|
US2779780A
(en)
|
1955-03-01 |
1957-01-29 |
Du Pont |
1, 4-diamino-2, 3-dicyano-1, 4-bis (substituted mercapto) butadienes and their preparation
|
|
GB8827305D0
(en)
|
1988-11-23 |
1988-12-29 |
British Bio Technology |
Compounds
|
|
FI941572L
(fi)
|
1991-10-07 |
1994-05-27 |
Oncologix Inc |
Anti-erbB-2-monoklonaalisten vasta-aineiden yhdistelmä ja käyttömenetelmä
|
|
CA2372813A1
(en)
|
1992-02-06 |
1993-08-19 |
L.L. Houston |
Biosynthetic binding protein for cancer marker
|
|
US6177401B1
(en)
|
1992-11-13 |
2001-01-23 |
Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften |
Use of organic compounds for the inhibition of Flk-1 mediated vasculogenesis and angiogenesis
|
|
US5455258A
(en)
|
1993-01-06 |
1995-10-03 |
Ciba-Geigy Corporation |
Arylsulfonamido-substituted hydroxamic acids
|
|
EP0647450A1
(en)
|
1993-09-09 |
1995-04-12 |
BEHRINGWERKE Aktiengesellschaft |
Improved prodrugs for enzyme mediated activation
|
|
IL112248A0
(en)
|
1994-01-25 |
1995-03-30 |
Warner Lambert Co |
Tricyclic heteroaromatic compounds and pharmaceutical compositions containing them
|
|
US5521173A
(en)
|
1995-01-17 |
1996-05-28 |
American Home Products Corporation |
Tricyclic benzazepine vasopressin antagonists
|
|
US5863949A
(en)
|
1995-03-08 |
1999-01-26 |
Pfizer Inc |
Arylsulfonylamino hydroxamic acid derivatives
|
|
CA2218503C
(en)
|
1995-04-20 |
2001-07-24 |
Pfizer Inc. |
Arylsulfonyl hydroxamic acid derivatives
|
|
GB9508538D0
(en)
|
1995-04-27 |
1995-06-14 |
Zeneca Ltd |
Quinazoline derivatives
|
|
US5747498A
(en)
|
1996-05-28 |
1998-05-05 |
Pfizer Inc. |
Alkynyl and azido-substituted 4-anilinoquinazolines
|
|
US5880141A
(en)
|
1995-06-07 |
1999-03-09 |
Sugen, Inc. |
Benzylidene-Z-indoline compounds for the treatment of disease
|
|
GB9520822D0
(en)
|
1995-10-11 |
1995-12-13 |
Wellcome Found |
Therapeutically active compounds
|
|
GB9523675D0
(en)
*
|
1995-11-20 |
1996-01-24 |
Celltech Therapeutics Ltd |
Chemical compounds
|
|
GB9624482D0
(en)
|
1995-12-18 |
1997-01-15 |
Zeneca Phaema S A |
Chemical compounds
|
|
DK0780386T3
(da)
|
1995-12-20 |
2003-02-03 |
Hoffmann La Roche |
Matrixmetalloproteaseinhibitorer
|
|
US6017919A
(en)
|
1996-02-06 |
2000-01-25 |
Japan Tobacco Inc. |
Compounds and pharmaceutical use thereof
|
|
NZ331191A
(en)
|
1996-03-05 |
2000-03-27 |
Zeneca Ltd |
4-anilinoquinazoline derivatives and pharmaceutical compositions thereof
|
|
JP3195756B2
(ja)
|
1996-07-04 |
2001-08-06 |
公子 吉水 |
潤滑補助体
|
|
EP0818442A3
(en)
|
1996-07-12 |
1998-12-30 |
Pfizer Inc. |
Cyclic sulphone derivatives as inhibitors of metalloproteinases and of the production of tumour necrosis factor
|
|
US6391874B1
(en)
|
1996-07-13 |
2002-05-21 |
Smithkline Beecham Corporation |
Fused heterocyclic compounds as protein tyrosine kinase inhibitors
|
|
AR007855A1
(es)
|
1996-07-13 |
1999-11-24 |
Glaxo Group Ltd |
Compuestos heterociclicos fusionados como inhibidores de proteina tirosina quinasa, sus metodos de preparacion, intermediarios, uso en medicinay composiciones farmaceuticas que los contienen
|
|
HRP970371A2
(en)
|
1996-07-13 |
1998-08-31 |
Kathryn Jane Smith |
Heterocyclic compounds
|
|
EP0923585B1
(en)
|
1996-07-18 |
2002-05-08 |
Pfizer Inc. |
Phosphinate based inhibitors of matrix metalloproteases
|
|
EP0922030A1
(en)
|
1996-08-23 |
1999-06-16 |
Pfizer Inc. |
Arylsulfonylamino hydroxamic acid derivatives
|
|
ID18494A
(id)
|
1996-10-02 |
1998-04-16 |
Novartis Ag |
Turunan pirazola leburan dan proses pembuatannya
|
|
DZ2376A1
(fr)
|
1996-12-19 |
2002-12-28 |
Smithkline Beecham Plc |
Dérivés de sulfonamides nouveaux procédé pour leurpréparation et compositions pharmaceutiques les c ontenant.
