JP2014521653A5 - - Google Patents
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- Publication number
- JP2014521653A5 JP2014521653A5 JP2014523015A JP2014523015A JP2014521653A5 JP 2014521653 A5 JP2014521653 A5 JP 2014521653A5 JP 2014523015 A JP2014523015 A JP 2014523015A JP 2014523015 A JP2014523015 A JP 2014523015A JP 2014521653 A5 JP2014521653 A5 JP 2014521653A5
- Authority
- JP
- Japan
- Prior art keywords
- nitrogen
- sulfur
- oxygen
- ring
- independently selected
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 C*(C)N1CCNCC1 Chemical compound C*(C)N1CCNCC1 0.000 description 1
- WQEBYNUXWYRLCB-UHFFFAOYSA-N CCN1CC2(CNC2)CC1 Chemical compound CCN1CC2(CNC2)CC1 WQEBYNUXWYRLCB-UHFFFAOYSA-N 0.000 description 1
- YSRSYYHGSQMAFV-UHFFFAOYSA-N CN(CC12)CC1C2N Chemical compound CN(CC12)CC1C2N YSRSYYHGSQMAFV-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161513432P | 2011-07-29 | 2011-07-29 | |
| US201161513428P | 2011-07-29 | 2011-07-29 | |
| US61/513,428 | 2011-07-29 | ||
| US61/513,432 | 2011-07-29 | ||
| US201261653588P | 2012-05-31 | 2012-05-31 | |
| US61/653,588 | 2012-05-31 | ||
| PCT/US2012/048368 WO2013019561A1 (en) | 2011-07-29 | 2012-07-26 | Nuclear transport modulators and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016176098A Division JP2016199604A (ja) | 2011-07-29 | 2016-09-09 | 核内輸送調節因子およびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014521653A JP2014521653A (ja) | 2014-08-28 |
| JP2014521653A5 true JP2014521653A5 (enExample) | 2015-08-20 |
| JP6006794B2 JP6006794B2 (ja) | 2016-10-12 |
Family
ID=46682903
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014523015A Active JP6006794B2 (ja) | 2011-07-29 | 2012-07-26 | 核内輸送調節因子およびその使用 |
| JP2016176098A Withdrawn JP2016199604A (ja) | 2011-07-29 | 2016-09-09 | 核内輸送調節因子およびその使用 |
| JP2018006773A Active JP6752235B2 (ja) | 2011-07-29 | 2018-01-18 | 核内輸送調節因子およびその使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016176098A Withdrawn JP2016199604A (ja) | 2011-07-29 | 2016-09-09 | 核内輸送調節因子およびその使用 |
| JP2018006773A Active JP6752235B2 (ja) | 2011-07-29 | 2018-01-18 | 核内輸送調節因子およびその使用 |
Country Status (15)
| Country | Link |
|---|---|
| US (5) | US9428490B2 (enExample) |
| EP (1) | EP2736883B1 (enExample) |
| JP (3) | JP6006794B2 (enExample) |
| KR (1) | KR102022715B1 (enExample) |
| CN (1) | CN103842340B (enExample) |
| AU (2) | AU2016213805A1 (enExample) |
| BR (1) | BR112014001933A2 (enExample) |
| CA (1) | CA2842364A1 (enExample) |
| CL (2) | CL2014000224A1 (enExample) |
| EA (1) | EA201490406A1 (enExample) |
| MX (1) | MX350442B (enExample) |
| PE (1) | PE20141003A1 (enExample) |
| SG (1) | SG10201609097PA (enExample) |
| UA (1) | UA117902C2 (enExample) |
| WO (1) | WO2013019561A1 (enExample) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103002742B (zh) | 2010-03-05 | 2016-07-13 | 卡尔约药物治疗公司 | 核转运调节剂及其应用 |
| JP6106605B2 (ja) | 2011-01-17 | 2017-04-05 | カリオファーム セラピューティクス，インコーポレイテッド | オレフィン含有核輸送調節剤およびその使用 |
