AU2010289321A1 - Compositions and methods for treatment of leukemia - Google Patents

Compositions and methods for treatment of leukemia Download PDF

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Publication number
AU2010289321A1
AU2010289321A1 AU2010289321A AU2010289321A AU2010289321A1 AU 2010289321 A1 AU2010289321 A1 AU 2010289321A1 AU 2010289321 A AU2010289321 A AU 2010289321A AU 2010289321 A AU2010289321 A AU 2010289321A AU 2010289321 A1 AU2010289321 A1 AU 2010289321A1
Authority
AU
Australia
Prior art keywords
compound
mll
substituted
compounds
menin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2010289321A
Other languages
English (en)
Inventor
Tomasz Cierpicki
Jolanta Grembecka
Jay Hess
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UVA Licensing and Ventures Group
University of Michigan System
Original Assignee
University of Michigan System
University of Virginia Patent Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Michigan System, University of Virginia Patent Foundation filed Critical University of Michigan System
Publication of AU2010289321A1 publication Critical patent/AU2010289321A1/en
Priority to AU2014203516A priority Critical patent/AU2014203516B2/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
AU2010289321A 2009-09-04 2010-09-03 Compositions and methods for treatment of leukemia Abandoned AU2010289321A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2014203516A AU2014203516B2 (en) 2009-09-04 2014-06-27 Compositions and methods for treatment of leukemia

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US24010209P 2009-09-04 2009-09-04
US61/240,102 2009-09-04
PCT/US2010/047894 WO2011029054A1 (en) 2009-09-04 2010-09-03 Compositions and methods for treatment of leukemia

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2014203516A Division AU2014203516B2 (en) 2009-09-04 2014-06-27 Compositions and methods for treatment of leukemia

Publications (1)

Publication Number Publication Date
AU2010289321A1 true AU2010289321A1 (en) 2012-04-05

Family

ID=43649670

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2010289321A Abandoned AU2010289321A1 (en) 2009-09-04 2010-09-03 Compositions and methods for treatment of leukemia
AU2014203516A Active AU2014203516B2 (en) 2009-09-04 2014-06-27 Compositions and methods for treatment of leukemia

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2014203516A Active AU2014203516B2 (en) 2009-09-04 2014-06-27 Compositions and methods for treatment of leukemia

Country Status (7)

Country Link
US (2) US8993552B2 (enExample)
EP (1) EP2473054B1 (enExample)
JP (2) JP5792171B2 (enExample)
CN (1) CN102984941B (enExample)
AU (2) AU2010289321A1 (enExample)
CA (1) CA2773131C (enExample)
WO (1) WO2011029054A1 (enExample)

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Also Published As

Publication number Publication date
US20110065690A1 (en) 2011-03-17
CN102984941A (zh) 2013-03-20
JP2015143283A (ja) 2015-08-06
EP2473054A1 (en) 2012-07-11
WO2011029054A1 (en) 2011-03-10
JP2013503906A (ja) 2013-02-04
AU2014203516B2 (en) 2016-06-09
US8993552B2 (en) 2015-03-31
JP5792171B2 (ja) 2015-10-07
CA2773131C (en) 2015-07-14
EP2473054A4 (en) 2013-05-01
US20160045504A1 (en) 2016-02-18
EP2473054B1 (en) 2017-06-14
AU2014203516A1 (en) 2014-07-17
CA2773131A1 (en) 2011-03-10
CN102984941B (zh) 2016-08-17

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