|
|
US6077864A
(en)
|
1997-01-06 |
2000-06-20 |
Pfizer Inc. |
Cyclic sulfone derivatives
|
|
HUP0000852A2
(hu)
|
1997-02-03 |
2001-05-28 |
Pfizer Products Inc. |
Aril-szulfonil-amino-hidroxámsav-származékok, valamint e vegyületeket tartalmazó gyógyászati készítmények
|
|
JP2000507975A
(ja)
|
1997-02-07 |
2000-06-27 |
ファイザー・インク |
N−ヒドロキシ−β−スルホニルプロピオンアミド誘導体類及びそれらのマトリックスメタロプロテイナーゼ阻害薬としての使用
|
|
NZ336836A
(en)
|
1997-02-11 |
2001-02-23 |
Pfizer |
Arylsulfonyl hydroxamic acid derivatives suitable for a broad range of medicinal treatments
|
|
CA2289102A1
(en)
|
1997-05-07 |
1998-11-12 |
Sugen, Inc. |
2-indolinone derivatives as modulators of protein kinase activity
|
|
CA2291709A1
(en)
|
1997-05-30 |
1998-12-03 |
Merck & Co., Inc. |
Novel angiogenesis inhibitors
|
|
US5835420A
(en)
|
1997-06-27 |
1998-11-10 |
Aplus Flash Technology, Inc. |
Node-precise voltage regulation for a MOS memory system
|
|
TR200000368T2
(tr)
|
1997-08-08 |
2000-07-21 |
Pfizer Products Inc. |
Ariloksiariarilsülfonilamino hidroksamik asit türevleri.
|
|
DE69838172T2
(de)
|
1997-08-22 |
2008-04-10 |
Astrazeneca Ab |
Oxindolylchinazolinderivate als angiogenesehemmer
|
|
AU744939B2
(en)
|
1997-09-26 |
2002-03-07 |
Merck & Co., Inc. |
Novel angiogenesis inhibitors
|
|
SK6652000A3
(en)
|
1997-11-11 |
2002-05-09 |
Pfizer Prod Inc |
Thienopyrimidine and thienopyridine derivatives useful as anticancer agents
|
|
GB9725782D0
(en)
|
1997-12-05 |
1998-02-04 |
Pfizer Ltd |
Therapeutic agents
|
|
GB9800575D0
(en)
|
1998-01-12 |
1998-03-11 |
Glaxo Group Ltd |
Heterocyclic compounds
|
|
RS49779B
(sr)
|
1998-01-12 |
2008-06-05 |
Glaxo Group Limited, |
Biciklična heteroaromatična jedinjenja kao inhibitori protein tirozin kinaze
|
|
GB9801690D0
(en)
|
1998-01-27 |
1998-03-25 |
Pfizer Ltd |
Therapeutic agents
|
|
GB2335781A
(en)
|
1998-03-24 |
1999-09-29 |
Soho Soundhouse Limited |
Method of selection of audio samples
|
|
JP4462654B2
(ja)
|
1998-03-26 |
2010-05-12 |
ソニー株式会社 |
映像素材選択装置及び映像素材選択方法
|
|
PA8469401A1
(es)
|
1998-04-10 |
2000-05-24 |
Pfizer Prod Inc |
Derivados biciclicos del acido hidroxamico
|
|
PA8469501A1
(es)
|
1998-04-10 |
2000-09-29 |
Pfizer Prod Inc |
Hidroxamidas del acido (4-arilsulfonilamino)-tetrahidropiran-4-carboxilico
|
|
KR100743287B1
(ko)
|
1998-05-29 |
2007-07-26 |
수젠, 인크. |
피롤기로 치환된 2-인돌리논 단백질 인산화 효소 억제제
|
|
UA60365C2
(uk)
|
1998-06-04 |
2003-10-15 |
Пфайзер Продактс Інк. |
Похідні ізотіазолу, спосіб їх одержання, фармацевтична композиція та спосіб лікування гіперпроліферативного захворювання у ссавця
|
|
EP1004578B1
(en)
|
1998-11-05 |
2004-02-25 |
Pfizer Products Inc. |
5-oxo-pyrrolidine-2-carboxylic acid hydroxamide derivatives
|
|
JP2002532415A
(ja)
|
1998-12-16 |
2002-10-02 |
ワーナー−ランバート・カンパニー |
Mek阻害剤による関節炎の治療
|
|
UA71945C2
(en)
|
1999-01-27 |
2005-01-17 |
Pfizer Prod Inc |
Substituted bicyclic derivatives being used as anticancer agents
|
|
TR200201296T2
(tr)
|
1999-02-11 |
