JP2021501756A5 JP2020524275A JP2020524275A JP2021501756A5 JP 2021501756 A5 JP2021501756 A5 JP 2021501756A5 JP 2020524275 A JP2020524275 A JP 2020524275A JP 2020524275 A JP2020524275 A JP 2020524275A JP 2021501756 A5 JP2021501756 A5 JP 2021501756A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- group
- phenyl
- cycloalkyl
- optionally substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 134
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 88
- 125000001424 substituent group Chemical group 0.000 claims 64
- PIGFYZPCRLYGLF-UHFFFAOYSA-N Aluminum nitride Chemical compound [Al]#N PIGFYZPCRLYGLF-UHFFFAOYSA-N 0.000 claims 55
- 125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 claims 43
- 229910052736 halogen Inorganic materials 0.000 claims 42
- 150000002367 halogens Chemical class 0.000 claims 42
- 229910052739 hydrogen Inorganic materials 0.000 claims 41
- 239000001257 hydrogen Substances 0.000 claims 41
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims 31
- 150000002431 hydrogen Chemical class 0.000 claims 29
- 125000000753 cycloalkyl group Chemical group 0.000 claims 28
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 28
- 125000000623 heterocyclic group Chemical group 0.000 claims 27
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims 22
- -1 quaternary ammonium cations Chemical class 0.000 claims 21
- 125000004076 pyridyl group Chemical group 0.000 claims 20
- 125000003545 alkoxy group Chemical group 0.000 claims 18
- 150000001413 amino acids Chemical class 0.000 claims 17
- 150000001875 compounds Chemical class 0.000 claims 15
- 150000002148 esters Chemical class 0.000 claims 15
- 150000003839 salts Chemical class 0.000 claims 15
- 239000000651 prodrug Substances 0.000 claims 14
- 229940002612 prodrug Drugs 0.000 claims 14
- 239000012453 solvate Substances 0.000 claims 14
- 239000008194 pharmaceutical composition Substances 0.000 claims 13
- 125000001453 quaternary ammonium group Chemical group 0.000 claims 13
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 12
- 125000002619 bicyclic group Chemical group 0.000 claims 11
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 11
- PXBRQCKWGAHEHS-UHFFFAOYSA-N dichlorodifluoromethane Chemical compound FC(F)(Cl)Cl PXBRQCKWGAHEHS-UHFFFAOYSA-N 0.000 claims 11
- 241000588921 Enterobacteriaceae Species 0.000 claims 10
- 208000015181 infectious disease Diseases 0.000 claims 8
- 125000004458 methylaminocarbonyl group Chemical group [H]N(C(*)=O)C([H])([H])[H] 0.000 claims 8
- 201000010099 disease Diseases 0.000 claims 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 7
- 125000002950 monocyclic group Chemical group 0.000 claims 6
- 239000000126 substance Substances 0.000 claims 5
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 4
- 125000004198 2-fluorophenyl group Chemical group [H]C1=C([H])C(F)=C(*)C([H])=C1[H] 0.000 claims 3
- 150000001768 cations Chemical class 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 239000008177 pharmaceutical agent Substances 0.000 claims 2
- 125000006164 6-membered heteroaryl group Chemical group 0.000 claims 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical group [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims 1
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- 125000004122 cyclic group Chemical group 0.000 claims 1
- 230000006806 disease prevention Effects 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 150000004677 hydrates Chemical class 0.000 claims 1
- 230000036571 hydration Effects 0.000 claims 1
- 238000006703 hydration reaction Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- UBQKCCHYAOITMY-UHFFFAOYSA-N pyridin-2-ol Chemical compound OC1=CC=CC=N1 UBQKCCHYAOITMY-UHFFFAOYSA-N 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
- 0 *C1=C(*)N=C(*)*1 Chemical compound *C1=C(*)N=C(*)*1 0.000 description 2
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021178557A JP2022025116A (ja) | 2017-11-03 | 2021-11-01 | 抗菌性化合物 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1718285.8 | 2017-11-03 | ||
