JP2015531773A5 - - Google Patents
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- JP2015531773A5 JP2015531773A5 JP2015529005A JP2015529005A JP2015531773A5 JP 2015531773 A5 JP2015531773 A5 JP 2015531773A5 JP 2015529005 A JP2015529005 A JP 2015529005A JP 2015529005 A JP2015529005 A JP 2015529005A JP 2015531773 A5 JP2015531773 A5 JP 2015531773A5
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- 229910052739 hydrogen Inorganic materials 0.000 claims description 54
- 125000000217 alkyl group Chemical group 0.000 claims description 31
- 150000001875 compounds Chemical class 0.000 claims description 31
- 125000001424 substituent group Chemical group 0.000 claims description 24
- 229910052757 nitrogen Inorganic materials 0.000 claims description 23
- 125000005842 heteroatom Chemical group 0.000 claims description 22
- 239000001257 hydrogen Substances 0.000 claims description 21
- 150000003839 salts Chemical class 0.000 claims description 19
- 125000005843 halogen group Chemical group 0.000 claims description 18
- 229910052760 oxygen Inorganic materials 0.000 claims description 18
- 229910052717 sulfur Inorganic materials 0.000 claims description 17
- 239000012453 solvate Substances 0.000 claims description 16
- 125000003545 alkoxy group Chemical group 0.000 claims description 12
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical group C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 claims description 10
- 125000003118 aryl group Chemical group 0.000 claims description 5
- 208000015181 infectious disease Diseases 0.000 claims description 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 5
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 5
- 229930192474 thiophene Chemical group 0.000 claims description 5
- 229910052736 halogen Inorganic materials 0.000 claims description 4
- 150000002367 halogens Chemical class 0.000 claims description 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 3
- 241000124008 Mammalia Species 0.000 claims description 3
- 229910052799 carbon Inorganic materials 0.000 claims description 3
- 125000002950 monocyclic group Chemical group 0.000 claims description 3
- 239000008194 pharmaceutical composition Substances 0.000 claims description 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 2
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 239000003112 inhibitor Substances 0.000 claims description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 2
- 125000004430 oxygen atom Chemical group O* 0.000 claims description 2
- 230000002265 prevention Effects 0.000 claims description 2
- 125000002837 carbocyclic group Chemical group 0.000 claims 19
- 150000002431 hydrogen Chemical class 0.000 claims 5
- 125000001153 fluoro group Chemical group F* 0.000 claims 2
- 230000001548 androgenic effect Effects 0.000 claims 1
- 150000001721 carbon Chemical group 0.000 claims 1
- 125000001309 chloro group Chemical group Cl* 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 125000003003 spiro group Chemical group 0.000 claims 1
- 229920006395 saturated elastomer Polymers 0.000 description 18
- 125000004435 hydrogen atom Chemical class [H]* 0.000 description 14
- 125000004432 carbon atom Chemical group C* 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2018207904A JP6895938B2 (ja) | 2012-08-28 | 2018-11-05 | スルファモイル−アリールアミド及びｂ型肝炎の治療のための薬剤としてのその使用 |
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12182076.5 | 2012-08-28 | ||
| EP12182076 | 2012-08-28 | ||
| EP12185055.6 | 2012-09-19 | ||
| EP12185055 | 2012-09-19 | ||
| EP12190837.0 | 2012-10-31 | ||
| EP12190837 | 2012-10-31 | ||
| EP13157230 | 2013-02-28 | ||
| EP13157230.7 | 2013-02-28 | ||
| EP13169574 | 2013-05-28 | ||
| EP13169574.4 | 2013-05-28 | ||
