JP2013512903A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2013512903A5 JP2013512903A5 JP2012542060A JP2012542060A JP2013512903A5 JP 2013512903 A5 JP2013512903 A5 JP 2013512903A5 JP 2012542060 A JP2012542060 A JP 2012542060A JP 2012542060 A JP2012542060 A JP 2012542060A JP 2013512903 A5 JP2013512903 A5 JP 2013512903A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- compound according
- heterocyclyl
- alkyl
- optionally
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 CCCCN=C(*C)C(CCCC*C(*)=C(C)C(C)=C)=C(C)I*C(C)CC*C=C(C)N(*)[*+]C Chemical compound CCCCN=C(*C)C(CCCC*C(*)=C(C)C(C)=C)=C(C)I*C(C)CC*C=C(C)N(*)[*+]C 0.000 description 2
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26680109P | 2009-12-04 | 2009-12-04 | |
| US61/266,801 | 2009-12-04 | ||
| US35416510P | 2010-06-11 | 2010-06-11 | |
| US61/354,165 | 2010-06-11 | ||
| PCT/US2010/056712 WO2011068667A1 (en) | 2009-12-04 | 2010-11-15 | Pyrazolopyrimidines and related heterocycles as ck2 inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013512903A JP2013512903A (ja) | 2013-04-18 |
| JP2013512903A5 true JP2013512903A5 (enExample) | 2013-12-19 |
| JP5802676B2 JP5802676B2 (ja) | 2015-10-28 |
Family
ID=44115232
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012542060A Active JP5802676B2 (ja) | 2009-12-04 | 2010-11-15 | Ｃｋ２阻害剤としてのピラゾロピリミジンおよび関連複素環化合物 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US8575177B2 (enExample) |
| EP (1) | EP2509602B9 (enExample) |
| JP (1) | JP5802676B2 (enExample) |
| KR (1) | KR101851130B1 (enExample) |
| CN (1) | CN102762208A (enExample) |
| AU (1) | AU2010326268B2 (enExample) |
| BR (1) | BR112012013508A2 (enExample) |
| CA (1) | CA2782684C (enExample) |
| ES (1) | ES2629170T3 (enExample) |
| IL (1) | IL220086B (enExample) |
| PL (1) | PL2509602T3 (enExample) |
| RU (1) | RU2607453C2 (enExample) |
| SG (1) | SG181507A1 (enExample) |
| WO (1) | WO2011068667A1 (enExample) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2555261T3 (es) * | 2010-06-01 | 2015-12-30 | Bayer Intellectual Property Gmbh | Imidazopirazinas sustituidas |
| CA3007787C (en) | 2010-06-03 | 2020-03-10 | Pharmacyclics Llc | The use of inhibitors of bruton's tyrosine kinase (btk) |
| WO2012170827A2 (en) * | 2011-06-08 | 2012-12-13 | Cylene Pharmaceuticals, Inc. | Pyrazolopyrimidines and related heterocycles as ck2 inhibitors |
| US9309250B2 (en) | 2011-06-22 | 2016-04-12 | Vertex Pharmaceuticals Incorporated | Substituted pyrrolo[2,3-b]pyrazines as ATR kinase inhibitors |
| EP2843072B1 (en) * | 2012-04-27 | 2017-06-14 | Nippon Steel & Sumitomo Metal Corporation | Seamless steel pipe and method for manufacturing same |
