UY28438A1 - Composicion de un antagonista de vegf y de un agente antiproliferativo - Google Patents
Composicion de un antagonista de vegf y de un agente antiproliferativoInfo
- Publication number
- UY28438A1 UY28438A1 UY28438A UY28438A UY28438A1 UY 28438 A1 UY28438 A1 UY 28438A1 UY 28438 A UY28438 A UY 28438A UY 28438 A UY28438 A UY 28438A UY 28438 A1 UY28438 A1 UY 28438A1
- Authority
- UY
- Uruguay
- Prior art keywords
- antiproliferative agent
- composition
- vegf antagonist
- vegf
- taxol
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/179—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/243—Platinum; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Inorganic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Métodos para tratar al cáncer y/o reducir o inhibir el crecimiento tumoral en un sujeto con dicha necesidad, que comprenda el administrar un composición farmacéutica comprendiendo un antagonista de factor de crecimiento de células del endotelio vascular (VEGF), tal como una trampa de VEGF, y un agente antiproliferativo, tal como taxol, y un portador farmacéuticamente aceptable.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US49000203P | 2003-07-25 | 2003-07-25 | |
US49397103P | 2003-08-08 | 2003-08-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
UY28438A1 true UY28438A1 (es) | 2004-11-08 |
Family
ID=34118812
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UY28438A UY28438A1 (es) | 2003-07-25 | 2004-07-26 | Composicion de un antagonista de vegf y de un agente antiproliferativo |
Country Status (17)
Country | Link |
---|---|
US (1) | US7354579B2 (es) |
EP (1) | EP1648428A2 (es) |
JP (1) | JP5355856B2 (es) |
KR (1) | KR101175990B1 (es) |
AR (1) | AR046510A1 (es) |
AU (1) | AU2004261165C1 (es) |
BR (1) | BRPI0412798A (es) |
CA (1) | CA2529742C (es) |
IL (1) | IL172406A (es) |
MX (1) | MXPA05013642A (es) |
MY (1) | MY149169A (es) |
NO (1) | NO20060924L (es) |
NZ (1) | NZ544570A (es) |
RU (1) | RU2353353C2 (es) |
TW (1) | TWI351953B (es) |
UY (1) | UY28438A1 (es) |
WO (1) | WO2005011734A2 (es) |
Families Citing this family (72)
Publication number | Priority date | Publication date | Assignee | Title |
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DE60237282D1 (de) * | 2001-06-28 | 2010-09-23 | Domantis Ltd | Doppelspezifischer ligand und dessen verwendung |
US20050271663A1 (en) * | 2001-06-28 | 2005-12-08 | Domantis Limited | Compositions and methods for treating inflammatory disorders |
US7696320B2 (en) | 2004-08-24 | 2010-04-13 | Domantis Limited | Ligands that have binding specificity for VEGF and/or EGFR and methods of use therefor |
DK1517921T3 (da) * | 2002-06-28 | 2006-10-09 | Domantis Ltd | Immunglobulin-enkeltvariable antigen-bindende domæner og dobbeltspecifikke konstruktioner deraf |
US9321832B2 (en) * | 2002-06-28 | 2016-04-26 | Domantis Limited | Ligand |
CA2511910A1 (en) * | 2002-12-27 | 2004-07-15 | Domantis Limited | Dual specific single domain antibodies specific for a ligand and for the receptor of the ligand |
CA2519875C (en) * | 2003-06-06 | 2014-01-14 | Regeneron Pharmaceuticals, Inc. | Method of tumor regression with vegf inhibitors |
FR2878749B1 (fr) * | 2004-12-03 | 2007-12-21 | Aventis Pharma Sa | Combinaisons antitumorales contenant en agent inhibiteur de vegt et du 5fu ou un de ses derives |
US7354581B2 (en) * | 2005-02-11 | 2008-04-08 | Regeneron Pharmaceuticals, Inc. | Therapeutic combination of a VEGF antagonist and anti-hypertensive agent |
PT1853250E (pt) * | 2005-02-18 | 2012-02-03 | Abraxis Bioscience Llc | Combinações e modos de administração de agentes terapêuticos e terapia de combinação |