| GBGB1718285.8A GB201718285D0 (en) | 2017-11-03 | 2017-11-03 | Antibacterial Compounds |
| PCT/GB2018/053183 WO2019086890A1 (en) | 2017-11-03 | 2018-11-02 | Antibacterial compounds |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021178557A Division JP2022025116A (ja) | 2017-11-03 | 2021-11-01 | 抗菌性化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021501756A JP2021501756A (ja) | 2021-01-21 |
| JP2021501756A5 true JP2021501756A5 (enExample) | 2021-12-09 |
| JP7348897B2 JP7348897B2 (ja) | 2023-09-21 |
Family
ID=60664899
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020524275A Active JP7348897B2 (ja) | 2017-11-03 | 2018-11-02 | 抗菌性化合物 |
| JP2021178557A Withdrawn JP2022025116A (ja) | 2017-11-03 | 2021-11-01 | 抗菌性化合物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021178557A Withdrawn JP2022025116A (ja) | 2017-11-03 | 2021-11-01 | 抗菌性化合物 |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US11345694B2 (enExample) |
| EP (2) | EP4606375A3 (enExample) |
| JP (2) | JP7348897B2 (enExample) |
| KR (1) | KR102470319B1 (enExample) |
| CN (1) | CN111566099B (enExample) |
| AU (1) | AU2018361828B2 (enExample) |
| BR (1) | BR112020008531A2 (enExample) |
| CA (1) | CA3081423A1 (enExample) |
| CL (2) | CL2020001147A1 (enExample) |
| CO (1) | CO2020005420A2 (enExample) |
| EA (1) | EA202091118A1 (enExample) |
| ES (1) | ES3005164T3 (enExample) |
| GB (1) | GB201718285D0 (enExample) |
| GE (2) | GEP20237522B (enExample) |
| IL (1) | IL274229B2 (enExample) |
| MA (1) | MA50504A (enExample) |
| MX (2) | MX2020004562A (enExample) |
| PE (2) | PE20211390A1 (enExample) |
| SG (1) | SG11202003717UA (enExample) |
| UA (1) | UA128475C2 (enExample) |
| WO (1) | WO2019086890A1 (enExample) |
| ZA (1) | ZA202002093B (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201718285D0 (en) * | 2017-11-03 | 2017-12-20 | Discuva Ltd | Antibacterial Compounds |
| UA127357C2 (uk) | 2018-04-18 | 2023-07-26 | Констеллатіон Фармацеутікалс, Інк. | Модулятори метилмодифікуючих ферментів, композиції та їх використання |
| EP3797108B1 (en) | 2018-05-21 | 2022-07-20 | Constellation Pharmaceuticals, Inc. | Modulators of methyl modifying enzymes, compositions and uses thereof |
| MD4003532T2 (ro) | 2019-07-24 | 2025-01-31 | Constellation Pharmaceuticals Inc | Forme cristaline de 7-clor-2-(4-(3-metoxiazetidin-1-il)ciclohexil)-2,4-dimetil-N-((6-metil-4-(metiltio)-2-oxo-1,2-dihidropiridin-3-il)metil)benzo[d][1,3]dioxol-5-carboxamidă |
| CN111635372B (zh) * | 2020-06-28 | 2022-05-27 | 齐鲁工业大学 | 一种恶唑酮衍生物及其合成方法 |
| CN117545485A (zh) * | 2021-05-03 | 2024-02-09 | 迪斯库瓦有限公司 | 抗菌化合物 |
| CA3217343A1 (en) * | 2021-05-03 | 2022-11-10 | Discuva Limited | Antibacterial compound |
| EP4484609A1 (en) | 2022-02-21 | 2025-01-01 | Mitsui Chemicals, Inc. | Metal member, metal-resin composite body, and method for producing metal member |
| CN120208965B (zh) * | 2025-05-28 | 2025-08-12 | 四川大学 | 靶向革兰氏阴性菌外膜组装关键蛋白质机器的4-(吡啶-4-基)-1h-咪唑-2-胺类衍生物、组合物 |
| CN121471219A (zh) * | 2026-01-09 | 2026-02-06 | 四川大学 | 用于革兰氏阴性菌特异性抗菌治疗的咪唑-2-胺类衍生物 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA869348B (en) | 1985-12-12 | 1987-10-28 | Smithkline Beckman Corp | Inhibition of the 5-lipoxygenase pathway |
| US4780470A (en) * | 1986-08-19 | 1988-10-25 | Smithkline Beckman Corporation | Inhibition of interleukin-1 by monocytes and/or macrophages |
| JP2808460B2 (ja) * | 1989-11-16 | 1998-10-08 | 大正製薬株式会社 | イミダゾール誘導体 |
| JPH09124640A (ja) | 1995-08-25 | 1997-05-13 | Nippon Soda Co Ltd | ピリジルイミダゾール化合物、製法および農園芸用殺菌剤 |
| US6207687B1 (en) | 1998-07-31 | 2001-03-27 | Merck & Co., Inc. | Substituted imidazoles having cytokine inhibitory activity |
| CO5271680A1 (es) * | 2000-02-21 | 2003-04-30 | Smithkline Beecham Corp | Compuestos |
| AU2003249977A1 (en) * | 2002-07-05 | 2004-01-23 | Axxima Pharmaceuticals Ag | Imidazole compounds for the treatment of hepatitis c virus infections |