| CA2842364A1 (en) * | 2011-07-29 | 2013-02-07 | Karyopharm Therapeutics, Inc. | Nuclear transport modulators and uses thereof |
| ES2954991T3 (es) | 2011-07-29 | 2023-11-28 | Karyopharm Therapeutics Inc | Moduladores del transporte nuclear que contienen hidrazida y usos de los mismos |
| SMT202000347T1 (it) | 2012-05-09 | 2020-07-08 | Biogen Ma Inc | Modulatori di trasporto nucleare e loro usi |
| JO3407B1 (ar) | 2012-05-31 | 2019-10-20 | Eisai R&D Man Co Ltd | مركبات رباعي هيدرو بيرازولو بيريميدين |
| US9013997B2 (en) | 2012-06-01 | 2015-04-21 | Broadcom Corporation | System for performing distributed data cut-through |
| WO2014144772A1 (en) * | 2013-03-15 | 2014-09-18 | Karyopharm Therapeutics Inc. | Methods of promoting wound healing using crm1 inhibitors |
| PL3010892T3 (pl) | 2013-06-21 | 2019-07-31 | Karyopharm Therapeutics, Inc. | 1,2,4-triazole jako modulatory transportu jądrowego i ich zastosowania |
| WO2014205393A1 (en) * | 2013-06-21 | 2014-12-24 | Karyopharm Therapeutics Inc. | Nuclear transport modulators and uses thereof |
| MX368059B (es) | 2013-07-18 | 2019-09-18 | Novartis Ag | Inhibidores de autotaxina que comprenden un núcleo de anillo heteroaromático de bencil-amida cíclica. |
| US9487536B2 (en) | 2013-11-08 | 2016-11-08 | Board Of Trustees Of The University Of Arkansas | Melampomagnolide B derivatives |
| US9469650B2 (en) | 2013-11-08 | 2016-10-18 | Board Of Trustees Of The University Of Arkansas | Melampomagnolide B derivatives |
| WO2015079031A1 (en) * | 2013-11-28 | 2015-06-04 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of beta-thalassemias |
| EP3116501A1 (en) | 2014-03-13 | 2017-01-18 | Proteostasis Therapeutics, Inc. | Compounds, compositions, and methods for increasing cftr activity |
| EP3116870A1 (en) | 2014-03-13 | 2017-01-18 | Proteostasis Therapeutics, Inc. | Compounds, compositions, and methods for increasing cftr activity |
| CA2952862A1 (en) | 2014-06-19 | 2015-12-23 | Proteostasis Therapeutics, Inc. | Compounds, compositions and methods of increasing cftr activity |
| CN111484483B (zh) | 2014-08-15 | 2023-05-26 | 卡尔约药物治疗公司 | 赛灵克斯的多晶型物 |
| WO2016090166A1 (en) | 2014-12-03 | 2016-06-09 | Board Of Trustees Of The University Of Arkansas | Melampomagnolide b dimers |
| US10344023B2 (en) | 2014-12-23 | 2019-07-09 | Proteostasis Therapeutics, Inc. | Derivatives of 3-heteroarylisoxazol-5-carboxylic amide useful for the treatment of inter alia cystic fibrosis |
| US10392378B2 (en) | 2014-12-23 | 2019-08-27 | Proteostasis Therapeutics, Inc. | Derivatives of 5-phenyl- or 5-heteroarylathiazol-2-carboxylic amide useful for the treatment of inter alia cystic fibrosis |
| US10738011B2 (en) | 2014-12-23 | 2020-08-11 | Proteostasis Therapeutics, Inc. | Derivatives of 5-(hetero)arylpyrazol-3-carboxylic amide or 1-(hetero)aryltriazol-4-carboxylic amide useful for the treatment of inter alia cystic fibrosis |
| MA41253A (fr) | 2014-12-23 | 2017-10-31 | Proteostasis Therapeutics Inc | Composés, compositions et procédés pour augmenter l'activité du cftr |
