JP2015143283A5 - - Google Patents
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- JP2015143283A5 JP2015143283A5 JP2015098562A JP2015098562A JP2015143283A5 JP 2015143283 A5 JP2015143283 A5 JP 2015143283A5 JP 2015098562 A JP2015098562 A JP 2015098562A JP 2015098562 A JP2015098562 A JP 2015098562A JP 2015143283 A5 JP2015143283 A5 JP 2015143283A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- ring
- hydrogen bond
- aromatic ring
- halogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229910052739 hydrogen Inorganic materials 0.000 claims 8
- 239000001257 hydrogen Chemical group 0.000 claims 8
- 125000003118 aryl group Chemical group 0.000 claims 7
- 150000001875 compounds Chemical class 0.000 claims 7
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 6
- 125000000217 alkyl group Chemical group 0.000 claims 4
- 229910052736 halogen Inorganic materials 0.000 claims 4
- 150000002367 halogens Chemical class 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 125000004429 atom Chemical group 0.000 claims 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 3
- 125000002837 carbocyclic group Chemical group 0.000 claims 3
- 229910052799 carbon Inorganic materials 0.000 claims 3
- 229910052757 nitrogen Inorganic materials 0.000 claims 3
- 229910052760 oxygen Inorganic materials 0.000 claims 3
- 239000001301 oxygen Substances 0.000 claims 3
- 229910052717 sulfur Inorganic materials 0.000 claims 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 2
- 125000006615 aromatic heterocyclic group Chemical group 0.000 claims 2
- 125000003310 benzodiazepinyl group Chemical group N1N=C(C=CC2=C1C=CC=C2)* 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 125000006574 non-aromatic ring group Chemical group 0.000 claims 2
- 239000011593 sulfur Substances 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 102100030550 Menin Human genes 0.000 claims 1
- 101710169972 Menin Proteins 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 150000001721 carbon Chemical group 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 125000004122 cyclic group Chemical group 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 230000003993 interaction Effects 0.000 claims 1
- 150000002576 ketones Chemical class 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 125000006413 ring segment Chemical group 0.000 claims 1
- 125000004434 sulfur atom Chemical group 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24010209P | 2009-09-04 | 2009-09-04 | |
| US61/240,102 | 2009-09-04 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012528106A Division JP5792171B2 (ja) | 2009-09-04 | 2010-09-03 | 白血病を治療するための組成物および方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015143283A JP2015143283A (ja) | 2015-08-06 |
| JP2015143283A5 true JP2015143283A5 (enExample) | 2015-09-17 |
Family
ID=43649670
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012528106A Active JP5792171B2 (ja) | 2009-09-04 | 2010-09-03 | 白血病を治療するための組成物および方法 |
| JP2015098562A Pending JP2015143283A (ja) | 2009-09-04 | 2015-05-13 | 白血病を治療するための組成物および方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012528106A Active JP5792171B2 (ja) | 2009-09-04 | 2010-09-03 | 白血病を治療するための組成物および方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US8993552B2 (enExample) |
| EP (1) | EP2473054B1 (enExample) |
| JP (2) | JP5792171B2 (enExample) |
| CN (1) | CN102984941B (enExample) |