2002-07-22 |
Pfizer Products Inc. |
Antikanser maddeleri olarak faydalı heteroaril-ikame edilmiş kinolin-2-on türevleri
|
|
US6511993B1
(en)
|
1999-06-03 |
2003-01-28 |
Kevin Neil Dack |
Metalloprotease inhibitors
|
|
CA2277654A1
(en)
*
|
1999-07-19 |
2001-01-19 |
Luxell Technologies Inc. |
Electroluminescent display packaging and method therefor
|
|
EP1081137A1
(en)
|
1999-08-12 |
2001-03-07 |
Pfizer Products Inc. |
Selective inhibitors of aggrecanase in osteoarthritis treatment
|
|
GB9924862D0
(en)
|
1999-10-20 |
1999-12-22 |
Celltech Therapeutics Ltd |
Chemical compounds
|
|
HRP20020751B1
(hr)
|
2000-02-15 |
2011-01-31 |
Sugen |
Pirolom supstituirani 2-indolinoni kao inhibitori protein kinaze
|
|
KR20030024659A
(ko)
*
|
2000-02-17 |
2003-03-26 |
암겐 인코포레이티드 |
키나제 억제제
|
|
US6440207B1
(en)
|
2000-03-03 |
2002-08-27 |
Bayer Corporation |
Method for preparing organic pigments
|
|
AU4876701A
(en)
|
2000-04-14 |
2001-10-30 |
Nippon Shinyaku Co. Ltd. |
Peptide derivatives and medicinal compositions
|
|
NZ522990A
(en)
|
2000-06-05 |
2003-08-29 |
Dong A Pharm |
Novel oxazolidinone derivatives and a process for the preparation thereof
|
|
AU7349801A
(en)
|
2000-07-19 |
2002-01-30 |
Warner Lambert Co |
Oxygenated esters of 4-iodo phenylamino benzhydroxamic acids
|
|
US6995162B2
(en)
|
2001-01-12 |
2006-02-07 |
Amgen Inc. |
Substituted alkylamine derivatives and methods of use
|
|
WO2002094766A1
(en)
|
2001-05-18 |
2002-11-28 |
Nihon Nohyaku Co., Ltd. |
Phthalamide derivative, agricultural or horticultural insecticide, and use thereof
|
|
WO2003003009A1
(en)
|
2001-06-29 |
2003-01-09 |
7Tm Pharma A/S |
Use of metal-ion chelates in validating biological molecules as drug targets in test animal models
|
|
US6939874B2
(en)
|
2001-08-22 |
2005-09-06 |
Amgen Inc. |
Substituted pyrimidinyl derivatives and methods of use
|
|
IL161576A0
(en)
|
2001-10-26 |
2004-09-27 |
Aventis Pharma Inc |
Benzimidazoles and analogues and their use as protein kinases inhibitors
|
|
US6897208B2
(en)
|
2001-10-26 |
2005-05-24 |
Aventis Pharmaceuticals Inc. |
Benzimidazoles
|
|
AU2002367087A1
(en)
|
2001-12-21 |
2003-07-15 |
7Tm Pharma A/S |
Method for the treatment of mc receptor related disorders with a chelate and/or a chelator
|
|
TWI329105B
(en)
|
2002-02-01 |
2010-08-21 |
Rigel Pharmaceuticals Inc |
2,4-pyrimidinediamine compounds and their uses
|
|
RU2343148C2
(ru)
|
2002-02-01 |
2009-01-10 |
Райджел Фармасьютикалз, Инк |
Соединения 2,4-пиримидиндиаминов и их применение
|
|
CA2478065C
(en)
|
2002-03-08 |
2013-01-08 |
Eisai Co. Ltd. |
Macrocyclic compounds useful as pharmaceuticals
|
|
SG2013013339A
(en)
|
2002-03-13 |
2014-12-30 |
Array Biopharma Inc |
N3 alkylated benzimidazole derivatives as mek inhibitors
|
|
GB0206215D0
(en)
|
2002-03-15 |
2002-05-01 |
Novartis Ag |
Organic compounds
|
|
GB0206860D0
(en)
|
2002-03-22 |
2002-05-01 |
Glaxo Group Ltd |
Compounds
|
|
DE60322857D1
