|
US4673641A
(en)
|
1982-12-16 |
1987-06-16 |
Molecular Genetics Research And Development Limited Partnership |
Co-aggregate purification of proteins
|
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
|
DE69334191T2
(de)
|
1992-03-13 |
2008-11-27 |
bioMérieux B.V. |
Epstein-Barr-Virus verwandte Peptide und Nukleinsäuresegmente
|
|
US5770565A
(en)
|
1994-04-13 |
1998-06-23 |
La Jolla Cancer Research Center |
Peptides for reducing or inhibiting bone resorption
|
|
US5688781A
(en)
|
1994-08-19 |
1997-11-18 |
Bristol-Myers Squibb Company |
Method for treating vascular leak syndrome
|
|
US5994128A
(en)
|
1995-06-15 |
1999-11-30 |
Introgene B.V. |
Packaging systems for human recombinant adenovirus to be used in gene therapy
|
|
US20030040463A1
(en)
|
1996-04-05 |
2003-02-27 |
Wiegand Stanley J. |
TIE-2 ligands, methods of making and uses thereof
|
|
WO1998018914A1
(en)
|
1996-10-31 |
1998-05-07 |
Duke University |
Soluble tie2 receptor
|
|
JPH11225351A
(ja)
|
1998-02-04 |
1999-08-17 |
Matsushita Electric Ind Co Ltd |
ページャー機能を備える無線通信装置のメッセージ消去方法および装置
|
|
US5919813C1
(en)
|
1998-03-13 |
2002-01-29 |
Univ Johns Hopkins Med |
Use of a protein tyrosine kinase pathway inhibitor in the treatment of diabetic retinopathy
|
|
US5980929A
(en)
|
1998-03-13 |
1999-11-09 |
Johns Hopkins University, School Of Medicine |
Use of a protein tyrosine kinase pathway inhibitor in the treatment of retinal ischmemia or ocular inflammation
|
|
AR022303A1
(es)
|
1999-01-22 |
2002-09-04 |
Lundbeck & Co As H |
Derivados de piperidina, tetrahidropiridina y piperazina, su preparacion y utilizacion
|
|
SK287357B6
(sk)
*
|
1999-02-12 |
2010-08-09 |
The Scripps Research Institute |
Použitie antagonistu alfa v beta 3 na prípravu farmaceutickej kompozície na liečbu tumorových buniek a terapeutická kompozícia a súprava na liečenie tumoru alebo tumorových metastáz
|
|
US6455035B1
(en)
|
1999-03-26 |
2002-09-24 |
Regeneron Pharmaceuticals, Inc. |
Angiopoietins and methods of use thereof
|
|
DE60003011T2
(de)
|
1999-03-26 |
2004-04-08 |
Regeneron Pharmaceuticals, Inc. |
Modulierung der gefässepermeabilität mittels tie2 rezeptoraktivatoren
|
|
EP1046715A1
(en)
|
1999-04-23 |
2000-10-25 |
Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. |
Interaction of vascular-endothelial protein-tyrosine phosphatase with the angiopoietin receptor tie-2
|
|
WO2000065088A2
(en)
|
1999-04-26 |
2000-11-02 |
Amersham Pharmacia Biotech Ab |
Primers for identifying typing or classifying nucleic acids
|
|
EP1185559A2
(en)
|
1999-04-28 |
2002-03-13 |
Board Of Regents, The University Of Texas System |
Compositions and methods for cancer treatment by selectively inhibiting vegf
|
|
WO2000070030A1
(en)
|
1999-05-19 |
2000-11-23 |
Amgen Inc. |
Crystal of a lymphocyte kinase-ligand complex and methods of use
|
|
NZ517426A
(en)
|
1999-08-27 |
2004-04-30 |
Sugen Inc |
Phosphate mimics and methods of treatment using phosphatase inhibitors
|
|
US6589758B1
(en)
|
2000-05-19 |
2003-07-08 |
Amgen Inc. |
Crystal of a kinase-ligand complex and methods of use
|
|
DK1292335T3
(da)
|
2000-06-23 |
2007-09-17 |
Bayer Schering Pharma Ag |
Kombinationer og sammensætninger, som interfererer med VEGF/VEGF og angiopoietin/Tie receptor funktion og deres anvendelse (II)
|
|
PL362003A1
(en)
|
2000-09-27 |