| US10548878B2 (en) | 2015-07-24 | 2020-02-04 | Proteostasis Therapeutics, Inc. | Compounds, compositions, and methods of increasing CFTR activity |
| EP4119539A1 (en) | 2015-09-23 | 2023-01-18 | XWPharma Ltd. | Prodrugs of gamma-hydroxybutyric acid, compositions and uses thereof |
| NZ741093A (en) | 2015-10-06 | 2022-12-23 | Proteostasis Therapeutics Inc | Compounds, compositions, and methods for modulating cftr |
| CN105384673B (zh) * | 2015-11-09 | 2017-11-14 | 南京富润凯德生物医药有限公司 | 3‑氟代‑氮杂环丁烷衍生物的合成方法 |
| EP3397633A1 (en) | 2015-12-31 | 2018-11-07 | Karyopharm Therapeutics, Inc. | Nuclear transport modulators and uses thereof |
| EP3397634A1 (en) | 2015-12-31 | 2018-11-07 | Karyopharm Therapeutics, Inc. | Nuclear transport modulators and uses thereof |
| JP2019509980A (ja) | 2016-01-29 | 2019-04-11 | バイオベンチャーズ・リミテッド・ライアビリティ・カンパニーＢｉｏＶｅｎｔｕｒｅｓ， ＬＬＣ | メランポマグノリドｂのトリアゾール誘導体及びその使用方法 |
| BR112018070747B1 (pt) | 2016-04-07 | 2024-01-09 | Proteostasis Therapeutics, Inc | Átomos de silicone contendo análogos de ivacaftor, composições farmacêuticas e usos terapêuticos |
| US10851053B2 (en) * | 2016-06-08 | 2020-12-01 | Glaxosmithkline Intellectual Property Development Limited | Chemical compounds |
| EP3472156B1 (en) | 2016-06-21 | 2023-06-07 | Proteostasis Therapeutics, Inc. | Compounds, compositions, and methods for increasing cftr activity |
| WO2018050801A1 (en) | 2016-09-16 | 2018-03-22 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of systemic mastocytosis |
| US11602530B2 (en) | 2016-11-28 | 2023-03-14 | Biogen Ma Inc. | CRM1 inhibitors for treating epilepsy |
| CN106831731B (zh) * | 2017-01-17 | 2019-11-08 | 广州市闻皓生物科技有限公司 | 一种Selinexor原料药的合成方法 |
| EP3601235B1 (en) | 2017-03-30 | 2026-03-04 | XWPharma Ltd. | Bicyclic heteroaryl derivatives, preparation and therapeutic uses thereof |
| JP7167168B2 (ja) | 2018-01-10 | 2022-11-08 | エックスダブリューファルマ リミテッド | ケタミンのプロドラッグ、組成物及びそれらの使用 |
| WO2019232724A1 (en) * | 2018-06-06 | 2019-12-12 | Xw Laboratories, Inc. | Compounds as nuclear transport modulators and uses thereof |
| CN110592141B (zh) * | 2018-06-13 | 2023-07-07 | 中国科学院上海有机化学研究所 | 用于调控基因编辑效率的化合物及其应用 |
| CN114042070A (zh) | 2018-09-30 | 2022-02-15 | 凯瑞康宁生物工程（武汉）有限公司 | 作为神经元组胺受体-3拮抗剂的化合物及其用途 |
| CN111606890A (zh) * | 2019-02-26 | 2020-09-01 | 微境生物医药科技(上海)有限公司 | 含丙烯酰基的核转运调节剂及其用途 |
| JP2020141256A (ja) | 2019-02-28 | 2020-09-03 | ソニーセミコンダクタソリューションズ株式会社 | 復調回路、復調方法、送信装置 |
| CA3135712A1 (en) | 2019-05-01 | 2020-11-05 | Brian Clinton AUSTAD | Process for preparing xpo1 inhibitors and intermediates for use in the preparation of xp01 inhibitors |
| CN115244028A (zh) | 2019-12-20 | 2022-10-25 | 凯瑞康宁生物工程有限公司 | 4-缬氨酰氧基丁酸的合成方法 |
| US11357734B2 (en) | 2020-06-18 | 2022-06-14 | XWPharma Ltd. | Pharmaceutical granulations of water-soluble active pharmaceutical ingredients |
| AU2021292406B2 (en) | 2020-06-18 | 2024-03-14 | XWPharma Ltd. | Controlled release granulations of water-soluble active pharmaceutical ingredients |
