JP2019519587A5 - - Google Patents
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- JP2019519587A5 JP2019519587A5 JP2018568810A JP2018568810A JP2019519587A5 JP 2019519587 A5 JP2019519587 A5 JP 2019519587A5 JP 2018568810 A JP2018568810 A JP 2018568810A JP 2018568810 A JP2018568810 A JP 2018568810A JP 2019519587 A5 JP2019519587 A5 JP 2019519587A5
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- 150000001875 compounds Chemical class 0.000 claims description 76
- 229910052739 hydrogen Inorganic materials 0.000 claims description 25
- 239000001257 hydrogen Substances 0.000 claims description 25
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 20
- 208000035475 disorder Diseases 0.000 claims description 20
- 150000003839 salts Chemical class 0.000 claims description 19
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 18
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 16
- 150000002431 hydrogen Chemical class 0.000 claims description 14
- 125000000217 alkyl group Chemical group 0.000 claims description 11
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 10
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 9
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 8
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims description 8
- 239000008194 pharmaceutical composition Substances 0.000 claims description 8
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 8
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims description 6
- 229930182558 Sterol Natural products 0.000 claims description 6
- 230000015572 biosynthetic process Effects 0.000 claims description 6
- 230000002496 gastric effect Effects 0.000 claims description 6
- 235000003702 sterols Nutrition 0.000 claims description 6
- 238000003786 synthesis reaction Methods 0.000 claims description 6
- 208000002551 irritable bowel syndrome Diseases 0.000 claims description 4
- 150000003432 sterols Chemical class 0.000 claims description 4
- 206010002091 Anaesthesia Diseases 0.000 claims description 2
- 208000016583 Anus disease Diseases 0.000 claims description 2
- 208000019901 Anxiety disease Diseases 0.000 claims description 2
- 208000014644 Brain disease Diseases 0.000 claims description 2
- 206010009944 Colon cancer Diseases 0.000 claims description 2
- 208000030814 Eating disease Diseases 0.000 claims description 2
- 208000019454 Feeding and Eating disease Diseases 0.000 claims description 2
- 208000016621 Hearing disease Diseases 0.000 claims description 2
- 208000019022 Mood disease Diseases 0.000 claims description 2
- 208000016285 Movement disease Diseases 0.000 claims description 2
- 206010028980 Neoplasm Diseases 0.000 claims description 2
- 208000029726 Neurodevelopmental disease Diseases 0.000 claims description 2
- 208000002193 Pain Diseases 0.000 claims description 2
- 208000028017 Psychotic disease Diseases 0.000 claims description 2
- 206010039897 Sedation Diseases 0.000 claims description 2
- 208000006011 Stroke Diseases 0.000 claims description 2
- 208000009205 Tinnitus Diseases 0.000 claims description 2
- 208000030886 Traumatic Brain injury Diseases 0.000 claims description 2
- 208000013521 Visual disease Diseases 0.000 claims description 2
- 208000012826 adjustment disease Diseases 0.000 claims description 2
- 230000037005 anaesthesia Effects 0.000 claims description 2
- 208000029560 autism spectrum disease Diseases 0.000 claims description 2
- 201000011510 cancer Diseases 0.000 claims description 2
- 125000004452 carbocyclyl group Chemical group 0.000 claims description 2
- 229910052799 carbon Inorganic materials 0.000 claims description 2
- 125000004432 carbon atom Chemical group C* 0.000 claims description 2
- 208000010877 cognitive disease Diseases 0.000 claims description 2
- 206010009887 colitis Diseases 0.000 claims description 2
- 208000029742 colonic neoplasm Diseases 0.000 claims description 2
- 206010012601 diabetes mellitus Diseases 0.000 claims description 2