2004-10-18 |
The Procter & Gamble Company |
Melanocortin receptor ligands
|
|
WO2003034990A2
(en)
|
2001-10-25 |
2003-05-01 |
Regeneron Pharmaceuticals, Inc. |
Angiopoietins and methods of use thereof
|
|
WO2003084565A2
(en)
|
2002-04-08 |
2003-10-16 |
MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. |
Ve-ptp as regulator of ve-cadherin mediated processes or disorders
|
|
RU2376029C2
(ru)
|
2002-04-25 |
2009-12-20 |
Юниверсити Оф Коннектикут Хелт Сентер |
Применение белков теплового шока для улучшения терапевтического эффекта невакцинного лечебного воздействия
|
|
US7226755B1
(en)
|
2002-09-25 |
2007-06-05 |
The Procter & Gamble Company |
HPTPbeta as a target in treatment of angiogenesis mediated disorders
|
|
US7507568B2
(en)
|
2002-09-25 |
2009-03-24 |
The Proctor & Gamble Company |
Three dimensional coordinates of HPTPbeta
|
|
US6930117B2
(en)
|
2002-11-09 |
2005-08-16 |
The Procter & Gamble Company |
N-alkyl-4-methyleneamino-3-hydroxy-2-pyridones
|
|
US6946479B2
(en)
|
2002-11-09 |
2005-09-20 |
The Procter & Gamble Company |
N-sulfonyl-4-methyleneamino-3-hydroxy-2-pyridones
|
|
US20050154011A1
(en)
|
2003-02-20 |
2005-07-14 |
The Procter & Gamble Company |
Tetrahydroisoquinolnyl sulfamic acids
|
|
AR046510A1
(es)
|
2003-07-25 |
2005-12-14 |
Regeneron Pharma |
Composicion de un antagonista de vegf y un agente anti-proliferativo
|
|
US20050158320A1
(en)
*
|
2003-11-12 |
2005-07-21 |
Nichols M. J. |
Combinations for the treatment of proliferative diseases
|
|
US8298532B2
(en)
|
2004-01-16 |
2012-10-30 |
Regeneron Pharmaceuticals, Inc. |
Fusion polypeptides capable of activating receptors
|
|
LT2653465T
(lt)
|
2004-03-15 |
2016-09-12 |
Janssen Pharmaceutica Nv |
Opioidinio receptoriaus moduliatoriai
|
|
US7771742B2
(en)
|
2004-04-30 |
2010-08-10 |
Allergan, Inc. |
Sustained release intraocular implants containing tyrosine kinase inhibitors and related methods
|
|
DK1771474T3
(da)
|
2004-07-20 |
2010-05-31 |
Genentech Inc |
Inhibitorer af angiopoitin-like 4 protein, kombinationer og anvendelser deraf
|
|
DK2457578T3
(en)
|
2004-09-28 |
2015-12-07 |
Aprogen Inc |
A chimeric molecule comprising angiopoietin-1 and a coiled-coil domain for use in the treatment of erectile dysfunction of the penis
|
|
BRPI0519596B1
(pt)
|
2004-12-21 |
2022-01-18 |
Astrazeneca Ab |
Agente de ligação alvejado, anticorpo monoclonal que se liga a angiopoietina-2, molécula de ácido nucleico, vetor, e, uso do agente de ligação alvejado
|
|
CA2609788A1
(en)
*
|
2005-04-26 |
2006-11-02 |
Coley Pharmaceutical Gmbh |
Modified oligoribonucleotide analogs with enhanced immunostimulatory activity
|
|
JO2787B1
(en)
|
2005-04-27 |
2014-03-15 |
امجين إنك, |
Alternative amide derivatives and methods of use
|
|
US7893040B2
(en)
|
2005-07-22 |
2011-02-22 |
Oculis Ehf |
Cyclodextrin nanotechnology for ophthalmic drug delivery
|
|
US20070154482A1
(en)
|
2005-09-12 |
2007-07-05 |
Beth Israel Deaconess Medical Center |
Methods and compositions for the treatment and diagnosis of diseases characterized by vascular leak, hypotension, or a procoagulant state
|
|
CA2633211A1
(en)
|
2005-12-15 |
2007-06-21 |
Astrazeneca Ab |
Combination of angiopoietin-2 antagonist and of vegf-a, kdr and/or flt1 antagonist for treating cancer
|
|
US7588924B2
(en)
|
2006-03-07 |
2009-09-15 |
