MX375556B - Compuestos de benzoxaborol tricíclicos y usos de los mismos. - Google Patents
Compuestos de benzoxaborol tricíclicos y usos de los mismos.Info
- Publication number
- MX375556B MX375556B MX2016001732A MX2016001732A MX375556B MX 375556 B MX375556 B MX 375556B MX 2016001732 A MX2016001732 A MX 2016001732A MX 2016001732 A MX2016001732 A MX 2016001732A MX 375556 B MX375556 B MX 375556B
- Authority
- MX
- Mexico
- Prior art keywords
- sub
- compounds
- benzoxaborole compounds
- tricyclic benzoxaborole
- tricyclic
- Prior art date
Links
- GDMJXXLVTYSBBE-UHFFFAOYSA-N 1,2-benzoxaborole Chemical class C1=CC=C2OB=CC2=C1 GDMJXXLVTYSBBE-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 1
- 206010062207 Mycobacterial infection Diseases 0.000 abstract 1
- 239000003926 antimycobacterial agent Substances 0.000 abstract 1
- 125000001246 bromo group Chemical group Br* 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 125000002346 iodo group Chemical group I* 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 208000027531 mycobacterial infectious disease Diseases 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/69—Boron compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/04—Esters of boric acids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Pulmonology (AREA)
- Oncology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Se proporcionan compuestos de la fórmula II: (ver Fórmula) en donde X se selecciona a partir de cloro, flúor, bromo y yodo, R1 y R2 se seleccionan cada uno independientemente a partir de H, -CH3, -CH2CH3, -CH2CH2CH3, o -CH(CH3)2,; composiciones que los contienen, su uso en terapia, incluyendo su uso como agentes anti-micobacterianos, por ejemplo, en el tratamiento de una infección micobacteriana en un mamífero, y métodos para la preparación de estos compuestos.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361864496P | 2013-08-09 | 2013-08-09 | |
| US201361918976P | 2013-12-20 | 2013-12-20 | |
| PCT/US2014/050370 WO2015021396A2 (en) | 2013-08-09 | 2014-08-08 | Tricyclic benzoxaborole compounds and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2016001732A MX2016001732A (es) | 2016-05-18 |
| MX375556B true MX375556B (es) | 2025-03-06 |
Family
ID=52462052
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2016001732A MX375556B (es) | 2013-08-09 | 2014-08-08 | Compuestos de benzoxaborol tricíclicos y usos de los mismos. |
Country Status (35)
| Country | Link |
|---|---|
| US (5) | US20160251380A1 (es) |
| EP (2) | EP3030519B1 (es) |
| JP (2) | JP6499175B2 (es) |
| KR (1) | KR102093783B1 (es) |
| CN (2) | CN105492388B (es) |
| AP (1) | AP2016009046A0 (es) |
| AU (2) | AU2014305792C1 (es) |
| BR (1) | BR112016002651B1 (es) |
| CA (1) | CA2919888C (es) |
| CL (1) | CL2016000313A1 (es) |
| CR (1) | CR20160064A (es) |
| CY (1) | CY1125030T1 (es) |
| DK (1) | DK3030519T3 (es) |
| DO (1) | DOP2016000045A (es) |
| EA (1) | EA032844B1 (es) |
| ES (1) | ES2905413T3 (es) |
| HR (1) | HRP20220384T1 (es) |
| HU (1) | HUE057365T2 (es) |
| IL (1) | IL243874B (es) |