| CN116261451A (zh) | 2020-07-24 | 2023-06-13 | 凯瑞康宁生物工程有限公司 | γ-羟基丁酸衍生物的药物组合物和药物动力学 |
| CA3194665A1 (en) | 2020-10-05 | 2022-04-14 | Jia-Ning Xiang | Modified release compositions of a gamma-hydroxybutyric acid derivative |
| WO2022143779A1 (zh) * | 2020-12-29 | 2022-07-07 | 南京明德新药研发有限公司 | 含烯基类化合物及其应用 |
| CN117098533A (zh) | 2021-03-19 | 2023-11-21 | 凯瑞康宁公司 | γ-羟基丁酸衍生物的组合释放型制剂的药物动力学 |
| AU2022326513B9 (en) | 2021-08-13 | 2025-10-23 | XWPharma Ltd. | Pharmaceutical compositions and oral dosage forms of ketamine derivatives |
| CN121001993A (zh) * | 2023-02-24 | 2025-11-21 | 鲁汶天主教大学 | 核转运调节剂 |
| CN116514773B (zh) * | 2023-04-24 | 2024-12-03 | 重庆汉佩生物科技有限公司 | 一种Verdinexor(KPT-335)及其盐酸盐的合成方法 |
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| KR840000529A (ko) * | 1981-07-07 | 1984-02-25 | 콘스탄틴 루이스 클레멘트 | 인돌 유도체의 제조방법 |
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| IL97249A (en) | 1990-02-23 | 1995-01-24 | Takeda Chemical Industries Ltd | Compounds of 7,6,5,4-tetrahydrothiazole] B-5,4 [pyridine and compounds of 5,6-dihydro-H4-pyrrolo] D-3,2 [thiazole, their manufacture, and pharmaceutical compositions including or |
| US5541213A (en) * | 1993-06-24 | 1996-07-30 | Eisai Co., Ltd. | Propenoic acid derivatives diazole propenoic acid compounds which have useful pharmaceutical utility |
| US5468353A (en) * | 1994-05-05 | 1995-11-21 | Minnesota Mining And Manufacturing Company | Mist suppressant for solvent extraction metal electrowinning |
| BR9509760A (pt) * | 1994-11-23 | 1998-06-30 | Neurogen Corp | Composto |
| US20030018025A1 (en) | 1995-06-07 | 2003-01-23 | Neurogen Corporation, Corporation Of The State Of Delaware | Certain 4-aminomethyl-2-substituted imidazole derivatives and 2-aminomethyl-4-substituted imidazole derivatives: new classes of dopamine receptor subtype specific ligands |
| JPH11513382A (ja) * | 1995-10-20 | 1999-11-16 | ドクトル カルル トーマエ ゲゼルシャフト ミット ベシュレンクテル ハフツング | ５員複素環化合物、これらの化合物を含む医薬品、それらの使用及びそれらの調製方法 |
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| JP4416198B2 (ja) * | 1997-12-19 | 2010-02-17 | 武田薬品工業株式会社 | アニリド誘導体、その製造法および用途 |
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| CO5271680A1 (es) * | 2000-02-21 | 2003-04-30 | Smithkline Beecham Corp | Compuestos |
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| JP4999923B2 (ja) | 2006-06-13 | 2012-08-15 | 中国科学院上海薬物研究所 | 複素環非ヌクレオシド系化合物、抗ウィルス医薬組成物、及びウィルス性疾病治療薬物 |
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| JP4388997B2 (ja) * | 2006-09-05 | 2009-12-24 | 協和発酵キリン株式会社 | イミダゾール誘導体 |
| EP1942104A1 (en) * | 2006-12-20 | 2008-07-09 | sanofi-aventis | Heteroarylcyclopropanecarboxamides and their use as pharmaceuticals |
| EP1939180A1 (en) | 2006-12-20 | 2008-07-02 | sanofi-aventis | Heteroarylacrylamides and their use as pharmaceuticals for the stimulation of the expression of endothelial NO synthase |
| CN103002742B (zh) * | 2010-03-05 | 2016-07-13 | 卡尔约药物治疗公司 | 核转运调节剂及其应用 |
