JP2015520770A5 - - Google Patents

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Publication number
JP2015520770A5
JP2015520770A5 JP2015514538A JP2015514538A JP2015520770A5 JP 2015520770 A5 JP2015520770 A5 JP 2015520770A5 JP 2015514538 A JP2015514538 A JP 2015514538A JP 2015514538 A JP2015514538 A JP 2015514538A JP 2015520770 A5 JP2015520770 A5 JP 2015520770A5
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JP
Japan
Prior art keywords
alkyl group
branched alkyl
linear
general formula
ring structure
Prior art date
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Application number
JP2015514538A
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English (en)
Japanese (ja)
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JP2015520770A (ja
JP6138928B2 (ja
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Priority claimed from PCT/EP2013/061363 external-priority patent/WO2013178821A1/en
Publication of JP2015520770A publication Critical patent/JP2015520770A/ja
Publication of JP2015520770A5 publication Critical patent/JP2015520770A5/ja
Application granted granted Critical
Publication of JP6138928B2 publication Critical patent/JP6138928B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2015514538A 2012-06-01 2013-06-03 医薬に使用されるｎｏｔｃｈシグナル伝達経路及び分泌の阻害物質 Expired - Fee Related JP6138928B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12170403.5 2012-06-01
EP12170403 2012-06-01
PCT/EP2013/061363 WO2013178821A1 (en) 2012-06-01 2013-06-03 Inhibitors of the notch signalling pathway and secretion for use in medicine

Publications (3)

Publication Number Publication Date
JP2015520770A JP2015520770A (ja) 2015-07-23
JP2015520770A5 true JP2015520770A5 (enExample) 2015-12-17
JP6138928B2 JP6138928B2 (ja) 2017-05-31

Family

ID=48577739

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2015514538A Expired - Fee Related JP6138928B2 (ja) 2012-06-01 2013-06-03 医薬に使用されるｎｏｔｃｈシグナル伝達経路及び分泌の阻害物質

Country Status (5)

Country Link
US (1) US9828344B2 (enExample)
EP (1) EP2854809B1 (enExample)
JP (1) JP6138928B2 (enExample)
HK (1) HK1204928A1 (enExample)
WO (1) WO2013178821A1 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3139942B1 (en) 2014-05-05 2019-12-18 Bioventures, Llc COMPOSITIONS AND METHODS FOR INHIBITING ANTIAPOPTOTIC Bcl-2 PROTEINS AS ANTI-AGING AGENTS
JP2017522388A (ja) 2014-07-22 2017-08-10 バイオベンチャーズ・リミテッド・ライアビリティ・カンパニーＢｉｏＶｅｎｔｕｒｅｓ， ＬＬＣ 老化細胞を選択的に枯渇させるための組成物及び方法
CN120661674A (zh) 2016-03-15 2025-09-19 奥莱松基因组股份有限公司 用于治疗实体瘤的lsd1抑制剂的组合
JP6936498B2 (ja) 2016-04-21 2021-09-15 バイオベンチャーズ・リミテッド・ライアビリティ・カンパニーＢｉｏＶｅｎｔｕｒｅｓ， ＬＬＣ 抗アポトーシス性Ｂｃｌ−２ファミリータンパク質の分解を誘導する化合物及びその使用
IT201600132360A1 (it) 2016-12-29 2018-06-29 Univ Degli Studi Roma La Sapienza Inibitori di notch per uso nel trattamento della leucemia linfoblastica acuta a cellule t
ES3041854T3 (en) 2018-01-22 2025-11-17 Bioventures Llc Bcl-2 proteins degraders for cancer treatment
WO2019221755A1 (en) 2018-05-18 2019-11-21 Bioventures, Llc Piperlongumine analogues and uses thereof
EP3860562A1 (en) 2018-10-02 2021-08-11 Frequency Therapeutics, Inc. Pharmaceutical compositions comprising otic therapeutic agents and related methods
SG11202111191YA (en) 2019-04-08 2021-11-29 Frequency Therapeutics Inc Combination of chir99021 and valproic acid for treating hearing loss
JP2023504284A (ja) * 2019-12-09 2023-02-02 ウィスコンシン アラムニ リサーチ ファンデーション 疾患モデリング及び創薬を促進するためにヒトニューロンの老化を誘導するための化学カクテル
US20230183215A1 (en) * 2020-05-21 2023-06-15 Stemsynergy Therapeutics, Inc. Notch Inhibitors and Uses Thereof
WO2022158610A1 (en) * 2021-01-20 2022-07-28 Prism BioLab Co., Ltd. Novel bicyclic compounds

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA7152B (en) * 1970-01-24 1971-10-27 Bayer Ag New pharmaceutically active 1,4-dihydropyridines
DE2003148A1 (de) * 1970-01-24 1971-07-29 Bayer Ag Neue 1,4-Dihydropyridinderivate
US7244757B2 (en) * 2004-04-01 2007-07-17 Pfizer Inc Pyrazole-amine compounds for the treatment of neurodegenerative disorders
AU2006203819A1 (en) 2005-01-07 2006-07-13 Roskamp Research Llc Compounds for inhibiting beta-amyloid production and methods of identifying the compounds
WO2008070875A2 (en) 2006-12-08 2008-06-12 Roskamp Research Llc Polyhydroquinoline compounds and dihydropyridine compounds for inhibiting beta-amyloid production
WO2008103470A2 (en) 2007-02-21 2008-08-28 Trustees Of Columbia University In The City Of New York Oncogenic-ras-signal dependent lethal compounds
WO2009006580A1 (en) 2007-07-05 2009-01-08 Cv Therapeutics, Inc. Optionally condensed dihydropyridine, dihydropyrimidine and dihydropyrane derivatives acting as late sodium channel blockers
WO2009102864A1 (en) 2008-02-12 2009-08-20 Stanford University Hedgehog pathway antagonists and methods of use
CA2770302A1 (en) * 2008-09-17 2010-03-25 Burnham Institute For Medical Research Small molecule compounds for stem cell differentiation
US20110281356A1 (en) * 2008-09-17 2011-11-17 Human Biomolecular Research Institute Compounds for stem cell differentiation
AU2010310477A1 (en) 2009-10-23 2012-05-03 Health Research Inc. Method for treating androgen receptor positive cancers
WO2012063085A2 (en) * 2010-11-11 2012-05-18 Redx Pharma Limited Drug derivatives

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