JP2016518437A5 - - Google Patents
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- JP2016518437A5 JP2016518437A5 JP2016513394A JP2016513394A JP2016518437A5 JP 2016518437 A5 JP2016518437 A5 JP 2016518437A5 JP 2016513394 A JP2016513394 A JP 2016513394A JP 2016513394 A JP2016513394 A JP 2016513394A JP 2016518437 A5 JP2016518437 A5 JP 2016518437A5
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- JP
- Japan
- Prior art keywords
- compound according
- pharmaceutically acceptable
- group
- solvate
- hydrogen atom
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 claims description 30
- 229910052731 fluorine Inorganic materials 0.000 claims description 18
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 18
- 125000001153 fluoro group Chemical group F* 0.000 claims description 14
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 10
- 150000003839 salts Chemical class 0.000 claims description 10
- 229920006395 saturated elastomer Polymers 0.000 claims description 10
- 239000012453 solvate Substances 0.000 claims description 10
- 229910052760 oxygen Inorganic materials 0.000 claims description 8
- 125000000217 alkyl group Chemical group 0.000 claims description 7
- 125000005843 halogen group Chemical group 0.000 claims description 7
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 6
- YUCFVHQCAFKDQG-UHFFFAOYSA-N fluoromethane Chemical compound F[CH] YUCFVHQCAFKDQG-UHFFFAOYSA-N 0.000 claims description 5
- 208000015181 infectious disease Diseases 0.000 claims description 5
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims description 4
- 125000005842 heteroatom Chemical group 0.000 claims description 4
- 229910052757 nitrogen Inorganic materials 0.000 claims description 4
- 239000001301 oxygen Substances 0.000 claims description 4
- 239000008194 pharmaceutical composition Substances 0.000 claims description 4
- 229910052717 sulfur Inorganic materials 0.000 claims description 4
- 241000124008 Mammalia Species 0.000 claims description 3
- 239000003112 inhibitor Substances 0.000 claims description 3
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims description 2
- 125000004429 atom Chemical group 0.000 claims description 2
- 229910052801 chlorine Inorganic materials 0.000 claims description 2
- 125000001309 chloro group Chemical group Cl* 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 230000002265 prevention Effects 0.000 claims description 2
- 125000001424 substituent group Chemical group 0.000 claims description 2
- -1 C 1 -C 3 alkyl Chemical group 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13168295 | 2013-05-17 | ||
| EP13168295.7 | 2013-05-17 | ||
| EP13185227.9 | 2013-09-19 | ||
| EP13185227 | 2013-09-19 | ||
| EP14157917.7 | 2014-03-05 | ||
| EP14157917 | 2014-03-05 | ||
| PCT/EP2014/060132 WO2014184365A1 (en) | 2013-05-17 | 2014-05-16 | Sulphamoylthiophenamide derivatives and the use thereof as medicaments for the treatment of hepatitis b |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016518437A JP2016518437A (ja) | 2016-06-23 |
| JP2016518437A5 true JP2016518437A5 (enExample) | 2017-10-12 |
| JP6441315B2 JP6441315B2 (ja) | 2018-12-19 |
Family
ID=50729521
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016513394A Expired - Fee Related JP6441315B2 (ja) | 2013-05-17 | 2014-05-16 | スルファモイルチオフェンアミド誘導体およびｂ型肝炎を治療するための医薬品としてのその使用 |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US10160743B2 (enExample) |
| EP (1) | EP2997019B1 (enExample) |
| JP (1) | JP6441315B2 (enExample) |
| CN (1) | CN105960400B (enExample) |
| AU (1) | AU2014267235B2 (enExample) |
| BR (1) | BR112015028538A2 (enExample) |