Procter & Gamble Company |
Crystal of hypoxia inducible factor 1 alpha prolyl hydroxylase
|
|
EP2371865B1
(en)
|
2006-04-07 |
2017-07-12 |
Aerpio Therapeutics, Inc. |
Antibodies that bind human protein tyrosine phosphatase beta (HPTP-ß) and uses thereof
|
|
US20130023542A1
(en)
|
2006-06-27 |
2013-01-24 |
Aerpio Therapeutics Inc. |
Human protein tyrosine phosphatase inhibitors and methods of use
|
|
US7589212B2
(en)
|
2006-06-27 |
2009-09-15 |
Procter & Gamble Company |
Human protein tyrosine phosphatase inhibitors and methods of use
|
|
US7622593B2
(en)
|
2006-06-27 |
2009-11-24 |
The Procter & Gamble Company |
Human protein tyrosine phosphatase inhibitors and methods of use
|
|
US7795444B2
(en)
|
2006-06-27 |
2010-09-14 |
Warner Chilcott Company |
Human protein tyrosine phosphatase inhibitors and methods of use
|
|
US8846685B2
(en)
|
2006-06-27 |
2014-09-30 |
Aerpio Therapeutics Inc. |
Human protein tyrosine phosphatase inhibitors and methods of use
|
|
CA2693383C
(en)
|
2006-10-27 |
2017-03-28 |
Sunnybrook Health Sciences Center |
Multimeric tie 2 agonists and uses thereof in stimulating angiogenesis
|
|
US8642067B2
(en)
|
2007-04-02 |
2014-02-04 |
Allergen, Inc. |
Methods and compositions for intraocular administration to treat ocular conditions
|
|
US11078262B2
(en)
|
2007-04-30 |
2021-08-03 |
Allergan, Inc. |
High viscosity macromolecular compositions for treating ocular conditions
|
|
US9403789B2
(en)
|
2008-02-21 |
2016-08-02 |
Sequoia Pharmaceuticals, Inc. |
Benzofuran-containing amino acid inhibitors of cytochrome P450
|
|
US9096555B2
(en)
|
2009-01-12 |
2015-08-04 |
Aerpio Therapeutics, Inc. |
Methods for treating vascular leak syndrome
|
|
RU2014146121A
(ru)
*
|
2009-01-12 |
2015-06-10 |
Аэрпио Терапьютикс Инк. |
Способы лечения синдрома сосудистой утечки
|
|
KR20110123789A
(ko)
|
2009-03-03 |
2011-11-15 |
알콘 리서치, 리미티드 |
리셉터 티로신 키나제 저해(ＲＴＫｉ) 화합물을 눈에 전달하기 위한 약학 조성물
|
|
JP5583146B2
(ja)
|
2009-03-03 |
2014-09-03 |
アルコン リサーチ， リミテッド |
レセプターチロシンキナーゼ阻害（ＲＴＫｉ）化合物の眼への送達のための薬学的組成物
|
|
EP3556367A1
(en)
|
2009-07-06 |
2019-10-23 |
Aerpio Therapeutics, Inc. |
Benzosulfonamide derivatives, compositions thereof, and their use in the treatment of cancer or metastasis
|
|
US8883832B2
(en)
|
2009-07-06 |
2014-11-11 |
Aerpio Therapeutics Inc. |
Compounds, compositions, and methods for preventing metastasis of cancer cells
|
|
CN102612367B
(zh)
|
2009-11-06 |
2014-02-19 |
阿尔皮奥治疗学股份有限公司 |
脯氨酰羟化酶抑制剂
|
|
ES2649340T3
(es)
|
2010-07-12 |
2018-01-11 |
Threshold Pharmaceuticals, Inc. |
Administración de fármacos activados por hipoxia y agentes antiangiogénicos para el tratamiento del cáncer
|
|
KR101823924B1
(ko)
|
2010-10-07 |
2018-01-31 |
에르피오 세러퓨틱스 인코포레이티드 |
안구 부종, 신생혈관화 및 관련 질환의 치료를 위한 조성물 및 방법
|
|
EP2857032A3
(en)
|
2010-12-02 |
2015-07-15 |
Maruzen Pharmaceuticals Co., Ltd. |
Tie2 activator, vascular endothelial growth factor (vegf) inhibitor, anti-angiogenic agent, agent for maturing blood vessels, agent for normalizing blood vessels, agent for stabilizing blood vessels, and pharmaceutical composition
|
|
CA2850830A1
(en)
|
2011-10-13 |
2013-04-18 |
Aerpio Therapeutics, Inc. |
Methods for treating vascular leak syndrome and cancer
|
|
MX347226B
(es)
|
2011-10-13 |
2017-04-19 |
Aerpio Therapeutics Inc |
Tratamiento de enfermedad ocular.