(de)
|
2002-03-25 |
2008-09-25 |
Nippon Kayaku Kk |
Neues alpha-amino-n-(diaminophosphinyl)lactamderivat
|
|
AR039241A1
(es)
|
2002-04-04 |
2005-02-16 |
Biogen Inc |
Heteroarilos trisustituidos y metodos para su produccion y uso de los mismos
|
|
WO2003095448A1
(en)
|
2002-05-06 |
2003-11-20 |
Bayer Pharmaceuticals Corporation |
Pyridinyl amino pyrimidine derivatives useful for treating hyper-proliferative disorders
|
|
MXPA05000725A
(es)
|
2002-08-09 |
2005-04-08 |
Taisho Pharma Co Ltd |
Procedimiento para la produccion selectiva de aril-5-tio-??-d-aldohexopiranosidos.
|
|
UA80295C2
(en)
|
2002-09-06 |
2007-09-10 |
Biogen Inc |
Pyrazolopyridines and using the same
|
|
JP4608852B2
(ja)
|
2002-10-15 |
2011-01-12 |
チッソ株式会社 |
液晶性ビニルケトン誘導体およびその重合体
|
|
AU2003287880A1
(en)
|
2002-12-11 |
2004-06-30 |
7Tm Pharma A/S |
Cyclic quinoline compounds for use in mch receptor related disorders
|
|
ES2325440T3
(es)
|
2003-02-20 |
2009-09-04 |
Smithkline Beecham Corporation |
Compuestos de pirimidina.
|
|
BRPI0300660B8
(pt)
|
2003-02-28 |
2021-07-27 |
Fapesp Fund De Amparo A Pesquisa Do Estado De Sao Paulo |
método para quantificar liberação mitocondrial de citocromo c e kit para detectar liberação mitocondrial de citocromo c
|
|
GB0319227D0
(en)
*
|
2003-08-15 |
2003-09-17 |
Novartis Ag |
Organic compounds
|
|
GB0305929D0
(en)
|
2003-03-14 |
2003-04-23 |
Novartis Ag |
Organic compounds
|
|
CA2527024C
(en)
|
2003-05-28 |
2012-08-21 |
Paul Anziano |
Compositions and methods for inhibiting an isoform of human manganese superoxide dismutase
|
|
US20050070554A1
(en)
*
|
2003-08-27 |
2005-03-31 |
Amgen Inc. |
Substituted heterocyclic compounds and methods of use
|
|
AU2004272288B2
(en)
|
2003-09-18 |
2008-11-13 |
Novartis Ag |
2,4-di (phenylamino) pyrimidines useful in the treatment of proliferative disorders
|
|
WO2005082892A2
(en)
|
2004-02-17 |
2005-09-09 |
Dr. Reddy's Laboratories Ltd. |
Triazole compounds as antibacterial agents and pharmaceutical compositions containing them
|
|
CA2561311A1
(en)
|
2004-04-09 |
2005-10-27 |
Merck & Co., Inc. |
Inhibitors of akt activity
|
|
JP2008511631A
(ja)
|
2004-08-31 |
2008-04-17 |
バイオジェン・アイデック・エムエイ・インコーポレイテッド |
TGF−βインヒビターとしてのピリミジニルイミダゾール
|
|
US7786153B2
(en)
|
2005-03-02 |
2010-08-31 |
Abbott Laboratories Inc. |
Compounds that are useful for improving pharmacokinetics
|
|
JP2008540436A
(ja)
|
2005-05-03 |
2008-11-20 |
ライジェル ファーマシューティカルズ, インコーポレイテッド |
Jakキナーゼインヒビターおよびそれらの使用
|
|
WO2006124874A2
(en)
|
2005-05-12 |
2006-11-23 |
Kalypsys, Inc. |
Inhibitors of b-raf kinase
|
|
CA2612234C
(en)
|
2005-06-29 |
2010-09-21 |
Saint-Gobain Abrasives, Inc. |
High-performance resin for abrasive products
|
|
US20070032514A1
(en)
|
2005-07-01 |
2007-02-08 |
Zahn Stephan K |
2,4-diamino-pyrimidines as aurora inhibitors
|
|
MX2008002114A
(es)
|
2005-07-21 |
2008-04-17 |
Ardea Biosciences Inc |
Inhibidores de n-(arilamino)-sulfonamida de mek.
