JP6166845B2 - ２，６−置換プリン誘導体および増殖性障害の治療におけるそれらの使用 - Google Patents
２，６−置換プリン誘導体および増殖性障害の治療におけるそれらの使用 Download PDFInfo
- Publication number
- JP6166845B2 JP6166845B2 JP2016532623A JP2016532623A JP6166845B2 JP 6166845 B2 JP6166845 B2 JP 6166845B2 JP 2016532623 A JP2016532623 A JP 2016532623A JP 2016532623 A JP2016532623 A JP 2016532623A JP 6166845 B2 JP6166845 B2 JP 6166845B2
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- pharmaceutically acceptable
- formula
- acceptable salt
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 C*c(nc1NC2=C(*)C=C(*)**2)nc2c1nc[n]2* Chemical compound C*c(nc1NC2=C(*)C=C(*)**2)nc2c1nc[n]2* 0.000 description 8
- FWYAVJNYLNZEQE-UHFFFAOYSA-N CC(C)(C)OC(N(C1)CC1[n](cc1[N+]([O-])=O)nc1OC)=O Chemical compound CC(C)(C)OC(N(C1)CC1[n](cc1[N+]([O-])=O)nc1OC)=O FWYAVJNYLNZEQE-UHFFFAOYSA-N 0.000 description 1
- SUECTKVSIDXQQE-ZETCQYMHSA-N CC(C)(C)OC(N(CC1)C[C@H]1F)=O Chemical compound CC(C)(C)OC(N(CC1)C[C@H]1F)=O SUECTKVSIDXQQE-ZETCQYMHSA-N 0.000 description 1
- QCSJJFLDYGDLTQ-UHFFFAOYSA-N CC(C)(C)OC(N(CC1OS(C(F)(F)F)(=O)=O)CC1(F)F)=O Chemical compound CC(C)(C)OC(N(CC1OS(C(F)(F)F)(=O)=O)CC1(F)F)=O QCSJJFLDYGDLTQ-UHFFFAOYSA-N 0.000 description 1
- NXZIGGBPLGAPTI-UHFFFAOYSA-N CC(C)(C)OC(N1CC2OC2C1)=O Chemical compound CC(C)(C)OC(N1CC2OC2C1)=O NXZIGGBPLGAPTI-UHFFFAOYSA-N 0.000 description 1
- BZSDDSIFAGBZLT-RNFRBKRXSA-N CC(C)(C)OC(N[C@H](CNC1)[C@@H]1F)=O Chemical compound CC(C)(C)OC(N[C@H](CNC1)[C@@H]1F)=O BZSDDSIFAGBZLT-RNFRBKRXSA-N 0.000 description 1
- ICEWACHGGQESMP-UHFFFAOYSA-N CC(C)N(CC=C1)C1=O Chemical compound CC(C)N(CC=C1)C1=O ICEWACHGGQESMP-UHFFFAOYSA-N 0.000 description 1
- KWJIZHBFFSSKHT-UHFFFAOYSA-N CS(CCC(NC(CNC1)C1(F)F)=O)(=O)=O Chemical compound CS(CCC(NC(CNC1)C1(F)F)=O)(=O)=O KWJIZHBFFSSKHT-UHFFFAOYSA-N 0.000 description 1
- FBXYUPNTYGIGCU-RNFRBKRXSA-N CS(CCC(N[C@H](CNC1)[C@@H]1F)=O)(=O)=O Chemical compound CS(CCC(N[C@H](CNC1)[C@@H]1F)=O)(=O)=O FBXYUPNTYGIGCU-RNFRBKRXSA-N 0.000 description 1
- ZQLLPWMNXQYESO-UHFFFAOYSA-N Cc(cc1)ccc1S(OC=C(F)F)(=O)=O Chemical compound Cc(cc1)ccc1S(OC=C(F)F)(=O)=O ZQLLPWMNXQYESO-UHFFFAOYSA-N 0.000 description 1
- PUJDIJCNWFYVJX-UHFFFAOYSA-N NC(OCc1ccccc1)=O Chemical compound NC(OCc1ccccc1)=O PUJDIJCNWFYVJX-UHFFFAOYSA-N 0.000 description 1
- ABZJTBIFOXKWPB-GHMZBOCLSA-N N[C@H](CN(Cc1ccccc1)C1)[C@@H]1F Chemical compound N[C@H](CN(Cc1ccccc1)C1)[C@@H]1F ABZJTBIFOXKWPB-GHMZBOCLSA-N 0.000 description 1
- DOUJBFAVFSNBCD-UHFFFAOYSA-N O=C(CC1(F)F)N(Cc2ccccc2)C1=O Chemical compound O=C(CC1(F)F)N(Cc2ccccc2)C1=O DOUJBFAVFSNBCD-UHFFFAOYSA-N 0.000 description 1
- KZWUUEWPRQZDNF-QWRGUYRKSA-N O=C(N[C@@H](CNC1)[C@H]1F)OCc1ccccc1 Chemical compound O=C(N[C@@H](CNC1)[C@H]1F)OCc1ccccc1 KZWUUEWPRQZDNF-QWRGUYRKSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361907322P | 2013-11-21 | 2013-11-21 | |
| US61/907,322 | 2013-11-21 | ||
