AR046510A1 - Composicion de un antagonista de vegf y un agente anti-proliferativo - Google Patents
Composicion de un antagonista de vegf y un agente anti-proliferativoInfo
- Publication number
- AR046510A1 AR046510A1 ARP040102585A ARP040102585A AR046510A1 AR 046510 A1 AR046510 A1 AR 046510A1 AR P040102585 A ARP040102585 A AR P040102585A AR P040102585 A ARP040102585 A AR P040102585A AR 046510 A1 AR046510 A1 AR 046510A1
- Authority
- AR
- Argentina
- Prior art keywords
- vegf
- proliferative agent
- composition
- agent
- vegf antagonist
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/179—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/243—Platinum; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Abstract
Una composición farmacéutica que comprende un antagonista del factor de crecimiento celular endotelial vascular (VEGF), tal como una trampa VEGF, una agente anti-proliferativo, tal como taxol, y un portador farmacéuticamente aceptable. Reivindicación 6: Un articulo de fabricación, que comprende: (a) material de envasado; y (b) un agente farmacéutico contenido dentro del material envasado, donde el agente farmacéutico comprende por lo menos una dosis de trampa de factor del crecimiento endotelial vascular (VEGF) y por lo menos un agente anti-proliferativo, y donde el material de envasado indica que el antagonista de VEGF y el agente anti-proliferativo pueden utilizarse para tratar el cáncer o reducir el crecimiento tumoral.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US49000203P | 2003-07-25 | 2003-07-25 | |
US49397103P | 2003-08-08 | 2003-08-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR046510A1 true AR046510A1 (es) | 2005-12-14 |
Family
ID=34118812
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP040102585A AR046510A1 (es) | 2003-07-25 | 2004-07-21 | Composicion de un antagonista de vegf y un agente anti-proliferativo |
Country Status (17)
Country | Link |
---|---|
US (1) | US7354579B2 (es) |
EP (1) | EP1648428A2 (es) |
JP (1) | JP5355856B2 (es) |
KR (1) | KR101175990B1 (es) |
AR (1) | AR046510A1 (es) |
AU (1) | AU2004261165C1 (es) |
BR (1) | BRPI0412798A (es) |
CA (1) | CA2529742C (es) |
IL (1) | IL172406A (es) |
MX (1) | MXPA05013642A (es) |
MY (1) | MY149169A (es) |
NO (1) | NO20060924L (es) |
NZ (1) | NZ544570A (es) |
RU (1) | RU2353353C2 (es) |
TW (1) | TWI351953B (es) |
UY (1) | UY28438A1 (es) |
WO (1) | WO2005011734A2 (es) |
Families Citing this family (69)
Publication number | Priority date | Publication date | Assignee | Title |
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EP1399484B1 (en) * | 2001-06-28 | 2010-08-11 | Domantis Limited | Dual-specific ligand and its use |
US20050271663A1 (en) * | 2001-06-28 | 2005-12-08 | Domantis Limited | Compositions and methods for treating inflammatory disorders |
WO2004003019A2 (en) * | 2002-06-28 | 2004-01-08 | Domantis Limited | Immunoglobin single variant antigen-binding domains and dual-specific constructs |