|
|
US8604042B2
(en)
|
2005-11-01 |
2013-12-10 |
Targegen, Inc. |
Bi-aryl meta-pyrimidine inhibitors of kinases
|
|
UA109411C2
(uk)
*
|
2005-11-01 |
2015-08-25 |
|
N-трет-бутил-3-(2-хлор-5-метилпіримідин-4-іламіно)бензолсульфонамід та його застосування в способі одержання сполуки
|
|
WO2007053452A1
(en)
|
2005-11-01 |
2007-05-10 |
Targegen, Inc. |
Bi-aryl meta-pyrimidine inhibitors of kinases
|
|
US8133900B2
(en)
|
2005-11-01 |
2012-03-13 |
Targegen, Inc. |
Use of bi-aryl meta-pyrimidine inhibitors of kinases
|
|
KR20080098490A
(ko)
|
2006-01-13 |
2008-11-10 |
파마시클릭스, 인코포레이티드 |
티로신 키나제 억제제 및 이의 용도
|
|
JO2660B1
(en)
|
2006-01-20 |
2012-06-17 |
نوفارتيس ايه جي |
Pi-3 inhibitors and methods of use
|
|
CN101421250A
(zh)
*
|
2006-01-30 |
2009-04-29 |
埃克塞里艾克西斯公司 |
作为jak-2调节剂的4-芳基-2-氨基-嘧啶或4-芳基-2-氨基烷基-嘧啶及包含它们的药物组合物
|
|
EA200870217A1
(ru)
|
2006-01-30 |
2009-02-27 |
Экселиксис, Инк. |
4-арил-2-аминопиримидины или 4-арил-2-аминоалкилпиримидины в качестве модуляторов jak-2 и содержащие их фармацевтические композиции
|
|
WO2007098507A2
(en)
|
2006-02-24 |
2007-08-30 |
Rigel Pharmaceuticals, Inc. |
Compositions and methods for inhibition of the jak pathway
|
|
CA2652385A1
(en)
|
2006-06-08 |
2007-12-21 |
Eli Lilly And Company |
Novel mch receptor antagonists
|
|
AU2007257650A1
(en)
*
|
2006-06-15 |
2007-12-21 |
Boehringer Ingelheim International Gmbh |
2-anilino-4-(heterocyclic)amino-pyrimidines as inhibitors of protein kinase C-alpha
|
|
EP2529621B1
(en)
|
2006-09-22 |
2016-10-05 |
Pharmacyclics LLC |
Inhibitors of bruton's tyrosine kinase
|
|
MX2009004426A
(es)
|
2006-10-23 |
2009-08-12 |
Cephalon Inc |
Derivados biciclicos fusionados de 2,4-diaminopirimidina como inhibidores alk y c-met.
|
|
WO2008054827A2
(en)
|
2006-11-03 |
2008-05-08 |
Pharmacyclics, Inc. |
Bruton's tyrosine kinase activity probe and method of using
|
|
PE20081636A1
(es)
|
2007-01-26 |
2009-01-10 |
Smithkline Beecham Corp |
Inhibidores de antranilamida para aurora quinasa
|
|
CA2702647C
(en)
|
2007-01-31 |
2016-03-22 |
Ym Biosciences Australia Pty Ltd |
Thiopyrimidine-based compounds and uses thereof
|
|
MX2009009117A
(es)
|
2007-03-01 |
2009-09-03 |
Supergen Inc |
Derivados de pirimidin-2,4-diamina y su uso como inhibidores de la cinasa jak2.
