BR112017017888A2 - derivados fluorados do ácido tetraidronaftiridinil nonanoico derivados e usos destes - Google Patents
derivados fluorados do ácido tetraidronaftiridinil nonanoico derivados e usos destesInfo
- Publication number
- BR112017017888A2 BR112017017888A2 BR112017017888A BR112017017888A BR112017017888A2 BR 112017017888 A2 BR112017017888 A2 BR 112017017888A2 BR 112017017888 A BR112017017888 A BR 112017017888A BR 112017017888 A BR112017017888 A BR 112017017888A BR 112017017888 A2 BR112017017888 A2 BR 112017017888A2
- Authority
- BR
- Brazil
- Prior art keywords
- derivatives
- tetrahydronaphthyridinyl
- fluorinated
- nonanoic acid
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/70—One oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Gastroenterology & Hepatology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
a presente invenção refere-se a compostos fluorados da fórmula i e métodos de sintetizar estes compostos. a presente invenção também refere-se a composições farmacêuticas contendo os compostos fluorados da invenção, e métodos de tratar fibrose, degeneração macular, retinopatia diabética (dr), edema macular, edema macular diabético (dme), e edema macular a seguir de oclusão da veia retiniana (rvo), administrando-se estes compostos e composições farmacêuticas a sujeitos em necessidade deste.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562118303P | 2015-02-19 | 2015-02-19 | |
PCT/US2016/018612 WO2016134223A2 (en) | 2015-02-19 | 2016-02-19 | Fluorinated tetrahydronaphthyridinyl nonanoic acid derivatives and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112017017888A2 true BR112017017888A2 (pt) | 2018-04-10 |
Family
ID=56689184
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112017017888A BR112017017888A2 (pt) | 2015-02-19 | 2016-02-19 | derivados fluorados do ácido tetraidronaftiridinil nonanoico derivados e usos destes |
Country Status (13)
Country | Link |
---|---|
US (5) | US9790222B2 (pt) |
EP (2) | EP3925959A1 (pt) |
JP (2) | JP2018510139A (pt) |
KR (1) | KR102647026B1 (pt) |
CN (2) | CN114805342A (pt) |
AU (1) | AU2016219906B2 (pt) |
BR (1) | BR112017017888A2 (pt) |
CA (1) | CA2976634C (pt) |
ES (1) | ES2892954T3 (pt) |
IL (1) | IL253873A0 (pt) |
RU (1) | RU2017132433A (pt) |
TW (1) | TWI736529B (pt) |
WO (1) | WO2016134223A2 (pt) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8901144B2 (en) * | 2013-02-07 | 2014-12-02 | Scifluor Life Sciences, Llc | Fluorinated 3-(2-oxo-3-(3-arylpropyl)imidazolidin-1-yl)-3-arylpropanoic acid derivatives |
ES2763556T3 (es) | 2013-02-07 | 2020-05-29 | Scifluor Life Sciences Inc | Antagonistas fluorados de integrina |
GB201305668D0 (en) | 2013-03-28 | 2013-05-15 | Glaxosmithkline Ip Dev Ltd | Avs6 Integrin Antagonists |
GB201417094D0 (en) | 2014-09-26 | 2014-11-12 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