- 235000014632 disordered eating Nutrition 0.000 claims description 2
- 208000018459 dissociative disease Diseases 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 2
- 230000001939 inductive effect Effects 0.000 claims description 2
- 201000006417 multiple sclerosis Diseases 0.000 claims description 2
- 230000036407 pain Effects 0.000 claims description 2
- 230000001314 paroxysmal effect Effects 0.000 claims description 2
- 208000022821 personality disease Diseases 0.000 claims description 2
- 208000014081 polyp of colon Diseases 0.000 claims description 2
- 201000000980 schizophrenia Diseases 0.000 claims description 2
- 230000036280 sedation Effects 0.000 claims description 2
- 208000019116 sleep disease Diseases 0.000 claims description 2
- 125000002328 sterol group Chemical group 0.000 claims description 2
- 208000011117 substance-related disease Diseases 0.000 claims description 2
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 2
- 231100000886 tinnitus Toxicity 0.000 claims description 2
- 230000009529 traumatic brain injury Effects 0.000 claims description 2
- 208000029257 vision disease Diseases 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 8
- 238000000034 method Methods 0.000 description 10
- 238000011282 treatment Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021132225A JP2021175761A (ja) | 2016-07-07 | 2021-08-16 | オキシステロールおよびその使用方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662359532P | 2016-07-07 | 2016-07-07 | |
| US62/359,532 | 2016-07-07 | ||
| PCT/US2017/041199 WO2018009867A1 (en) | 2016-07-07 | 2017-07-07 | Oxysterols and methods of use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021132225A Division JP2021175761A (ja) | 2016-07-07 | 2021-08-16 | オキシステロールおよびその使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019519587A JP2019519587A (ja) | 2019-07-11 |
| JP2019519587A5 true JP2019519587A5 (enExample) | 2020-08-13 |
| JP6966486B2 JP6966486B2 (ja) | 2021-11-17 |
Family
ID=59383635
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018568810A Active JP6966486B2 (ja) | 2016-07-07 | 2017-07-07 | オキシステロールおよびその使用方法 |
| JP2021132225A Withdrawn JP2021175761A (ja) | 2016-07-07 | 2021-08-16 | オキシステロールおよびその使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021132225A Withdrawn JP2021175761A (ja) | 2016-07-07 | 2021-08-16 | オキシステロールおよびその使用方法 |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US10781231B2 (enExample) |
| EP (2) | EP3481846B1 (enExample) |
| JP (2) | JP6966486B2 (enExample) |
| AU (3) | AU2017292870B2 (enExample) |
| CY (1) | CY1124631T1 (enExample) |
| DK (1) | DK3481846T3 (enExample) |
| ES (1) | ES2884071T3 (enExample) |
| HR (1) | HRP20211272T8 (enExample) |
| HU (1) | HUE055263T2 (enExample) |
| LT (1) | LT3481846T (enExample) |
| MA (1) | MA45598B1 (enExample) |
| MD (1) | MD3481846T2 (enExample) |
| PL (1) | PL3481846T3 (enExample) |
| PT (1) | PT3481846T (enExample) |
| RS (1) | RS62222B1 (enExample) |
| SI (1) | SI3481846T1 (enExample) |
| SM (1) | SMT202100468T1 (enExample) |
| TW (1) | TWI752976B (enExample) |
| WO (1) | WO2018009867A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4245369A3 (en) | 2011-09-08 | 2023-11-22 | Sage Therapeutics, Inc. | Neuroactive steroids, compositions, and uses thereof |
| MX362544B (es) | 2013-03-13 | 2019-01-24 | Sage Therapeutics Inc | Esteroides neuroactivos y metodos para su uso. |
| JP6628745B2 (ja) | 2014-06-18 | 2020-01-15 | セージ セラピューティクス， インコーポレイテッド | オキシステロールおよびその使用方法 |
| SI3812392T1 (sl) | 2015-07-06 | 2025-09-30 | Sage Therapeutics, Inc. | Oksisteroli in postopki za uporabo le-teh |
| MA42410B1 (fr) | 2015-07-06 | 2021-04-30 | Sage Therapeutics Inc | Oxystérols et leurs méthodes d'utilisation |
| HUE059491T2 (hu) | 2016-04-01 | 2022-11-28 | Sage Therapeutics Inc | Oxiszterolok és azok alkalmazási eljárásai |
| WO2017193046A1 (en) | 2016-05-06 | 2017-11-09 | Sage Therapeutics, Inc. | Oxysterols and methods of use thereof |
