PE20160156A1 - Derivados de prodroga de triazolpiridinas sustituidas - Google Patents
Derivados de prodroga de triazolpiridinas sustituidasInfo
- Publication number
- PE20160156A1 PE20160156A1 PE2015002605A PE2015002605A PE20160156A1 PE 20160156 A1 PE20160156 A1 PE 20160156A1 PE 2015002605 A PE2015002605 A PE 2015002605A PE 2015002605 A PE2015002605 A PE 2015002605A PE 20160156 A1 PE20160156 A1 PE 20160156A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- derivatives
- triazolpyridines
- prodrog
- substituted
- Prior art date
Links
- 230000024932 T cell mediated immunity Effects 0.000 abstract 2
- 102100022681 40S ribosomal protein S27 Human genes 0.000 abstract 1
- 208000003174 Brain Neoplasms Diseases 0.000 abstract 1
- -1 DERIVATIVES OF 2-ANILINO-6- (4 - {[(2R) -2- (4-FLUOROPHENYL) PROPANOYL] AMINO} PHENYL) [1, 2, 4] TRIAZOLO [1, 5-A] PYRIDINE Chemical class 0.000 abstract 1
- 101000678466 Homo sapiens 40S ribosomal protein S27 Proteins 0.000 abstract 1
- 206010025323 Lymphomas Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 108091000080 Phosphotransferase Proteins 0.000 abstract 1
- 101000977048 Streptomyces cinnamonensis Uncharacterized protein in mutB 3'region Proteins 0.000 abstract 1
- 230000010261 cell growth Effects 0.000 abstract 1
- 230000004663 cell proliferation Effects 0.000 abstract 1
- 230000001413 cellular effect Effects 0.000 abstract 1
- 230000006364 cellular survival Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 208000032839 leukemia Diseases 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 102000020233 phosphotransferase Human genes 0.000 abstract 1
- 230000002685 pulmonary effect Effects 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
- C07K5/06052—Val-amino acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06086—Dipeptides with the first amino acid being basic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
SE REFIERE A DERIVADOS SUSTITUIDOS DE 2-ANILINO-6-(4-{[(2R)-2-(4-FLUOROFENIL)PROPANOIL]AMINO}FENIL)[1, 2, 4]TRIAZOLO[1, 5-A]PIRIDINA DE FORMULA (I), EN DONDE RA ES -C(O)-(CH2)3-NH-C1-C6-ALQUILO, -C(O)O-(CH2)2-NH-C1-C6-ALQUILO, O -C(O)O-CH2-O-C(O)-C1-C6-ALQUILO, ENTRE OTROS; R1 ES METOXI O 2, 2, 2-TRIFLUOROETOXI; Y R2 ES -S(O)2-CH3, AZETIDIN-1-IL-CARBONILO, 3-FLUOROAZETIDIN-1-IL-CARBONILO O -C(O)-N(CH3)2. DICHOS COMPUESTOS SON INHIBIDORES DE LA QUINASA MPS-1, POR LO CUAL SON UTILES EN LA TERAPIA DE ENFERMEDADES RELACIONADAS CON UN CRECIMIENTO, PROLIFERACION O SUPERVIVENCIA CELULAR DESCONTROLADA, O CON UNA RESPUESTA INMUNE CELULAR INAPROPIADA, O CON UNA RESPUESTA INFLAMATORIA CELULAR INAPROPIADA, TALES COMO LAS LEUCEMIAS, LINFOMAS MALIGNOS, TUMORES CEREBRALES, TUMORES DE LAS CELULAS PULMONARES, ENTRE OTRAS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13171508 | 2013-06-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20160156A1 true PE20160156A1 (es) | 2016-04-20 |
Family
ID=48576905
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2015002605A PE20160156A1 (es) | 2013-06-11 | 2014-06-06 | Derivados de prodroga de triazolpiridinas sustituidas |