| AU (2) | AU2010289321A1 (enExample) |
| CA (1) | CA2773131C (enExample) |
| WO (1) | WO2011029054A1 (enExample) |
Families Citing this family (75)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101694931B1 (ko) | 2009-01-06 | 2017-01-10 | 큐어론 엘엘씨 | 이. 콜라이에 의한 구강 감염의 치료 또는 예방을 위한 조성물 및 방법 |
| US9056050B2 (en) | 2009-04-13 | 2015-06-16 | Curemark Llc | Enzyme delivery systems and methods of preparation and use |
| LT2473487T (lt) | 2009-09-03 | 2017-01-10 | Bristol-Myers Squibb Company | Chinazolinai kaip kalio jonų kanalų inhibitoriai |
| US9511125B2 (en) | 2009-10-21 | 2016-12-06 | Curemark Llc | Methods and compositions for the treatment of influenza |
| EP3239154A1 (en) | 2011-01-10 | 2017-11-01 | Nimbus Iris, Inc. | Irak inhibitors and uses thereof |
| GB201114212D0 (en) | 2011-08-18 | 2011-10-05 | Ucb Pharma Sa | Therapeutic agents |
| WO2013068592A1 (en) * | 2011-11-10 | 2013-05-16 | Fondation Jerome Lejeune | Inhibitors of cystathionine beta synthase to reduce the neurotoxic overproduction of endogenous hydrogen sulfide |
| AR090037A1 (es) | 2011-11-15 | 2014-10-15 | Xention Ltd | Derivados de tieno y/o furo-pirimidinas y piridinas inhibidores de los canales de potasio |
| BR112014017021A8 (pt) | 2012-01-10 | 2017-07-04 | Nimbus Iris Inc | inibidores de irak e usos dos mesmos |
| AU2013202368B2 (en) * | 2012-01-25 | 2016-06-16 | Proteostasis Therapeutics, Inc. | Proteasome activity modulating compounds |
| US10350278B2 (en) | 2012-05-30 | 2019-07-16 | Curemark, Llc | Methods of treating Celiac disease |
| EP2671575A1 (en) * | 2012-06-04 | 2013-12-11 | Universität Regensburg | Ras inhibitors |
| KR102092984B1 (ko) | 2012-06-11 | 2020-03-24 | 브리스톨-마이어스 스큅 컴퍼니 | 5-[5-페닐-4-(피리딘-2-일메틸아미노)퀴나졸린-2-일]피리딘-3-술폰아미드의 포스포르아미드산 전구약물 |
| WO2014011906A2 (en) | 2012-07-11 | 2014-01-16 | Nimbus Iris, Inc. | Irak inhibitors and uses thereof |
| US9085586B2 (en) | 2012-07-11 | 2015-07-21 | Nimbus Iris, Inc. | IRAK inhibitors and uses thereof |
| MX2015002887A (es) * | 2012-09-06 | 2015-07-06 | Plexxikon Inc | Compuestos y metodos para la modulacion de cinasas, e indicaciones para ello. |
| AU2013323360B2 (en) * | 2012-09-28 | 2017-09-07 | Cancer Research Technology Limited | Azaquinazoline inhibitors of atypical protein kinase C |
| GB201217704D0 (en) * | 2012-10-03 | 2012-11-14 | Ucb Pharma Sa | Therapeutic agents |
| US20140136295A1 (en) | 2012-11-13 | 2014-05-15 | Apptio, Inc. | Dynamic recommendations taken over time for reservations of information technology resources |
| WO2014110114A1 (en) | 2013-01-10 | 2014-07-17 | Nimbus Iris, Inc. | Irak inhibitors and uses thereof |
| US9862746B2 (en) | 2013-02-15 | 2018-01-09 | The Regents Of The University Of Michigan | Compositions and methods relating to hindering DOT1L recruitment by MLL-fusion proteins |
| EP2968342B1 (en) | 2013-03-13 | 2018-10-03 | The Regents of the University of Michigan | Compositions comprising thienopyrimidine and thienopyridine compounds and methods of use thereof |
| CN104119343A (zh) * | 2013-04-25 | 2014-10-29 | 苏州科捷生物医药有限公司 | 2-三氟甲基噻二唑类化合物及其用途 |
| BR112016006319A2 (pt) | 2013-09-27 | 2017-08-01 | Nimbus Iris Inc | inibidores de irak e usos dos mesmos |
| TWI648281B (zh) * | 2013-10-17 | 2019-01-21 | 日商安斯泰來製藥股份有限公司 | 含硫二環式化合物 |
| JP2017001954A (ja) * | 2013-11-08 | 2017-01-05 | 石原産業株式会社 | 含窒素飽和複素環化合物 |
| CN104892589A (zh) * | 2014-03-07 | 2015-09-09 | 中国科学院上海药物研究所 | 一类杂环化合物、其制备方法和用途 |