| PT3481846T (pt) | 2016-07-07 | 2021-08-13 | Sage Therapeutics Inc | 24-hidroxiesteroides 11-substituídos para utilização no tratamento de afeções relacionadas com nmda |
| EP3519422B1 (en) | 2016-09-30 | 2022-08-31 | Sage Therapeutics, Inc. | C7 substituted oxysterols and these compounds for use as nmda modulators |
| MA46566A (fr) | 2016-10-18 | 2019-08-28 | Sage Therapeutics Inc | Oxystérols et leurs procédés d'utilisation |
| EP4105223B1 (en) | 2016-10-18 | 2025-04-30 | Sage Therapeutics, Inc. | Oxysterols and methods of use thereof |
| US10857163B1 (en) | 2019-09-30 | 2020-12-08 | Athenen Therapeutics, Inc. | Compositions that preferentially potentiate subtypes of GABAA receptors and methods of use thereof |
| CN111777654B (zh) * | 2020-06-11 | 2021-08-10 | 浙江神洲药业有限公司 | 一种泼尼松的制备方法 |
| CA3223179A1 (en) | 2021-06-11 | 2022-12-15 | Sage Therapeutics, Inc. | Neuroactive steroid for the treatment of alzheimer's disease |
| WO2023114224A1 (en) | 2021-12-13 | 2023-06-22 | Sage Therapeutics, Inc. | Combination of muscarinic receptor positive modulators and nmda positive allosteric modulators |
| CN115057906B (zh) * | 2022-07-28 | 2022-12-02 | 中节能万润股份有限公司 | 利用去氢表雄酮合成胆固醇的方法 |
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| WO2014115167A2 (en) | 2013-01-23 | 2014-07-31 | Sphaera Pharma Pvt. Ltd. | Novel compounds of 11beta-hydroxy-steroids for use in mitochondria biogenesis and diseases associated with mitochondrial dysfunction or depletion |
| EA031905B1 (ru) | 2013-01-29 | 2019-03-29 | Аптиникс Инк. | Спиролактамные модуляторы рецептора nmda и их применение |
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| US10238664B2 (en) | 2014-07-09 | 2019-03-26 | Duke University | Compositions and methods for the repair of myelin |
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| WO2017193046A1 (en) | 2016-05-06 | 2017-11-09 | Sage Therapeutics, Inc. | Oxysterols and methods of use thereof |
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| MA46566A (fr) | 2016-10-18 | 2019-08-28 | Sage Therapeutics Inc | Oxystérols et leurs procédés d'utilisation |
| EP4105223B1 (en) | 2016-10-18 | 2025-04-30 | Sage Therapeutics, Inc. | Oxysterols and methods of use thereof |
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2017
- 2017-07-07 PT PT177425956T patent/PT3481846T/pt unknown
- 2017-07-07 JP JP2018568810A patent/JP6966486B2/ja active Active
- 2017-07-07 DK DK17742595.6T patent/DK3481846T3/da active
- 2017-07-07 EP EP17742595.6A patent/EP3481846B1/en active Active
- 2017-07-07 WO PCT/US2017/041199 patent/WO2018009867A1/en not_active Ceased
- 2017-07-07 MA MA45598A patent/MA45598B1/fr unknown
- 2017-07-07 ES ES17742595T patent/ES2884071T3/es active Active
- 2017-07-07 MD MDE20190582T patent/MD3481846T2/ro unknown
- 2017-07-07 EP EP21172788.8A patent/EP3919502A1/en not_active Withdrawn
- 2017-07-07 TW TW106122956A patent/TWI752976B/zh active
- 2017-07-07 HU HUE17742595A patent/HUE055263T2/hu unknown
- 2017-07-07 LT LTEP17742595.6T patent/LT3481846T/lt unknown
- 2017-07-07 PL PL17742595T patent/PL3481846T3/pl unknown
- 2017-07-07 HR HRP20211272TT patent/HRP20211272T8/hr unknown
- 2017-07-07 RS RS20211006A patent/RS62222B1/sr unknown
- 2017-07-07 AU AU2017292870A patent/AU2017292870B2/en active Active
- 2017-07-07 SI SI201730870T patent/SI3481846T1/sl unknown
- 2017-07-07 US US16/315,250 patent/US10781231B2/en active Active
- 2017-07-07 SM SM20210468T patent/SMT202100468T1/it unknown
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2020
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2021
- 2021-08-06 CY CY20211100708T patent/CY1124631T1/el unknown
- 2021-08-16 JP JP2021132225A patent/JP2021175761A/ja not_active Withdrawn
- 2021-09-17 AU AU2021232833A patent/AU2021232833B2/en active Active
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2023
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