|
|
CN101657431A
(zh)
|
2007-03-01 |
2010-02-24 |
休普基因公司 |
嘧啶-2,4-二胺衍生物及其作为jak2激酶抑制剂的用途
|
|
US7947698B2
(en)
*
|
2007-03-23 |
2011-05-24 |
Rigel Pharmaceuticals, Inc. |
Compositions and methods for inhibition of the JAK pathway
|
|
WO2008118823A2
(en)
|
2007-03-26 |
2008-10-02 |
Rigel Pharmaceuticals, Inc. |
Compositions and methods for inhibition of the jak pathway
|
|
US8809273B2
(en)
|
2007-03-28 |
2014-08-19 |
Pharmacyclics, Inc. |
Inhibitors of Bruton's tyrosine kinase
|
|
WO2008124085A2
(en)
|
2007-04-03 |
2008-10-16 |
Exelixis, Inc. |
Methods of using combinations of mek and jak-2 inhibitors
|
|
AU2008240188A1
(en)
|
2007-04-13 |
2008-10-23 |
Supergen, Inc. |
Axl kinase inhibitors useful for the treatment of cancer or hyperproliferative disorders
|
|
CA2686378C
(en)
|
2007-05-04 |
2012-07-24 |
Irm Llc |
Pyrimidine derivatives and compositions as c-kit and pdgfr kinase inhibitors
|
|
WO2009010794A1
(en)
|
2007-07-19 |
2009-01-22 |
Astrazeneca Ab |
2,4-diamino-pyrimidine derivatives
|
|
BRPI0816769A2
(pt)
|
2007-09-12 |
2016-11-29 |
Hoffmann La Roche |
combinações de compostos inibidores de fosfoinositida 3-cinase e agentes quimioterapêuticos, e métodos de uso
|
|
WO2009055730A1
(en)
|
2007-10-25 |
2009-04-30 |
Genentech, Inc. |
Process for making thienopyrimidine compounds
|
|
CA2710118A1
(en)
*
|
2007-12-20 |
2009-07-02 |
Cellzome Limited |
Sulfamides as zap-70 inhibitors
|
|
JP2011523646A
(ja)
*
|
2008-05-21 |
2011-08-18 |
アリアド・ファーマシューティカルズ・インコーポレイテッド |
キナーゼ阻害剤としてのリン誘導体
|
|
WO2009158431A2
(en)
*
|
2008-06-25 |
2009-12-30 |
Irm Llc |
Compounds and compositions as kinase inhibitors
|
|
AU2009262068C1
(en)
|
2008-06-27 |
2015-07-02 |
Celgene Car Llc |
Heteroaryl compounds and uses thereof
|
|
US8338439B2
(en)
|
2008-06-27 |
2012-12-25 |
Celgene Avilomics Research, Inc. |
2,4-disubstituted pyrimidines useful as kinase inhibitors
|
|
CN102159214A
(zh)
|
2008-07-16 |
2011-08-17 |
药品循环公司 |
用于实体肿瘤的治疗的布鲁顿酪氨酸激酶的抑制剂
|
|
US20110257171A1
(en)
|
2008-07-18 |
2011-10-20 |
Sanofi-Aventis |
Novel imidazo[1,2-a]pyridine derivatives, method for the preparation thereof, use thereof as medicaments, pharmaceutical compositions and novel use in particular as met inhibitors
|
|
US20100029675A1
(en)
|
2008-07-25 |
2010-02-04 |
Hwang Soo-In |
Pyrimidine-2, 4-diamine JAK2 Kinase inhibiting anti-inflammation use
|
|
BRPI0917575A2
(pt)
*
|
2008-08-05 |
2019-09-24 |
Targegen Inc |
métodos de tratamento de talassemia
|
|
PL2389372T3
(pl)
|
2009-01-23 |
2016-02-29 |
Rigel Pharmaceuticals Inc |
Kompozycje i sposoby hamowania szlaku JAK
|
|
SG172857A1
(en)
|
2009-02-09 |
2011-08-29 |
Supergen Inc |
Pyrrolopyrimidinyl axl kinase inhibitors
|
|
WO2010118986A1
(en)
|
2009-04-14 |
2010-10-21 |
Cellzome Limited |
Fluoro substituted pyrimidine compounds as jak3 inhibitors
|
|
KR20120063515A
(ko)
|
2009-09-09 |
2012-06-15 |
아빌라 테라퓨틱스, 인크. |
Pi3 키나제 억제제 및 이들의 용도
|
|
CN102713618B
(zh)
|
2009-09-16 |
2015-07-15 |
新基阿维罗米克斯研究公司 |
蛋白激酶复合物和抑制剂
|
|
US7741330B1
(en)
|
2009-10-12 |
2010-06-22 |
Pharmacyclics, Inc. |
Pyrazolo-pyrimidine inhibitors of Bruton's tyrosine kinase
|
|
KR20120114224A
(ko)
|
2009-10-12 |
2012-10-16 |
마이렉시스 인코포레이티드 |
Ikk 엡실론 및/또는 tbk1의 억제제로서의 아미노-피리미딘 화합물
|
|
PH12012501532A1
(en)
|
2010-01-29 |
2012-10-22 |
Otsuka Pharma Co Ltd |
Di-substituted pyridine derivatives as anticancers
|
|
WO2011106168A1
(en)
|
2010-02-24 |
2011-09-01 |
Dcam Pharma Inc |
Purine compounds for treating autoimmune and demyelinating diseases
|
|
WO2011121223A1
(fr)
|
2010-03-30 |
2011-10-06 |
Sanofi-Aventis |
Derives de 6-(alkyl- ou cycloalkyl-triazolopyridazine-sulfanyl) benzothiazoles: preparation, application comme medicaments et utilisation comme inhibiteurs de met
|
|
MX380504B
(es)
|
2010-06-03 |
2025-03-12 |
Pharmacyclics Llc |
El uso de inhibidores de la tirosina quinasa de bruton (btk).