| US20180169100A1 (en) * | 2014-03-11 | 2018-06-21 | Godavari Biorefineries Limited | Cancer Stem Cell Targeting Compounds |
| US10246464B2 (en) | 2014-09-09 | 2019-04-02 | The Regents Of The University Of Michigan | Thienopyrimidine and thienopyridine compounds and methods of use thereof |
| US10526341B2 (en) | 2014-11-19 | 2020-01-07 | Memorial Sloan-Kettering Cancer Center | Thienopyrimidines and uses thereof |
| CN104592248A (zh) * | 2014-12-31 | 2015-05-06 | 芜湖杨燕制药有限公司 | 一种4-氯-6-取代噻吩并[2,3-d]嘧啶化合物的制备方法 |
| AR104020A1 (es) * | 2015-06-04 | 2017-06-21 | Kura Oncology Inc | Métodos y composiciones para inhibir la interacción de menina con proteínas mill |
| US10588907B2 (en) | 2015-06-04 | 2020-03-17 | Kura Oncology, Inc. | Methods and compositions for inhibiting the interaction of menin with MLL proteins |
| GB201519573D0 (en) | 2015-11-05 | 2015-12-23 | King S College London | Combination |
| ES3044036T3 (en) | 2016-01-26 | 2025-11-26 | Memorial Sloan Kettering Cancer Center | Targeting chromatin regulators for inhibiting leukemogenic gene expression in npm1 |
| MA43823A (fr) | 2016-03-16 | 2018-11-28 | Kura Oncology Inc | Inhibiteurs bicycliques pontés de ménine-mll et méthodes d'utilisation |
| DK3429591T3 (da) | 2016-03-16 | 2023-06-19 | Kura Oncology Inc | Substituerede thieno[2,3-D]pyrimidin-derivater som inhibitorer af Menin-MLL og fremgangsmåder til anvendelse |
| SG11201809714TA (en) | 2016-05-02 | 2018-11-29 | Univ Michigan Regents | Piperidines as menin inhibitors |
| WO2017207387A1 (en) | 2016-05-31 | 2017-12-07 | Bayer Pharma Aktiengesellschaft | Spiro condensed azetidine derivatives as inhibitors of the menin-mml1 interaction |
| WO2018024602A1 (en) | 2016-08-04 | 2018-02-08 | Bayer Aktiengesellschaft | 2,7-diazaspiro[4.4]nonanes |
| US12084462B2 (en) | 2016-09-14 | 2024-09-10 | Janssen Pharmaceutica Nv | Spiro bicyclic inhibitors of menin-MLL interaction |
| KR102493364B1 (ko) | 2016-09-14 | 2023-01-27 | 얀센 파마슈티카 엔.브이. | Menin-mll 상호작용의 융합 바이사이클릭 억제제 |
| SI3512857T1 (sl) * | 2016-09-14 | 2021-07-30 | Janssen Pharmaceutica Nv | Spiro biciklični zaviralci interakcije menin-MLL |
| EA201990699A1 (ru) | 2016-10-05 | 2019-09-30 | Янссен Фармацевтика Нв | Спиробициклические ингибиторы взаимодействия менин–mll |
| EP3532464A4 (en) | 2016-10-28 | 2020-07-08 | Icahn School of Medicine at Mount Sinai | COMPOSITIONS AND METHODS FOR THE TREATMENT OF EZH2 MEDIATION CANCER |
| WO2018106870A1 (en) | 2016-12-08 | 2018-06-14 | Icahn School Of Medicine At Mount Sinai | Compositions and methods for treating cdk4/6-mediated cancer |
| WO2018109088A1 (en) | 2016-12-15 | 2018-06-21 | Janssen Pharmaceutica Nv | Azepane inhibitors of menin-mll interaction |
| ES2901227T3 (es) * | 2016-12-15 | 2022-03-21 | Janssen Pharmaceutica Nv | Inhibidores de azepano de la interacción menina-MLL |
| EA038388B1 (ru) * | 2017-01-16 | 2021-08-19 | Кура Онколоджи, Инк. | Замещенные ингибиторы менина-mll и способы применения |
| WO2018175746A1 (en) | 2017-03-24 | 2018-09-27 | Kura Oncology, Inc. | Methods for treating hematological malignancies and ewing's sarcoma |
| MX2019011412A (es) | 2017-03-31 | 2020-02-07 | Univ Michigan Regents | Piperidinas como inhibidores de menina covalentes. |
| US11542248B2 (en) | 2017-06-08 | 2023-01-03 | Kura Oncology, Inc. | Methods and compositions for inhibiting the interaction of menin with MLL proteins |