| PCT/EP2013/067821 WO2014033170A1 (en) | 2012-08-28 | 2013-08-28 | Sulfamoyl-arylamides and the use thereof as medicaments for the treatment of hepatitis b |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018207904A Division JP6895938B2 (ja) | 2012-08-28 | 2018-11-05 | スルファモイル−アリールアミド及びｂ型肝炎の治療のための薬剤としてのその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015531773A JP2015531773A (ja) | 2015-11-05 |
| JP2015531773A5 true JP2015531773A5 (enExample) | 2018-03-01 |
| JP6505013B2 JP6505013B2 (ja) | 2019-04-24 |
Family
ID=49085019
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015529007A Withdrawn JP2015533782A (ja) | 2012-08-28 | 2013-08-28 | スルファモイル−アリールアミド及びｂ型肝炎の治療のための薬剤としてのその使用 |
| JP2015529005A Expired - Fee Related JP6505013B2 (ja) | 2012-08-28 | 2013-08-28 | スルファモイル−アリールアミド及びｂ型肝炎の治療のための薬剤としてのその使用 |
| JP2018208063A Expired - Fee Related JP6907173B2 (ja) | 2012-08-28 | 2018-11-05 | スルファモイル−アリールアミド及びｂ型肝炎の治療のための薬剤としてのその使用 |
| JP2018207904A Expired - Fee Related JP6895938B2 (ja) | 2012-08-28 | 2018-11-05 | スルファモイル−アリールアミド及びｂ型肝炎の治療のための薬剤としてのその使用 |
| JP2021095380A Withdrawn JP2021176846A (ja) | 2012-08-28 | 2021-06-07 | スルファモイル−アリールアミド及びｂ型肝炎の治療のための薬剤としてのその使用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015529007A Withdrawn JP2015533782A (ja) | 2012-08-28 | 2013-08-28 | スルファモイル−アリールアミド及びｂ型肝炎の治療のための薬剤としてのその使用 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018208063A Expired - Fee Related JP6907173B2 (ja) | 2012-08-28 | 2018-11-05 | スルファモイル−アリールアミド及びｂ型肝炎の治療のための薬剤としてのその使用 |
| JP2018207904A Expired - Fee Related JP6895938B2 (ja) | 2012-08-28 | 2018-11-05 | スルファモイル−アリールアミド及びｂ型肝炎の治療のための薬剤としてのその使用 |
| JP2021095380A Withdrawn JP2021176846A (ja) | 2012-08-28 | 2021-06-07 | スルファモイル−アリールアミド及びｂ型肝炎の治療のための薬剤としてのその使用 |
Country Status (27)
| Country | Link |
|---|---|
| US (5) | US20150274653A1 (enExample) |
| EP (2) | EP2890375B1 (enExample) |
| JP (5) | JP2015533782A (enExample) |
| KR (4) | KR102122244B1 (enExample) |
| CN (4) | CN113444063A (enExample) |
| AP (2) | AP2015008249A0 (enExample) |
| AR (2) | AR092269A1 (enExample) |
| AU (5) | AU2013307331A1 (enExample) |
| BR (2) | BR112015004192B1 (enExample) |
| CA (2) | CA2881057C (enExample) |
| CL (2) | CL2015000487A1 (enExample) |
| CR (2) | CR20200276A (enExample) |
| EA (2) | EA038942B1 (enExample) |
| EC (2) | ECSP15007335A (enExample) |
| GT (2) | GT201500020A (enExample) |
| HK (2) | HK1208465A1 (enExample) |
| IL (3) | IL236967A0 (enExample) |
| JO (1) | JOP20130256B1 (enExample) |
| MX (2) | MX373711B (enExample) |
| NI (2) | NI201500030A (enExample) |
| NZ (4) | NZ743499A (enExample) |
| PH (3) | PH12015500317A1 (enExample) |
| SG (4) | SG11201501362PA (enExample) |
| TW (4) | TW201900607A (enExample) |
| UA (2) | UA123256C2 (enExample) |
| UY (2) | UY34992A (enExample) |
| WO (2) | WO2014033176A1 (enExample) |
Families Citing this family (162)
| Publication number | Priority date | Publication date | Assignee | Title |
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| MX359634B (es) | 2011-12-21 | 2018-10-03 | Novira Therapeutics Inc | Agentes antivirales contra la hepatitis b. |
| UY34992A (es) * | 2012-08-28 | 2014-02-28 | Janssen R & D Ireland | Sulfamoilarilamidas y su uso como medicamentos para el tratamiento de la hepatitis b |
| CA2896554C (en) * | 2012-12-27 | 2019-11-05 | Drexel University | Novel antiviral agents against hbv infection |
| PT2961732T (pt) | 2013-02-28 | 2017-06-26 | Janssen Sciences Ireland Uc | Sulfamoil-arilamidas e utilização das mesmas como medicamentos para o tratamento de hepatite b |
| WO2014165128A2 (en) | 2013-03-12 | 2014-10-09 | Novira Therapeutics, Inc. | Hepatitis b antiviral agents |
| WO2014161888A1 (en) | 2013-04-03 | 2014-10-09 | Janssen R&D Ireland | N-phenyl-carboxamide derivatives and the use thereof as medicaments for the treatment of hepatitis b |
| JO3603B1 (ar) * | 2013-05-17 | 2020-07-05 | Janssen Sciences Ireland Uc | مشتقات سلفامويل بيرولاميد واستخدامها كادوية لمعالجة التهاب الكبد نوع بي |