GB201417002D0 (en) | 2014-09-26 | 2014-11-12 | Glaxosmithkline Ip Dev Ltd | Novel compound |
GB201417011D0 (en) | 2014-09-26 | 2014-11-12 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
GB201417018D0 (en) | 2014-09-26 | 2014-11-12 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
EP3925959A1 (en) * | 2015-02-19 | 2021-12-22 | OcuTerra Therapeutics, Inc. | Fluorinated derivatives of 3-(2-oxo-3-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl)imidazolidin-1-yl)propanoic acid and uses thereof |
EP3273965A4 (en) * | 2015-03-26 | 2018-12-05 | Merck Sharp & Dohme Corp. | Composition and methods for treating chronic kidney disease |
JP2018514568A (ja) * | 2015-04-30 | 2018-06-07 | サイフルーア ライフ サイエンシズ インコーポレイテッド | テトラヒドロナフチリジニルプロピオン酸誘導体およびその使用法 |
GB201604680D0 (en) | 2016-03-21 | 2016-05-04 | Glaxosmithkline Ip Dev Ltd | Chemical Compounds |
WO2017189828A1 (en) | 2016-04-27 | 2017-11-02 | Scifluor Life Sciences, Inc. | Nonanoic and decanoic acid derivatives and uses thereof |
CN109996541A (zh) | 2016-09-07 | 2019-07-09 | 普利安特治疗公司 | N-酰基氨基酸化合物及其使用方法 |
MA46746A (fr) | 2016-11-08 | 2019-09-18 | Bristol Myers Squibb Co | Amides d'azole et amines en tant qu'inhibiteurs d'intégrine alpha v |
MA46744A (fr) * | 2016-11-08 | 2019-09-18 | Bristol Myers Squibb Co | Composés mono et spirocycliques contenant du cyclobutane et de l'azétidine en tant qu'inhibiteurs de l'intégrine alpha v |
EA038164B1 (ru) | 2016-11-08 | 2021-07-16 | Бристол-Маерс Сквибб Компани | 3-замещенные пропановые кислоты в качестве ингибиторов интегрина v |
EA201991123A1 (ru) | 2016-11-08 | 2019-11-29 | ИНДАЗОЛОВЫЕ ПРОИЗВОДНЫЕ В КАЧЕСТВЕ АНТАГОНИСТОВ ИНТЕГРИНА αV | |
DK3538528T3 (da) | 2016-11-08 | 2021-02-15 | Bristol Myers Squibb Co | Pyrrolamider som alpha v-integrinhæmmere |
EP3760202A1 (en) | 2017-02-28 | 2021-01-06 | Morphic Therapeutic, Inc. | Inhibitors of (alpha-v)(beta-6) integrin |
RU2769702C2 (ru) | 2017-02-28 | 2022-04-05 | Морфик Терапьютик, Инк. | Ингибиторы интегрина avb6 |
US10253025B2 (en) | 2017-03-30 | 2019-04-09 | Scifluor Life Sciences, Inc. | Method of making tetrahydronaphthyridinyl nonanoic acid compounds |
KR20200084879A (ko) | 2017-11-07 | 2020-07-13 | 브리스톨-마이어스 스큅 컴퍼니 | 알파 v 인테그린 억제제로서의 피롤로피라진 유도체 |
JP2021522269A (ja) | 2018-04-27 | 2021-08-30 | アローヘッド ファーマシューティカルズ インコーポレイテッド | インテグリン標的化リガンドとその使用 |
AR116036A1 (es) * | 2018-08-29 | 2021-03-25 | Morphic Therapeutic Inc | DERIVADOS DE NAFTIRIDINA COMO INHIBIDORES DE INTEGRINA avb6 |
EP4086254A1 (en) | 2018-08-29 | 2022-11-09 | Morphic Therapeutic, Inc. | Integrin inhibitors |
WO2021231581A1 (en) | 2020-05-12 | 2021-11-18 | Scifluor Life Sciences, Inc. | METHODS OF TREATING OR PREVENTING VIRAL INFECTION WITH FLUORINATED α V INTEGRIN ANTAGONISTS |
CN116390754A (zh) * | 2020-10-20 | 2023-07-04 | 莱兰斯坦福初级大学评议会 | 用于过继细胞治疗的可注射水凝胶 |
