JP2017532360A5 - - Google Patents
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- Publication number
- JP2017532360A5 JP2017532360A5 JP2017522890A JP2017522890A JP2017532360A5 JP 2017532360 A5 JP2017532360 A5 JP 2017532360A5 JP 2017522890 A JP2017522890 A JP 2017522890A JP 2017522890 A JP2017522890 A JP 2017522890A JP 2017532360 A5 JP2017532360 A5 JP 2017532360A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- oxo
- dimethyl
- carboxamide
- propyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 16
- 150000003839 salts Chemical class 0.000 claims 15
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 206010038389 Renal cancer Diseases 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 201000010982 kidney cancer Diseases 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- -1 oxazolylmethyl Chemical group 0.000 claims 2
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 1
- ZGINJZVAJWSMEY-UHFFFAOYSA-N 2-[1-[1-(2,2-difluoropropyl)piperidin-4-yl]propyl]-5-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-3-methyl-6,7-dihydrothieno[3,2-c]pyridin-4-one Chemical compound CCC(C1CCN(CC(C)(F)F)CC1)C1=C(C)C2=C(CCN(CC3=C(C)C=C(C)NC3=O)C2=O)S1 ZGINJZVAJWSMEY-UHFFFAOYSA-N 0.000 claims 1
- ABYOCYPONVIIAR-UHFFFAOYSA-N 2-[1-[4-(dimethylamino)piperidin-1-yl]propyl]-5-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-3-methyl-6,7-dihydrothieno[3,2-c]pyridin-4-one Chemical compound CC1=C(C(NC(=C1)C)=O)CN1C(C2=C(CC1)SC(=C2C)C(CC)N1CCC(CC1)N(C)C)=O ABYOCYPONVIIAR-UHFFFAOYSA-N 0.000 claims 1
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims 1
- GTNKQQKZLOXKKJ-OAHLLOKOSA-N 5-[(1R)-1-[1-(2,2-difluoroethyl)piperidin-4-yl]ethyl]-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-4-methylthiophene-3-carboxamide Chemical compound C[C@H](C1CCN(CC(F)F)CC1)C1=C(C)C(=CS1)C(=O)NCC1=C(C)C=C(C)NC1=O GTNKQQKZLOXKKJ-OAHLLOKOSA-N 0.000 claims 1
- ICLKDBHKJKQWFI-GOSISDBHSA-N 5-[(1R)-1-[1-(2,2-difluoroethyl)piperidin-4-yl]propyl]-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-4-methylthiophene-3-carboxamide Chemical compound CC[C@H](C1CCN(CC(F)F)CC1)C1=C(C)C(=CS1)C(=O)NCC1=C(C)C=C(C)NC1=O ICLKDBHKJKQWFI-GOSISDBHSA-N 0.000 claims 1
- ZTKJBAWUDZMEOX-LJQANCHMSA-N 5-[(1R)-1-[1-(2,2-difluoropropyl)piperidin-4-yl]propyl]-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-4-methylthiophene-3-carboxamide Chemical compound FC(CN1CCC(CC1)[C@@H](CC)C1=C(C(=CS1)C(=O)NCC=1C(NC(=CC=1C)C)=O)C)(C)F ZTKJBAWUDZMEOX-LJQANCHMSA-N 0.000 claims 1
- ZTKJBAWUDZMEOX-IBGZPJMESA-N 5-[(1S)-1-[1-(2,2-difluoropropyl)piperidin-4-yl]propyl]-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-4-methylthiophene-3-carboxamide Chemical compound CC[C@@H](C1CCN(CC(C)(F)F)CC1)C1=C(C)C(=CS1)C(=O)NCC1=C(C)C=C(C)NC1=O ZTKJBAWUDZMEOX-IBGZPJMESA-N 0.000 claims 1
- QYQMXWRRXKMXGX-UHFFFAOYSA-N 5-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-2-[1-[1-(2-fluoropropyl)piperidin-4-yl]propyl]-3-methyl-6,7-dihydrothieno[3,2-c]pyridin-4-one Chemical compound CC1=C(C(NC(=C1)C)=O)CN1C(C2=C(CC1)SC(=C2C)C(CC)C1CCN(CC1)CC(C)F)=O QYQMXWRRXKMXGX-UHFFFAOYSA-N 0.000 claims 1
