JP2018510139A5 - - Google Patents
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- JP2018510139A5 JP2018510139A5 JP2017544035A JP2017544035A JP2018510139A5 JP 2018510139 A5 JP2018510139 A5 JP 2018510139A5 JP 2017544035 A JP2017544035 A JP 2017544035A JP 2017544035 A JP2017544035 A JP 2017544035A JP 2018510139 A5 JP2018510139 A5 JP 2018510139A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- compound
- substituted
- fluorine atoms
- chf
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims description 91
- 125000001153 fluoro group Chemical group F* 0.000 claims description 35
- 229910052731 fluorine Inorganic materials 0.000 claims description 32
- 239000008194 pharmaceutical composition Substances 0.000 claims description 32
- 150000003839 salts Chemical class 0.000 claims description 15
- 239000012453 solvate Substances 0.000 claims description 15
- 206010016654 Fibrosis Diseases 0.000 claims description 6
- 230000004761 fibrosis Effects 0.000 claims description 6
- 102000006495 integrins Human genes 0.000 claims description 6
- 108010044426 integrins Proteins 0.000 claims description 6
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 4
- 201000010099 disease Diseases 0.000 claims description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 210000002216 heart Anatomy 0.000 claims description 2
- 210000000936 intestine Anatomy 0.000 claims description 2
- 210000003734 kidney Anatomy 0.000 claims description 2
- 210000004185 liver Anatomy 0.000 claims description 2
- 210000004072 lung Anatomy 0.000 claims description 2
- 230000001404 mediated effect Effects 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 239000011737 fluorine Substances 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 description 8
- 125000000217 alkyl group Chemical group 0.000 description 8
- 0 CN(CCN1C)C1=* Chemical compound CN(CCN1C)C1=* 0.000 description 5
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562118303P | 2015-02-19 | 2015-02-19 | |
| US62/118,303 | 2015-02-19 | ||
| PCT/US2016/018612 WO2016134223A2 (en) | 2015-02-19 | 2016-02-19 | Fluorinated tetrahydronaphthyridinyl nonanoic acid derivatives and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020171641A Division JP7191299B2 (ja) | 2015-02-19 | 2020-10-12 | フッ化テトラヒドロナフチリジニルノナン酸誘導体およびその使用法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018510139A JP2018510139A (ja) | 2018-04-12 |
| JP2018510139A5 true JP2018510139A5 (enExample) | 2019-03-14 |
Family
ID=56689184
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017544035A Pending JP2018510139A (ja) | 2015-02-19 | 2016-02-19 | フッ化テトラヒドロナフチリジニルノナン酸誘導体およびその使用法 |
| JP2020171641A Active JP7191299B2 (ja) | 2015-02-19 | 2020-10-12 | フッ化テトラヒドロナフチリジニルノナン酸誘導体およびその使用法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020171641A Active JP7191299B2 (ja) | 2015-02-19 | 2020-10-12 | フッ化テトラヒドロナフチリジニルノナン酸誘導体およびその使用法 |
Country Status (13)
| Country | Link |
|---|---|
| US (5) | US9790222B2 (enExample) |
| EP (2) | EP3925959A1 (enExample) |
| JP (2) | JP2018510139A (enExample) |
| KR (1) | KR102647026B1 (enExample) |
| CN (2) | CN114805342A (enExample) |
| AU (1) | AU2016219906B2 (enExample) |
| BR (1) | BR112017017888A2 (enExample) |
| CA (1) | CA2976634C (enExample) |
| ES (1) | ES2892954T3 (enExample) |
| IL (1) | IL253873A0 (enExample) |
| RU (1) | RU2017132433A (enExample) |
| TW (1) | TWI736529B (enExample) |
| WO (1) | WO2016134223A2 (enExample) |
Families Citing this family (30)
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|---|---|---|---|---|
| US8901144B2 (en) * | 2013-02-07 | 2014-12-02 | Scifluor Life Sciences, Llc | Fluorinated 3-(2-oxo-3-(3-arylpropyl)imidazolidin-1-yl)-3-arylpropanoic acid derivatives |