US8735394B2 (en) | 2005-02-18 | 2014-05-27 | Abraxis Bioscience, Llc | Combinations and modes of administration of therapeutic agents and combination therapy |
US20070166388A1 (en) * | 2005-02-18 | 2007-07-19 | Desai Neil P | Combinations and modes of administration of therapeutic agents and combination therapy |
PT1861116E (pt) | 2005-03-25 | 2015-11-04 | Regeneron Pharma | Formulações de antagonista do vegf |
KR20080077238A (ko) * | 2005-12-01 | 2008-08-21 | 도만티스 리미티드 | 인터루킨 1 수용체 타입 1에 결합하는 비경쟁적 도메인항체 포맷 |
FR2895258B1 (fr) * | 2005-12-22 | 2008-03-21 | Aventis Pharma Sa | Combinaison comprenant de la combretastatine et des agents anticancereux |
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MX2008014953A (es) * | 2006-05-26 | 2009-03-05 | Bayer Healthcare Llc | Combinaciones de medicamentos con diarilureas sustituidas para el tratamiento de cancer. |
CN101478949A (zh) | 2006-06-16 | 2009-07-08 | 瑞泽恩制药公司 | 适合玻璃体内施用的vegf拮抗剂的制剂 |
US7622593B2 (en) | 2006-06-27 | 2009-11-24 | The Procter & Gamble Company | Human protein tyrosine phosphatase inhibitors and methods of use |
US20100047234A1 (en) * | 2007-03-14 | 2010-02-25 | Markovic Svetomir N | Treating skin cancer |
CA2683801A1 (en) * | 2007-06-06 | 2008-12-11 | Domantis Limited | Polypeptides, antibody variable domains and antagonists |
FR2918279B1 (fr) * | 2007-07-05 | 2010-10-22 | Aventis Pharma Sa | Combinaisons antitumorales contenant un agent inhibiteur de vegf et de l'irinotecan |
LT5610B (lt) | 2007-12-17 | 2009-11-25 | Uab Baltec Cnc Technologies, , | Kompleksinė sveikatinimo ir sporto įrangos sistema ir jos įgyvendinimo būdas |
KR20180128078A (ko) * | 2008-06-17 | 2018-11-30 | 와이어쓰 엘엘씨 | Hki-272 및 비노렐빈을 함유하는 항신생물성 조합물 |
WO2010005527A1 (en) | 2008-06-30 | 2010-01-14 | Angioblast Systems, Inc. | Treatment of eye diseases and excessive neovascularization using a combined therapy |
WO2010003057A2 (en) | 2008-07-03 | 2010-01-07 | Mayo Foundation For Medical Education And Research | Treating cancer |
MY160399A (en) | 2009-07-06 | 2017-03-15 | Aerpio Therapeutics Inc | Compounds, compositions, and methods for preventing metastasis of cancer cells |
AR080794A1 (es) * | 2010-03-26 | 2012-05-09 | Hoffmann La Roche | Anticuerpos bivalentes biespecificos anti- vegf/ anti-ang-2 |
MX364637B (es) | 2010-03-29 | 2019-05-03 | Abraxis Bioscience Llc Star | Platino y nanopartículas que incluyen placlitaxel/albúmina para usarse en el trartamiento de nsclc. |
CA2794147A1 (en) | 2010-03-29 | 2011-10-06 | Abraxis Bioscience, Llc | Use of a composition comprising nanoparticles comprising a taxane and an albumin to improve uptake of chemotherapeutics by tumors and for treating a cancer that is highly fibrotic and/or has a dense stroma |
KR20190130050A (ko) | 2010-06-04 | 2019-11-20 | 아브락시스 바이오사이언스, 엘엘씨 | 췌장암의 치료 방법 |
KR20220097542A (ko) | 2011-01-13 | 2022-07-07 | 리제너론 파아마슈티컬스, 인크. | 혈관신생 눈 장애를 치료하기 위한 vegf 길항제의 용도 |
JO3283B1 (ar) | 2011-04-26 | 2018-09-16 | Sanofi Sa | تركيب يتضمن أفليبيرسيبت, حمض فولينيك, 5- فلورويوراسيل (5- Fu) وإرينوسيتان (FOLFIRI) |
US9427477B2 (en) | 2011-05-09 | 2016-08-30 | Mayo Foundation For Medical Education And Research | Cancer treatments |
US8809562B2 (en) | 2011-06-06 | 2014-08-19 | Chevron Phillips Chemical Company Lp | Use of metallocene compounds for cancer treatment |
CA2850830A1 (en) | 2011-10-13 | 2013-04-18 | Aerpio Therapeutics, Inc. | Methods for treating vascular leak syndrome and cancer |
WO2014055415A1 (en) | 2012-10-01 | 2014-04-10 | Mayo Foundation For Medical Education And Research | Cancer treatments |
US20150050277A1 (en) | 2013-03-15 | 2015-02-19 | Aerpio Therapeutics Inc. | Compositions and methods for treating ocular diseases |
JP6483148B2 (ja) | 2014-03-14 | 2019-03-13 | エアーピオ セラピューティクス インコーポレイテッド | HPTP−β阻害剤 |