- ICLKDBHKJKQWFI-UHFFFAOYSA-N 5-[1-[1-(2,2-difluoroethyl)piperidin-4-yl]propyl]-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-4-methylthiophene-3-carboxamide Chemical compound CCC(C1CCN(CC(F)F)CC1)C1=C(C)C(=CS1)C(=O)NCC1=C(C)C=C(C)NC1=O ICLKDBHKJKQWFI-UHFFFAOYSA-N 0.000 claims 1
- SHUSPCBTMDNIOC-UHFFFAOYSA-N 5-[1-[1-(2,2-difluoroethyl)piperidin-4-ylidene]propyl]-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-4-methylthiophene-3-carboxamide Chemical compound CCC(C1=C(C)C(=CS1)C(=O)NCC1=C(C)C=C(C)NC1=O)=C1CCN(CC(F)F)CC1 SHUSPCBTMDNIOC-UHFFFAOYSA-N 0.000 claims 1
- JDCNHCLKYOTREH-UHFFFAOYSA-N 5-[1-[1-(2,2-difluoropropyl)piperidin-4-ylidene]propyl]-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-4-methylthiophene-3-carboxamide Chemical compound FC(CN1CCC(CC1)=C(CC)C1=C(C(=CS1)C(=O)NCC=1C(NC(=CC=1C)C)=O)C)(C)F JDCNHCLKYOTREH-UHFFFAOYSA-N 0.000 claims 1
- FWCNVCGKQUQSRK-UHFFFAOYSA-N 5-[1-[1-(N-cyano-N'-methylcarbamimidoyl)piperidin-4-yl]propyl]-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-4-methylthiophene-3-carboxamide Chemical compound C(#N)N=C(NC)N1CCC(CC1)C(CC)C1=C(C(=CS1)C(=O)NCC=1C(NC(=CC=1C)C)=O)C FWCNVCGKQUQSRK-UHFFFAOYSA-N 0.000 claims 1
- QWNARTFIXGUQQK-UHFFFAOYSA-N 5-[1-[1-(N-cyano-N'-methylcarbamimidoyl)piperidin-4-ylidene]propyl]-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-4-methylthiophene-3-carboxamide Chemical compound C(#N)N=C(NC)N1CCC(CC1)=C(CC)C1=C(C(=CS1)C(=O)NCC=1C(NC(=CC=1C)C)=O)C QWNARTFIXGUQQK-UHFFFAOYSA-N 0.000 claims 1
- CASPUOMRDFIWFM-UHFFFAOYSA-N 5-[1-[1-(dimethylamino)piperidin-4-ylidene]propyl]-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-4-methylthiophene-3-carboxamide Chemical compound CCC(C1=C(C)C(=CS1)C(=O)NCC1=C(C)C=C(C)NC1=O)=C1CCN(CC1)N(C)C CASPUOMRDFIWFM-UHFFFAOYSA-N 0.000 claims 1
- IDUHGUNBWPHVAI-UHFFFAOYSA-N 5-[1-[4-(dimethylamino)cyclohexyl]propyl]-n-[(4,6-dimethyl-2-oxo-1h-pyridin-3-yl)methyl]-4-methylthiophene-3-carboxamide Chemical compound S1C=C(C(=O)NCC=2C(NC(C)=CC=2C)=O)C(C)=C1C(CC)C1CCC(N(C)C)CC1 IDUHGUNBWPHVAI-UHFFFAOYSA-N 0.000 claims 1
- OCVFHWCDYDBBRP-UHFFFAOYSA-N 5-[1-[4-(dimethylamino)piperidin-1-yl]ethyl]-n-[(4,6-dimethyl-2-oxo-1h-pyridin-3-yl)methyl]-4-methylthiophene-3-carboxamide Chemical compound S1C=C(C(=O)NCC=2C(NC(C)=CC=2C)=O)C(C)=C1C(C)N1CCC(N(C)C)CC1 OCVFHWCDYDBBRP-UHFFFAOYSA-N 0.000 claims 1
- LVGCTQDARMZPSW-UHFFFAOYSA-N 5-[1-[4-(dimethylamino)piperidin-1-yl]propyl]-n-[(4,6-dimethyl-2-oxo-1h-pyridin-3-yl)methyl]-4-methylthiophene-3-carboxamide Chemical compound S1C=C(C(=O)NCC=2C(NC(C)=CC=2C)=O)C(C)=C1C(CC)N1CCC(N(C)C)CC1 LVGCTQDARMZPSW-UHFFFAOYSA-N 0.000 claims 1
- XHROKJJCFRMCBT-UHFFFAOYSA-N 5-[[4-(dimethylamino)cyclohexyl]-ethylamino]-n-[(4,6-dimethyl-2-oxo-1h-pyridin-3-yl)methyl]-4-methylthiophene-3-carboxamide Chemical compound S1C=C(C(=O)NCC=2C(NC(C)=CC=2C)=O)C(C)=C1N(CC)C1CCC(N(C)C)CC1 XHROKJJCFRMCBT-UHFFFAOYSA-N 0.000 claims 1
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 206010005949 Bone cancer Diseases 0.000 claims 1
