JP2016537382A5 - - Google Patents
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- Publication number
- JP2016537382A5 JP2016537382A5 JP2016532623A JP2016532623A JP2016537382A5 JP 2016537382 A5 JP2016537382 A5 JP 2016537382A5 JP 2016532623 A JP2016532623 A JP 2016532623A JP 2016532623 A JP2016532623 A JP 2016532623A JP 2016537382 A5 JP2016537382 A5 JP 2016537382A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- alkoxy
- cycloalkyl
- membered heterocycloalkyl
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 229910052739 hydrogen Inorganic materials 0.000 claims 36
- 239000001257 hydrogen Substances 0.000 claims 36
- 150000003839 salts Chemical class 0.000 claims 27
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 25
- 150000001875 compounds Chemical class 0.000 claims 24
- 229910052736 halogen Inorganic materials 0.000 claims 23
- 150000002367 halogens Chemical group 0.000 claims 23
- 150000002431 hydrogen Chemical class 0.000 claims 19
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 17
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 16
- -1 cyano, difluoromethyl Chemical group 0.000 claims 15
- 125000000753 cycloalkyl group Chemical group 0.000 claims 11
- 125000001072 heteroaryl group Chemical group 0.000 claims 10
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 9
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 9
- 125000001424 substituent group Chemical group 0.000 claims 9
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 9
- 125000006568 (C4-C7) heterocycloalkyl group Chemical group 0.000 claims 6
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 6
- 229910052799 carbon Inorganic materials 0.000 claims 6
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 6
- 229910052757 nitrogen Inorganic materials 0.000 claims 6
- 125000006584 (C3-C10) heterocycloalkyl group Chemical group 0.000 claims 4
- 125000003118 aryl group Chemical group 0.000 claims 4
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 3
- 125000004432 carbon atom Chemical group C* 0.000 claims 3
- 125000004093 cyano group Chemical group *C#N 0.000 claims 3
- 229910052731 fluorine Inorganic materials 0.000 claims 3
- 239000011737 fluorine Substances 0.000 claims 3
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 3
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 3
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 3
- 229910052760 oxygen Inorganic materials 0.000 claims 3
- 229910052717 sulfur Inorganic materials 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 230000002159 abnormal effect Effects 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 230000010261 cell growth Effects 0.000 claims 1
- 125000001028 difluoromethyl group Chemical group [H]C(F)(F)* 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- 0 *#CCC(NI)=O Chemical compound *#CCC(NI)=O 0.000 description 4
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361907322P | 2013-11-21 | 2013-11-21 | |
| US61/907,322 | 2013-11-21 | ||
| PCT/IB2014/065935 WO2015075598A1 (en) | 2013-11-21 | 2014-11-10 | 2,6-substituted purine derivatives and their use in the treatment of proliferative disorders |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017122759A Division JP2017214390A (ja) | 2013-11-21 | 2017-06-23 | ２，６−置換プリン誘導体および増殖性障害の治療におけるそれらの使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016537382A JP2016537382A (ja) | 2016-12-01 |
| JP2016537382A5 true JP2016537382A5 (enExample) | 2017-01-12 |
| JP6166845B2 JP6166845B2 (ja) | 2017-07-19 |
Family
ID=52004011
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016532623A Expired - Fee Related JP6166845B2 (ja) | 2013-11-21 | 2014-11-10 | ２，６−置換プリン誘導体および増殖性障害の治療におけるそれらの使用 |
| JP2017122759A Pending JP2017214390A (ja) | 2013-11-21 | 2017-06-23 | ２，６−置換プリン誘導体および増殖性障害の治療におけるそれらの使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017122759A Pending JP2017214390A (ja) | 2013-11-21 | 2017-06-23 | ２，６−置換プリン誘導体および増殖性障害の治療におけるそれらの使用 |
Country Status (39)
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201311888D0 (en) | 2013-07-03 | 2013-08-14 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
| GB201311891D0 (en) | 2013-07-03 | 2013-08-14 | Glaxosmithkline Ip Dev Ltd | Novel compound |
| US9840517B2 (en) | 2013-09-18 | 2017-12-12 | Beijing Hanmi Pharmaceutical Co., Ltd. | Compound inhibiting activities of BTK and/or JAK3 kinases |