| JP2004196678A (ja) | 2002-12-17 | 2004-07-15 | Dainippon Pharmaceut Co Ltd | ピラゾール系誘導体 |
| US8969372B2 (en) | 2003-11-14 | 2015-03-03 | Aptose Boisciences Inc. | Aryl imidazoles and their use as anti-cancer agents |
| KR101150077B1 (ko) | 2004-03-05 | 2012-06-01 | 다이쇼 세이야꾸 가부시끼가이샤 | 티아졸 유도체 |
| JP2007277230A (ja) * | 2006-03-15 | 2007-10-25 | Tanabe Seiyaku Co Ltd | 医薬組成物 |
| US8865732B2 (en) | 2008-03-21 | 2014-10-21 | Novartis Ag | Heterocyclic compounds and uses thereof |
| WO2011080132A2 (en) * | 2009-12-17 | 2011-07-07 | Katholieke Universiteit Leuven, K.U. Leuven R&D | Compounds, compositions and methods for controlling biofilms |
| GB201016261D0 (en) | 2010-09-28 | 2010-11-10 | Univ Leuven Kath | Compounds for controlling biofilms and process for their production |
| WO2012135016A2 (en) | 2011-03-25 | 2012-10-04 | North Carolina State University | Inhibition of bacterial biofilms and microbial growth with imidazole derivatives |
| TR201808033T4 (tr) | 2011-07-13 | 2018-06-21 | Tiumbio Co Ltd | Alk5 ve veya alk4 inhibitörleri olarak 2 pridil ikameli imidazollar. |
| US8840912B2 (en) | 2012-01-09 | 2014-09-23 | North Carolina State University | Imidazole derivatives useful for controlling microbial growth |
| EA039897B1 (ru) * | 2014-05-16 | 2022-03-24 | Атрива Терепьютикс Гмбх | Применение ингибитора мек для лечения коинфекции, включающей бактериальную инфекцию и инфекцию, вызванную вирусом гриппа |
| EA037112B1 (ru) | 2015-03-02 | 2021-02-08 | Ригель Фармасьютикалс, Инк. | Ингибиторы tgf- |
| US20180044316A1 (en) | 2015-03-05 | 2018-02-15 | University Of Notre Dame Du Lac | Potentiators of beta-lactam antibiotics |
| US10844051B2 (en) | 2015-07-22 | 2020-11-24 | The Royal Institution For The Advancement Of Learning/Mcgill University | Substituted oxazoles for the treatment of cancer |
| GB201718285D0 (en) * | 2017-11-03 | 2017-12-20 | Discuva Ltd | Antibacterial Compounds |
-
2017
- 2017-11-03 GB GBGB1718285.8A patent/GB201718285D0/en not_active Ceased
-
2018
- 2018-11-02 EP EP24200101.4A patent/EP4606375A3/en active Pending
- 2018-11-02 UA UAA202003341A patent/UA128475C2/uk unknown
- 2018-11-02 JP JP2020524275A patent/JP7348897B2/ja active Active
- 2018-11-02 AU AU2018361828A patent/AU2018361828B2/en active Active
- 2018-11-02 PE PE2020000454A patent/PE20211390A1/es unknown
- 2018-11-02 SG SG11202003717UA patent/SG11202003717UA/en unknown
- 2018-11-02 GE GEAP201815801A patent/GEP20237522B/en unknown
- 2018-11-02 GE GEAP202315801A patent/GEAP202315801A/en unknown
- 2018-11-02 MA MA050504A patent/MA50504A/fr unknown
- 2018-11-02 PE PE2022000118A patent/PE20221006A1/es unknown
- 2018-11-02 EA EA202091118A patent/EA202091118A1/ru unknown
- 2018-11-02 EP EP18800297.6A patent/EP3704105B9/en active Active
- 2018-11-02 US US16/761,016 patent/US11345694B2/en active Active
- 2018-11-02 KR KR1020207015574A patent/KR102470319B1/ko active Active
- 2018-11-02 ES ES18800297T patent/ES3005164T3/es active Active
- 2018-11-02 CA CA3081423A patent/CA3081423A1/en active Pending
- 2018-11-02 CN CN201880085171.5A patent/CN111566099B/zh active Active
- 2018-11-02 MX MX2020004562A patent/MX2020004562A/es unknown
- 2018-11-02 BR BR112020008531-6A patent/BR112020008531A2/pt active Search and Examination
- 2018-11-02 WO PCT/GB2018/053183 patent/WO2019086890A1/en not_active Ceased
-
2020
- 2020-04-26 IL IL274229A patent/IL274229B2/en unknown
- 2020-04-30 CO CONC2020/0005420A patent/CO2020005420A2/es unknown
- 2020-04-30 CL CL2020001147A patent/CL2020001147A1/es unknown
- 2020-05-04 ZA ZA2020/02093A patent/ZA202002093B/en unknown
- 2020-07-13 MX MX2021010246A patent/MX2021010246A/es unknown
-
2021
- 2021-08-27 CL CL2021002263A patent/CL2021002263A1/es unknown
- 2021-11-01 JP JP2021178557A patent/JP2022025116A/ja not_active Withdrawn
-
2022
- 2022-04-25 US US17/728,335 patent/US20220372027A1/en active Pending
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