Country Status (35)
| Country | Link |
|---|---|
| US (1) | US9586958B2 (es) |
| EP (1) | EP3008062B1 (es) |
| JP (1) | JP2016526534A (es) |
| KR (1) | KR20160019492A (es) |
| CN (1) | CN105377848A (es) |
| AP (1) | AP2015008898A0 (es) |
| AR (1) | AR096585A1 (es) |
| AU (1) | AU2014280356A1 (es) |
| CA (1) | CA2914745A1 (es) |
| CL (1) | CL2015003605A1 (es) |
| CR (1) | CR20150659A (es) |
| CU (1) | CU20150176A7 (es) |
| DK (1) | DK3008062T3 (es) |
| DO (1) | DOP2015000299A (es) |
| EA (1) | EA201600002A1 (es) |
| ES (1) | ES2626790T3 (es) |
| HK (1) | HK1221955A1 (es) |
| HR (1) | HRP20170717T1 (es) |
| HU (1) | HUE033131T2 (es) |
| IL (1) | IL242847A0 (es) |
| LT (1) | LT3008062T (es) |
| MA (1) | MA38654B1 (es) |
| MX (1) | MX2015017119A (es) |
| NI (1) | NI201500176A (es) |
| PE (1) | PE20160156A1 (es) |
| PH (1) | PH12015502746A1 (es) |
| PL (1) | PL3008062T3 (es) |
| PT (1) | PT3008062T (es) |
| RS (1) | RS56034B1 (es) |
| SG (1) | SG11201509858QA (es) |
| SI (1) | SI3008062T1 (es) |
| TN (1) | TN2015000545A1 (es) |
| UY (1) | UY35610A (es) |
| WO (1) | WO2014198647A2 (es) |
| ZA (1) | ZA201508868B (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MA41136A (fr) * | 2014-12-09 | 2017-10-17 | Bayer Pharma AG | Composés pour le traitement d'un cancer |
| KR20180011089A (ko) | 2015-04-17 | 2018-01-31 | 네덜런즈 트랜슬레이셔널 리서치 센터 비.브이. | Ttk 억제제 화학요법을 위한 예후 바이오마커 |
| NZ747259A (en) | 2016-04-04 | 2022-11-25 | Chemocentryx Inc | Soluble c5ar antagonists |
| WO2023113478A1 (en) * | 2021-12-15 | 2023-06-22 | Sillajen, Inc. | Methods of treating neoplastic diseases |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2263566C (en) | 1996-08-28 | 2003-09-09 | Pfizer Inc. | Substituted 6,5-hetero-bicyclic derivatives |
| SK158099A3 (en) | 1997-05-28 | 2000-06-12 | Rhone Poulenc Rorer Pharma | Quinoline and quinoxaline compounds which inhibit platelet-derived growth factor and/or p56lck tyrosine kinases |
| US6514989B1 (en) | 2001-07-20 | 2003-02-04 | Hoffmann-La Roche Inc. | Aromatic and heteroaromatic substituted 1,2,4-triazolo pyridine derivatives |
| JP2004346016A (ja) | 2003-05-22 | 2004-12-09 | Otsuka Chemical Co Ltd | トリフルオロメチルキノキサリン化合物、その製造方法、及び有害生物防除剤 |
| CA2530679A1 (en) | 2003-06-30 | 2005-04-07 | Hif Bio, Inc. | Compounds for treating angiogenesis |
| JP2008515874A (ja) | 2004-10-07 | 2008-05-15 | ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー | 抗菌薬 |
| US20070049591A1 (en) | 2005-08-25 | 2007-03-01 | Kalypsys, Inc. | Inhibitors of MAPK/Erk Kinase |
| US7723336B2 (en) | 2005-09-22 | 2010-05-25 | Bristol-Myers Squibb Company | Fused heterocyclic compounds useful as kinase modulators |
| US20070078136A1 (en) | 2005-09-22 | 2007-04-05 | Bristol-Myers Squibb Company | Fused heterocyclic compounds useful as kinase modulators |
| WO2007065010A2 (en) | 2005-12-02 | 2007-06-07 | Hif Bio, Inc. | Anti-angiogenesis compounds |
| EA200870592A1 (ru) | 2006-05-31 | 2009-08-28 | Галапагос Н.В. | Триазолопиразиновые соединения, пригодные для лечения дегенеративных и воспалительных заболеваний |
