JP2018501215A5 - - Google Patents
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- Publication number
- JP2018501215A5 JP2018501215A5 JP2017529357A JP2017529357A JP2018501215A5 JP 2018501215 A5 JP2018501215 A5 JP 2018501215A5 JP 2017529357 A JP2017529357 A JP 2017529357A JP 2017529357 A JP2017529357 A JP 2017529357A JP 2018501215 A5 JP2018501215 A5 JP 2018501215A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- alkyl
- salt according
- salt
- medicament
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 7
- 125000000217 alkyl group Chemical group 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 206010053219 non-alcoholic steatohepatitis Diseases 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462086844P | 2014-12-03 | 2014-12-03 | |
| US62/086,844 | 2014-12-03 | ||
| PCT/IB2015/058965 WO2016087975A1 (en) | 2014-12-03 | 2015-11-19 | Cd38 inhibitors and methods of treatment |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018501215A JP2018501215A (ja) | 2018-01-18 |
| JP2018501215A5 true JP2018501215A5 (enExample) | 2018-11-01 |
| JP6550132B2 JP6550132B2 (ja) | 2019-07-24 |
Family
ID=54708091
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017529357A Active JP6550132B2 (ja) | 2014-12-03 | 2015-11-19 | Ｃｄ３８阻害剤及び治療の方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US9840496B2 (enExample) |
| EP (1) | EP3227275B1 (enExample) |
| JP (1) | JP6550132B2 (enExample) |
| KR (1) | KR20170090478A (enExample) |
| CN (1) | CN107428733A (enExample) |
| AU (1) | AU2015356721B2 (enExample) |
| BR (1) | BR112017011642A2 (enExample) |
| CA (1) | CA2969178A1 (enExample) |
| ES (1) | ES2717260T3 (enExample) |
| RU (1) | RU2017121002A (enExample) |
| WO (1) | WO2016087975A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3544612A4 (en) | 2016-11-23 | 2020-05-13 | Acetylon Pharmaceuticals, Inc. | PHARMACEUTICAL COMBINATIONS COMPRISING A HISTONE DEACETYLASE INHIBITOR AND A CD38 INHIBITOR AND METHODS OF USING THE SAME |
| BR112021012685A2 (pt) | 2019-01-11 | 2021-12-28 | Omeros Corp | Métodos para tratar câncer, para aumentar o nível de citocinas th1 nas células mononucleares de sangue periférico humanas, para realçar uma resposta imune antitumoral e para estimular e/ou amplificar uma resposta imune em um sujeito mamífero sofrendo de ou em risco de desenvolver câncer ou metástase de câncer, e, composição farmacêutica |
| CN119431323A (zh) * | 2019-07-31 | 2025-02-14 | 贝林格尔·英格海姆国际有限公司 | 作为cd38抑制剂的杂双环酰胺 |
| WO2021087087A1 (en) | 2019-10-30 | 2021-05-06 | Mitobridge Inc. | N-cyclohexyl-5-(thiazol-5-yl)-1h-indole-7-carboxamide derivatives and related compounds as cd38 inhibitors for increasing nad+ and for the treatment of e.g. muscular disorders |
| TW202204331A (zh) | 2020-04-07 | 2022-02-01 | 美商米突倍基公司 | Cd38抑制劑 |
| WO2022077034A1 (en) * | 2020-10-09 | 2022-04-14 | Napa Therapeutics Ltd. | Heteroaryl amide inhibitors of cd38 |
| PE20232047A1 (es) | 2021-01-29 | 2023-12-27 | Boehringer Ingelheim Int | Quinolinas y azaquinolinas como inhibidores de cd38 |
| JP2024517750A (ja) * | 2021-04-30 | 2024-04-23 | ナンキン イムノファージ バイオテック カンパニー リミテッド | 化合物及びそれらのｃｄ３８阻害剤としての使用 |
| JP2024525692A (ja) * | 2021-07-12 | 2024-07-12 | サイトキネティックス， インコーポレイテッド | Ｃｄ３８調節因子及びその使用方法 |
| WO2024254396A1 (en) * | 2023-06-07 | 2024-12-12 | Flagship Pioneering Innovations, Vi, Llc | Condensed azines as inhibitors of cyclic adp ribose hydrolase |
| CN119775288B (zh) * | 2024-12-31 | 2025-10-10 | 浙江工业大学 | 一种cd38抑制化合物及应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2433840C (en) * | 2001-01-04 | 2010-05-04 | Albert Einstein College Of Medicine Of Yeshiva University | Inhibitors of adp-ribosyl transferases, cyclases, and hydrolases, and uses thereof |
| US7022680B2 (en) * | 2002-05-30 | 2006-04-04 | Albert Einstein College Of Medicine Of Yeshiva University | Inhibitors of ADP-ribosyl transferases, cyclases, and hydrolases |
| WO2010025235A1 (en) * | 2008-08-29 | 2010-03-04 | Regents Of The University Of Michigan | Selective ligands for the dopamine 3 (d3) receptor and methods of using the same |
| EP2801573A1 (en) * | 2013-05-09 | 2014-11-12 | Sanofi | Hydantoine derivatives as CD38 inhibitors |
-
2015
- 2015-11-19 US US15/529,120 patent/US9840496B2/en active Active
- 2015-11-19 WO PCT/IB2015/058965 patent/WO2016087975A1/en not_active Ceased
- 2015-11-19 BR BR112017011642A patent/BR112017011642A2/pt not_active Application Discontinuation
- 2015-11-19 RU RU2017121002A patent/RU2017121002A/ru not_active Application Discontinuation
- 2015-11-19 ES ES15801951T patent/ES2717260T3/es active Active
- 2015-11-19 CA CA2969178A patent/CA2969178A1/en not_active Abandoned
- 2015-11-19 JP JP2017529357A patent/JP6550132B2/ja active Active
- 2015-11-19 KR KR1020177018180A patent/KR20170090478A/ko not_active Withdrawn
- 2015-11-19 EP EP15801951.3A patent/EP3227275B1/en active Active
- 2015-11-19 AU AU2015356721A patent/AU2015356721B2/en not_active Ceased
- 2015-11-19 CN CN201580073761.2A patent/CN107428733A/zh active Pending
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