WO2004058821A2 (en) * | 2002-12-27 | 2004-07-15 | Domantis Limited | Dual specific single domain antibodies specific for a ligand and for the receptor of the ligand |
US9321832B2 (en) * | 2002-06-28 | 2016-04-26 | Domantis Limited | Ligand |
US7696320B2 (en) | 2004-08-24 | 2010-04-13 | Domantis Limited | Ligands that have binding specificity for VEGF and/or EGFR and methods of use therefor |
WO2004110490A2 (en) * | 2003-06-06 | 2004-12-23 | Regeneron Pharmaceuticals, Inc. | Use of vegf inhibitors for tumor regression |
FR2878749B1 (fr) * | 2004-12-03 | 2007-12-21 | Aventis Pharma Sa | Combinaisons antitumorales contenant en agent inhibiteur de vegt et du 5fu ou un de ses derives |
CA2597247A1 (en) * | 2005-02-11 | 2006-08-17 | Regeneron Pharmaceuticals, Inc. | Therapeutic combination of a vegf antagonist (vegf trap) and an anti-hypertensive agent |
US20070166388A1 (en) * | 2005-02-18 | 2007-07-19 | Desai Neil P | Combinations and modes of administration of therapeutic agents and combination therapy |
ATE531365T1 (de) | 2005-02-18 | 2011-11-15 | Abraxis Bioscience Llc | Kombinationen und modi zur verabreichung therapeutischer mittel und kombinationstherapie |
US8735394B2 (en) * | 2005-02-18 | 2014-05-27 | Abraxis Bioscience, Llc | Combinations and modes of administration of therapeutic agents and combination therapy |
WO2006104852A2 (en) | 2005-03-25 | 2006-10-05 | Regeneron Pharmaceuticals, Inc. | Vegf antagonist formulations |
EP1957536A2 (en) * | 2005-12-01 | 2008-08-20 | Domantis Limited | Noncompetitive domain antibody formats that bind interleukin 1 receptor type 1 |
FR2895258B1 (fr) * | 2005-12-22 | 2008-03-21 | Aventis Pharma Sa | Combinaison comprenant de la combretastatine et des agents anticancereux |
NZ571300A (en) | 2006-04-07 | 2011-12-22 | Warner Chilcott Co Llc | Antibodies that bind human protein tyrosine phosphatase beta (HPTPBeta) and uses thereof |
WO2007139930A2 (en) * | 2006-05-26 | 2007-12-06 | Bayer Healthcare Llc | Drug combinations with substituted diaryl ureas for the treatment of cancer |
MX2008016124A (es) * | 2006-06-16 | 2009-01-20 | Regeneron Pharma | Formulaciones antagonistas de vegf adecuadas para la administracion intravitreal. |
US7622593B2 (en) | 2006-06-27 | 2009-11-24 | The Procter & Gamble Company | Human protein tyrosine phosphatase inhibitors and methods of use |
EP2125002A4 (en) * | 2007-03-14 | 2011-02-23 | Mayo Foundation | TREATMENT OF SKIN CANCER |
NZ580530A (en) * | 2007-06-06 | 2012-04-27 | Domantis Ltd | Anti vegf polypeptides, antibody variable domains and antagonists |
FR2918279B1 (fr) * | 2007-07-05 | 2010-10-22 | Aventis Pharma Sa | Combinaisons antitumorales contenant un agent inhibiteur de vegf et de l'irinotecan |
LT5610B (lt) | 2007-12-17 | 2009-11-25 | Uab Baltec Cnc Technologies, , | Kompleksinė sveikatinimo ir sporto įrangos sistema ir jos įgyvendinimo būdas |
SI2310011T1 (sl) * | 2008-06-17 | 2013-10-30 | Wyeth Llc | Antineoplastične kombinacije, ki vsebujejo HKI-272 in vinorelbin |