| PCT/IB2014/065935 WO2015075598A1 (en) | 2013-11-21 | 2014-11-10 | 2,6-substituted purine derivatives and their use in the treatment of proliferative disorders |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017122759A Division JP2017214390A (ja) | 2013-11-21 | 2017-06-23 | ２，６−置換プリン誘導体および増殖性障害の治療におけるそれらの使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016537382A JP2016537382A (ja) | 2016-12-01 |
| JP2016537382A5 JP2016537382A5 (enExample) | 2017-01-12 |
| JP6166845B2 true JP6166845B2 (ja) | 2017-07-19 |
Family
ID=52004011
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016532623A Expired - Fee Related JP6166845B2 (ja) | 2013-11-21 | 2014-11-10 | ２，６−置換プリン誘導体および増殖性障害の治療におけるそれらの使用 |
| JP2017122759A Pending JP2017214390A (ja) | 2013-11-21 | 2017-06-23 | ２，６−置換プリン誘導体および増殖性障害の治療におけるそれらの使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017122759A Pending JP2017214390A (ja) | 2013-11-21 | 2017-06-23 | ２，６−置換プリン誘導体および増殖性障害の治療におけるそれらの使用 |
Country Status (39)
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201311888D0 (en) | 2013-07-03 | 2013-08-14 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
| GB201311891D0 (en) | 2013-07-03 | 2013-08-14 | Glaxosmithkline Ip Dev Ltd | Novel compound |
| US9840517B2 (en) | 2013-09-18 | 2017-12-12 | Beijing Hanmi Pharmaceutical Co., Ltd. | Compound inhibiting activities of BTK and/or JAK3 kinases |
| US20180228907A1 (en) | 2014-04-14 | 2018-08-16 | Arvinas, Inc. | Cereblon ligands and bifunctional compounds comprising the same |
| CA2984496A1 (en) * | 2015-05-12 | 2016-11-17 | Kalyra Pharmaceuticals, Inc. | Bicyclic compounds |
| EP4086257A1 (en) * | 2016-09-30 | 2022-11-09 | SRI International | Dual clk/cdk1 inhibitors for cancer treatment |
| US20190275049A1 (en) * | 2016-11-16 | 2019-09-12 | Pfizer Inc. | Combination of an EGFR T790M Inhibitor and a CDK Inhibitor for the Treatment of Non-Small Cell Lung Cancer |
| RU2019121527A (ru) | 2016-12-23 | 2021-01-15 | Эрвинэс Оперейшнс, Инк. | Химерные молекулы, нацеливающиеся на протеолиз egfr, и связанные с ними способы применения |
| WO2018163030A1 (en) | 2017-03-10 | 2018-09-13 | Pfizer Inc. | Cyclic substituted imidazo[4,5-c]quinoline derivatives |
| WO2018163066A1 (en) | 2017-03-10 | 2018-09-13 | Pfizer Inc. | Novel imidazo[4,5-c]quinoline derivatives as lrrk2 inhibitors |
| US12012408B2 (en) | 2018-06-22 | 2024-06-18 | The Royal Institution For The Advancement Of Learning/Mcgill University | Purine compounds and method for the treatment of cancer |
| KR20200105631A (ko) * | 2019-02-28 | 2020-09-08 | 보로노이바이오 주식회사 | N을 포함하는 헤테로아릴 유도체 및 이를 유효성분으로 포함하는 약학적 조성물 |
| JP7599228B2 (ja) * | 2020-05-20 | 2024-12-13 | ティーワイケー メディシンズ インコーポレーテッド | Ｒｅｔキナーゼ阻害剤としての化合物およびその応用 |
| CN117940420A (zh) | 2021-09-14 | 2024-04-26 | 勃林格殷格翰国际有限公司 | 3-苯氧基氮杂环丁烷-1-基-杂芳基吡咯烷衍生物及其作为药物的用途 |
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