|
|
US20130190324A1
(en)
|
2011-12-23 |
2013-07-25 |
The Regents Of The University Of Colorado, A Body Corporate |
Topical ocular drug delivery
|
|
US20150071941A1
(en)
|
2012-04-13 |
2015-03-12 |
The Johns Hopkins University |
Treatment of ischemic retinopathies
|
|
HUE039520T2
(hu)
|
2012-07-31 |
2019-01-28 |
Univ Texas |
Eljárások és készítmények hasnyálmirigy béta sejtek kialakulásának in vivo indukálására
|
|
NZ706853A
(en)
|
2012-10-11 |
2018-04-27 |
Ascendis Pharma Ophthalmology Div A/S |
Vegf neutralizing prodrugs for the treatment of ocular conditions
|
|
CA2890471C
(en)
|
2012-11-08 |
2021-07-27 |
Clearside Biomedical, Inc. |
Methods and devices for the treatment of ocular diseases in human subjects
|
|
EP2922572A1
(en)
|
2012-11-23 |
2015-09-30 |
AB Science |
Use of small molecule inhibitors/activators in combination with (deoxy)nucleoside or (deoxy)nucleotide analogs for treatment of cancer and hematological malignancies or viral infections
|
|
BR112015023753A2
(pt)
|
2013-03-15 |
2017-07-18 |
Aerpio Therapeutics Inc |
composições, formulações e métodos para o tratamento de doenças oculares
|
|
US20150050277A1
(en)
|
2013-03-15 |
2015-02-19 |
Aerpio Therapeutics Inc. |
Compositions and methods for treating ocular diseases
|
|
WO2014165963A1
(en)
|
2013-04-11 |
2014-10-16 |
Sunnybrook Research Institute |
Methods, uses and compositions of tie2 agonists
|
|
EP3010525A1
(en)
|
2013-06-20 |
2016-04-27 |
Novartis AG |
Use of a vegf antagonist in treating choroidal neovascularisation
|
|
WO2014203183A1
(en)
|
2013-06-20 |
2014-12-24 |
Novartis Ag |
Use of a vegf antagonist in treating macular edema
|
|
US20160151410A1
(en)
|
2013-07-02 |
2016-06-02 |
The Trustees Of Columbia University In The City Of New York |
Clearance of bioactive lipids from membrane structures by cyclodextrins
|
|
US20160159893A1
(en)
|
2013-07-11 |
2016-06-09 |
Gabriela Burian |
Use of a VEGF Antagonist in Treating Retinopathy of Prematurity
|
|
WO2015004616A1
(en)
|
2013-07-11 |
2015-01-15 |
Novartis Ag |
Use of a vegf antagonist in treating chorioretinal neovascular and permeability disorders in paediatric patients
|
|
EP3381940B1
(en)
|
2013-07-29 |
2022-09-07 |
Samsung Electronics Co., Ltd. |
Anti-ang2 antibody
|
|
US10617755B2
(en)
|
2013-08-30 |
2020-04-14 |
Genentech, Inc. |
Combination therapy for the treatment of glioblastoma
|
|
ES2731531T3
(es)
|
2013-10-01 |
2019-11-15 |
Sphingotec Gmbh |
Método para predecir el riesgo de experimentar un episodio cardiaco adverso grave
|
|
PT3062811T
(pt)
|
2013-11-01 |
2019-06-11 |
Regeneron Pharma |
Intervenções à base de angiopoietina para o tratamento da malária cerebral
|
|
JP6549140B2
(ja)
|
2014-02-19 |
2019-07-24 |
エアーピオ セラピューティクス インコーポレイテッド |
Ｎ−ベンジル−３−ヒドロキシ−４−置換ピリジン−２−（１ｈ）−オン
|
|
CN106456614A
(zh)
|
2014-03-14 |
2017-02-22 |
爱尔皮奥治疗有限公司 |
HPTP‑β抑制剂
|
|
JP2015199733A
(ja)
|
2014-04-04 |
2015-11-12 |
国立大学法人東北大学 |
眼圧降下剤
|
|
US9719135B2
(en)
|
2014-07-03 |
2017-08-01 |
Mannin Research Inc. |
Conditional angiopoietin-1/angiopoietin-2 double knock-out mice with defective ocular drainage system
|
|
WO2016022813A1
(en)
|
2014-08-07 |
2016-02-11 |
Aerpio Therapeutics, Inc. |
Combination of immunotherapies with activators of tie-2
|
|
WO2016049183A1
(en)
|
2014-09-24 |
2016-03-31 |
Aerpio Therapeutics, Inc. |
Ve-ptp extracellular domain antibodies delivered by a gene therapy vector
|
|
TWI705827B
(zh)
|
2014-11-07 |
2020-10-01 |
瑞士商諾華公司 |
治療眼部疾病之方法
|
|
US20160144025A1
(en)
|
2014-11-25 |
2016-05-26 |
Regeneron Pharmaceuticals, Inc. |
Methods and formulations for treating vascular eye diseases
|
|
ES2981607T3
(es)
|
2015-09-23 |
2024-10-09 |
Eyepoint Pharmaceuticals Inc |
Activadores de Tie-2 para uso en el tratamiento de la presión intraocular
|