| LT (1) | LT3030519T (es) |
| MX (1) | MX375556B (es) |
| MY (1) | MY175823A (es) |
| NZ (1) | NZ716350A (es) |
| PE (1) | PE20160752A1 (es) |
| PH (1) | PH12016500234B1 (es) |
| PL (1) | PL3030519T3 (es) |
| PT (1) | PT3030519T (es) |
| RS (1) | RS62887B1 (es) |
| SA (1) | SA516370551B1 (es) |
| SG (2) | SG11201600787PA (es) |
| SI (1) | SI3030519T1 (es) |
| SM (1) | SMT202200113T1 (es) |
| UA (1) | UA116908C2 (es) |
| WO (1) | WO2015021396A2 (es) |
| ZA (1) | ZA201600792B (es) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR094961A1 (es) * | 2013-03-15 | 2015-09-09 | Lilly Co Eli | 1-hidroxi-benzooxaboroles como agentes antiparasitarios |
| KR101636431B1 (ko) | 2013-07-30 | 2016-07-05 | 동아에스티 주식회사 | 트리사이클릭 벤즈옥사보롤 화합물, 이의 제조방법 및 용도 |
| SMT202200113T1 (it) | 2013-08-09 | 2022-05-12 | Glaxosmithkline Ip No 2 Ltd | Composti di benzossaborolo triciclici e loro usi |
| CN106459097A (zh) | 2014-07-01 | 2017-02-22 | 第三共株式会社 | 作为抗菌剂的三环苯并氧杂硼杂环戊烯类 |
| MA41495A (fr) | 2015-02-12 | 2017-12-19 | Anacor Pharmaceuticals Inc | Composés benzoxaborole et leurs utilisations |
| EP3578562B1 (en) | 2016-05-12 | 2021-06-23 | Anacor Pharmaceuticals, Inc | L-valinate amide benzoxaborole derivatives for the treatment of parasitic diseases |
| CN109387594B (zh) * | 2017-08-08 | 2021-01-19 | 武汉武药科技有限公司 | 一种分离和分析贝达喹啉光学异构体的方法 |
| WO2019138422A1 (en) * | 2018-01-09 | 2019-07-18 | Halcyon Labs Private Limited | Process for the preparation of crisaborole and its intermediates |
| EP4164645A4 (en) * | 2020-06-15 | 2024-07-10 | The Global Alliance for TB Drug Development, Inc. | COMBINED ANTIBACTERIAL COMPOSITION AND ANTIBACTERIAL THERAPY METHOD |
| CN111606850B (zh) * | 2020-07-07 | 2023-07-25 | 安徽贝克生物制药有限公司 | 贝达喹啉及其中间体的制备方法 |
| US11793808B2 (en) | 2021-02-22 | 2023-10-24 | Mannkind Corp. | Compositions of clofazimine, combinations comprising them, processes for their preparation, uses and methods comprising them |
| JP2025520237A (ja) * | 2022-06-23 | 2025-07-03 | ミクウルク ファーマシューティカルズ， インコーポレイテッド | ホウ素化合物を用いて非結核性マイコバクテリア感染症を治療する方法及びその用途、並びに同じ疾患を治療するための医薬組成物 |
| WO2023246842A1 (en) * | 2022-06-23 | 2023-12-28 | Shanghai Micurx Pharmaceutical Co., Ltd. | Prodrugs of boron compounds and their use in treating bacterial infections |
| WO2024208907A1 (en) | 2023-04-05 | 2024-10-10 | Glaxosmithkline Intellectual Property (No. 2) Limited | Synthesis of 3-(aminomethyl)-4-chloro-7-(2-hydroxyethoxy)benzo[c][1,2]oxaborol-1(3h)-ol |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6632955B1 (en) | 1996-12-02 | 2003-10-14 | Chisso Corporation | Optically active nitro alcohol derivatives, optically active amino alcohol derivatives, and process for preparing the same |
| DE60313357T2 (de) | 2002-12-02 | 2008-01-03 | Solvias Ag | Verfahren zur katalytischen hydrierung von kohlenstoff-heteroatom-doppelbindungen |
| RU2414906C2 (ru) * | 2005-02-16 | 2011-03-27 | Анакор Фармасьютикалз, Инк. | Борсодержащие малые молекулы |
| JP5084717B2 (ja) | 2005-03-08 | 2012-11-28 | エージェンシー フォー サイエンス，テクノロジー アンド リサーチ | キラル・ビスオキサゾリン触媒 |
| CN101505603A (zh) * | 2005-12-30 | 2009-08-12 | 安纳考尔医药公司 | 含硼的小分子 |
