JP2016518437A5 - - Google Patents
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- JP2016518437A5 JP2016518437A5 JP2016513394A JP2016513394A JP2016518437A5 JP 2016518437 A5 JP2016518437 A5 JP 2016518437A5 JP 2016513394 A JP2016513394 A JP 2016513394A JP 2016513394 A JP2016513394 A JP 2016513394A JP 2016518437 A5 JP2016518437 A5 JP 2016518437A5
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- JP
- Japan
- Prior art keywords
- compound according
- pharmaceutically acceptable
- group
- solvate
- hydrogen atom
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 claims description 30
- 229910052731 fluorine Inorganic materials 0.000 claims description 18
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 18
- 125000001153 fluoro group Chemical group F* 0.000 claims description 14
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 10
- 150000003839 salts Chemical class 0.000 claims description 10
- 229920006395 saturated elastomer Polymers 0.000 claims description 10
- 239000012453 solvate Substances 0.000 claims description 10
- 229910052760 oxygen Inorganic materials 0.000 claims description 8
- 125000000217 alkyl group Chemical group 0.000 claims description 7
- 125000005843 halogen group Chemical group 0.000 claims description 7
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 6
- YUCFVHQCAFKDQG-UHFFFAOYSA-N fluoromethane Chemical compound F[CH] YUCFVHQCAFKDQG-UHFFFAOYSA-N 0.000 claims description 5
- 208000015181 infectious disease Diseases 0.000 claims description 5
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims description 4
- 125000005842 heteroatom Chemical group 0.000 claims description 4
- 229910052757 nitrogen Inorganic materials 0.000 claims description 4
- 239000001301 oxygen Substances 0.000 claims description 4
- 239000008194 pharmaceutical composition Substances 0.000 claims description 4
- 229910052717 sulfur Inorganic materials 0.000 claims description 4
- 241000124008 Mammalia Species 0.000 claims description 3
- 239000003112 inhibitor Substances 0.000 claims description 3
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims description 2
- 125000004429 atom Chemical group 0.000 claims description 2
- 229910052801 chlorine Inorganic materials 0.000 claims description 2
- 125000001309 chloro group Chemical group Cl* 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 230000002265 prevention Effects 0.000 claims description 2
- 125000001424 substituent group Chemical group 0.000 claims description 2
- -1 C 1 -C 3 alkyl Chemical group 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13168295.7 | 2013-05-17 | ||
| EP13168295 | 2013-05-17 | ||
| EP13185227.9 | 2013-09-19 | ||
| EP13185227 | 2013-09-19 | ||
| EP14157917.7 | 2014-03-05 | ||
| EP14157917 | 2014-03-05 | ||
| PCT/EP2014/060132 WO2014184365A1 (en) | 2013-05-17 | 2014-05-16 | Sulphamoylthiophenamide derivatives and the use thereof as medicaments for the treatment of hepatitis b |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016518437A JP2016518437A (ja) | 2016-06-23 |
| JP2016518437A5 true JP2016518437A5 (enExample) | 2017-10-12 |
| JP6441315B2 JP6441315B2 (ja) | 2018-12-19 |
Family
ID=50729521
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016513394A Expired - Fee Related JP6441315B2 (ja) | 2013-05-17 | 2014-05-16 | スルファモイルチオフェンアミド誘導体およびｂ型肝炎を治療するための医薬品としてのその使用 |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US10160743B2 (enExample) |
| EP (1) | EP2997019B1 (enExample) |
| JP (1) | JP6441315B2 (enExample) |
| CN (1) | CN105960400B (enExample) |
| AU (1) | AU2014267235B2 (enExample) |
| BR (1) | BR112015028538A2 (enExample) |
| CA (1) | CA2909742C (enExample) |
| CY (1) | CY1122337T1 (enExample) |
| DK (1) | DK2997019T3 (enExample) |
| EA (1) | EA035500B1 (enExample) |
| ES (1) | ES2695182T3 (enExample) |
| HR (1) | HRP20181863T1 (enExample) |
| HU (1) | HUE040446T2 (enExample) |
| IL (1) | IL242141B (enExample) |
| LT (1) | LT2997019T (enExample) |
| MX (1) | MX366787B (enExample) |
| PL (1) | PL2997019T3 (enExample) |
| PT (1) | PT2997019T (enExample) |
| RS (1) | RS57999B1 (enExample) |
| SI (1) | SI2997019T1 (enExample) |
| SM (1) | SMT201800577T1 (enExample) |
| WO (1) | WO2014184365A1 (enExample) |
Families Citing this family (123)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA037918B1 (ru) | 2011-12-21 | 2021-06-07 | Новира Терапьютикс, Инк. | Противовирусные агенты против гепатита в |
| HK1208465A1 (en) * | 2012-08-28 | 2016-03-04 | Janssen Sciences Ireland Uc | Sulfamoyl-arylamides and the use thereof as medicaments for the treatment of hepatitis b |
| DK2961732T3 (en) | 2013-02-28 | 2017-07-10 | Janssen Sciences Ireland Uc | SULFAMOYLARYLAMIDS AND USE THEREOF AS MEDICINES TO TREAT HEPATITIS B |
| WO2014161888A1 (en) | 2013-04-03 | 2014-10-09 | Janssen R&D Ireland | N-phenyl-carboxamide derivatives and the use thereof as medicaments for the treatment of hepatitis b |
| RS57999B1 (sr) | 2013-05-17 | 2019-01-31 | Janssen Sciences Ireland Uc | Derivati sulfamoiltiofenamida i njihova primena kao lekovi za tretman hepatitisa b |
| JO3603B1 (ar) | 2013-05-17 | 2020-07-05 | Janssen Sciences Ireland Uc | مشتقات سلفامويل بيرولاميد واستخدامها كادوية لمعالجة التهاب الكبد نوع بي |
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| KR102290189B1 (ko) | 2013-10-23 | 2021-08-17 | 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 | 카르복스아미드 유도체 및 ｂ형 간염 치료용 의약으로서의 이의 용도 |
| US10392349B2 (en) | 2014-01-16 | 2019-08-27 | Novira Therapeutics, Inc. | Azepane derivatives and methods of treating hepatitis B infections |
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2018
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