|
|
CN103080136B
(zh)
|
2010-06-18 |
2015-08-12 |
霍夫曼-拉罗奇有限公司 |
抗Axl抗体及使用方法
|
|
US9249124B2
(en)
|
2011-03-30 |
2016-02-02 |
H. Lee Moffitt Cancer Center And Research Institute, Inc. |
Aurora kinase inhibitors and methods of making and using thereof
|
|
EP2694486B1
(en)
|
2011-04-01 |
2018-01-10 |
University of Utah Research Foundation |
Substituted n-(3-(pyrimidin-4-yl)phenyl)acrylamide analogs as tyrosine receptor kinase btk inhibitors
|
|
EP3628665B1
(en)
|
2011-04-01 |
2022-11-02 |
University of Utah Research Foundation |
Substituted n-phenylpyrimidin-2-amine analogs as inhibitors of the axl kinase
|
|
CN106822153B
(zh)
|
2011-06-06 |
2019-12-17 |
爱荷华大学研究基金会 |
用于抑制肌萎缩的方法
|
|
KR20140048968A
(ko)
|
2011-07-13 |
2014-04-24 |
파마시클릭스, 인코포레이티드 |
브루톤형 티로신 키나제의 억제제
|
|
US20140303191A1
(en)
|
2011-10-19 |
2014-10-09 |
Pharmacyclics, Inc. |
Use of inhibitors of bruton's tyrosine kinase (btk)
|
|
CN103087077B
(zh)
|
2011-11-03 |
2016-05-18 |
上海希迈医药科技有限公司 |
噻吩并嘧啶和呋喃并嘧啶类衍生物、其制备方法及其在医药上的应用
|
|
US8377946B1
(en)
|
2011-12-30 |
2013-02-19 |
Pharmacyclics, Inc. |
Pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine compounds as kinase inhibitors
|
|
US8501724B1
(en)
|
2012-01-31 |
2013-08-06 |
Pharmacyclics, Inc. |
Purinone compounds as kinase inhibitors
|
|
WO2013173518A1
(en)
|
2012-05-16 |
2013-11-21 |
Pharmacyclics, Inc. |
Inhibitors of bruton's tyrosine kinase
|
|
MA37711A1
(fr)
|
2012-06-04 |
2017-05-31 |
Pharmacyclics Inc |
Formes cristallines d'un inhibiteur de tyrosine kinase de bruton
|
|
HK1206073A1
(en)
|
2012-07-24 |
2015-12-31 |
药品循环有限责任公司 |
Mutations associated with resistance to inhibitors of bruton's tyrosine kinase (btk)
|
|
US8703981B2
(en)
|
2012-08-03 |
2014-04-22 |
Xerox Corporation |
Lignosulfonate compounds for solid ink applications
|
|
HRP20170311T1
(hr)
|
2012-08-06 |
2017-04-21 |
Acea Biosciences Inc. |
Novi spojevi pirolopirimidina kao inhibitori protein kinaza
|
|
KR101446742B1
(ko)
|
2012-08-10 |
2014-10-01 |
한국화학연구원 |
N2,n4-비스(4-(피페라진-1-일)페닐)피리미딘-2,4-디아민 유도체 또는 이의 약학적으로 허용가능한 염 및 이를 유효성분으로 함유하는 암의 예방 또는 치료용 약학적 조성물
|
|
HK1212683A1
(zh)
|
2012-09-26 |
2016-06-17 |
Mannkind Corporation |
多个激酶途径抑制剂
|
|
KR20150084923A
(ko)
|
2012-11-15 |
2015-07-22 |
파마시클릭스, 인코포레이티드 |
키나제 억제제로서의 피롤로피리미딘 화합물
|
|
CN105188371A
(zh)
*
|
2013-02-08 |
2015-12-23 |
西建阿维拉米斯研究公司 |
Erk抑制剂及其用途
|
|
US10322125B2
(en)
|
2013-02-22 |
2019-06-18 |
Emory University |
