JP2016518434A5 - - Google Patents
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- JP2016518434A5 JP2016518434A5 JP2016513385A JP2016513385A JP2016518434A5 JP 2016518434 A5 JP2016518434 A5 JP 2016518434A5 JP 2016513385 A JP2016513385 A JP 2016513385A JP 2016513385 A JP2016513385 A JP 2016513385A JP 2016518434 A5 JP2016518434 A5 JP 2016518434A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- fluoro
- compound
- pharmaceutically acceptable
- solvate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 claims description 54
- 125000001153 fluoro group Chemical group F* 0.000 claims description 50
- 229910052739 hydrogen Inorganic materials 0.000 claims description 36
- 239000001257 hydrogen Substances 0.000 claims description 36
- 150000003839 salts Chemical class 0.000 claims description 24
- 239000012453 solvate Substances 0.000 claims description 24
- 229920006395 saturated elastomer Polymers 0.000 claims description 22
- 150000002431 hydrogen Chemical class 0.000 claims description 17
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 15
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 14
- 125000001309 chloro group Chemical group Cl* 0.000 claims description 12
- 229910052760 oxygen Inorganic materials 0.000 claims description 12
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 11
- 125000001246 bromo group Chemical group Br* 0.000 claims description 8
- 125000005842 heteroatom Chemical group 0.000 claims description 8
- 229910052757 nitrogen Inorganic materials 0.000 claims description 8
- 229910052717 sulfur Inorganic materials 0.000 claims description 8
- -1 —OH Chemical group 0.000 claims description 8
- 229910052799 carbon Inorganic materials 0.000 claims description 7
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 6
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 6
- 208000015181 infectious disease Diseases 0.000 claims description 5
- 125000002950 monocyclic group Chemical group 0.000 claims description 4
- 239000001301 oxygen Substances 0.000 claims description 4
- 239000008194 pharmaceutical composition Substances 0.000 claims description 4
- 125000003367 polycyclic group Chemical group 0.000 claims description 4
- 125000001424 substituent group Chemical group 0.000 claims description 4
- 241000124008 Mammalia Species 0.000 claims description 3
- 239000003112 inhibitor Substances 0.000 claims description 3
- 239000003937 drug carrier Substances 0.000 claims description 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 2
- 230000002265 prevention Effects 0.000 claims description 2
- 125000006645 (C3-C4) cycloalkyl group Chemical group 0.000 claims 6
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 4
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 description 25
- 125000003545 alkoxy group Chemical group 0.000 description 2
- 125000003342 alkenyl group Chemical group 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
Applications Claiming Priority (13)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13168291.6 | 2013-05-17 | ||
| EP13168291 | 2013-05-17 | ||
| EP13175181 | 2013-07-04 | ||
| EP13175181.0 | 2013-07-04 | ||
| EP13182281.9 | 2013-08-29 | ||
| EP13182281 | 2013-08-29 | ||
| EP13191209.9 | 2013-10-31 | ||
| EP13191209 | 2013-10-31 | ||
| EP13198160.7 | 2013-12-18 | ||
| EP13198160 | 2013-12-18 | ||
| EP14157900 | 2014-03-05 | ||
| EP14157900.3 | 2014-03-05 | ||
| PCT/EP2014/060102 WO2014184350A1 (en) | 2013-05-17 | 2014-05-16 | Sulphamoylpyrrolamide derivatives and the use thereof as medicaments for the treatment of hepatitis b |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018068887A Division JP2018118990A (ja) | 2013-05-17 | 2018-03-30 | スルファモイルピロールアミド誘導体およびｂ型肝炎を処置するための医薬品としてのその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016518434A JP2016518434A (ja) | 2016-06-23 |
| JP2016518434A5 true JP2016518434A5 (enExample) | 2017-10-19 |
| JP6318238B2 JP6318238B2 (ja) | 2018-04-25 |
Family
ID=50884356
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016513385A Expired - Fee Related JP6318238B2 (ja) | 2013-05-17 | 2014-05-16 | スルファモイルピロールアミド誘導体およびｂ型肝炎を処置するための医薬品としてのその使用 |
| JP2018068887A Withdrawn JP2018118990A (ja) | 2013-05-17 | 2018-03-30 | スルファモイルピロールアミド誘導体およびｂ型肝炎を処置するための医薬品としてのその使用 |
| JP2020069365A Ceased JP2020117530A (ja) | 2013-05-17 | 2020-04-07 | スルファモイルピロールアミド誘導体およびｂ型肝炎を処置するための医薬品としてのその使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018068887A Withdrawn JP2018118990A (ja) | 2013-05-17 | 2018-03-30 | スルファモイルピロールアミド誘導体およびｂ型肝炎を処置するための医薬品としてのその使用 |
| JP2020069365A Ceased JP2020117530A (ja) | 2013-05-17 | 2020-04-07 | スルファモイルピロールアミド誘導体およびｂ型肝炎を処置するための医薬品としてのその使用 |
Country Status (35)
Families Citing this family (160)
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| UA118680C2 (uk) | 2013-07-25 | 2019-02-25 | ЯНССЕН САЙЄНСЕЗ АЙРЛЕНД ЮСі | Похідні заміщеного гліоксамідом піроламіду та їхнє застосування як лікарських препаратів для лікування гепатиту в |
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| CN106413402B (zh) | 2014-03-13 | 2020-10-30 | 美国印第安纳大学研究和技术公司 | 乙型肝炎核心蛋白变构调节剂 |
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2015
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2017
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