TWI743024B (zh) | 2014-06-06 | 2021-10-21 | 美商健臻公司 | 灌注培養方法及其用途 |
US10213513B2 (en) | 2014-06-16 | 2019-02-26 | Mayo Foundation For Medical Education And Research | Treating myelomas |
US9840553B2 (en) | 2014-06-28 | 2017-12-12 | Kodiak Sciences Inc. | Dual PDGF/VEGF antagonists |
EP3170005B1 (en) | 2014-07-18 | 2019-04-10 | Sanofi | Method for predicting the outcome of a treatment with aflibercept of a patient suspected to suffer from a cancer |
US9446148B2 (en) | 2014-10-06 | 2016-09-20 | Mayo Foundation For Medical Education And Research | Carrier-antibody compositions and methods of making and using the same |
TW201707725A (zh) | 2015-08-18 | 2017-03-01 | 美國馬友醫藥教育研究基金會 | 載體-抗體組合物及其製造及使用方法 |
CN113713101B (zh) | 2015-09-23 | 2023-07-28 | 视点制药公司 | 用tie-2的激活剂治疗眼内压的方法 |
TW201713360A (en) | 2015-10-06 | 2017-04-16 | Mayo Foundation | Methods of treating cancer using compositions of antibodies and carrier proteins |
IL290457B1 (en) | 2015-12-30 | 2024-10-01 | Kodiak Sciences Inc | Antibodies and their conjugates |
WO2017120501A1 (en) | 2016-01-07 | 2017-07-13 | Mayo Foundation For Medical Education And Research | Methods of treating cancer with interferon |
WO2017139417A1 (en) | 2016-02-08 | 2017-08-17 | Vitrisa Therapeutics, Inc. | Compositions with improved intravitreal half-life and uses thereof |
AU2017217881B2 (en) | 2016-02-12 | 2022-11-17 | Mayo Foundation For Medical Education And Research | Hematologic cancer treatments |
WO2017165440A1 (en) | 2016-03-21 | 2017-09-28 | Mayo Foundation For Medical Education And Research | Methods for reducing toxicity of a chemotherapeutic drug |
US11878061B2 (en) | 2016-03-21 | 2024-01-23 | Mayo Foundation For Medical Education And Research | Methods for improving the therapeutic index for a chemotherapeutic drug |
US10618969B2 (en) | 2016-04-06 | 2020-04-14 | Mayo Foundation For Medical Education And Research | Carrier-binding agent compositions and methods of making and using the same |
WO2017197199A1 (en) * | 2016-05-13 | 2017-11-16 | Askgene Pharma Inc. | Novel angiopoietin 2, vegf dual antagonists |
US11059885B2 (en) | 2016-05-13 | 2021-07-13 | Askgene Pharma Inc. | Angiopoietin 2, VEGF dual antagonists |
EP3506942B1 (en) | 2016-09-01 | 2022-11-16 | Mayo Foundation for Medical Education and Research | Carrier-pd-l1 binding agent compositions for treating cancers |
JP2019526579A (ja) | 2016-09-01 | 2019-09-19 | マヨ ファウンデーション フォー メディカル エデュケーション アンド リサーチMayo Foundation For Medical Education And Research | T細胞癌を標的とする為の方法及び組成物 |
EP3510048A1 (en) | 2016-09-06 | 2019-07-17 | Mayo Foundation for Medical Education and Research | Methods of treating pd-l1 expressing cancer |
CN109890422A (zh) | 2016-09-06 | 2019-06-14 | 梅约医学教育与研究基金会 | 紫杉醇-白蛋白-结合剂组合物及使用和制备该组合物的方法 |
WO2018048815A1 (en) | 2016-09-06 | 2018-03-15 | Nantibodyfc, Llc | Methods of treating triple-negative breast cancer using compositions of antibodies and carrier proteins |
JP2020510673A (ja) | 2017-03-03 | 2020-04-09 | ヤンセン バイオテツク,インコーポレーテツド | がんの治療のための低分子csf−1r阻害剤とcd40に特異的に結合するアゴニスト抗体とを含む併用療法 |
CN116059318A (zh) | 2018-01-26 | 2023-05-05 | 加利福尼亚大学董事会 | 用于使用抗vegf剂治疗血管生成病症的方法和组合物 |
MX2020009152A (es) | 2018-03-02 | 2020-11-09 | Kodiak Sciences Inc | Anticuerpos de il-6 y constructos de fusion y conjugados de los mismos. |
MA52570A (fr) | 2018-05-10 | 2021-03-17 | Regeneron Pharma | Formulations contenant des protéines de fusion du récepteur vegf à haute concentration |
JP7564824B2 (ja) | 2019-04-29 | 2024-10-09 | アイポイント ファーマシューティカルズ, インコーポレイテッド | シュレム管を標的とするTie-2活性化物質 |
CA3157509A1 (en) | 2019-10-10 | 2021-04-15 | Kodiak Sciences Inc. | Methods of treating an eye disorder |
BR112022010113A2 (pt) | 2019-11-25 | 2022-09-06 | Univ California | Inibidores de vegf de longa ação para neovascularização intraocular |