| CA2880896C (en) | 2012-06-26 | 2021-11-16 | Del Mar Pharmaceuticals | Methods for treating tyrosine-kinase-inhibitor-resistant malignancies in patients with genetic polymorphisms or ahi1 dysregulations or mutations employing dianhydrogalactitol, diacetyldianhydrogalactitol, dibromodulcitol, or analogs or derivatives thereof |
| TW201414737A (zh) * | 2012-07-13 | 2014-04-16 | 必治妥美雅史谷比公司 | 作爲激酶抑制劑之咪唑并三□甲腈 |
| CA2879570A1 (en) | 2012-07-24 | 2014-01-30 | Pharmacyclics, Inc. | Mutations associated with resistance to inhibitors of bruton's tyrosine kinase (btk) |
| WO2014089379A1 (en) | 2012-12-07 | 2014-06-12 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
| CA2897200C (en) | 2013-01-14 | 2021-07-06 | Incyte Corporation | Bicyclic aromatic carboxamide compounds useful as pim kinase inhibitors |
| PE20191245A1 (es) | 2013-01-15 | 2019-09-18 | Incyte Holdings Corp | Compuestos de tiazolcarboxamidas y piridinacarboxamida utiles como inhibidores de quinasa pim |
| EP2970289A1 (en) | 2013-03-15 | 2016-01-20 | Vertex Pharmaceuticals Inc. | Compounds useful as inhibitors of atr kinase |
| US9663519B2 (en) | 2013-03-15 | 2017-05-30 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of ATR kinase |
| EP2970288A1 (en) | 2013-03-15 | 2016-01-20 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
| CN105492011A (zh) | 2013-04-08 | 2016-04-13 | 丹尼斯·M·布朗 | 不理想给药化学化合物的治疗增效 |
| CN103360399B (zh) * | 2013-08-02 | 2016-03-02 | 北京大学 | 6-芳基取代-咪唑-[1,2-b]哒嗪类衍生物，其制备方法及用途 |
| CN105658653A (zh) | 2013-08-23 | 2016-06-08 | 因赛特公司 | 可用作pim激酶抑制剂的呋喃并-和噻吩并-吡啶甲酰胺化合物 |
| CN103570728B (zh) * | 2013-11-12 | 2015-12-30 | 山东大学 | 一种取代吡唑并[1,5-a]嘧啶类衍生物及其制备方法与应用 |
| WO2015085132A1 (en) | 2013-12-06 | 2015-06-11 | Vertex Pharmaceuticals Incorporated | 2-amino-6-fluoro-n-[5-fluoro-pyridin-3-yl]pyrazolo[1,5-a]pyrimidin-3-carboxamide compound useful as atr kinase inhibitor, its preparation, different solid forms and radiolabelled derivatives thereof |
| CN105992768B (zh) * | 2013-12-10 | 2018-04-20 | 百时美施贵宝公司 | 用作IL‑12、IL‑23和/或IFNα响应的调节剂的咪唑并哒嗪化合物 |
| TWI534148B (zh) * | 2014-02-13 | 2016-05-21 | 生華生物科技股份有限公司 | 吡唑並嘧啶前藥及其使用方法 |
| GB201403093D0 (en) | 2014-02-21 | 2014-04-09 | Cancer Rec Tech Ltd | Therapeutic compounds and their use |
| KR20170007311A (ko) * | 2014-05-28 | 2017-01-18 | 노파르티스 아게 | 신규 피라졸로 피리미딘 유도체 및 malt1 억제제로서의 그의 용도 |
| HRP20200186T1 (hr) | 2014-06-05 | 2020-05-29 | Vertex Pharmaceuticals Inc. | Radioaktivno obilježeni derivati 2-amino-6-fluoro-n-[5-fluoro-piridin-3-il]-pirazolo[1,5-a]pirimidin-3-karboksamid spojeva koji se koriste kao inhibitori atr kinaze, priprava navedenih spojeva i njihovi različiti čvrsti oblici |
| JP6936007B2 (ja) | 2014-06-17 | 2021-09-15 | バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ | Ｃｈｋ１阻害剤とａｔｒ阻害剤との組み合わせを使用してがんを処置する方法 |
| US9822124B2 (en) | 2014-07-14 | 2017-11-21 | Incyte Corporation | Bicyclic heteroaromatic carboxamide compounds useful as Pim kinase inhibitors |
