JP2016528273A5 - - Google Patents
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- Publication number
- JP2016528273A5 JP2016528273A5 JP2016535487A JP2016535487A JP2016528273A5 JP 2016528273 A5 JP2016528273 A5 JP 2016528273A5 JP 2016535487 A JP2016535487 A JP 2016535487A JP 2016535487 A JP2016535487 A JP 2016535487A JP 2016528273 A5 JP2016528273 A5 JP 2016528273A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally
- compound according
- substituted
- group
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 20
- 125000000217 alkyl group Chemical group 0.000 claims 10
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 7
- 229910052736 halogen Inorganic materials 0.000 claims 4
- 150000002367 halogens Chemical class 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 125000001072 heteroaryl group Chemical group 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims 2
- 239000013543 active substance Substances 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims 2
- 125000004076 pyridyl group Chemical group 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 230000032823 cell division Effects 0.000 claims 1
- 125000002883 imidazolyl group Chemical group 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13181577 | 2013-08-23 | ||
| EP13181577.1 | 2013-08-23 | ||
| PCT/EP2014/067859 WO2015025019A1 (en) | 2013-08-23 | 2014-08-21 | New 6-alkynyl pyridine |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016528273A JP2016528273A (ja) | 2016-09-15 |
| JP2016528273A5 true JP2016528273A5 (enExample) | 2017-09-28 |
| JP6338665B2 JP6338665B2 (ja) | 2018-06-06 |
Family
ID=49003719
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016535487A Active JP6338665B2 (ja) | 2013-08-23 | 2014-08-21 | 新規６−アルキニルピリジン |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US9278978B2 (enExample) |
| EP (1) | EP3036228B1 (enExample) |
| JP (1) | JP6338665B2 (enExample) |
| AR (1) | AR097435A1 (enExample) |
| TW (1) | TW201605798A (enExample) |
| UY (1) | UY35710A (enExample) |
| WO (1) | WO2015025019A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2015240465B2 (en) | 2014-04-04 | 2020-02-27 | Del Mar Pharmaceuticals | Use of dianhydrogalactitol and analogs or derivatives thereof to treat non-small-cell carcinoma of the lung and ovarian cancer |
| AR101479A1 (es) | 2014-08-11 | 2016-12-21 | Boehringer Ingelheim Int | Derivados de 6-alquinil-piridina |
| CN109153645B (zh) | 2016-05-19 | 2022-06-21 | 勃林格殷格翰国际有限公司 | 制备6-炔基-吡啶衍生物的方法 |
| CN109152843A (zh) | 2016-05-20 | 2019-01-04 | 豪夫迈·罗氏有限公司 | Protac抗体缀合物及其使用方法 |
| US20200046684A1 (en) | 2017-03-31 | 2020-02-13 | Boehringer Ingelheim International Gmbh | Anticancer combination therapy |
| WO2020109328A1 (en) | 2018-11-26 | 2020-06-04 | Debiopharm International S.A. | Combination treatment of hiv infections |
| TWI894135B (zh) | 2019-01-25 | 2025-08-21 | 德商百靈佳殷格翰國際股份有限公司 | 編碼ccl21之重組棒狀病毒 |
| CA3148504A1 (en) | 2019-08-08 | 2021-02-11 | Institute For Cancer Research D/B/A/ The Research Institute Of Fox Chase Cancer Center | Combination therapy for treatment of cancer |
| EP4034102A1 (en) | 2019-09-25 | 2022-08-03 | Debiopharm International SA | Dosing regimens for treatment of patients with locally advanced squamous cell carcinoma |
| PE20231293A1 (es) | 2020-06-03 | 2023-08-22 | Boehringer Ingelheim Int | Rhabdovirus recombinante que codifica una proteina de fusion fc de dominio extracelular cd80 |
| WO2023056069A1 (en) | 2021-09-30 | 2023-04-06 | Angiex, Inc. | Degrader-antibody conjugates and methods of using same |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2253614B1 (en) * | 2004-04-07 | 2012-09-19 | Novartis AG | Inhibitors of IAP |
| US8058272B2 (en) * | 2006-12-07 | 2011-11-15 | Novartis Ag | Organic compounds |
| DE102007036075A1 (de) * | 2007-08-01 | 2009-02-05 | Bayer Healthcare Ag | Prodrugs und ihre Verwendung |
| US20110105436A1 (en) * | 2008-03-10 | 2011-05-05 | Auckland Uniservices Limited | Heteroaryl compounds, compositions, and methods of use in cancer treatment |
| US8859541B2 (en) * | 2012-02-27 | 2014-10-14 | Boehringer Ingelheim International Gmbh | 6-alkynylpyridines |
-
2014
- 2014-08-20 US US14/463,692 patent/US9278978B2/en active Active
- 2014-08-21 EP EP14753105.7A patent/EP3036228B1/en active Active
- 2014-08-21 UY UY35710A patent/UY35710A/es unknown
- 2014-08-21 JP JP2016535487A patent/JP6338665B2/ja active Active
- 2014-08-21 WO PCT/EP2014/067859 patent/WO2015025019A1/en not_active Ceased
- 2014-08-22 TW TW103129098A patent/TW201605798A/zh unknown
- 2014-08-22 AR ARP140103170A patent/AR097435A1/es unknown
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