DOP2016000115A - Derivados de purina - Google Patents

Derivados de purina

Info

Publication number
DOP2016000115A
DOP2016000115A DO2016000115A DO2016000115A DOP2016000115A DO P2016000115 A DOP2016000115 A DO P2016000115A DO 2016000115 A DO2016000115 A DO 2016000115A DO 2016000115 A DO2016000115 A DO 2016000115A DO P2016000115 A DOP2016000115 A DO P2016000115A
Authority
DO
Dominican Republic
Prior art keywords
compounds
mammals
ring
cellular growth
abnormal cellular
Prior art date
Application number
DO2016000115A
Other languages
English (en)
Inventor
Theodore Otto Johnson Jr
John Charles Kath
Hengmiao Cheng
Sajiv Krishnan Nair
Douglas Carl Behenna
Sujin Cho-Schultz
Asako Nagata
Simon Paul Planken
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of DOP2016000115A publication Critical patent/DOP2016000115A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

LA PRESENTE INVENCIÓN SE REFIERE A COMPUESTOS DE LA FÓRMULA (I) O SALES DE AQUELLOS ACEPTABLES DESDE EL PUNTO DE VISTA FARMACÉUTICO, EN DONDE Q, G, ANILLO A, ANILLO B, R1, R2, R3, R4, R5, R5A, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R17, R18, R19, R20, R21, R22, R23, R24 Y M SON COMO SE DEFINEN EN LA PRESENTE. LOS DERIVADOS DE PURINA NOVEDOSOS SON ÚTILES PARA TRATAR EL CRECIMIENTO CELULAR ANORMAL, TAL COMO EL CÁNCER, EN MAMÍFEROS. OTRAS FORMAS DE REALIZACIÓN SE REFIEREN A COMPOSICIONES FARMACÉUTICAS QUE CONTIENEN LOS COMPUESTOS Y A MÉTODOS PARA USAR LOS COMPUESTOS Y LAS COMPOSICIONES EN EL TRATAMIENTO DEL CRECIMIENTO CELULAR ANORMAL EN MAMÍFEROS.
DO2016000115A 2013-11-21 2016-05-19 Derivados de purina DOP2016000115A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201361907322P 2013-11-21 2013-11-21

Publications (1)

Publication Number Publication Date
DOP2016000115A true DOP2016000115A (es) 2016-07-15

Family

ID=52004011

Family Applications (1)

Application Number Title Priority Date Filing Date
DO2016000115A DOP2016000115A (es) 2013-11-21 2016-05-19 Derivados de purina

Country Status (39)

Country Link
US (1) US9290496B2 (es)
EP (1) EP3071570B1 (es)
JP (2) JP6166845B2 (es)
KR (1) KR101919672B1 (es)
CN (1) CN105916853B (es)
AP (1) AP2016009219A0 (es)
AR (1) AR098492A1 (es)
AU (1) AU2014351433B2 (es)
CA (1) CA2931034C (es)
CL (1) CL2016001151A1 (es)
CR (1) CR20160236A (es)
CU (1) CU24402B1 (es)
CY (1) CY1120478T1 (es)
DK (1) DK3071570T3 (es)
DO (1) DOP2016000115A (es)
EA (1) EA029842B1 (es)
ES (1) ES2681799T3 (es)
GE (1) GEP20186878B (es)
GT (1) GT201600091A (es)
HR (1) HRP20181036T1 (es)
HU (1) HUE039858T2 (es)
IL (1) IL245698B (es)
LT (1) LT3071570T (es)
MA (1) MA39043B1 (es)
MD (1) MD20160053A2 (es)
MX (1) MX2016006397A (es)
MY (1) MY184433A (es)
NI (1) NI201600072A (es)
PE (1) PE20160885A1 (es)
PH (1) PH12016500911A1 (es)
PL (1) PL3071570T3 (es)
PT (1) PT3071570T (es)
RS (1) RS57537B1 (es)
SI (1) SI3071570T1 (es)
TN (1) TN2016000188A1 (es)
TW (1) TWI538913B (es)
UA (1) UA115388C2 (es)
UY (1) UY35845A (es)
WO (1) WO2015075598A1 (es)

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WO2020175968A1 (ko) * 2019-02-28 2020-09-03 주식회사 보로노이 N을 포함하는 헤테로아릴 유도체 및 이를 유효성분으로 포함하는 약학적 조성물
KR20230015944A (ko) * 2020-05-20 2023-01-31 티와이케이 메디슨즈, 인코포레이티드 Ret 키나아제 억제제로 사용되는 화합물 및 이의 용도
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