Family Cites Families (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0307483A4 (en) | 1987-03-30 | 1990-02-06 | Anritsu Corp | LIGHT SIGNAL GENERATOR AND CALIBRATION METHOD OF A LIGHT POWER MEASURING DEVICE WITH THIS LIGHT SIGNAL GENERATOR. |
CA1318254C (en) | 1988-01-06 | 1993-05-25 | Munehiro Tomikawa | Inhibitory agent of hepatic fibrosis containing pantethine |
DE69220050T2 (de) | 1991-04-01 | 1998-01-22 | Univ Duke | Verfahren zur inhibierung der fibrose |
US5501969A (en) | 1994-03-08 | 1996-03-26 | Human Genome Sciences, Inc. | Human osteoclast-derived cathepsin |
JP3818322B2 (ja) | 1994-04-28 | 2006-09-06 | 敏一 中村 | コラーゲン分解促進剤 |
US5736357A (en) | 1994-10-27 | 1998-04-07 | Arris Pharmaceutical | Cathespin O protease |
US6544767B1 (en) | 1994-10-27 | 2003-04-08 | Axys Pharmaceuticals, Inc. | Cathespin O2 protease |
US5645839A (en) | 1995-06-07 | 1997-07-08 | Trustees Of Boston University | Combined use of angiotensin inhibitors and nitric oxide stimulators to treat fibrosis |
US6664227B1 (en) | 1996-03-01 | 2003-12-16 | Genetics Institute, Llc | Treatment of fibrosis by antagonism of IL-13 and IL-13 receptor chains |
US6211184B1 (en) | 1996-08-29 | 2001-04-03 | Merck & Co., Inc. | Integrin antagonists |
WO1998008528A1 (en) | 1996-08-30 | 1998-03-05 | Biomeasure Incorporated | Method of inhibiting fibrosis with a somatostatin agonist |
US6048861A (en) | 1997-12-17 | 2000-04-11 | Merck & Co., Inc. | Integrin receptor antagonists |
ES2243016T3 (es) * | 1997-12-17 | 2005-11-16 | MERCK & CO., INC. | Antagonistas de receptores de integrinas. |
US6066648A (en) | 1997-12-17 | 2000-05-23 | Merck & Co., Inc. | Integrin receptor antagonists |
US6017926A (en) | 1997-12-17 | 2000-01-25 | Merck & Co., Inc. | Integrin receptor antagonists |
CN1284955A (zh) | 1997-12-17 | 2001-02-21 | 麦克公司 | 整联蛋白受体拮抗剂 |
DE69829996T2 (de) | 1997-12-17 | 2006-02-23 | Merck & Co., Inc. (A New Jersey Corp.) | Integrin-rezeptor-antagonisten |
WO1999030709A1 (en) | 1997-12-17 | 1999-06-24 | Merck & Co., Inc. | Integrin receptor antagonists |
US6117445A (en) | 1998-01-28 | 2000-09-12 | Link Technology Inc. | Methods for the prevention and treatment of fibrosis and sclerosis |
US6677360B2 (en) | 1998-12-16 | 2004-01-13 | Bayer Aktiengesellschaft | Biphenyl and biphenyl-analogous compounds as integrin antagonists |
US6420396B1 (en) * | 1998-12-16 | 2002-07-16 | Beiersdorf Ag | Biphenyl and biphenyl-analogous compounds as integrin antagonists |
US6291503B1 (en) * | 1999-01-15 | 2001-09-18 | Bayer Aktiengesellschaft | β-phenylalanine derivatives as integrin antagonists |
SK17442001A3 (sk) * | 1999-06-02 | 2002-03-05 | Merck & Co., Inc. | Deriváty kyseliny nonánovej, farmaceutický prostriedok s ich obsahom a ich použitie |
US6407241B1 (en) | 1999-11-08 | 2002-06-18 | Merck & Co., Inc. | Process and intermediates for the preparation of imidazolidinone αv integrin antagonists |