| US20180228907A1 (en) | 2014-04-14 | 2018-08-16 | Arvinas, Inc. | Cereblon ligands and bifunctional compounds comprising the same |
| AU2016261730A1 (en) * | 2015-05-12 | 2017-11-16 | Zeno Royalties & Milestones, LLC | Bicyclic compounds |
| CN114149432B (zh) * | 2016-09-30 | 2024-07-05 | 斯坦福国际研究院 | 用于癌症治疗的双重clk/cdk1抑制剂 |
| US20190275049A1 (en) * | 2016-11-16 | 2019-09-12 | Pfizer Inc. | Combination of an EGFR T790M Inhibitor and a CDK Inhibitor for the Treatment of Non-Small Cell Lung Cancer |
| KR20190101406A (ko) | 2016-12-23 | 2019-08-30 | 아비나스 오퍼레이션스, 인코포레이티드 | Egfr 단백질분해 표적화 키메라 분자 및 관련 사용 방법 |
| IL269215B (en) | 2017-03-10 | 2022-09-01 | Pfizer | Disubstituted imidazole[4,5-c]quinoline derivatives |
| KR102582626B1 (ko) | 2017-03-10 | 2023-09-22 | 화이자 인코포레이티드 | Lrrk2 억제제로서의 신규 이미다조[4,5-c]퀴놀린 유도체 |
| US12012408B2 (en) | 2018-06-22 | 2024-06-18 | The Royal Institution For The Advancement Of Learning/Mcgill University | Purine compounds and method for the treatment of cancer |
| WO2020175968A1 (ko) * | 2019-02-28 | 2020-09-03 | 주식회사 보로노이 | N을 포함하는 헤테로아릴 유도체 및 이를 유효성분으로 포함하는 약학적 조성물 |
| WO2021233133A1 (zh) * | 2020-05-20 | 2021-11-25 | 浙江同源康医药股份有限公司 | 用作ret激酶抑制剂的化合物及其应用 |
| JP2024533565A (ja) | 2021-09-14 | 2024-09-12 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ３－フェノキシアゼチジン－１－イル－ヘテロアリールピロリジン誘導体及び医薬としてのその使用 |
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-
2014
- 2014-10-11 UA UAA201605505A patent/UA115388C2/uk unknown
- 2014-11-10 EP EP14806447.0A patent/EP3071570B1/en active Active
- 2014-11-10 PE PE2016000650A patent/PE20160885A1/es unknown
- 2014-11-10 TN TN2016000188A patent/TN2016000188A1/fr unknown
- 2014-11-10 PL PL14806447T patent/PL3071570T3/pl unknown
- 2014-11-10 RS RS20180909A patent/RS57537B1/sr unknown
- 2014-11-10 KR KR1020167016053A patent/KR101919672B1/ko not_active Expired - Fee Related
- 2014-11-10 CN CN201480073530.7A patent/CN105916853B/zh not_active Expired - Fee Related
- 2014-11-10 MD MDA20160053A patent/MD20160053A2/ro not_active Application Discontinuation
- 2014-11-10 HU HUE14806447A patent/HUE039858T2/hu unknown
- 2014-11-10 AP AP2016009219A patent/AP2016009219A0/en unknown
- 2014-11-10 CU CU2016000073A patent/CU24402B1/es unknown
- 2014-11-10 JP JP2016532623A patent/JP6166845B2/ja not_active Expired - Fee Related
- 2014-11-10 SI SI201430806T patent/SI3071570T1/sl unknown
- 2014-11-10 LT LTEP14806447.0T patent/LT3071570T/lt unknown
- 2014-11-10 MA MA39043A patent/MA39043B1/fr unknown
- 2014-11-10 AU AU2014351433A patent/AU2014351433B2/en not_active Ceased
- 2014-11-10 EA EA201600337A patent/EA029842B1/ru not_active IP Right Cessation
- 2014-11-10 MY MYPI2016701796A patent/MY184433A/en unknown
- 2014-11-10 ES ES14806447.0T patent/ES2681799T3/es active Active
- 2014-11-10 HR HRP20181036TT patent/HRP20181036T1/hr unknown
- 2014-11-10 PT PT148064470T patent/PT3071570T/pt unknown
- 2014-11-10 MX MX2016006397A patent/MX2016006397A/es unknown
- 2014-11-10 WO PCT/IB2014/065935 patent/WO2015075598A1/en not_active Ceased
- 2014-11-10 DK DK14806447.0T patent/DK3071570T3/en active
- 2014-11-10 GE GEAP201414151A patent/GEP20186878B/en unknown
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- 2014-11-10 CA CA2931034A patent/CA2931034C/en active Active
- 2014-11-19 UY UY0001035845A patent/UY35845A/es not_active Application Discontinuation
- 2014-11-20 US US14/548,749 patent/US9290496B2/en active Active
- 2014-11-20 AR ARP140104368A patent/AR098492A1/es unknown
- 2014-11-20 TW TW103140297A patent/TWI538913B/zh not_active IP Right Cessation
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2016
- 2016-05-13 CL CL2016001151A patent/CL2016001151A1/es unknown
- 2016-05-17 PH PH12016500911A patent/PH12016500911A1/en unknown
- 2016-05-18 IL IL24569816A patent/IL245698B/en active IP Right Grant
- 2016-05-19 DO DO2016000115A patent/DOP2016000115A/es unknown
- 2016-05-20 NI NI201600072A patent/NI201600072A/es unknown
- 2016-05-20 GT GT201600091A patent/GT201600091A/es unknown
- 2016-05-20 CR CR20160236A patent/CR20160236A/es unknown
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2017
- 2017-06-23 JP JP2017122759A patent/JP2017214390A/ja active Pending
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2018
- 2018-07-25 CY CY20181100779T patent/CY1120478T1/el unknown
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