| EP2056829B9 (en) | 2006-08-16 | 2012-09-26 | Exelixis, Inc. | Using pi3k and mek modulators in treatments of cancer |
| BRPI0716239A2 (pt) | 2006-08-30 | 2013-08-13 | Cellzome Ltd | derivados de triazol como inibidores de cinase |
| JP2010526823A (ja) | 2007-05-10 | 2010-08-05 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー | Ｐｉ３キナーゼ阻害物質としてのキノキサリン誘導体 |
| CN101801966A (zh) | 2007-07-18 | 2010-08-11 | 诺瓦提斯公司 | 双环杂芳基化合物和它们作为激酶抑制剂的用途 |
| JP2010535804A (ja) | 2007-08-09 | 2010-11-25 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー | Ｐｉ３キナーゼ阻害薬としてのキノキサリン誘導体 |
| EA201000341A1 (ru) | 2007-08-23 | 2010-10-29 | Астразенека Аб | 2-анилинопурин-8-оны в качестве ингибиторов ttk/mps1 для лечения пролиферативных нарушений |
| EP2181112A1 (en) | 2007-08-31 | 2010-05-05 | Merck Serono S.A. | Triazolopyridine compounds and their use as ask inhibitors |
| GB0719803D0 (en) | 2007-10-10 | 2007-11-21 | Cancer Rec Tech Ltd | Therapeutic compounds and their use |
| CA2706578A1 (en) | 2007-11-27 | 2009-06-04 | Cellzome Limited | Amino triazoles as pi3k inhibitors |
| US8415376B2 (en) | 2008-05-30 | 2013-04-09 | Amgen Inc. | Inhibitors of PI3 kinase |
| TWI491610B (zh) | 2008-10-09 | 2015-07-11 | 必治妥美雅史谷比公司 | 作為激酶抑制劑之咪唑并嗒腈 |
| WO2010092015A1 (en) | 2009-02-10 | 2010-08-19 | Cellzome Limited | Urea triazololo [1, 5-a] pyridine derivatives as pi3k inhibitors |
| PE20120110A1 (es) | 2009-02-13 | 2012-02-20 | Fovea Pharmaceuticals | [1,2,4]triazolo[1,5-a]piridinas como inhibidores de cinasa |
| US8729082B2 (en) | 2009-04-29 | 2014-05-20 | Bayer Intellectual Property Gmbh | Substituted imidazoquinoxalines |
| TW201107329A (en) | 2009-07-30 | 2011-03-01 | Oncotherapy Science Inc | Fused imidazole derivative having ttk inhibitory action |
| EP2473498A1 (en) | 2009-09-04 | 2012-07-11 | Bayer Pharma Aktiengesellschaft | Substituted aminoquinoxalines as tyrosine threonine kinase inhibitors |
| EP2343294A1 (en) * | 2009-11-30 | 2011-07-13 | Bayer Schering Pharma AG | Substituted triazolopyridines |
| EP2343297A1 (en) | 2009-11-30 | 2011-07-13 | Bayer Schering Pharma AG | Triazolopyridines |
| EP2343295A1 (en) * | 2009-11-30 | 2011-07-13 | Bayer Schering Pharma AG | Triazolopyridine derivates |
| ES2512840T3 (es) | 2010-01-15 | 2014-10-24 | Janssen Pharmaceuticals, Inc. | Derivados de triazol bicíclicos sustituidos novedosos como moduladores de gamma-secretasa |
| US20110190269A1 (en) | 2010-02-01 | 2011-08-04 | Karlheinz Baumann | Gamma secretase modulators |
| UY33452A (es) * | 2010-06-16 | 2012-01-31 | Bayer Schering Pharma Ag | Triazolopiridinas sustituidas |
| TWI541243B (zh) | 2010-09-10 | 2016-07-11 | 拜耳知識產權公司 | 經取代咪唑并嗒 |
| WO2012143329A1 (en) | 2011-04-21 | 2012-10-26 | Bayer Intellectual Property Gmbh | Triazolopyridines |
| UA112096C2 (uk) * | 2011-12-12 | 2016-07-25 | Байєр Інтеллектуал Проперті Гмбх | Заміщені триазолопіридини та їх застосування як інгібіторів ttk |
| ES2605946T3 (es) | 2012-03-14 | 2017-03-17 | Bayer Intellectual Property Gmbh | Imidazopiridazinas sustituidas |