US6455539B2 (en) * | 1999-12-23 | 2002-09-24 | Celltech R&D Limited | Squaric acid derivates |
WO2001053297A1 (en) | 2000-01-20 | 2001-07-26 | Merck & Co., Inc. | Alpha v integrin receptor antagonists |
AU780988B2 (en) | 2000-01-24 | 2005-04-28 | Merck & Co., Inc. | Alpha V integrin receptor antagonists |
WO2001062292A1 (fr) | 2000-02-22 | 2001-08-30 | Suntory Limited | Medicaments preventifs ou therapeutiques pour traiter la fibrose et contenant des inhibiteurs de chymase comme ingredients actifs |
GB0011817D0 (en) | 2000-05-16 | 2000-07-05 | Pharmacia & Upjohn Spa | Antagonists of integrin receptors |
ATE353219T1 (de) | 2000-07-26 | 2007-02-15 | Merck & Co Inc | Alpha v integrin-rezeptor-antagonisten |
WO2002022616A2 (en) | 2000-09-14 | 2002-03-21 | Merck & Co., Inc. | Alpha v integrin receptor antagonists |
CA2421652A1 (en) | 2000-09-14 | 2002-03-21 | Merck And Co., Inc. | Alpha v integrin receptor antagonists |
EP1322311A1 (en) | 2000-09-18 | 2003-07-02 | Merck & Co., Inc. | Treatment of inflammation with a combination of a cyclooxygenase-2 inhibitor and an integrin alpha-v antagonist |
EP1444231A4 (en) | 2001-11-06 | 2005-11-09 | Merck & Co Inc | AMINO SALTS OF AN INTEGRIN RECEPTOR ANTAGONIST |
US20040053968A1 (en) | 2001-12-28 | 2004-03-18 | Hartman George D. | Methods and compositions for treating peridontal disease |
CA2499149A1 (en) | 2002-09-20 | 2004-04-01 | Merck & Co., Inc. | Mannitol formulation for integrin receptor antagonist |
US20050043344A1 (en) | 2002-12-20 | 2005-02-24 | Pharmacia Corporation | Heteroarylalkanoic acids as integrin receptor antagonists derivatives |
ATE399542T1 (de) * | 2003-10-01 | 2008-07-15 | Merck Patent Gmbh | Alfavbeta3 und alfavbeta6 integrin antagonisten als antifibrotische mittel |
CN104225613A (zh) * | 2008-03-14 | 2014-12-24 | Visen医药公司 | 整联蛋白靶向试剂及使用其的体内和体外成像方法 |
WO2011060395A1 (en) | 2009-11-16 | 2011-05-19 | Schering Corporation | Cyclic ureas useful as hiv inhibitors |
WO2011150156A2 (en) | 2010-05-26 | 2011-12-01 | Sunovion Pharmaceuticals Inc. | Heteroaryl compounds and methods of use thereof |
EP2707036A4 (en) | 2011-05-09 | 2015-03-18 | Allegro Pharmaceuticals Inc | INTEGRIN RECEPTOR ANTAGONISTS AND METHOD FOR THEIR USE |
JP2014518232A (ja) | 2011-06-28 | 2014-07-28 | バイエル・ヘルスケア・エルエルシー | ソラフェニブを含有する眼科用局所医薬組成物 |
ES2763556T3 (es) | 2013-02-07 | 2020-05-29 | Scifluor Life Sciences Inc | Antagonistas fluorados de integrina |
US8901144B2 (en) | 2013-02-07 | 2014-12-02 | Scifluor Life Sciences, Llc | Fluorinated 3-(2-oxo-3-(3-arylpropyl)imidazolidin-1-yl)-3-arylpropanoic acid derivatives |
EP3925959A1 (en) | 2015-02-19 | 2021-12-22 | OcuTerra Therapeutics, Inc. | Fluorinated derivatives of 3-(2-oxo-3-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl)imidazolidin-1-yl)propanoic acid and uses thereof |