| EP3266782B1 (en) | 2013-02-07 | 2019-10-30 | SciFluor Life Sciences, Inc. | Fluorinated integrin antagonists |
| GB201305668D0 (en) | 2013-03-28 | 2013-05-15 | Glaxosmithkline Ip Dev Ltd | Avs6 Integrin Antagonists |
| GB201417094D0 (en) | 2014-09-26 | 2014-11-12 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
| GB201417018D0 (en) | 2014-09-26 | 2014-11-12 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
| GB201417002D0 (en) | 2014-09-26 | 2014-11-12 | Glaxosmithkline Ip Dev Ltd | Novel compound |
| GB201417011D0 (en) | 2014-09-26 | 2014-11-12 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
| EP3925959A1 (en) * | 2015-02-19 | 2021-12-22 | OcuTerra Therapeutics, Inc. | Fluorinated derivatives of 3-(2-oxo-3-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl)imidazolidin-1-yl)propanoic acid and uses thereof |
| EP3273965A4 (en) * | 2015-03-26 | 2018-12-05 | Merck Sharp & Dohme Corp. | Composition and methods for treating chronic kidney disease |
| JP2018514568A (ja) * | 2015-04-30 | 2018-06-07 | サイフルーア ライフ サイエンシズ インコーポレイテッド | テトラヒドロナフチリジニルプロピオン酸誘導体およびその使用法 |
| GB201604680D0 (en) | 2016-03-21 | 2016-05-04 | Glaxosmithkline Ip Dev Ltd | Chemical Compounds |
| US10118929B2 (en) | 2016-04-27 | 2018-11-06 | Scifluor Life Sciences, Inc. | Nonanoic and decanoic acid derivatives and uses thereof |
| CN109996541A (zh) | 2016-09-07 | 2019-07-09 | 普利安特治疗公司 | N-酰基氨基酸化合物及其使用方法 |
| EA201991123A1 (ru) | 2016-11-08 | 2019-11-29 | ИНДАЗОЛОВЫЕ ПРОИЗВОДНЫЕ В КАЧЕСТВЕ АНТАГОНИСТОВ ИНТЕГРИНА αV | |
| EP3538528B1 (en) | 2016-11-08 | 2020-12-23 | Bristol-Myers Squibb Company | Pyrrole amides as alpha v integrin inhibitors |
| PT3538525T (pt) | 2016-11-08 | 2022-08-16 | Bristol Myers Squibb Co | Ácidos propiónicos 3-substituídos por inibidores de alfa v integrina |
| CN110167934B (zh) * | 2016-11-08 | 2022-06-10 | 百时美施贵宝公司 | 作为αV整联蛋白抑制剂的含有环丁烷和含有氮杂环丁烷的单环和螺环化合物 |
| AU2017359028A1 (en) | 2016-11-08 | 2019-06-20 | Bristol-Myers Squibb Company | Azole amides and amines as alpha V integrin inhibitors |
| US11046685B2 (en) | 2017-02-28 | 2021-06-29 | Morphic Therapeutic, Inc. | Inhibitors of (α-v)(β-6) integrin |
| EP4159727B1 (en) | 2017-02-28 | 2026-04-08 | Morphic Therapeutic, Inc. | Inhibitors of (alpha-v)(beta-6) integrin |
| WO2018183795A1 (en) | 2017-03-30 | 2018-10-04 | Scifluor Life Sciences, Inc. | Method of making tetrahydronaphthyridinyl nonanoic acid compounds |
| JP7291696B2 (ja) | 2017-11-07 | 2023-06-15 | ブリストル－マイヤーズ スクイブ カンパニー | アルファｖインテグリン阻害剤としてのピロロピラジン誘導体 |
| IL309955A (en) * | 2018-04-27 | 2024-03-01 | Arrowhead Pharmaceuticals Inc | Integrin-targeting ligands and their uses |
| PT3844162T (pt) * | 2018-08-29 | 2025-03-28 | Morphic Therapeutic Inc | Inibidores da integrina alfa v beta6 |
| AU2019327475B2 (en) | 2018-08-29 | 2025-06-05 | Morphic Therapeutic, Inc. | INHIBITING αV β6 INTEGRIN |
| WO2020047208A1 (en) | 2018-08-29 | 2020-03-05 | Morphic Therapeutic, Inc. | Inhibitors of (alpha-v)(beta-6) integrin |
| KR20230049584A (ko) * | 2020-05-07 | 2023-04-13 | 플라이언트 테라퓨틱스, 인크. | 아미노산 화합물을 사용한 호흡기 질환의 치료 |
| WO2021231581A1 (en) | 2020-05-12 | 2021-11-18 | Scifluor Life Sciences, Inc. | METHODS OF TREATING OR PREVENTING VIRAL INFECTION WITH FLUORINATED α V INTEGRIN ANTAGONISTS |
| CN116390754A (zh) * | 2020-10-20 | 2023-07-04 | 莱兰斯坦福初级大学评议会 | 用于过继细胞治疗的可注射水凝胶 |
| TW202235417A (zh) | 2020-11-19 | 2022-09-16 | 美商普萊恩醫療公司 | 整合素抑制劑及其用途 |
Family Cites Families (48)
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| WO1988007700A1 (fr) | 1987-03-30 | 1988-10-06 | Anritsu Corporation | Generateur de signaux lumineux et systeme d'etalonnage d'un appareil de mesure de la puissance lumineuse utilisant ledit generateur |