- 208000018084 Bone neoplasm Diseases 0.000 claims 1
- 208000003174 Brain Neoplasms Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- KWPFVIZLZMVNJS-UHFFFAOYSA-N CC(C1CCN(CC(C)(F)F)CC1)C1=C(C(NCC2=C(C)C=C(C)NC2=O)=O)C(C)=CS1 Chemical compound CC(C1CCN(CC(C)(F)F)CC1)C1=C(C(NCC2=C(C)C=C(C)NC2=O)=O)C(C)=CS1 KWPFVIZLZMVNJS-UHFFFAOYSA-N 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000012609 Cowden disease Diseases 0.000 claims 1
- 201000002847 Cowden syndrome Diseases 0.000 claims 1
- 206010014967 Ependymoma Diseases 0.000 claims 1
- 208000006168 Ewing Sarcoma Diseases 0.000 claims 1
- 208000007569 Giant Cell Tumors Diseases 0.000 claims 1
- 208000032612 Glial tumor Diseases 0.000 claims 1
- 206010018338 Glioma Diseases 0.000 claims 1
- 102100038970 Histone-lysine N-methyltransferase EZH2 Human genes 0.000 claims 1
- 101000882127 Homo sapiens Histone-lysine N-methyltransferase EZH2 Proteins 0.000 claims 1
- 208000005726 Inflammatory Breast Neoplasms Diseases 0.000 claims 1
- 206010021980 Inflammatory carcinoma of the breast Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- 208000000172 Medulloblastoma Diseases 0.000 claims 1
- 208000008770 Multiple Hamartoma Syndrome Diseases 0.000 claims 1
- 241001529936 Murinae Species 0.000 claims 1
- LOYKAXLOUFUJMQ-UHFFFAOYSA-N N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-5-[1-(1-hydroxypiperidin-4-ylidene)propyl]-4-methylthiophene-3-carboxamide Chemical compound CCC(C1=C(C)C(=CS1)C(=O)NCC1=C(C)C=C(C)NC1=O)=C1CCN(O)CC1 LOYKAXLOUFUJMQ-UHFFFAOYSA-N 0.000 claims 1
- IUHDGIJHSJSHEB-UHFFFAOYSA-N N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-5-[1-(4-hydroxycyclohexylidene)propyl]-4-methylthiophene-3-carboxamide Chemical compound CC1=C(C(NC(=C1)C)=O)CNC(=O)C1=CSC(=C1C)C(CC)=C1CCC(CC1)O IUHDGIJHSJSHEB-UHFFFAOYSA-N 0.000 claims 1
- VCELFVLWXRMZGZ-UHFFFAOYSA-N N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-5-[1-[1-(2-fluoro-2-methylpropyl)piperidin-4-yl]propyl]-4-methylthiophene-3-carboxamide Chemical compound CCC(C1CCN(CC(C)(C)F)CC1)C1=C(C)C(=CS1)C(=O)NCC1=C(C)C=C(C)NC1=O VCELFVLWXRMZGZ-UHFFFAOYSA-N 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 206010039491 Sarcoma Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 208000024770 Thyroid neoplasm Diseases 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 208000008383 Wilms tumor Diseases 0.000 claims 1
- 210000000988 bone and bone Anatomy 0.000 claims 1
- 210000004556 brain Anatomy 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 208000005017 glioblastoma Diseases 0.000 claims 1
- 201000010536 head and neck cancer Diseases 0.000 claims 1
- 208000014829 head and neck neoplasm Diseases 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 201000004653 inflammatory breast carcinoma Diseases 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 208000014018 liver neoplasm Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- FBXFKRLTSXFVRZ-UHFFFAOYSA-N n-[(4,6-dimethyl-2-oxo-1h-pyridin-3-yl)methyl]-5-[ethyl-[4-[ethyl(methyl)amino]cyclohexyl]amino]-4-methylthiophene-3-carboxamide Chemical compound C1CC(N(C)CC)CCC1N(CC)C1=C(C)C(C(=O)NCC=2C(NC(C)=CC=2C)=O)=CS1 FBXFKRLTSXFVRZ-UHFFFAOYSA-N 0.000 claims 1