EP2294184A4 (en) | 2008-06-30 | 2013-03-06 | Mesoblast Inc | TREATMENT OF EYE DISEASES AND EXCESSIVE NEOVASCULARIZATION WITH THE HELP OF COMBINED THERAPY |
WO2010003057A2 (en) | 2008-07-03 | 2010-01-07 | Mayo Foundation For Medical Education And Research | Treating cancer |
ES2726946T3 (es) | 2009-07-06 | 2019-10-10 | Aerpio Therapeutics Inc | Derivados de benzosulfonamida, composiciones de los mismos y su uso en la prevención de la metástasis de las células cancerosas |
TWI426920B (zh) * | 2010-03-26 | 2014-02-21 | Hoffmann La Roche | 雙專一性、雙價抗-vegf/抗-ang-2抗體 |
PL2552415T3 (pl) | 2010-03-29 | 2017-03-31 | Abraxis Bioscience, Llc | Sposoby leczenia nowotworu |
CN105147613A (zh) | 2010-03-29 | 2015-12-16 | 阿布拉科斯生物科学有限公司 | 增强药物递送和治疗剂有效性的方法 |
MY162903A (en) | 2010-06-04 | 2017-07-31 | Abraxis Bioscience Llc | Methods of treatment of pancreatic cancer |
KR20190049934A (ko) | 2011-01-13 | 2019-05-09 | 리제너론 파아마슈티컬스, 인크. | 혈관신생 눈 장애를 치료하기 위한 vegf 길항제의 용도 |
JO3283B1 (ar) * | 2011-04-26 | 2018-09-16 | Sanofi Sa | تركيب يتضمن أفليبيرسيبت, حمض فولينيك, 5- فلورويوراسيل (5- Fu) وإرينوسيتان (FOLFIRI) |
US9427477B2 (en) | 2011-05-09 | 2016-08-30 | Mayo Foundation For Medical Education And Research | Cancer treatments |
US8809562B2 (en) | 2011-06-06 | 2014-08-19 | Chevron Phillips Chemical Company Lp | Use of metallocene compounds for cancer treatment |
JP2014530244A (ja) | 2011-10-13 | 2014-11-17 | エアピオ セラピューティックス, インコーポレイテッド | 血管漏出症候群および癌を治療する方法 |
ES2899643T3 (es) | 2012-10-01 | 2022-03-14 | Mayo Found Medical Education & Res | Tratamientos para el cáncer |
US20150050277A1 (en) | 2013-03-15 | 2015-02-19 | Aerpio Therapeutics Inc. | Compositions and methods for treating ocular diseases |
US9994560B2 (en) | 2014-03-14 | 2018-06-12 | Aerpio Therapeutics, Inc. | HPTP-β inhibitors |
TWI743024B (zh) | 2014-06-06 | 2021-10-21 | 美商健臻公司 | 灌注培養方法及其用途 |
CN113134095A (zh) | 2014-06-16 | 2021-07-20 | 梅约医学教育与研究基金会 | 治疗骨髓瘤 |
US9840553B2 (en) | 2014-06-28 | 2017-12-12 | Kodiak Sciences Inc. | Dual PDGF/VEGF antagonists |
ES2732925T3 (es) | 2014-07-18 | 2019-11-26 | Sanofi Sa | Método para predecir el resultado de un tratamiento con aflibercept de un paciente que se sospecha que padece un cáncer |
US9446148B2 (en) | 2014-10-06 | 2016-09-20 | Mayo Foundation For Medical Education And Research | Carrier-antibody compositions and methods of making and using the same |
TW201707725A (zh) | 2015-08-18 | 2017-03-01 | 美國馬友醫藥教育研究基金會 | 載體-抗體組合物及其製造及使用方法 |
AU2016326510B2 (en) | 2015-09-23 | 2022-03-10 | EyePoint Pharmaceuticals, Inc. | Methods of treating intraocular pressure with activators of Tie-2 |
TW201713360A (en) | 2015-10-06 | 2017-04-16 | Mayo Foundation | Methods of treating cancer using compositions of antibodies and carrier proteins |
BR112018013407A2 (pt) | 2015-12-30 | 2018-12-18 | Kodiak Sciences Inc | anticorpos e conjugados dos mesmos |
WO2017120501A1 (en) | 2016-01-07 | 2017-07-13 | Mayo Foundation For Medical Education And Research | Methods of treating cancer with interferon |