| JP6106605B2 (ja) | 2011-01-17 | 2017-04-05 | カリオファーム セラピューティクス，インコーポレイテッド | オレフィン含有核輸送調節剤およびその使用 |
| US9152882B2 (en) * | 2011-06-17 | 2015-10-06 | Microsoft Technology Licensing, Llc. | Location-aided recognition |
| CA2842364A1 (en) * | 2011-07-29 | 2013-02-07 | Karyopharm Therapeutics, Inc. | Nuclear transport modulators and uses thereof |
| ES2954991T3 (es) | 2011-07-29 | 2023-11-28 | Karyopharm Therapeutics Inc | Moduladores del transporte nuclear que contienen hidrazida y usos de los mismos |
| SMT202000347T1 (it) | 2012-05-09 | 2020-07-08 | Biogen Ma Inc | Modulatori di trasporto nucleare e loro usi |
| WO2014144772A1 (en) | 2013-03-15 | 2014-09-18 | Karyopharm Therapeutics Inc. | Methods of promoting wound healing using crm1 inhibitors |
| WO2014152263A1 (en) | 2013-03-15 | 2014-09-25 | Karyopharm Therapeutics Inc. | Exo olefin-containing nuclear transport modulators and uses thereof |
| PL3010892T3 (pl) | 2013-06-21 | 2019-07-31 | Karyopharm Therapeutics, Inc. | 1,2,4-triazole jako modulatory transportu jądrowego i ich zastosowania |
| WO2014205393A1 (en) | 2013-06-21 | 2014-12-24 | Karyopharm Therapeutics Inc. | Nuclear transport modulators and uses thereof |
-
2012
- 2012-07-26 CA CA2842364A patent/CA2842364A1/en not_active Abandoned
- 2012-07-26 UA UAA201401884A patent/UA117902C2/uk unknown
- 2012-07-26 WO PCT/US2012/048368 patent/WO2013019561A1/en not_active Ceased
- 2012-07-26 PE PE2014000137A patent/PE20141003A1/es active IP Right Grant
- 2012-07-26 EA EA201490406A patent/EA201490406A1/ru unknown
- 2012-07-26 MX MX2014001180A patent/MX350442B/es active IP Right Grant
- 2012-07-26 SG SG10201609097PA patent/SG10201609097PA/en unknown
- 2012-07-26 US US14/235,342 patent/US9428490B2/en active Active
- 2012-07-26 EP EP12748083.8A patent/EP2736883B1/en active Active
- 2012-07-26 JP JP2014523015A patent/JP6006794B2/ja active Active
- 2012-07-26 CN CN201280047930.1A patent/CN103842340B/zh active Active
- 2012-07-26 BR BR112014001933A patent/BR112014001933A2/pt not_active Application Discontinuation
- 2012-07-26 KR KR1020147005649A patent/KR102022715B1/ko active Active
-
2014
- 2014-01-29 CL CL2014000224A patent/CL2014000224A1/es unknown
-
2015
- 2015-05-11 CL CL2015001259A patent/CL2015001259A1/es unknown
-
2016
- 2016-07-22 US US15/217,514 patent/US20170137430A1/en not_active Abandoned
- 2016-08-11 AU AU2016213805A patent/AU2016213805A1/en not_active Abandoned
- 2016-09-09 JP JP2016176098A patent/JP2016199604A/ja not_active Withdrawn
-
2018
- 2018-01-18 JP JP2018006773A patent/JP6752235B2/ja active Active
- 2018-06-14 AU AU2018204256A patent/AU2018204256A1/en not_active Abandoned
-
2019
- 2019-04-25 US US16/394,986 patent/US20200087313A1/en not_active Abandoned
-
2021
- 2021-05-04 US US17/307,656 patent/US20220056038A1/en not_active Abandoned
-
2023
- 2023-12-01 US US18/526,900 patent/US20240376114A1/en active Pending
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