| CN106008571A (zh) | 2005-12-30 | 2016-10-12 | 安纳考尔医药公司 | 含硼的小分子 |
| KR100848491B1 (ko) | 2007-01-16 | 2008-07-28 | 영진약품공업주식회사 | 베타아미노기를 갖는 2-싸이아졸리딘 유도체, 이의약학적으로 허용 가능한 염 및 이의 제조 방법 |
| JO3396B1 (ar) | 2007-06-20 | 2019-10-20 | Anacor Pharmaceuticals Inc | جزيئات صغيرة تحتوي على البورون |
| JP2012512262A (ja) | 2008-12-17 | 2012-05-31 | アナコール ファーマシューティカルズ，インコーポレーテッド | （ｓ）−３−アミノメチル−７−（３−ヒドロキシ−プロポキシ）−３ｈ−ベンゾ［ｃ］［１，２］オキサボロール−１−オールの多形体 |
| WO2011127143A1 (en) * | 2010-04-07 | 2011-10-13 | Glaxosmithkline Llc | Process for preparing benzoxaboroles |
| CN108610356B (zh) * | 2010-09-07 | 2021-02-26 | 阿纳科制药公司 | 苯并氧杂硼杂环戊二烯衍生物用于治疗细菌感染 |
| EP2793901A1 (en) * | 2011-12-22 | 2014-10-29 | Micurx Pharmaceuticals, Inc. | Tricyclic boron compounds for antimicrobial therapy |
| KR101636431B1 (ko) | 2013-07-30 | 2016-07-05 | 동아에스티 주식회사 | 트리사이클릭 벤즈옥사보롤 화합물, 이의 제조방법 및 용도 |
| SMT202200113T1 (it) | 2013-08-09 | 2022-05-12 | Glaxosmithkline Ip No 2 Ltd | Composti di benzossaborolo triciclici e loro usi |
| MA41495A (fr) * | 2015-02-12 | 2017-12-19 | Anacor Pharmaceuticals Inc | Composés benzoxaborole et leurs utilisations |
-
2014
- 2014-08-08 SM SM20220113T patent/SMT202200113T1/it unknown
- 2014-08-08 PE PE2016000234A patent/PE20160752A1/es unknown
- 2014-08-08 CN CN201480049562.3A patent/CN105492388B/zh active Active
- 2014-08-08 AU AU2014305792A patent/AU2014305792C1/en active Active
- 2014-08-08 HU HUE14834292A patent/HUE057365T2/hu unknown
- 2014-08-08 CN CN201811396796.1A patent/CN110003253B/zh active Active
- 2014-08-08 EP EP14834292.6A patent/EP3030519B1/en active Active
- 2014-08-08 SG SG11201600787PA patent/SG11201600787PA/en unknown
- 2014-08-08 KR KR1020167006314A patent/KR102093783B1/ko active Active
- 2014-08-08 WO PCT/US2014/050370 patent/WO2015021396A2/en not_active Ceased
- 2014-08-08 RS RS20220108A patent/RS62887B1/sr unknown
- 2014-08-08 LT LTEPPCT/US2014/050370T patent/LT3030519T/lt unknown
- 2014-08-08 MY MYPI2016700458A patent/MY175823A/en unknown
- 2014-08-08 AP AP2016009046A patent/AP2016009046A0/en unknown
- 2014-08-08 EA EA201690135A patent/EA032844B1/ru unknown
- 2014-08-08 NZ NZ716350A patent/NZ716350A/en unknown
- 2014-08-08 DK DK14834292.6T patent/DK3030519T3/da active
- 2014-08-08 SI SI201431939T patent/SI3030519T1/sl unknown
- 2014-08-08 JP JP2016533471A patent/JP6499175B2/ja active Active
- 2014-08-08 UA UAA201600796A patent/UA116908C2/uk unknown
- 2014-08-08 CA CA2919888A patent/CA2919888C/en active Active
- 2014-08-08 MX MX2016001732A patent/MX375556B/es active IP Right Grant
- 2014-08-08 US US14/387,384 patent/US20160251380A1/en not_active Abandoned
- 2014-08-08 SG SG10201914073PA patent/SG10201914073PA/en unknown
- 2014-08-08 EP EP21214787.0A patent/EP4029870A1/en not_active Withdrawn
- 2014-08-08 BR BR112016002651-9A patent/BR112016002651B1/pt active IP Right Grant
- 2014-08-08 PT PT148342926T patent/PT3030519T/pt unknown
- 2014-08-08 HR HRP20220384TT patent/HRP20220384T1/hr unknown
- 2014-08-08 ES ES14834292T patent/ES2905413T3/es active Active
- 2014-08-08 PL PL14834292T patent/PL3030519T3/pl unknown