| CA1318254C (en) | 1988-01-06 | 1993-05-25 | Munehiro Tomikawa | Inhibitory agent of hepatic fibrosis containing pantethine |
| DK0581904T3 (da) | 1991-04-01 | 1997-12-29 | Univ Duke | Fremgangsmåde til inhibering af fibrose |
| US5501969A (en) | 1994-03-08 | 1996-03-26 | Human Genome Sciences, Inc. | Human osteoclast-derived cathepsin |
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| US6420396B1 (en) * | 1998-12-16 | 2002-07-16 | Beiersdorf Ag | Biphenyl and biphenyl-analogous compounds as integrin antagonists |
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| US6291503B1 (en) * | 1999-01-15 | 2001-09-18 | Bayer Aktiengesellschaft | β-phenylalanine derivatives as integrin antagonists |
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| ES2820855T3 (es) | 2011-05-09 | 2021-04-22 | Allegro Pharmaceuticals Llc | Antagonistas del receptor de integrina y sus métodos de uso |
| CA2840491A1 (en) | 2011-06-28 | 2013-01-03 | Bayer Healthcare Llc | Topical ophthalmological pharmaceutical composition containing sorafenib |
| US8901144B2 (en) | 2013-02-07 | 2014-12-02 | Scifluor Life Sciences, Llc | Fluorinated 3-(2-oxo-3-(3-arylpropyl)imidazolidin-1-yl)-3-arylpropanoic acid derivatives |
| EP3266782B1 (en) * | 2013-02-07 | 2019-10-30 | SciFluor Life Sciences, Inc. | Fluorinated integrin antagonists |
| EP3925959A1 (en) | 2015-02-19 | 2021-12-22 | OcuTerra Therapeutics, Inc. | Fluorinated derivatives of 3-(2-oxo-3-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl)imidazolidin-1-yl)propanoic acid and uses thereof |
| JP2018514568A (ja) | 2015-04-30 | 2018-06-07 | サイフルーア ライフ サイエンシズ インコーポレイテッド | テトラヒドロナフチリジニルプロピオン酸誘導体およびその使用法 |
| WO2018183795A1 (en) | 2017-03-30 | 2018-10-04 | Scifluor Life Sciences, Inc. | Method of making tetrahydronaphthyridinyl nonanoic acid compounds |
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2016
- 2016-02-19 EP EP21171386.2A patent/EP3925959A1/en not_active Withdrawn
- 2016-02-19 JP JP2017544035A patent/JP2018510139A/ja active Pending
- 2016-02-19 CN CN202210129062.7A patent/CN114805342A/zh active Pending
- 2016-02-19 US US15/047,717 patent/US9790222B2/en not_active Expired - Fee Related
- 2016-02-19 ES ES16753120T patent/ES2892954T3/es active Active
- 2016-02-19 WO PCT/US2016/018612 patent/WO2016134223A2/en not_active Ceased
- 2016-02-19 TW TW105104964A patent/TWI736529B/zh not_active IP Right Cessation
- 2016-02-19 BR BR112017017888A patent/BR112017017888A2/pt not_active Application Discontinuation
- 2016-02-19 RU RU2017132433A patent/RU2017132433A/ru not_active Application Discontinuation
- 2016-02-19 CN CN201680022826.5A patent/CN107531699A/zh active Pending
- 2016-02-19 KR KR1020177026258A patent/KR102647026B1/ko active Active
- 2016-02-19 EP EP16753120.1A patent/EP3259271B1/en active Active
- 2016-02-19 AU AU2016219906A patent/AU2016219906B2/en not_active Ceased
- 2016-02-19 CA CA2976634A patent/CA2976634C/en active Active
-
2017
- 2017-08-07 IL IL253873A patent/IL253873A0/en active IP Right Grant
- 2017-09-11 US US15/700,351 patent/US10301307B2/en active Active
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2019
- 2019-04-03 US US16/373,780 patent/US20190225609A1/en not_active Abandoned
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2020
- 2020-10-12 JP JP2020171641A patent/JP7191299B2/ja active Active
- 2020-10-22 US US17/076,891 patent/US11685738B2/en active Active
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2023
- 2023-05-31 US US18/203,776 patent/US12286432B2/en active Active