JP2017509689A5 - - Google Patents
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- Publication number
- JP2017509689A5 JP2017509689A5 JP2016562463A JP2016562463A JP2017509689A5 JP 2017509689 A5 JP2017509689 A5 JP 2017509689A5 JP 2016562463 A JP2016562463 A JP 2016562463A JP 2016562463 A JP2016562463 A JP 2016562463A JP 2017509689 A5 JP2017509689 A5 JP 2017509689A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- alkyl
- independently hydrogen
- carbon atoms
- cycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 60
- 229910052739 hydrogen Inorganic materials 0.000 claims 44
- 239000001257 hydrogen Substances 0.000 claims 42
- 125000005842 heteroatom Chemical group 0.000 claims 35
- 229910052760 oxygen Inorganic materials 0.000 claims 32
- 229910052717 sulfur Inorganic materials 0.000 claims 32
- 125000004432 carbon atom Chemical group C* 0.000 claims 29
- 125000000623 heterocyclic group Chemical group 0.000 claims 29
- 150000002431 hydrogen Chemical class 0.000 claims 28
- 125000005843 halogen group Chemical group 0.000 claims 21
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 18
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 14
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 13
- 150000001875 compounds Chemical class 0.000 claims 12
- 150000003839 salts Chemical class 0.000 claims 11
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 10
- 229910052799 carbon Inorganic materials 0.000 claims 10
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 10
- 125000002837 carbocyclic group Chemical group 0.000 claims 8
- 150000001721 carbon Chemical group 0.000 claims 8
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 7
- 125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 claims 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 5
- 125000003118 aryl group Chemical group 0.000 claims 3
- 208000035475 disorder Diseases 0.000 claims 3
- 125000003341 7 membered heterocyclic group Chemical group 0.000 claims 2
- 208000023275 Autoimmune disease Diseases 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000030159 metabolic disease Diseases 0.000 claims 2
- 125000001960 7 membered carbocyclic group Chemical group 0.000 claims 1
- 206010002556 Ankylosing Spondylitis Diseases 0.000 claims 1
- -1 CF 3 Chemical group 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 206010009900 Colitis ulcerative Diseases 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 201000001263 Psoriatic Arthritis Diseases 0.000 claims 1
- 208000036824 Psoriatic arthropathy Diseases 0.000 claims 1
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
- 208000024340 acute graft versus host disease Diseases 0.000 claims 1
- 208000026935 allergic disease Diseases 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461923906P | 2014-01-06 | 2014-01-06 | |
| US61/923,906 | 2014-01-06 | ||
| PCT/US2015/010084 WO2015103507A1 (en) | 2014-01-06 | 2015-01-05 | Cyclohexyl sulfone rorϒ modulators |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017509689A JP2017509689A (ja) | 2017-04-06 |
| JP2017509689A5 true JP2017509689A5 (enExample) | 2018-02-15 |
| JP6548664B2 JP6548664B2 (ja) | 2019-07-24 |
Family
ID=52392245
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016562463A Expired - Fee Related JP6548664B2 (ja) | 2014-01-06 | 2015-01-05 | シクロヘキシルスルホンＲＯＲγ調節因子 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US9708253B2 (enExample) |
| EP (1) | EP3092215B1 (enExample) |
| JP (1) | JP6548664B2 (enExample) |
| CN (1) | CN106061947B (enExample) |
| ES (1) | ES2704460T3 (enExample) |
| WO (1) | WO2015103507A1 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3044219A1 (en) | 2013-09-09 | 2016-07-20 | Bristol-Myers Squibb Company | Rorgamma modulators |
| EP3046906B1 (en) | 2013-09-20 | 2017-08-16 | Bristol-Myers Squibb Company | Ror gamma modulators |
| EP3092216B1 (en) | 2014-01-06 | 2018-12-12 | Bristol-Myers Squibb Company | Carbocyclic sulfone ror gamma modulators |
| CN106061956B (zh) | 2014-01-06 | 2021-03-12 | 百时美施贵宝公司 | 作为RORγ调节剂的杂环砜 |
| US9708253B2 (en) | 2014-01-06 | 2017-07-18 | Bristol-Myers Squibb Company | Cyclohexyl sulfone RORγ modulators |