- 201000008026 nephroblastoma Diseases 0.000 claims 1
- 201000008968 osteosarcoma Diseases 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 1
- 201000009410 rhabdomyosarcoma Diseases 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- DAUYIKBTMNZABP-UHFFFAOYSA-N thiophene-3-carboxamide Chemical compound NC(=O)C=1C=CSC=1 DAUYIKBTMNZABP-UHFFFAOYSA-N 0.000 claims 1
- 201000002510 thyroid cancer Diseases 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
- 0 **(CC1)CC*1=*(*)c1c(*)c(C(N(*)CC2=C(*)C=C(*)NC2=O)=O)c(*)[s]1 Chemical compound **(CC1)CC*1=*(*)c1c(*)c(C(N(*)CC2=C(*)C=C(*)NC2=O)=O)c(*)[s]1 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462069438P | 2014-10-28 | 2014-10-28 | |
| US62/069,438 | 2014-10-28 | ||
| US201462075596P | 2014-11-05 | 2014-11-05 | |
| US62/075,596 | 2014-11-05 | ||
| PCT/EP2015/075009 WO2016066697A1 (en) | 2014-10-28 | 2015-10-28 | Enhancer of zeste homolog 2 inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017532360A JP2017532360A (ja) | 2017-11-02 |
| JP2017532360A5 true JP2017532360A5 (enExample) | 2018-12-06 |
| JP6571180B2 JP6571180B2 (ja) | 2019-09-04 |
Family
ID=54360465
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017522890A Expired - Fee Related JP6571180B2 (ja) | 2014-10-28 | 2015-10-28 | Ｚｅｓｔｅホモログ２エンハンサー阻害剤 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20170334891A1 (enExample) |
| EP (1) | EP3212639A1 (enExample) |
| JP (1) | JP6571180B2 (enExample) |
| KR (1) | KR20170068603A (enExample) |
| CN (1) | CN107148419A (enExample) |
| AU (1) | AU2015340614B2 (enExample) |
| BR (1) | BR112017008840A2 (enExample) |
| CA (1) | CA2965729A1 (enExample) |
| MA (1) | MA40848A (enExample) |
| RU (1) | RU2017118165A (enExample) |
| WO (1) | WO2016066697A1 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UY36758A (es) * | 2015-06-30 | 2016-12-30 | Glaxosmithkline Ip No 2 Ltd | Inhibidores del potenciador del homólogo zeste 2 |
| TW201718598A (zh) | 2015-08-27 | 2017-06-01 | 美國禮來大藥廠 | Ｅｚｈ２抑制劑 |
| KR20190003699A (ko) * | 2016-05-05 | 2019-01-09 | 글락소스미스클라인 인털렉츄얼 프로퍼티 (넘버 2) 리미티드 | 제스트 인핸서 상동체 2 억제제 |
| TW201831181A (zh) | 2017-01-19 | 2018-09-01 | 日商第一三共股份有限公司 | 用以用於治療ｈｔｌｖ－１相關脊髓病之醫藥組成物 |
| US10266542B2 (en) | 2017-03-15 | 2019-04-23 | Mirati Therapeutics, Inc. | EZH2 inhibitors |
| WO2018177993A1 (de) | 2017-03-31 | 2018-10-04 | Bayer Cropscience Aktiengesellschaft | Pyrazole zur bekämpfung von arthropoden |
| MX2020007974A (es) | 2018-01-31 | 2020-09-07 | Mirati Therapeutics Inc | Inhibidores de complejo represivo polycomb 2 (prc2). |
| HRP20240793T1 (hr) | 2018-04-18 | 2024-09-13 | Constellation Pharmaceuticals, Inc. | Modulatori enzima koji modificiraju metil, njihovi pripravci i upotreba |
| EP3797108B1 (en) | 2018-05-21 | 2022-07-20 | Constellation Pharmaceuticals, Inc. | Modulators of methyl modifying enzymes, compositions and uses thereof |
| EP3823671B1 (en) | 2018-07-09 | 2024-02-07 | Fondation Asile Des Aveugles | Inhibition of prc2 subunits to treat eye disorders |