| US9580418B2 (en) | 2014-07-14 | 2017-02-28 | Incyte Corporation | Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors |
| CN105457029A (zh) * | 2014-09-29 | 2016-04-06 | 中国科学院上海巴斯德研究所 | 抑制酪蛋白激酶2活性在促进i型干扰素表达的应用 |
| CA2968884A1 (en) * | 2014-12-10 | 2016-06-16 | Massachusetts Institute Of Technology | Fused 1,3-azole derivatives useful for the treatment of proliferative diseases |
| EP3247713B1 (en) * | 2015-01-23 | 2019-08-28 | GlaxoSmithKline Intellectual Property Development Limited | Pyrazolo[3,4-d]pyrimidin derivative and its use for the treatment of leishmaniasis |
| WO2016196244A1 (en) | 2015-05-29 | 2016-12-08 | Incyte Corporation | Pyridineamine compounds useful as pim kinase inhibitors |
| AR105967A1 (es) | 2015-09-09 | 2017-11-29 | Incyte Corp | Sales de un inhibidor de pim quinasa |
| EP3355926B1 (en) | 2015-09-30 | 2025-12-24 | Vertex Pharmaceuticals Inc. | Combination of dna damaging agents and atr inhibitors for use in a method for treating cancer using |
| WO2017059251A1 (en) | 2015-10-02 | 2017-04-06 | Incyte Corporation | Heterocyclic compounds useful as pim kinase inhibitors |
| CN109071456A (zh) | 2016-02-16 | 2018-12-21 | 麻省理工学院 | 作为myc调节剂的max结合剂及其用途 |
| EP3474855B1 (en) | 2016-06-24 | 2022-01-26 | Polaris Pharmaceuticals, Inc. | Ck2 inhibitors, compositions and methods thereof |
| TWI778050B (zh) | 2017-04-21 | 2022-09-21 | 美商醫肯納腫瘤學公司 | 吲哚ahr抑制劑及其用途 |
| CN107188901A (zh) * | 2017-05-27 | 2017-09-22 | 无锡捷化医药科技有限公司 | 一种(3‑(3‑(二甲氨基)丙氧基)苯基)硼酸的制备方法 |
| MX393995B (es) | 2017-07-28 | 2025-03-24 | Yuhan Corp | Proceso mejorado para preparar derivados de aminopirimidina |
| JP7216705B2 (ja) | 2017-07-28 | 2023-02-02 | ニンバス ラクシュミ， インコーポレイテッド | Ｔｙｋ２阻害剤およびその使用方法 |
| GB201715194D0 (en) | 2017-09-20 | 2017-11-01 | Carrick Therapeutics Ltd | Compounds and their therapeutic use |
| WO2019113487A1 (en) | 2017-12-08 | 2019-06-13 | Incyte Corporation | Low dose combination therapy for treatment of myeloproliferative neoplasms |
| US11071727B2 (en) | 2018-01-26 | 2021-07-27 | Northwestern University | Therapeutic targeting of proteolytic cleavage of the mixed lineage leukemia gene product (MLL1) by taspase1 using kinase inhibitors |
| MY210039A (en) | 2018-10-30 | 2025-08-22 | Kronos Bio Inc | Compounds, compositions, and methods for modulating cdk9 activity |
| CN112608316B (zh) * | 2019-07-30 | 2022-10-21 | 厦门宝太生物科技股份有限公司 | 一种吡唑并三嗪类腺苷受体拮抗剂 |
| PL4065582T3 (pl) | 2019-11-26 | 2025-08-18 | Ikena Oncology, Inc. | Polimorficzne pochodne karbazolu i ich zastosowania |
| GB201918541D0 (en) | 2019-12-16 | 2020-01-29 | Carrick Therapeutics Ltd | Therapeutic compounds and their use |
| KR102337404B1 (ko) * | 2020-01-03 | 2021-12-10 | 연세대학교 산학협력단 | 조직 재생용 조성물 |
