CL2015003605A1 - Derivados de prodroga de triazolpiridinas sustituidas - Google Patents

Derivados de prodroga de triazolpiridinas sustituidas

Info

Publication number
CL2015003605A1
CL2015003605A1 CL2015003605A CL2015003605A CL2015003605A1 CL 2015003605 A1 CL2015003605 A1 CL 2015003605A1 CL 2015003605 A CL2015003605 A CL 2015003605A CL 2015003605 A CL2015003605 A CL 2015003605A CL 2015003605 A1 CL2015003605 A1 CL 2015003605A1
Authority
CL
Chile
Prior art keywords
triazolpyridines
substituted
prodrug derivatives
triazolpiridinas
profilaxis
Prior art date
Application number
CL2015003605A
Other languages
English (en)
Inventor
Gerhard Siemeister
Donald Bierer
Volker Schulze
Dirk Kosemund
Philip Lienau
Michael Brüning
Antje Margaret Wengner
Ulrich Lücking
Hans-Georg Lerchen
Ursula Krenz
Detlef Stöckigh
Ildikó Terebesi
Original Assignee
Bayer Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Pharma AG filed Critical Bayer Pharma AG
Publication of CL2015003605A1 publication Critical patent/CL2015003605A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06052—Val-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

COMPUESTOS DERIVADOS DE PRODROGA DE TRIAZOLPIRIDINAS SUSTITUIDAS; COMPOSICION FARAMCEUTICA; Y SU USO PARA EL TRATAMIENTO O PROFILAXIS DE UNA ENFERMEDAD RELACIONADA CON UN CRECIMIENTO, PROLIFERACION O SUPERVIVENCIA CELULAR DESCONTROLADA, TAL COMO CANCER
CL2015003605A 2013-06-11 2015-12-11 Derivados de prodroga de triazolpiridinas sustituidas CL2015003605A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP13171508 2013-06-11

Publications (1)

Publication Number Publication Date
CL2015003605A1 true CL2015003605A1 (es) 2016-06-24

Family

ID=48576905

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2015003605A CL2015003605A1 (es) 2013-06-11 2015-12-11 Derivados de prodroga de triazolpiridinas sustituidas

Country Status (35)

Country Link
US (1) US9586958B2 (es)
EP (1) EP3008062B1 (es)
JP (1) JP2016526534A (es)
KR (1) KR20160019492A (es)
CN (1) CN105377848A (es)
AP (1) AP2015008898A0 (es)
AR (1) AR096585A1 (es)
AU (1) AU2014280356A1 (es)
CA (1) CA2914745A1 (es)
CL (1) CL2015003605A1 (es)
CR (1) CR20150659A (es)
CU (1) CU20150176A7 (es)
DK (1) DK3008062T3 (es)
DO (1) DOP2015000299A (es)
EA (1) EA201600002A1 (es)
ES (1) ES2626790T3 (es)
HK (1) HK1221955A1 (es)
HR (1) HRP20170717T1 (es)
HU (1) HUE033131T2 (es)
IL (1) IL242847A0 (es)
LT (1) LT3008062T (es)
MA (1) MA38654B1 (es)
MX (1) MX2015017119A (es)
NI (1) NI201500176A (es)
PE (1) PE20160156A1 (es)
PH (1) PH12015502746A1 (es)
PL (1) PL3008062T3 (es)
PT (1) PT3008062T (es)
RS (1) RS56034B1 (es)
SG (1) SG11201509858QA (es)
SI (1) SI3008062T1 (es)
TN (1) TN2015000545A1 (es)
UY (1) UY35610A (es)
WO (1) WO2014198647A2 (es)
ZA (1) ZA201508868B (es)

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MA41136A (fr) * 2014-12-09 2017-10-17 Bayer Pharma AG Composés pour le traitement d'un cancer
CN114592061A (zh) 2015-04-17 2022-06-07 荷兰转化研究中心有限责任公司 用于ttk抑制剂化疗的预后生物标记
JP7121722B2 (ja) 2016-04-04 2022-08-18 ケモセントリックス，インコーポレイティド 可溶性Ｃ５ａＲアンタゴニスト
WO2023113478A1 (en) * 2021-12-15 2023-06-22 Sillajen, Inc. Methods of treating neoplastic diseases

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WO2005030121A2 (en) 2003-06-30 2005-04-07 Hif Bio, Inc. Compounds, compositions and methods
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Also Published As

Publication number Publication date
EP3008062B1 (en) 2017-04-05
WO2014198647A2 (en) 2014-12-18
CR20150659A (es) 2016-01-29
JP2016526534A (ja) 2016-09-05
PH12015502746A1 (en) 2016-03-21
CN105377848A (zh) 2016-03-02
CU20150176A7 (es) 2016-05-30
AP2015008898A0 (en) 2015-12-31
MX2015017119A (es) 2016-04-06
PE20160156A1 (es) 2016-04-20
LT3008062T (lt) 2017-06-12
NI201500176A (es) 2016-01-06
EP3008062A2 (en) 2016-04-20
AR096585A1 (es) 2016-01-20
US20160207915A1 (en) 2016-07-21
DK3008062T3 (en) 2017-06-12
RS56034B1 (sr) 2017-09-29
DOP2015000299A (es) 2016-03-15
CA2914745A1 (en) 2014-12-18
UY35610A (es) 2015-01-30
US9586958B2 (en) 2017-03-07
SG11201509858QA (en) 2015-12-30
HK1221955A1 (zh) 2017-06-16
HUE033131T2 (en) 2017-11-28
SI3008062T1 (sl) 2017-06-30
TN2015000545A1 (en) 2017-04-06
PT3008062T (pt) 2017-06-07
WO2014198647A3 (en) 2015-02-05
IL242847A0 (en) 2016-02-01
AU2014280356A1 (en) 2015-12-24
KR20160019492A (ko) 2016-02-19
EA201600002A1 (ru) 2016-06-30
HRP20170717T1 (hr) 2017-07-28
ES2626790T3 (es) 2017-07-26
PL3008062T3 (pl) 2017-08-31
ZA201508868B (en) 2017-08-30
MA38654B1 (fr) 2018-11-30

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