| US12421228B2 (en) | 2019-04-22 | 2025-09-23 | Mirati Therapeutics, Inc. | Naphthyridine derivatives as PRC2 inhibitors |
| EP3980422A1 (en) | 2019-06-05 | 2022-04-13 | Mirati Therapeutics, Inc. | Imidazo[1,2-c]pyrimidine derivatives as prc2 inhibitors for treating cancer |
| MX2022000933A (es) * | 2019-07-24 | 2022-05-06 | Constellation Pharmaceuticals Inc | Inhibición de ezh2 en tratamientos combinados para el tratamiento del cáncer. |
| LT4003532T (lt) | 2019-07-24 | 2024-11-11 | Constellation Pharmaceuticals, Inc. | 7-chlor-2- (4-(3-metoksiazetidin-1-il)cikloheksil)-2,4-dimetil-n-((6-metil-4-(metiltio)-2-okso-1,2-dihidropiridin-3-il)metil)benzo[d][1,3]dioksol-5-karboksamido kristalinės formos |
| CN114555112A (zh) | 2019-08-22 | 2022-05-27 | 朱诺治疗学股份有限公司 | T细胞疗法和zeste增强子同源物2(ezh2)抑制剂的组合疗法及相关方法 |
| CN110950834A (zh) * | 2019-11-26 | 2020-04-03 | 济南大学 | 新型eed-ezh2相互作用小分子抑制剂的确定和评价 |
| EP4514391A1 (en) | 2022-04-27 | 2025-03-05 | Daiichi Sankyo Company, Limited | Combination of antibody-drug conjugate with ezh1 and/or ezh2 inhibitor |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA023788B1 (ru) * | 2010-05-07 | 2016-07-29 | ГЛЭКСОСМИТКЛАЙН ЭлЭлСи | Производные индола и фармацевтические композиции на их основе |
| TW201733984A (zh) * | 2011-04-13 | 2017-10-01 | 雅酶股份有限公司 | 經取代之苯化合物 |
| JO3363B1 (ar) * | 2011-04-13 | 2019-03-13 | Epizyme Inc | مركبات بنزين مستبدلة بأريل أو أريل غير متجانس |
| CN104039956A (zh) * | 2011-11-04 | 2014-09-10 | 葛兰素史密斯克莱知识产权（第2号）有限公司 | 治疗方法 |
| JP5989805B2 (ja) * | 2012-02-10 | 2016-09-07 | コンステレーション・ファーマシューティカルズ・インコーポレイテッドＣｏｎｓｔｅｌｌａｔｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． | メチル基変更酵素の調節物質、組成物及びその使用 |
| UA111305C2 (uk) * | 2012-12-21 | 2016-04-11 | Пфайзер Інк. | Конденсовані лактами арилу та гетероарилу |
| WO2014177982A1 (en) * | 2013-04-30 | 2014-11-06 | Glaxosmithkline Intellectual Property (No.2) Limited | Enhancer of zeste homolog 2 inhibitors |
| AU2014288839B2 (en) * | 2013-07-10 | 2017-02-02 | Glaxosmithkline Intellectual Property (No.2) Limited | Enhancer of Zeste Homolog 2 inhibitors |
-
2015
- 2015-10-28 BR BR112017008840A patent/BR112017008840A2/pt not_active Application Discontinuation
- 2015-10-28 CA CA2965729A patent/CA2965729A1/en not_active Abandoned
- 2015-10-28 EP EP15786958.7A patent/EP3212639A1/en not_active Withdrawn
- 2015-10-28 CN CN201580058856.7A patent/CN107148419A/zh active Pending
- 2015-10-28 KR KR1020177014034A patent/KR20170068603A/ko not_active Withdrawn
- 2015-10-28 AU AU2015340614A patent/AU2015340614B2/en not_active Ceased
- 2015-10-28 JP JP2017522890A patent/JP6571180B2/ja not_active Expired - Fee Related
- 2015-10-28 US US15/522,373 patent/US20170334891A1/en not_active Abandoned
- 2015-10-28 WO PCT/EP2015/075009 patent/WO2016066697A1/en not_active Ceased
- 2015-10-28 MA MA040848A patent/MA40848A/fr unknown
- 2015-10-28 RU RU2017118165A patent/RU2017118165A/ru not_active Application Discontinuation
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