CA3012718A1 (en) | 2016-02-08 | 2017-08-17 | Vitrisa Therapeutics, Inc. | Compositions with improved intravitreal half-life and uses thereof |
EP3413874A4 (en) | 2016-02-12 | 2020-01-22 | Mayo Foundation for Medical Education and Research | HEMATOLOGICAL CANCER TREATMENTS |
EP3432928A4 (en) | 2016-03-21 | 2019-11-20 | Mayo Foundation for Medical Education and Research | PROCESS FOR IMPROVING THE THERAPEUTIC INDEX FOR CHEMOTHERAPEUTIC |
EP3432926A4 (en) | 2016-03-21 | 2019-11-20 | Mayo Foundation for Medical Education and Research | METHODS OF REDUCING THE TOXICITY OF A CHEMOTHERAPEUTIC MEDICAMENT |
US10618969B2 (en) | 2016-04-06 | 2020-04-14 | Mayo Foundation For Medical Education And Research | Carrier-binding agent compositions and methods of making and using the same |
CN109310756B (zh) * | 2016-05-13 | 2022-06-28 | 奥美药业有限公司 | 新型血管生成素2,vegf双特异性拮抗剂 |
EP3506950A1 (en) | 2016-09-01 | 2019-07-10 | Mayo Foundation for Medical Education and Research | Methods and compositions for targeting t-cell cancers |
JP2019526578A (ja) | 2016-09-01 | 2019-09-19 | マヨ ファウンデーション フォー メディカル エデュケーション アンド リサーチMayo Foundation For Medical Education And Research | キャリアー−pd−l1結合剤組成物及び癌を処置する為にそれを使用する方法 |
CA3035655A1 (en) | 2016-09-06 | 2018-03-15 | Mayo Foundation For Medical Education And Research | Methods of treating pd-l1 expressing cancer |
WO2018048815A1 (en) | 2016-09-06 | 2018-03-15 | Nantibodyfc, Llc | Methods of treating triple-negative breast cancer using compositions of antibodies and carrier proteins |
KR20230010817A (ko) | 2016-09-06 | 2023-01-19 | 메이오 파운데이션 포 메디칼 에쥬케이션 앤드 리써치 | 파클리탁셀-알부민-결합제 조성물 및 그의 사용 및 제조 방법 |
EP3589324A1 (en) | 2017-03-03 | 2020-01-08 | Janssen Biotech, Inc. | Co-therapy comprising a small molecule csf-1r inhibitor and an agonistic antibody that specifically binds cd40 for the treatment of cancer |
CN116059318A (zh) | 2018-01-26 | 2023-05-05 | 加利福尼亚大学董事会 | 用于使用抗vegf剂治疗血管生成病症的方法和组合物 |
AU2019265005A1 (en) | 2018-05-10 | 2020-12-17 | Regeneron Pharmaceuticals, Inc. | High concentration vegf receptor fusion protein containing formulations |
AU2020264969A1 (en) | 2019-04-29 | 2021-12-09 | EyePoint Pharmaceuticals, Inc. | Tie-2 activators targeting the schlemm's canal |
CA3157509A1 (en) | 2019-10-10 | 2021-04-15 | Kodiak Sciences Inc. | Methods of treating an eye disorder |
WO2021108255A1 (en) | 2019-11-25 | 2021-06-03 | The Regents Of The University Of California | Long-acting vegf inhibitors for intraocular neovascularization |
AU2022275786A1 (en) | 2021-05-17 | 2023-04-06 | Bayer Healthcare Llc | Extended, high dose VEGF antagonist regimens for treatment of angiogenic eye disorders |
US20240024420A1 (en) | 2022-03-15 | 2024-01-25 | Regeneron Pharmaceuticals, Inc. | Extended, High Dose VEGF Antagonist Regimens for Treatment of Angiogenic Eye Disorders |