JP2018514568A (ja) | 2015-04-30 | 2018-06-07 | サイフルーア ライフ サイエンシズ インコーポレイテッド | テトラヒドロナフチリジニルプロピオン酸誘導体およびその使用法 |
US10253025B2 (en) * | 2017-03-30 | 2019-04-09 | Scifluor Life Sciences, Inc. | Method of making tetrahydronaphthyridinyl nonanoic acid compounds |
-
2016
- 2016-02-19 EP EP21171386.2A patent/EP3925959A1/en active Pending
- 2016-02-19 AU AU2016219906A patent/AU2016219906B2/en active Active
- 2016-02-19 ES ES16753120T patent/ES2892954T3/es active Active
- 2016-02-19 CN CN202210129062.7A patent/CN114805342A/zh active Pending
- 2016-02-19 WO PCT/US2016/018612 patent/WO2016134223A2/en active Application Filing
- 2016-02-19 CN CN201680022826.5A patent/CN107531699A/zh active Pending
- 2016-02-19 KR KR1020177026258A patent/KR102647026B1/ko active IP Right Grant
- 2016-02-19 RU RU2017132433A patent/RU2017132433A/ru not_active Application Discontinuation
- 2016-02-19 CA CA2976634A patent/CA2976634C/en active Active
- 2016-02-19 EP EP16753120.1A patent/EP3259271B1/en active Active
- 2016-02-19 TW TW105104964A patent/TWI736529B/zh active
- 2016-02-19 BR BR112017017888A patent/BR112017017888A2/pt not_active Application Discontinuation
- 2016-02-19 US US15/047,717 patent/US9790222B2/en active Active
- 2016-02-19 JP JP2017544035A patent/JP2018510139A/ja active Pending
-
2017
- 2017-08-07 IL IL253873A patent/IL253873A0/en active IP Right Grant
- 2017-09-11 US US15/700,351 patent/US10301307B2/en active Active
-
2019
- 2019-04-03 US US16/373,780 patent/US20190225609A1/en not_active Abandoned
-
2020
- 2020-10-12 JP JP2020171641A patent/JP7191299B2/ja active Active
- 2020-10-22 US US17/076,891 patent/US11685738B2/en active Active
-
2023
- 2023-05-31 US US18/203,776 patent/US20240092775A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
CN114805342A (zh) | 2022-07-29 |
EP3259271B1 (en) | 2021-05-05 |
JP7191299B2 (ja) | 2022-12-19 |
CN107531699A (zh) | 2018-01-02 |
EP3925959A1 (en) | 2021-12-22 |
US9790222B2 (en) | 2017-10-17 |
CA2976634A1 (en) | 2016-08-25 |
EP3259271A4 (en) | 2018-07-11 |
CA2976634C (en) | 2023-10-17 |
RU2017132433A3 (pt) | 2019-03-25 |
US11685738B2 (en) | 2023-06-27 |
US20160244447A1 (en) | 2016-08-25 |
US10301307B2 (en) | 2019-05-28 |
JP2018510139A (ja) | 2018-04-12 |
WO2016134223A2 (en) | 2016-08-25 |
JP2021008511A (ja) | 2021-01-28 |
WO2016134223A3 (en) | 2016-10-20 |
US20210277000A1 (en) | 2021-09-09 |
ES2892954T3 (es) | 2022-02-07 |
KR102647026B1 (ko) | 2024-03-12 |
TWI736529B (zh) | 2021-08-21 |
AU2016219906B2 (en) | 2020-10-01 |
IL253873A0 (en) | 2017-10-31 |
AU2016219906A1 (en) | 2017-09-07 |
US20190225609A1 (en) | 2019-07-25 |
US20240092775A1 (en) | 2024-03-21 |
EP3259271A2 (en) | 2017-12-27 |
KR20170117578A (ko) | 2017-10-23 |
TW201643161A (zh) | 2016-12-16 |
RU2017132433A (ru) | 2019-03-19 |
US20170369490A1 (en) | 2017-12-28 |
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