| BR112022019558A2 (pt) * | 2020-03-30 | 2022-12-06 | Senhwa Biosciences Inc | Método para tratar uma infecção por vírus hepatotrópico, composição farmacêutica para tratar uma infecção viral hepatotrópica, e, uso de um composto |
| CN116323569A (zh) * | 2020-09-15 | 2023-06-23 | 田边三菱制药株式会社 | 三嗪化合物的盐、其晶型及制造方法 |
| CN115867553B (zh) * | 2021-01-09 | 2026-03-06 | 巴格沃克斯研究有限公司 | 作为腺苷2A受体和腺苷2B受体拮抗剂的二氨基吡唑[1, 5-a]并嘧啶-6-腈化合物 |
| US12343421B2 (en) * | 2021-11-01 | 2025-07-01 | Solaana MD LLC | Vitamin D base layer |
| JP2026509368A (ja) * | 2023-03-09 | 2026-03-18 | アクイナ ファーマシューティカルズ， インコーポレイテッド | Ｔｄｐ－４３及びタウ凝集の阻害剤 |
| US12269826B1 (en) * | 2023-11-16 | 2025-04-08 | King Faisal University | 7H-pyrido[4′,3′:4,5]pyrrolo[2,3-c][1,7]naphthyridine compounds as CK2 inhibitors |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5624677A (en) | 1995-06-13 | 1997-04-29 | Pentech Pharmaceuticals, Inc. | Controlled release of drugs delivered by sublingual or buccal administration |
| TWI238064B (en) * | 1995-06-20 | 2005-08-21 | Takeda Chemical Industries Ltd | A pharmaceutical composition for prophylaxis and treatment of diabetes |
| JP2005513026A (ja) * | 2001-11-15 | 2005-05-12 | インサイト サン ディエゴ インコーポレイテッド | 高コレステロール血症、異脂肪血症および他の代謝障害；癌、および他の疾患を治療するｎ−置換複素環 |
| US7206308B2 (en) * | 2001-12-22 | 2007-04-17 | International Business Machines Corporation | Method of providing a non-blocking routing network |
| JP2005530739A (ja) * | 2002-04-19 | 2005-10-13 | セルラー ジェノミクス，インコーポレーテッド | イミダゾ［１，２−ａ］ピラジン−８−イルアミン、生成方法、および使用方法 |
| AU2003255528B2 (en) | 2002-07-10 | 2009-07-16 | Merck Serono Sa | Azolidinone-vinyl fused-benzene derivatives |
| WO2004006916A1 (en) * | 2002-07-10 | 2004-01-22 | Applied Research Systems Ars Holding Nv | Use of compounds for increasing spermatozoa motility |
| CN1701073B (zh) * | 2002-09-04 | 2011-06-22 | 先灵公司 | 作为细胞周期蛋白依赖激酶抑制剂的吡唑并[1,5-a]嘧啶 |
| US7205308B2 (en) * | 2002-09-04 | 2007-04-17 | Schering Corporation | Trisubstituted 7-aminopyrazolopyrimidines as cyclin dependent kinase inhibitors |
| EP1551396A1 (en) | 2002-09-26 | 2005-07-13 | Pintex Pharmaceuticals, Inc. | Pin1-modulating compounds and methods of use thereof |
| EP1599482A4 (en) * | 2003-02-28 | 2008-10-01 | Teijin Pharma Ltd | PYRAZOLO1,5-A PYRIMIDINE DERIVATIVES |
| TW200536536A (en) * | 2004-02-25 | 2005-11-16 | Schering Corp | Pyrazolotriazines as kinase inhibitors |
| US7842698B2 (en) * | 2004-09-03 | 2010-11-30 | Merck Serono S.A. | Pyridine methylene azolidinones and use thereof phosphoinositide inhibitors |
| US20090215818A1 (en) * | 2006-07-24 | 2009-08-27 | Smithkline Beecham Corporation | Thiozolidinedione derivatives as pi3 kinase inhibitors |
| FR2907120B1 (fr) * | 2006-10-12 | 2013-01-11 | Sanofi Aventis | Nouveaux derives imidazolones,leur preparation a titre de medicaments,compositions pharmaceutiques,utilisation comme inhibiteurs de proteines kinases notamment cdc7 |