WO2021226444A2 (en) | 2020-05-08 | 2021-11-11 | Regeneron Pharmaceuticals, Inc. | Vegf traps and mini-traps and methods for treating ocular disorders and cancer |
KR20240008821A (ko) | 2021-05-17 | 2024-01-19 | 리제너론 파아마슈티컬스, 인크. | 혈관신생성 눈 장애 치료를 위한 연장된 고용량 vegf 길항제 요법 |
JP2023135645A (ja) | 2022-03-15 | 2023-09-28 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 血管新生性眼障害の処置のための長期高用量vegfアンタゴニストレジメン |
WO2023177691A1 (en) | 2022-03-15 | 2023-09-21 | Regeneron Pharmaceuticals, Inc. | Extended, high dose vegf antagonist regimens for treatment of angiogenic eye disorders |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6811779B2 (en) * | 1994-02-10 | 2004-11-02 | Imclone Systems Incorporated | Methods for reducing tumor growth with VEGF receptor antibody combined with radiation and chemotherapy |
US6100071A (en) * | 1996-05-07 | 2000-08-08 | Genentech, Inc. | Receptors as novel inhibitors of vascular endothelial growth factor activity and processes for their production |
CA2372053C (en) * | 1999-04-28 | 2008-09-02 | Board Of Regents, The University Of Texas System | Compositions and methods for cancer treatment by selectively inhibiting vegf |
JP4723140B2 (ja) * | 1999-06-08 | 2011-07-13 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 改善された薬物動態特性を有する改変キメラポリペプチド |
CA2519875C (en) * | 2003-06-06 | 2014-01-14 | Regeneron Pharmaceuticals, Inc. | Method of tumor regression with vegf inhibitors |
-
2004
- 2004-07-21 AR ARP040102585A patent/AR046510A1/es unknown
- 2004-07-23 WO PCT/US2004/023815 patent/WO2005011734A2/en active Application Filing
- 2004-07-23 NZ NZ544570A patent/NZ544570A/en not_active IP Right Cessation
- 2004-07-23 JP JP2006521281A patent/JP5355856B2/ja not_active Expired - Lifetime
- 2004-07-23 EP EP04779050A patent/EP1648428A2/en not_active Withdrawn
- 2004-07-23 MX MXPA05013642A patent/MXPA05013642A/es not_active Application Discontinuation
- 2004-07-23 KR KR1020067000521A patent/KR101175990B1/ko active IP Right Grant
- 2004-07-23 TW TW093121978A patent/TWI351953B/zh not_active IP Right Cessation
- 2004-07-23 BR BRPI0412798-6A patent/BRPI0412798A/pt not_active Application Discontinuation
- 2004-07-23 RU RU2006105496/15A patent/RU2353353C2/ru active
- 2004-07-23 CA CA2529742A patent/CA2529742C/en not_active Expired - Lifetime
- 2004-07-23 MY MYPI20042968A patent/MY149169A/en unknown
- 2004-07-23 US US10/897,802 patent/US7354579B2/en active Active
- 2004-07-23 AU AU2004261165A patent/AU2004261165C1/en not_active Expired
- 2004-07-26 UY UY28438A patent/UY28438A1/es not_active Application Discontinuation
-
2005
- 2005-12-06 IL IL172406A patent/IL172406A/en not_active IP Right Cessation
-
2006
- 2006-02-24 NO NO20060924A patent/NO20060924L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
KR20060028654A (ko) | 2006-03-30 |
RU2006105496A (ru) | 2006-06-10 |
WO2005011734A3 (en) | 2005-04-14 |
US7354579B2 (en) | 2008-04-08 |
IL172406A0 (en) | 2006-04-10 |
NZ544570A (en) | 2008-08-29 |
WO2005011734A2 (en) | 2005-02-10 |
IL172406A (en) | 2016-04-21 |
KR101175990B1 (ko) | 2012-08-23 |
TW200524589A (en) | 2005-08-01 |
CA2529742C (en) | 2012-09-18 |
MY149169A (en) | 2013-07-31 |
AR046510A1 (es) | 2005-12-14 |
JP2007500131A (ja) | 2007-01-11 |
MXPA05013642A (es) | 2006-03-10 |
EP1648428A2 (en) | 2006-04-26 |
AU2004261165C1 (en) | 2009-12-17 |
US20050032699A1 (en) | 2005-02-10 |
BRPI0412798A (pt) | 2006-09-26 |
JP5355856B2 (ja) | 2013-11-27 |
AU2004261165A1 (en) | 2005-02-10 |
TWI351953B (en) | 2011-11-11 |
NO20060924L (no) | 2006-04-25 |
RU2353353C2 (ru) | 2009-04-27 |
AU2004261165B2 (en) | 2009-07-16 |
CA2529742A1 (en) | 2005-02-10 |
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