-
2016
- 2016-01-28 IL IL243874A patent/IL243874B/en active IP Right Grant
- 2016-02-03 PH PH12016500234A patent/PH12016500234B1/en unknown
- 2016-02-04 ZA ZA2016/00792A patent/ZA201600792B/en unknown
- 2016-02-07 SA SA516370551A patent/SA516370551B1/ar unknown
- 2016-02-08 CL CL2016000313A patent/CL2016000313A1/es unknown
- 2016-02-09 DO DO2016000045A patent/DOP2016000045A/es unknown
- 2016-02-09 CR CR20160064A patent/CR20160064A/es unknown
-
2017
- 2017-08-03 AU AU2017210567A patent/AU2017210567B2/en active Active
- 2017-10-24 US US15/792,251 patent/US10308668B2/en active Active
-
2019
- 2019-03-14 JP JP2019046582A patent/JP6764970B2/ja active Active
- 2019-04-16 US US16/385,547 patent/US10526352B2/en active Active
- 2019-11-26 US US16/695,253 patent/US10858376B2/en active Active
-
2020
- 2020-11-04 US US17/089,058 patent/US20210053999A1/en not_active Abandoned
-
2022
- 2022-03-01 CY CY20221100169T patent/CY1125030T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX375556B (es) | Compuestos de benzoxaborol tricíclicos y usos de los mismos. | |
| PH12017501427A1 (en) | Benzoxaborole compounds and uses thereof | |
| EA201790306A1 (ru) | 2-(морфолин-4-ил)-1,7-нафтиридины | |
| PH12016500643B1 (en) | NEW OCTAHYDRO-CYCLOBUTA [1,2-c;3,4-c'] DIPYRROL-2-YL | |
| AR094918A1 (es) | Compuestos de tetrahidropirrolotiazina como inhibidores de bace | |
| SG10201805628TA (en) | Deuterated heterocyclic compounds and their use as imaging agents | |
| UY35641A (es) | PROCEDIMIENTO DE SÍNTESIS PARA PREPARAR ANÁLOGOS MACROCÍCLICOS C1-CETO DE HALICONDRINA B, E INTERMEDIARIOS ÚTILES INCLUYENDO INTERMEDIARIOS CONTENIENDO GRUPOS ?SO2-(p-TOLILO) | |
| CR20140216A (es) | 5,7-imidazo[1,2-c]pirimidinas sustituidas | |
| MX354021B (es) | Derivados de 5-fluor-4-imino-3- (sustituido) -3,4-dihidropirimidin -2 (1h) ona. | |
| MA40281A (fr) | Composés de pyrazole et leur utilisation en tant qu' agents de blocage des canaux calciques de type t | |
| EA201391558A1 (ru) | Тетрагидропиразоло[1,5-а]пиримидины как противотуберкулезные соединения | |
| PE20170703A1 (es) | Moduladores de pirrolopiridina de rorc2 sustituidos con metilo y trifluorometilo y metodos de uso de los mismos | |
| EA201401082A1 (ru) | Фармацевтические препараты, содержащие антагонисты ccr3 | |
| SA518390920B1 (ar) | مركبات فينوكسي أسيتاميد معالجة بإضافة حلقة | |
| EA201600434A1 (ru) | Применение производных бензимидазолпролина | |
| PH12018500377A1 (en) | Novel annelated benzamides | |
| MX378932B (es) | Triazoles sustituidos y métodos relacionados a estos. | |
| EA201700356A1 (ru) | Новые циклопропанбензофуранилпиридопиразиндионы | |
| GEP20186909B (en) | Substituted cyclopentanes, tetrahydrofuranes and pyrrolidines as orexin receptor antagonists | |
| JO3673B1 (ar) | مكونات البنزوكسابورول ثلاثي الحلقات واستخداماتها | |
| EA201990934A1 (ru) | Трициклические соединения бензоксаборола и их применение | |
| EP4365267A3 (en) | Fluorinated diester compounds and their use in heat transfer system |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |