JP2015520770A5 - - Google Patents

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Publication number
JP2015520770A5
JP2015520770A5 JP2015514538A JP2015514538A JP2015520770A5 JP 2015520770 A5 JP2015520770 A5 JP 2015520770A5 JP 2015514538 A JP2015514538 A JP 2015514538A JP 2015514538 A JP2015514538 A JP 2015514538A JP 2015520770 A5 JP2015520770 A5 JP 2015520770A5
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JP
Japan
Prior art keywords
alkyl group
branched alkyl
linear
general formula
ring structure
Prior art date
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JP2015514538A
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English (en)
Japanese (ja)
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JP2015520770A (ja
JP6138928B2 (ja
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Priority claimed from PCT/EP2013/061363 external-priority patent/WO2013178821A1/en
Publication of JP2015520770A publication Critical patent/JP2015520770A/ja
Publication of JP2015520770A5 publication Critical patent/JP2015520770A5/ja
Application granted granted Critical
Publication of JP6138928B2 publication Critical patent/JP6138928B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2015514538A 2012-06-01 2013-06-03 医薬に使用されるｎｏｔｃｈシグナル伝達経路及び分泌の阻害物質 Expired - Fee Related JP6138928B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12170403 2012-06-01
EP12170403.5 2012-06-01
PCT/EP2013/061363 WO2013178821A1 (en) 2012-06-01 2013-06-03 Inhibitors of the notch signalling pathway and secretion for use in medicine

Publications (3)

Publication Number Publication Date
JP2015520770A JP2015520770A (ja) 2015-07-23
JP2015520770A5 true JP2015520770A5 (enExample) 2015-12-17
JP6138928B2 JP6138928B2 (ja) 2017-05-31

Family

ID=48577739

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2015514538A Expired - Fee Related JP6138928B2 (ja) 2012-06-01 2013-06-03 医薬に使用されるｎｏｔｃｈシグナル伝達経路及び分泌の阻害物質

Country Status (5)

Country Link
US (1) US9828344B2 (enExample)
EP (1) EP2854809B1 (enExample)
JP (1) JP6138928B2 (enExample)
HK (1) HK1204928A1 (enExample)
WO (1) WO2013178821A1 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3139942B1 (en) 2014-05-05 2019-12-18 Bioventures, Llc COMPOSITIONS AND METHODS FOR INHIBITING ANTIAPOPTOTIC Bcl-2 PROTEINS AS ANTI-AGING AGENTS
EP3177144A4 (en) * 2014-07-22 2018-01-24 Bioventures, LLC. Compositions and methods for selectively depleting senescent cells
ES3057783T3 (en) 2016-03-15 2026-03-04 Oryzon Genomics Sa Combinations of lsd1 inhibitors for use in the treatment of neoplastic diseases
CN109152933B (zh) 2016-04-21 2022-12-02 生物风险投资有限责任公司 诱导抗细胞凋亡bcl-2家族蛋白的降解的化合物及其用途
IT201600132360A1 (it) 2016-12-29 2018-06-29 Univ Degli Studi Roma La Sapienza Inibitori di notch per uso nel trattamento della leucemia linfoblastica acuta a cellule t
EP3743069B1 (en) 2018-01-22 2025-08-06 BioVentures, LLC Bcl-2 proteins degraders for cancer treatment
US12084423B2 (en) 2018-05-18 2024-09-10 Bioventures, Llc Piperlongumine analogues and uses thereof
MX2021003773A (es) 2018-10-02 2021-07-16 Frequency Therapeutics Inc Composiciones farmacéuticas y métodos relacionados con los agentes terapéuticos óticos.
BR112021020141A2 (pt) 2019-04-08 2021-12-21 Frequency Therapeutics Inc Combinação de chir99021 e ácido valpróico para tratamento de perda auditiva
US20210311023A1 (en) * 2019-12-09 2021-10-07 Wisconsin Alumni Research Foundation Chemical cocktail for inducing senescence in human neurons to promote disease modeling and drug discovery
BR112022023559A2 (pt) * 2020-05-21 2023-01-24 Stemsynergy Therapeutics Inc Inibidores de notch e seus usos
CN116710455A (zh) * 2021-01-20 2023-09-05 株式会社棱镜生物实验室 新型双环化合物

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2003146A1 (de) 1970-01-24 1971-07-29 Bayer Ag Neue 1,4-Dihydropyridinderivate
DE2003148A1 (de) * 1970-01-24 1971-07-29 Bayer Ag Neue 1,4-Dihydropyridinderivate
US7244757B2 (en) 2004-04-01 2007-07-17 Pfizer Inc Pyrazole-amine compounds for the treatment of neurodegenerative disorders
US20060188938A1 (en) * 2005-01-07 2006-08-24 Mullan Michael J Compounds for inhibiting beta-amyloid production and methods of identifying the compounds
US20100119599A1 (en) 2006-12-08 2010-05-13 Archer Pharmaceuticals, Inc. Polyhydroquinoline compounds and dihydropyridine compounds for inhibiting beta-amyloid production
WO2008103470A2 (en) 2007-02-21 2008-08-28 Trustees Of Columbia University In The City Of New York Oncogenic-ras-signal dependent lethal compounds
WO2009006580A1 (en) 2007-07-05 2009-01-08 Cv Therapeutics, Inc. Optionally condensed dihydropyridine, dihydropyrimidine and dihydropyrane derivatives acting as late sodium channel blockers
WO2009102864A1 (en) 2008-02-12 2009-08-20 Stanford University Hedgehog pathway antagonists and methods of use
EP2348855A4 (en) * 2008-09-17 2013-01-09 Burnham Inst Medical Research Small-molecule bonds for stem cell differentiation
US20110281356A1 (en) * 2008-09-17 2011-11-17 Human Biomolecular Research Institute Compounds for stem cell differentiation
CN102573472A (zh) 2009-10-23 2012-07-11 健康研究公司 治疗雄激素受体阳性癌症的方法
CN103201260B (zh) 2010-11-11 2015-05-27 莱德克斯制药有限公司 药物衍生物

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