| WO2009100375A1 (en) * | 2008-02-06 | 2009-08-13 | Bristol-Myers Squibb Company | Substituted imidazopyridazines useful as kinase inhibitors |
| AU2010249493A1 (en) * | 2009-05-20 | 2011-12-08 | Cylene Pharmaceuticals, Inc. | Pyrazolopyrimidines and related heterocycles as kinase inhibitors |
-
2010
- 2010-11-15 KR KR1020127017450A patent/KR101851130B1/ko active Active
- 2010-11-15 BR BR112012013508A patent/BR112012013508A2/pt not_active IP Right Cessation
- 2010-11-15 WO PCT/US2010/056712 patent/WO2011068667A1/en not_active Ceased
- 2010-11-15 US US12/946,759 patent/US8575177B2/en active Active
- 2010-11-15 ES ES10834934.1T patent/ES2629170T3/es active Active
- 2010-11-15 SG SG2012041034A patent/SG181507A1/en unknown
- 2010-11-15 JP JP2012542060A patent/JP5802676B2/ja active Active
- 2010-11-15 RU RU2012127792A patent/RU2607453C2/ru active
- 2010-11-15 CN CN2010800630542A patent/CN102762208A/zh active Pending
- 2010-11-15 CA CA2782684A patent/CA2782684C/en active Active
- 2010-11-15 EP EP10834934.1A patent/EP2509602B9/en active Active
- 2010-11-15 AU AU2010326268A patent/AU2010326268B2/en active Active
- 2010-11-15 PL PL10834934T patent/PL2509602T3/pl unknown
-
2012
- 2012-05-31 IL IL220086A patent/IL220086B/en active IP Right Grant
-
2013
- 2013-09-13 US US14/026,591 patent/US9303033B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2013512903A5 (enExample) | ||
| RU2012127792A (ru) | Пиразолопиримидины и родственные гетероциклы как ск2 ингибиторы | |
| ES2660831T3 (es) | Derivados de imidazol condensados útiles como inhibidores de IDO | |
| JP2016517857A5 (enExample) | ||
| JP2017511360A5 (enExample) | ||
| JP2016513737A5 (enExample) | ||
| RU2015118647A (ru) | Аминопиримидиновые соединения в качестве ингибиторов содержащих т790м мутантных egfr | |
| JP2014500295A5 (enExample) | ||
| JP2015506348A5 (enExample) | ||
| JP2016516043A5 (enExample) | ||
| JP2010523522A5 (enExample) | ||
| JP2017528498A5 (enExample) | ||
| JP2016509047A5 (enExample) | ||
| HUE031367T2 (en) | A pharmaceutical combination comprising an Hsp 90 inhibitor and a mTOR inhibitor | |
| JP2016513661A5 (enExample) | ||
| JP2007529421A5 (enExample) | ||
| JP2017508782A5 (enExample) | ||
| JP2016525104A5 (enExample) | ||
| UA114177C2 (uk) | ЗАСТОСУВАННЯ ЗАМІЩЕНИХ 2,3-ДИГІДРОІМІДАЗО[1,2-c]ХІНАЗОЛІНІВ | |
| RU2015121037A (ru) | Производные фенилэтилпиридина в качестве ингибиторов pde-4 | |
| RU2019141734A (ru) | Терапевтические соединения и композиции и способы их применения | |
| WO2018152548A4 (en) | Selective inhibitors of protein arginine methyltransferase 5 (prmt5) | |
| JP2016513696A5 (enExample) | ||
| RU2012130929A (ru) | Гетероциклические соединения в качестве ингибиторов янус-киназы | |
| JP2015522018A5 (enExample) |