| WO2019060365A1 (en) | 2017-09-20 | 2019-03-28 | Kura Oncology, Inc. | SUBSTITUTED MÉNINE-MLL INHIBITORS AND METHODS OF USE |
| US11396517B1 (en) | 2017-12-20 | 2022-07-26 | Janssen Pharmaceutica Nv | Exo-aza spiro inhibitors of menin-MLL interaction |
| US11472799B2 (en) | 2018-03-06 | 2022-10-18 | Icahn School Of Medicine At Mount Sinai | Serine threonine kinase (AKT) degradation / disruption compounds and methods of use |
| JP7239562B2 (ja) | 2018-03-30 | 2023-03-14 | 住友ファーマ株式会社 | 光学活性な架橋型環状２級アミン誘導体 |
| EP3810145A4 (en) | 2018-06-21 | 2022-06-01 | Icahn School of Medicine at Mount Sinai | Wd40 repeat domain protein 5 (wdr5) degradation / disruption compounds and methods of use |
| JP2022502409A (ja) | 2018-10-03 | 2022-01-11 | ザ リージェンツ オブ ザ ユニヴァシティ オブ ミシガン | 低分子メニン阻害剤 |
| EP3965824B1 (en) | 2019-05-06 | 2025-01-08 | Icahn School of Medicine at Mount Sinai | Heterobifunctional compounds as degraders of hpk1 |
| WO2021067215A1 (en) | 2019-09-30 | 2021-04-08 | Agios Pharmaceuticals, Inc. | Piperidine compounds as menin inhibitors |
| CN112574224A (zh) * | 2019-09-30 | 2021-03-30 | 上海迪诺医药科技有限公司 | Kras g12c抑制剂及其应用 |
| KR20220118500A (ko) | 2019-12-19 | 2022-08-25 | 얀센 파마슈티카 엔.브이. | 치환 직쇄 스피로 유도체 |
| CN111297863B (zh) * | 2020-03-30 | 2021-06-25 | 四川大学华西医院 | menin-MLL抑制剂在制备治疗子宫内膜癌的药物中的应用 |
| TW202204334A (zh) | 2020-04-08 | 2022-02-01 | 美商阿吉歐斯製藥公司 | Menin抑制劑及治療癌症之使用方法 |
| WO2021204159A1 (en) | 2020-04-08 | 2021-10-14 | Agios Pharmaceuticals, Inc. | Menin inhibitors and methods of use for treating cancer |
| US12103924B2 (en) | 2020-06-01 | 2024-10-01 | Icahn School Of Medicine At Mount Sinai | Mitogen-activated protein kinase kinase (MEK) degradation compounds and methods of use |
| US11541009B2 (en) | 2020-09-10 | 2023-01-03 | Curemark, Llc | Methods of prophylaxis of coronavirus infection and treatment of coronaviruses |
| WO2022086937A1 (en) * | 2020-10-21 | 2022-04-28 | Icahn School Of Medicine At Mount Sinai | Heterobifunctional compounds as degraders of enl |
| CA3215379A1 (en) | 2021-05-08 | 2022-11-17 | Olivier Alexis Georges Querolle | Substituted spiro derivatives |
| BR112023021040A2 (pt) | 2021-05-08 | 2024-02-06 | Janssen Pharmaceutica Nv | Derivados espiro substituídos |
| EP4347588A1 (en) | 2021-06-01 | 2024-04-10 | JANSSEN Pharmaceutica NV | Substituted phenyl-1h-pyrrolo[2, 3-c]pyridine derivatives |
| WO2022253289A1 (en) | 2021-06-03 | 2022-12-08 | Janssen Pharmaceutica Nv | Pyridazines or 1,2,4-triazines substituted by spirocyclic amines |
| KR20240021808A (ko) | 2021-06-17 | 2024-02-19 | 얀센 파마슈티카 엔브이 | 암과 같은 질환의 치료를 위한 (r)-n-에틸-5-플루오로-n-아이소프로필-2-((5-(2-(6-((2-메톡시에틸)(메틸)아미노)-2-메틸헥산-3-일)-2,6-다이아자스피로[3.4]옥탄-6-일)-1,2,4-트라이아진-6-일)옥시)벤즈아미드 베실레이트 염 |
| WO2023056589A1 (en) | 2021-10-08 | 2023-04-13 | Servier Pharmaceuticals Llc | Menin inhibitors and methods of use for treating cancer |
| CN120529900A (zh) | 2022-11-24 | 2025-08-22 | 奥莱松基因组股份有限公司 | 用于治疗癌症的LSD1抑制剂和Menin抑制剂的组合 |
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|---|---|---|---|---|
| JPH10330377A (ja) | 1997-06-02 | 1998-12-15 | Kyowa Hakko Kogyo Co Ltd | ピペリジン誘導体 |
| PA8474101A1 (es) * | 1998-06-19 | 2000-09-29 | Pfizer Prod Inc | Compuestos de pirrolo [2,3-d] pirimidina |
| JP4310109B2 (ja) | 2001-04-26 | 2009-08-05 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | ピラゾリル基を置換基として有する含窒素縮合環化合物およびその医薬組成物 |