WO2023177689A1 (en) | 2022-03-15 | 2023-09-21 | Regeneron Pharmaceuticals, Inc. | Extended, high dose vegf antagonist regimens for treatment of angiogenic eye disorders |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6811779B2 (en) * | 1994-02-10 | 2004-11-02 | Imclone Systems Incorporated | Methods for reducing tumor growth with VEGF receptor antibody combined with radiation and chemotherapy |
US6100071A (en) * | 1996-05-07 | 2000-08-08 | Genentech, Inc. | Receptors as novel inhibitors of vascular endothelial growth factor activity and processes for their production |
KR100816572B1 (ko) * | 1999-04-28 | 2008-03-24 | 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 | 항-vegf 항체 및 이를 포함하는 약제학적 조성물 |
RS50073B (sr) * | 1999-06-08 | 2009-01-22 | Regeneron Pharmaceuticals I.N.C., | Modifikovani himerni polipeptidi sa poboljšanim farmakokinetičkim osobinama |
WO2004110490A2 (en) * | 2003-06-06 | 2004-12-23 | Regeneron Pharmaceuticals, Inc. | Use of vegf inhibitors for tumor regression |
-
2004
- 2004-07-21 AR ARP040102585A patent/AR046510A1/es unknown
- 2004-07-23 KR KR1020067000521A patent/KR101175990B1/ko active IP Right Grant
- 2004-07-23 WO PCT/US2004/023815 patent/WO2005011734A2/en active Application Filing
- 2004-07-23 MX MXPA05013642A patent/MXPA05013642A/es not_active Application Discontinuation
- 2004-07-23 MY MYPI20042968A patent/MY149169A/en unknown
- 2004-07-23 RU RU2006105496/15A patent/RU2353353C2/ru active
- 2004-07-23 JP JP2006521281A patent/JP5355856B2/ja active Active
- 2004-07-23 NZ NZ544570A patent/NZ544570A/en unknown
- 2004-07-23 TW TW093121978A patent/TWI351953B/zh active
- 2004-07-23 BR BRPI0412798-6A patent/BRPI0412798A/pt not_active Application Discontinuation
- 2004-07-23 EP EP04779050A patent/EP1648428A2/en not_active Withdrawn
- 2004-07-23 AU AU2004261165A patent/AU2004261165C1/en active Active
- 2004-07-23 US US10/897,802 patent/US7354579B2/en active Active
- 2004-07-23 CA CA2529742A patent/CA2529742C/en active Active
- 2004-07-26 UY UY28438A patent/UY28438A1/es not_active Application Discontinuation
-
2005
- 2005-12-06 IL IL172406A patent/IL172406A/en not_active IP Right Cessation
-
2006
- 2006-02-24 NO NO20060924A patent/NO20060924L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CA2529742C (en) | 2012-09-18 |
US20050032699A1 (en) | 2005-02-10 |
KR101175990B1 (ko) | 2012-08-23 |
TW200524589A (en) | 2005-08-01 |
NO20060924L (no) | 2006-04-25 |
CA2529742A1 (en) | 2005-02-10 |
US7354579B2 (en) | 2008-04-08 |
MY149169A (en) | 2013-07-31 |
AU2004261165B2 (en) | 2009-07-16 |
AU2004261165C1 (en) | 2009-12-17 |
WO2005011734A3 (en) | 2005-04-14 |
WO2005011734A2 (en) | 2005-02-10 |
EP1648428A2 (en) | 2006-04-26 |
AU2004261165A1 (en) | 2005-02-10 |
JP5355856B2 (ja) | 2013-11-27 |
BRPI0412798A (pt) | 2006-09-26 |
UY28438A1 (es) | 2004-11-08 |
NZ544570A (en) | 2008-08-29 |
IL172406A0 (en) | 2006-04-10 |
JP2007500131A (ja) | 2007-01-11 |
TWI351953B (en) | 2011-11-11 |
IL172406A (en) | 2016-04-21 |
RU2353353C2 (ru) | 2009-04-27 |
KR20060028654A (ko) | 2006-03-30 |
MXPA05013642A (es) | 2006-03-10 |
RU2006105496A (ru) | 2006-06-10 |
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