| CA (1) | CA2909742C (enExample) |
| CY (1) | CY1122337T1 (enExample) |
| DK (1) | DK2997019T3 (enExample) |
| EA (1) | EA035500B1 (enExample) |
| ES (1) | ES2695182T3 (enExample) |
| HR (1) | HRP20181863T1 (enExample) |
| HU (1) | HUE040446T2 (enExample) |
| IL (1) | IL242141B (enExample) |
| LT (1) | LT2997019T (enExample) |
| MX (1) | MX366787B (enExample) |
| PL (1) | PL2997019T3 (enExample) |
| PT (1) | PT2997019T (enExample) |
| RS (1) | RS57999B1 (enExample) |
| SI (1) | SI2997019T1 (enExample) |
| SM (1) | SMT201800577T1 (enExample) |
| WO (1) | WO2014184365A1 (enExample) |
Families Citing this family (123)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2794565B1 (en) | 2011-12-21 | 2017-07-26 | Novira Therapeutics Inc. | Hepatitis b antiviral agents |
| CA2881057C (en) * | 2012-08-28 | 2020-10-27 | Janssen Sciences Ireland Uc | Sulfamoyl-arylamides and the use thereof as medicaments for the treatment of hepatitis b |
| JP6466348B2 (ja) | 2013-02-28 | 2019-02-06 | ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー | スルファモイル−アリールアミドおよびｂ型肝炎を処置するための医薬品としてのその使用 |
| HUE033542T2 (en) | 2013-04-03 | 2017-12-28 | Janssen Sciences Ireland Uc | Their use as medicaments for the treatment of N-phenylcarboxamide derivatives and hepatitis B |
| HUE040446T2 (hu) | 2013-05-17 | 2019-03-28 | Janssen Sciences Ireland Uc | Szulfamoiltiofenamid-származékok és gyógyszerként történõ alkalmazásuk hepatitis B kezelésére |
| TW202126620A (zh) | 2013-05-17 | 2021-07-16 | 愛爾蘭商健生科學愛爾蘭無限公司 | 胺磺醯基吡咯醯胺衍生物及其作為用於治療ｂ型肝炎藥物的用途 |
| WO2015011281A1 (en) | 2013-07-25 | 2015-01-29 | Janssen R&D Ireland | Glyoxamide substituted pyrrolamide derivatives and the use thereof as medicaments for the treatment of hepatitis b |
| MX368158B (es) | 2013-10-23 | 2019-09-20 | Janssen Sciences Ireland Uc | Derivados de carboxamida y su uso como medicamentos para el tratamiento de la hepatitis b. |
| US10392349B2 (en) | 2014-01-16 | 2019-08-27 | Novira Therapeutics, Inc. | Azepane derivatives and methods of treating hepatitis B infections |
| US9169212B2 (en) | 2014-01-16 | 2015-10-27 | Novira Therapeutics, Inc. | Azepane derivatives and methods of treating hepatitis B infections |
| JP6553059B2 (ja) | 2014-02-05 | 2019-07-31 | ノヴィラ・セラピューティクス・インコーポレイテッド | Ｈｂｖ感染の治療のための併用療法 |
| PL3102572T3 (pl) | 2014-02-06 | 2019-04-30 | Janssen Sciences Ireland Uc | Pochodne sulfamoilopirolamidu i ich zastosowanie jako leki do leczenia wirusowego zapalenia wątroby typu B |
| ES2748029T3 (es) | 2014-03-13 | 2020-03-12 | Univ Indiana Res & Tech Corp | Moduladores alostéricos de proteína núcleo de hepatitis B |
| EP3271019A1 (en) | 2015-03-19 | 2018-01-24 | Novira Therapeutics Inc. | Azocane and azonane derivatives and methods of treating hepatitis b infections |
| WO2016161268A1 (en) | 2015-04-01 | 2016-10-06 | Enanta Pharmaceuticals, Inc. | Hepatitis b antviral agents |
| US10738035B2 (en) | 2015-05-13 | 2020-08-11 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
| US10875876B2 (en) | 2015-07-02 | 2020-12-29 | Janssen Sciences Ireland Uc | Cyclized sulfamoylarylamide derivatives and the use thereof as medicaments for the treatment of hepatitis B |
| WO2017011552A1 (en) | 2015-07-13 | 2017-01-19 | Enanta Pharmaceuticals, Inc. | Hepatitis b antiviral agents |
| US10301255B2 (en) | 2015-07-22 | 2019-05-28 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
| TWI730985B (zh) | 2015-09-15 | 2021-06-21 | 美商艾森伯利生物科學公司 | B型肝炎核心蛋白質調節劑 |
| AR106192A1 (es) | 2015-09-29 | 2017-12-20 | Novira Therapeutics Inc | Formas cristalinas de un agente antiviral contra la hepatitis b |