| PT2997019T (pt) * | 2013-05-17 | 2018-11-21 | Janssen Sciences Ireland Uc | Derivados de sulfamoíltiofenamida e o seu uso como medicamentos para o tratamento da hepatite b |
| UA118680C2 (uk) | 2013-07-25 | 2019-02-25 | ЯНССЕН САЙЄНСЕЗ АЙРЛЕНД ЮСі | Похідні заміщеного гліоксамідом піроламіду та їхнє застосування як лікарських препаратів для лікування гепатиту в |
| EP3060547B1 (en) | 2013-10-23 | 2017-10-11 | Janssen Sciences Ireland UC | Carboxamide derivatives and the use thereof as medicaments for the treatment of hepatitis b |
| US9169212B2 (en) | 2014-01-16 | 2015-10-27 | Novira Therapeutics, Inc. | Azepane derivatives and methods of treating hepatitis B infections |
| US9181288B2 (en) | 2014-01-16 | 2015-11-10 | Novira Therapeutics, Inc. | Azepane derivatives and methods of treating hepatitis B infections |
| US10392349B2 (en) | 2014-01-16 | 2019-08-27 | Novira Therapeutics, Inc. | Azepane derivatives and methods of treating hepatitis B infections |
| RU2702109C1 (ru) | 2014-02-05 | 2019-10-04 | Новира Терапьютикс, Инк. | Комбинированная терапия для лечения инфекций вгв |
| EA035848B1 (ru) | 2014-02-06 | 2020-08-20 | Янссен Сайенсиз Айрлэнд Юси | Производные сульфамоилпирроламида и их применение в качестве медикаментов для лечения гепатита b |
| CN106413402B (zh) | 2014-03-13 | 2020-10-30 | 美国印第安纳大学研究和技术公司 | 乙型肝炎核心蛋白变构调节剂 |
| US9400280B2 (en) | 2014-03-27 | 2016-07-26 | Novira Therapeutics, Inc. | Piperidine derivatives and methods of treating hepatitis B infections |
| US10065937B2 (en) * | 2014-07-31 | 2018-09-04 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | FLT3 receptor antagonists |
| US9765050B2 (en) | 2014-12-30 | 2017-09-19 | Novira Therapeutics, Inc. | Pyridyl reverse sulfonamides for HBV treatment |
| MA41338B1 (fr) | 2015-01-16 | 2019-07-31 | Hoffmann La Roche | Composés de pyrazine pour le traitement de maladies infectieuses |
| MY199989A (en) | 2015-03-04 | 2023-12-02 | Gilead Sciences Inc | Toll-like receptor modulating 4,6-diamino-pyrido[3,2-d]pyrimidine compounds |
| AU2016232801A1 (en) * | 2015-03-19 | 2017-10-12 | Novira Therapeutics, Inc. | Azocane and azonane derivatives and methods of treating hepatitis B infections |
| US10442788B2 (en) | 2015-04-01 | 2019-10-15 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
| US10738035B2 (en) | 2015-05-13 | 2020-08-11 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
| US10875876B2 (en) * | 2015-07-02 | 2020-12-29 | Janssen Sciences Ireland Uc | Cyclized sulfamoylarylamide derivatives and the use thereof as medicaments for the treatment of hepatitis B |
| WO2017011552A1 (en) | 2015-07-13 | 2017-01-19 | Enanta Pharmaceuticals, Inc. | Hepatitis b antiviral agents |
| US10301255B2 (en) | 2015-07-22 | 2019-05-28 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
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| TWI786639B (zh) | 2015-09-15 | 2022-12-11 | 美商艾森伯利生物科學公司 | B型肝炎核心蛋白質調節劑 |
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| US10280175B2 (en) | 2016-02-02 | 2019-05-07 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
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| SG11201903042VA (en) | 2016-10-14 | 2019-05-30 | Precision Biosciences Inc | Engineered meganucleases specific for recognition sequences in the hepatitis b virus genome |
| SG11201902944TA (en) | 2016-11-07 | 2019-05-30 | Arbutus Biopharma Corp | Substituted pyridinone-containing tricyclic compounds, and methods using same |
| CN109843855B (zh) * | 2016-11-08 | 2021-06-25 | 正大天晴药业集团股份有限公司 | 作为cccDNA抑制剂的磺酰胺类化合物 |
| CN108264520B (zh) * | 2017-01-03 | 2021-12-07 | 上海长森药业有限公司 | 用于治疗乙型肝炎的化合物及其用途 |
| TWI820984B (zh) | 2017-01-31 | 2023-11-01 | 美商基利科學股份有限公司 | 替諾福韋埃拉酚胺(tenofovir alafenamide)之晶型 |
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