| CA2936116A1 (en) | 2014-01-06 | 2015-07-09 | Bristol-Myers Squibb Company | Pyrrolidinyl sulfone derivatives and their use as ror gamma modulators |
| SMT201900706T1 (it) | 2014-10-30 | 2020-01-14 | Janssen Pharmaceutica Nv | Tiazoli sostituiti con ammide come modulatori di rorgammat |
| RS58250B1 (sr) | 2014-10-30 | 2019-03-29 | Janssen Pharmaceutica Nv | Tiazoli kao modulatori roryt |
| JOP20200117A1 (ar) | 2014-10-30 | 2017-06-16 | Janssen Pharmaceutica Nv | كحولات ثلاثي فلوروميثيل كمُعدلات للمستقبل النووي جاما تي المرتبط بحمض الريتيونَويك ROR?t |
| ES2887087T3 (es) | 2015-05-07 | 2021-12-21 | Bristol Myers Squibb Co | Sulfonas tricíclicas como moduladores ROR gamma |
| TWI691486B (zh) * | 2016-01-29 | 2020-04-21 | 日商東麗股份有限公司 | 環狀胺衍生物及其醫藥用途 |
| TW201803869A (zh) | 2016-04-27 | 2018-02-01 | 健生藥品公司 | 作為ＲＯＲγＴ調節劑之６－胺基吡啶－３－基噻唑 |
| KR102599437B1 (ko) * | 2016-11-09 | 2023-11-07 | 브리스톨-마이어스 스큅 컴퍼니 | Ror 감마 조정제로서의 트리시클릭 술폰 |
| WO2018166855A1 (en) | 2017-03-16 | 2018-09-20 | Basf Se | Heterobicyclic substituted dihydroisoxazoles |
| CN109206360B (zh) * | 2017-07-01 | 2022-05-17 | 复旦大学 | 咔唑酰胺类衍生物或其盐及其制备方法和用途 |
| EP3659602A4 (en) | 2017-07-27 | 2021-06-09 | Toray Industries, Inc. | THERAPEUTIC AGENT OR PROPHYLACTIC AGENT FOR ALOPECIA AREATA |
| WO2019022234A1 (ja) * | 2017-07-27 | 2019-01-31 | 東レ株式会社 | 炎症性腸疾患の治療剤又は予防剤 |
| US10975037B2 (en) | 2018-06-18 | 2021-04-13 | Janssen Pharmaceutica Nv | Phenyl substituted pyrazoles as modulators of RORγt |
| ES2928246T3 (es) | 2018-06-18 | 2022-11-16 | Janssen Pharmaceutica Nv | 6-aminopiridin-3-il pirazoles como moduladores de RORyt |
| JP2021527660A (ja) | 2018-06-18 | 2021-10-14 | ヤンセン ファーマシューティカ エヌ．ベー． | ＲＯＲγｔのモジュレータとしてのフェニル及びピリジニル置換イミダゾール |
| CN112292373A (zh) | 2018-06-18 | 2021-01-29 | 詹森药业有限公司 | 作为RORγt的调节剂的吡啶基吡唑类 |
| CN112513021B (zh) * | 2018-07-10 | 2023-06-27 | 广东东阳光药业有限公司 | RORγ拮抗剂及其在药物中的应用 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2002324123B2 (en) * | 2001-08-21 | 2007-07-12 | Merck Sharp & Dohme (Uk) Limited | Novel cyclohexyl sulphones |
| GB0223039D0 (en) * | 2002-10-04 | 2002-11-13 | Merck Sharp & Dohme | Therapeutic compounds |
| GB0513747D0 (en) * | 2005-07-06 | 2005-08-10 | Merck Sharp & Dohme | Therapeutic compounds |
| US9586928B2 (en) * | 2011-05-16 | 2017-03-07 | The Scripps Research Institute | Modulators of the nuclear hormone receptor ROR |
| US20130190356A1 (en) * | 2011-12-22 | 2013-07-25 | Genentech, Inc. | Benzyl sulfonamide derivatives as rorc modulators |
| US9216988B2 (en) * | 2011-12-22 | 2015-12-22 | Genentech, Inc. | Benzyl sulfonamide derivatives as RORc modulators |
| US9266827B2 (en) * | 2012-05-08 | 2016-02-23 | Merck Sharp & Dohme Corp. | Bicyclic sulfone compounds for inhibition of RORgamma activity and the treatment of disease |
| KR20150007300A (ko) * | 2012-05-08 | 2015-01-20 | 머크 샤프 앤드 돔 코포레이션 | Ror감마 활성의 억제를 위한 테트라히드로나프티리딘 및 관련 비시클릭 화합물 및 질환의 치료 |
| WO2014028669A1 (en) * | 2012-08-15 | 2014-02-20 | Biogen Idec Ma Inc. | Novel compounds for modulation of ror-gamma activity |
| WO2014062938A1 (en) | 2012-10-19 | 2014-04-24 | Bristol-Myers Squibb Company | Rory modulators |
| EP3044219A1 (en) | 2013-09-09 | 2016-07-20 | Bristol-Myers Squibb Company | Rorgamma modulators |
| EP3046906B1 (en) | 2013-09-20 | 2017-08-16 | Bristol-Myers Squibb Company | Ror gamma modulators |
| US9708253B2 (en) | 2014-01-06 | 2017-07-18 | Bristol-Myers Squibb Company | Cyclohexyl sulfone RORγ modulators |
| CA2936116A1 (en) * | 2014-01-06 | 2015-07-09 | Bristol-Myers Squibb Company | Pyrrolidinyl sulfone derivatives and their use as ror gamma modulators |
| CN106061956B (zh) * | 2014-01-06 | 2021-03-12 | 百时美施贵宝公司 | 作为RORγ调节剂的杂环砜 |
| EP3092216B1 (en) | 2014-01-06 | 2018-12-12 | Bristol-Myers Squibb Company | Carbocyclic sulfone ror gamma modulators |
-
2015
- 2015-01-05 US US15/109,733 patent/US9708253B2/en active Active
- 2015-01-05 EP EP15700816.0A patent/EP3092215B1/en not_active Not-in-force
- 2015-01-05 JP JP2016562463A patent/JP6548664B2/ja not_active Expired - Fee Related
- 2015-01-05 WO PCT/US2015/010084 patent/WO2015103507A1/en not_active Ceased
- 2015-01-05 CN CN201580012008.2A patent/CN106061947B/zh not_active Expired - Fee Related
- 2015-01-05 ES ES15700816T patent/ES2704460T3/es active Active