| MXPA03009925A (es) * | 2001-04-30 | 2004-06-30 | Bayer Pharmaceuticals Corp | Nuevas tiofeno [2,3-d]pirimidinas 4-amino-5,6-sustituidas. |
| WO2003022214A2 (en) | 2001-09-06 | 2003-03-20 | Millennium Pharmaceuticals, Inc. | Piperazine and homopiperazine compounds |
| AU2003255482A1 (en) | 2002-10-02 | 2004-04-23 | Merck Patent Gmbh | Use of 4 amino-quinazolines as anti cancer agents |
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| JP5335191B2 (ja) * | 2003-08-22 | 2013-11-06 | デンドレオン コーポレイション | Ｔｒｐ−ｐ８発現に関連する疾患の処置をするための組成物および方法 |
| US20050123906A1 (en) | 2003-11-06 | 2005-06-09 | Rana Tariq M. | Protein modulation |
| JP2008505907A (ja) | 2004-07-06 | 2008-02-28 | アンジオン バイオメディカ コーポレイション | 癌治療を目的として肝細胞増殖因子およびｃ−ｍｅｔ活性を調整するキナゾリンモジュレーター |
| US20060281769A1 (en) | 2005-06-10 | 2006-12-14 | Baumann Christian A | Synergistic modulation of flt3 kinase using thienopyrimidine and thienopyridine kinase modulators |
| US20060281771A1 (en) | 2005-06-10 | 2006-12-14 | Baumann Christian A | Synergistic modulation of flt3 kinase using aminoquinoline and aminoquinazoline kinase modulators |
| US20090221559A1 (en) * | 2005-09-02 | 2009-09-03 | Jean-Francois Bonfanti | Benzodiazepines as hcv inhibitors |
| CA2651898A1 (en) * | 2006-04-07 | 2007-10-18 | Develogen Aktiengesellschaft | Thienopyrimidines having mnk1/mnk2 inhibiting activity for pharmaceutical compositions |
| WO2008099019A1 (en) * | 2007-02-16 | 2008-08-21 | Tibotec Pharmaceuticals Ltd. | 6-hydroxy-dibenzodiazepinones useful as hepatitis c virus inhibitors |
| FR2913017A1 (fr) | 2007-02-23 | 2008-08-29 | Cerep Sa | Derives de piperidine et piperazine comme agents anti-neoplasiques ou inhibiteurs de proliferation cellulaire |
| US8309726B2 (en) * | 2007-03-19 | 2012-11-13 | Council Of Scientific & Industrial Research | Substituted piperazine compounds of formula 8 |
| EP2148944A1 (en) * | 2007-05-25 | 2010-02-03 | Burnham Institute for Medical Research | Inhibitors of thapsigargin-induced cell death |
| WO2009017838A2 (en) | 2007-08-01 | 2009-02-05 | Exelixis, Inc. | Combinations of jak-2 inhibitors and other agents |
| US20110124649A1 (en) * | 2007-11-09 | 2011-05-26 | The Johns Hopkins University | Inhibitors of human methionine aminopeptidase 1 and methods of treating disorders |
| AU2008345225A1 (en) * | 2007-12-21 | 2009-07-09 | University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
| AR073739A1 (es) * | 2008-09-10 | 2010-12-01 | Kalypsys Inc | Aminopirimidinas como inhibidores de los receptores de histamina |
| TW201105674A (en) * | 2009-07-08 | 2011-02-16 | Leo Pharma As | Novel JAK receptor and protein tyrosine kinase inhibitors and pharmaceutical use thereof |
-
2010
- 2010-09-03 WO PCT/US2010/047894 patent/WO2011029054A1/en not_active Ceased
- 2010-09-03 JP JP2012528106A patent/JP5792171B2/ja active Active
- 2010-09-03 US US12/875,968 patent/US8993552B2/en active Active
- 2010-09-03 AU AU2010289321A patent/AU2010289321A1/en not_active Abandoned
- 2010-09-03 CN CN201080050708.8A patent/CN102984941B/zh active Active
- 2010-09-03 EP EP10814591.3A patent/EP2473054B1/en active Active
- 2010-09-03 CA CA2773131A patent/CA2773131C/en active Active
-
2014
- 2014-06-27 AU AU2014203516A patent/AU2014203516B2/en active Active
-
2015
- 2015-03-23 US US14/665,600 patent/US20160045504A1/en not_active Abandoned
- 2015-05-13 JP JP2015098562A patent/JP2015143283A/ja active Pending
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