| PE20150354A1 (es) * | 2012-07-10 | 2015-03-21 | Bayer Pharma AG | Metodos para preparar triazolopiridinas sustituidas |
| AR096469A1 (es) * | 2013-06-06 | 2015-12-30 | Bayer Pharma AG | Composiciones farmacéuticas que comprenden compuestos del tipo triazolpiridinas |
| WO2014195276A1 (en) * | 2013-06-07 | 2014-12-11 | Bayer Pharma Aktiengesellschaft | Substituted triazolopyridines having activity as mps-1 inhibitors |
| AU2014280395A1 (en) * | 2013-06-10 | 2015-12-17 | Bayer Pharma Aktiengesellschaft | Novel compounds for the treatment of cancer |
| KR20160018534A (ko) * | 2013-06-11 | 2016-02-17 | 바이엘 파마 악티엔게젤샤프트 | Mps-1 키나제 억제제 및 유사분열 억제제를 포함하는 암의 치료를 위한 조합물 |
-
2014
- 2014-06-06 PE PE2015002605A patent/PE20160156A1/es not_active Application Discontinuation
- 2014-06-06 SI SI201430219A patent/SI3008062T1/sl unknown
- 2014-06-06 TN TN2015000545A patent/TN2015000545A1/en unknown
- 2014-06-06 AP AP2015008898A patent/AP2015008898A0/xx unknown
- 2014-06-06 SG SG11201509858QA patent/SG11201509858QA/en unknown
- 2014-06-06 ES ES14728949.0T patent/ES2626790T3/es active Active
- 2014-06-06 CN CN201480040729.XA patent/CN105377848A/zh active Pending
- 2014-06-06 KR KR1020167000270A patent/KR20160019492A/ko not_active Application Discontinuation
- 2014-06-06 PT PT147289490T patent/PT3008062T/pt unknown
- 2014-06-06 MA MA38654A patent/MA38654B1/fr unknown
- 2014-06-06 AU AU2014280356A patent/AU2014280356A1/en not_active Abandoned
- 2014-06-06 MX MX2015017119A patent/MX2015017119A/es unknown
- 2014-06-06 JP JP2016518941A patent/JP2016526534A/ja active Pending
- 2014-06-06 EA EA201600002A patent/EA201600002A1/ru unknown
- 2014-06-06 RS RS20170534A patent/RS56034B1/sr unknown
- 2014-06-06 LT LTEP14728949.0T patent/LT3008062T/lt unknown
- 2014-06-06 EP EP14728949.0A patent/EP3008062B1/en active Active
- 2014-06-06 WO PCT/EP2014/061779 patent/WO2014198647A2/en active Application Filing
- 2014-06-06 DK DK14728949.0T patent/DK3008062T3/en active
- 2014-06-06 PL PL14728949T patent/PL3008062T3/pl unknown
- 2014-06-06 HU HUE14728949A patent/HUE033131T2/en unknown
- 2014-06-06 CA CA2914745A patent/CA2914745A1/en not_active Abandoned
- 2014-06-06 US US14/897,951 patent/US9586958B2/en not_active Expired - Fee Related
- 2014-06-11 UY UY0001035610A patent/UY35610A/es not_active Application Discontinuation
- 2014-06-11 AR ARP140102239A patent/AR096585A1/es unknown
-
2015
- 2015-11-30 IL IL242847A patent/IL242847A0/en unknown
- 2015-12-03 ZA ZA2015/08868A patent/ZA201508868B/en unknown
- 2015-12-09 PH PH12015502746A patent/PH12015502746A1/en unknown
- 2015-12-11 CL CL2015003605A patent/CL2015003605A1/es unknown
- 2015-12-11 NI NI201500176A patent/NI201500176A/es unknown
- 2015-12-11 CU CUP2015000176A patent/CU20150176A7/es unknown
- 2015-12-11 DO DO2015000299A patent/DOP2015000299A/es unknown
- 2015-12-11 CR CR20150659A patent/CR20150659A/es unknown
-
2016
- 2016-08-29 HK HK16110219.6A patent/HK1221955A1/zh unknown
-
2017
- 2017-05-12 HR HRP20170717TT patent/HRP20170717T1/hr unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD | Application declared void or lapsed |