CN107428733A - Cd38抑制剂和治疗方法 - Google Patents
Cd38抑制剂和治疗方法 Download PDFInfo
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- CN107428733A CN107428733A CN201580073761.2A CN201580073761A CN107428733A CN 107428733 A CN107428733 A CN 107428733A CN 201580073761 A CN201580073761 A CN 201580073761A CN 107428733 A CN107428733 A CN 107428733A
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- cyclohexyl
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- 238000000034 method Methods 0.000 title claims abstract description 18
- 238000011282 treatment Methods 0.000 title claims description 8
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115697985A (zh) * | 2020-04-07 | 2023-02-03 | 米托布里奇公司 | Cd38抑制剂 |
| CN116710090A (zh) * | 2020-10-09 | 2023-09-05 | Napa医疗有限公司 | Cd38的杂芳基酰胺抑制剂 |
| CN119775288A (zh) * | 2024-12-31 | 2025-04-08 | 浙江工业大学 | 一种cd38抑制化合物及应用 |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7516047B2 (ja) | 2016-11-23 | 2024-07-16 | アセチロン ファーマシューティカルズ インコーポレイテッド | ヒストン脱アセチル化酵素阻害剤とｃｄ３８阻害剤とを含む医薬組み合わせ物及びその使用方法 |
| WO2020146795A1 (en) | 2019-01-11 | 2020-07-16 | Omeros Corporation | Methods and compositions for treating cancer |
| JP7721501B2 (ja) | 2019-07-31 | 2025-08-12 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｃｄ３８の阻害剤としてのヘテロ二環式アミド |
| TW202128677A (zh) | 2019-10-30 | 2021-08-01 | 美商米突倍基公司 | Cd38抑制劑 |
| MX2023008701A (es) | 2021-01-29 | 2023-11-29 | Boehringer Ingelheim Int | Quinolinas y azaquinolinas como inhibidores de cumulo de diferenciacion 38 (cd38). |
| AU2022265301B2 (en) * | 2021-04-30 | 2025-11-20 | Nanjing Immunophage Biotech Co., Ltd | Compounds and their uses as cd38 inhibitors |
| CA3225785A1 (en) * | 2021-07-12 | 2023-01-19 | Cytokinetics, Inc. | Cd38 modulators and methods of use thereof |
| WO2024254396A1 (en) * | 2023-06-07 | 2024-12-12 | Flagship Pioneering Innovations, Vi, Llc | Condensed azines as inhibitors of cyclic adp ribose hydrolase |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2002059084A2 (en) * | 2001-01-04 | 2002-08-01 | Albert Einstein College Of Medicine Of Yeshiva University | Inhibitors of adp-ribosyl transferases, cyclases, and hydrolases, and uses thereof |
| WO2003101198A1 (en) * | 2002-05-30 | 2003-12-11 | Albert Einstein College Of Medicine Of Zeshiva University | Improved inhibitors of adp-ribosyl transferases, cyclases, and hydrolases |
| WO2014180544A1 (en) * | 2013-05-09 | 2014-11-13 | Sanofi | Hydantoine derivatives as cd38 inhibitors |
Family Cites Families (1)
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| WO2010025235A1 (en) * | 2008-08-29 | 2010-03-04 | Regents Of The University Of Michigan | Selective ligands for the dopamine 3 (d3) receptor and methods of using the same |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2002059084A2 (en) * | 2001-01-04 | 2002-08-01 | Albert Einstein College Of Medicine Of Yeshiva University | Inhibitors of adp-ribosyl transferases, cyclases, and hydrolases, and uses thereof |
| WO2003101198A1 (en) * | 2002-05-30 | 2003-12-11 | Albert Einstein College Of Medicine Of Zeshiva University | Improved inhibitors of adp-ribosyl transferases, cyclases, and hydrolases |
| WO2014180544A1 (en) * | 2013-05-09 | 2014-11-13 | Sanofi | Hydantoine derivatives as cd38 inhibitors |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115697985A (zh) * | 2020-04-07 | 2023-02-03 | 米托布里奇公司 | Cd38抑制剂 |
| CN116710090A (zh) * | 2020-10-09 | 2023-09-05 | Napa医疗有限公司 | Cd38的杂芳基酰胺抑制剂 |
| CN119775288A (zh) * | 2024-12-31 | 2025-04-08 | 浙江工业大学 | 一种cd38抑制化合物及应用 |
| CN119775288B (zh) * | 2024-12-31 | 2025-10-10 | 浙江工业大学 | 一种cd38抑制化合物及应用 |
Also Published As
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| AU2015356721B2 (en) | 2018-03-15 |
| ES2717260T3 (es) | 2019-06-20 |
| JP2018501215A (ja) | 2018-01-18 |
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| EP3227275B1 (en) | 2019-01-02 |
| AU2015356721A1 (en) | 2017-06-08 |
| WO2016087975A1 (en) | 2016-06-09 |
| KR20170090478A (ko) | 2017-08-07 |
| EP3227275A1 (en) | 2017-10-11 |
| CA2969178A1 (en) | 2016-06-09 |
| BR112017011642A2 (pt) | 2018-03-06 |
| US20170260164A1 (en) | 2017-09-14 |
| JP6550132B2 (ja) | 2019-07-24 |
| RU2017121002A3 (enExample) | 2019-03-15 |
| RU2017121002A (ru) | 2019-01-11 |
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