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| JOP20190024A1 (ar) | 2016-08-26 | 2019-02-19 | Gilead Sciences Inc | مركبات بيروليزين بها استبدال واستخداماتها |
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| AU2017326356A1 (en) | 2016-09-15 | 2019-04-11 | Assembly Biosciences, Inc. | Hepatitis B core protein modulators |
| KR20230010826A (ko) | 2016-10-14 | 2023-01-19 | 프리시젼 바이오사이언시스 인코포레이티드 | B형 간염 바이러스 게놈 내의 인식 서열에 대해 특이적인 조작된 메가뉴클레아제 |
| JP7113009B2 (ja) | 2016-11-07 | 2022-08-04 | アービュタス バイオファーマ コーポレイション | 置換ピリジノン含有三環式化合物およびそれを使用する方法 |
| TWI714820B (zh) | 2017-01-31 | 2021-01-01 | 美商基利科學股份有限公司 | 替諾福韋艾拉酚胺(tenofovir alafenamide)之晶型 |
| BR112019018230A2 (pt) | 2017-03-02 | 2020-07-21 | Assembly Biosciences, Inc. | compostos de sulfamida cíclica e métodos de sua utilização |
| MA49014A (fr) | 2017-03-21 | 2020-02-05 | Arbutus Biopharma Corp | Dihydroindène-4-carboxamides substitués, leurs analogues et procédés d'utilisation correspondant |
| BR102018007822A2 (pt) | 2017-04-20 | 2018-11-06 | Gilead Sciences, Inc. | composto, métodos para inibir pd-1, pd-l1 e/ou interação de pd-1/pd-l1 e para tratamento de câncer, composição farmacêutica, e, kit para tratamento de ou prevenção de câncer ou uma doença ou condição |
| SG11202001685TA (en) * | 2017-08-28 | 2020-03-30 | Enanta Pharm Inc | Hepatitis b antiviral agents |
| EA202091113A1 (ru) | 2017-11-02 | 2020-08-28 | Айкурис Гмбх Унд Ко. Кг | Новые высокоактивные аминотиазолзамещенные индол-2-карбоксамиды, активные в отношении вируса гепатита b (hbv) |
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| US10723733B2 (en) | 2017-12-06 | 2020-07-28 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
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| US11203610B2 (en) | 2017-12-20 | 2021-12-21 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 2′3′ cyclic dinucleotides with phosphonate bond activating the sting adaptor protein |
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2014
- 2014-05-16 HU HUE14724109A patent/HUE040446T2/hu unknown
- 2014-05-16 ES ES14724109T patent/ES2695182T3/es active Active
- 2014-05-16 SM SM20180577T patent/SMT201800577T1/it unknown
- 2014-05-16 CA CA2909742A patent/CA2909742C/en not_active Expired - Fee Related
- 2014-05-16 RS RS20181358A patent/RS57999B1/sr unknown
- 2014-05-16 JP JP2016513394A patent/JP6441315B2/ja not_active Expired - Fee Related
- 2014-05-16 PL PL14724109T patent/PL2997019T3/pl unknown
- 2014-05-16 MX MX2015015771A patent/MX366787B/es active IP Right Grant
- 2014-05-16 BR BR112015028538A patent/BR112015028538A2/pt not_active Application Discontinuation
- 2014-05-16 HR HRP20181863TT patent/HRP20181863T1/hr unknown
- 2014-05-16 WO PCT/EP2014/060132 patent/WO2014184365A1/en not_active Ceased
- 2014-05-16 EP EP14724109.5A patent/EP2997019B1/en active Active
- 2014-05-16 AU AU2014267235A patent/AU2014267235B2/en not_active Ceased
- 2014-05-16 PT PT14724109T patent/PT2997019T/pt unknown
- 2014-05-16 DK DK14724109.5T patent/DK2997019T3/en active
- 2014-05-16 SI SI201430958T patent/SI2997019T1/sl unknown
- 2014-05-16 CN CN201480028318.9A patent/CN105960400B/zh not_active Expired - Fee Related
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- 2014-05-16 EA EA201592198A patent/EA035500B1/ru not_active IP Right Cessation
- 2014-05-16 US US14/891,895 patent/US10160743B2/en not_active Expired - Fee Related
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2015
- 2015-10-18 IL IL242141A patent/IL242141B/en active IP Right Grant
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2018
- 2018-11-08 CY CY20181101182T patent/CY1122337T1/el unknown
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