TGF-beta enhancing compositions for cartilage repair and methods related thereto
|
|
US9708326B2
(en)
|
2013-02-25 |
2017-07-18 |
Pharmacyclics Llc |
Inhibitors of bruton's tyrosine kinase
|
|
EP2964651A4
(en)
|
2013-03-04 |
2016-11-30 |
Brigham & Womens Hospital |
BMP HEMMER AND METHOD OF USE THEREOF
|
|
PT2970205T
(pt)
|
2013-03-14 |
2019-08-26 |
Tolero Pharmaceuticals Inc |
Inibidores da jak2 e da alk2 e métodos para a sua utilização
|
|
AU2014244518A1
(en)
|
2013-03-14 |
2015-09-17 |
Pharmacyclics Llc |
Combinations of Bruton's tyrosine kinase inhibitors and CYP3A4 inhibitors
|
|
WO2014143659A1
(en)
|
2013-03-15 |
2014-09-18 |
Araxes Pharma Llc |
Irreversible covalent inhibitors of the gtpase k-ras g12c
|
|
TW201524952A
(zh)
|
2013-03-15 |
2015-07-01 |
Araxes Pharma Llc |
Kras g12c之共價抑制劑
|
|
US20160287592A1
(en)
|
2013-04-08 |
2016-10-06 |
Pharmacyclics Llc |
Ibrutinib combination therapy
|
|
EP3016953A4
(en)
|
2013-07-02 |
2017-03-01 |
Pharmacyclics, LLC |
Purinone compounds as kinase inhibitors
|
|
CN105764896A
(zh)
|
2013-09-30 |
2016-07-13 |
药品循环有限责任公司 |
布鲁顿氏酪氨酸激酶的抑制剂
|
|
MX380928B
(es)
|
2013-10-10 |
2025-03-12 |
Araxes Pharma Llc |
Inhibidores de kras g12c.
|
|
JP6525236B2
(ja)
|
2014-09-01 |
2019-06-05 |
能美防災株式会社 |
減光式煙検知器
|
|
CA2971415A1
(en)
|
2014-12-23 |
2016-06-30 |
Shawn P. Allwein |
Methods for preparing fused bicyclic 2, 4-diaminopyrimidine derivatives
|
|
WO2016146651A1
(en)
|
2015-03-16 |
2016-09-22 |
Oncodesign Sa |
Macrocyclic activin-like receptor kinase inhibitors
|
|
EP3283475B1
(en)
|
2015-04-16 |
2019-10-16 |
Merck Patent GmbH |
3-(1h-benzimidazol-2-yl)-1h-pyridin-2-one derivatives
|
|
HUE045585T2
(hu)
|
2015-05-18 |
2020-01-28 |
Tolero Pharmaceuticals Inc |
Megnövelt biológiai hozzáférhetõséggel rendelkezõ Alvocidib gyógyszer-elõanyagok
|
|
FI3442977T3
(fi)
|
2016-04-15 |
2023-09-26 |
Blueprint Medicines Corp |
Aktiviinireseptorin kaltaisen kinaasin estäjät
|
|
EP3564232B1
(en)
|
2016-12-27 |
2022-01-26 |
Riken |
Bmp-signal-inhibiting compound
|
|
AR112027A1
(es)
|
2017-06-15 |
2019-09-11 |
Biocryst Pharm Inc |
Inhibidores de alk 2 quinasa que contienen imidazol
|
|
BR112020020246A8
(pt)
|
2018-04-05 |
2022-10-18 |
Sumitomo Dainippon Pharma Oncology Inc |
Inibidores de cinase axl e uso dos mesmos
|
|
KR20210038906A
(ko)
|
2018-07-26 |
2021-04-08 |
스미토모 다이니폰 파마 온콜로지, 인크. |
비정상적 acvr1 발현과 연관된 질환을 치료하는 방법 및 그에 사용하기 위한 acvr1 억제제
|