|
US2779780A
(en)
|
1955-03-01 |
1957-01-29 |
Du Pont |
1, 4-diamino-2, 3-dicyano-1, 4-bis (substituted mercapto) butadienes and their preparation
|
|
GB8827305D0
(en)
|
1988-11-23 |
1988-12-29 |
British Bio Technology |
Compounds
|
|
FI941572L
(fi)
|
1991-10-07 |
1994-05-27 |
Oncologix Inc |
Anti-erbB-2-monoklonaalisten vasta-aineiden yhdistelmä ja käyttömenetelmä
|
|
WO1993016185A2
(en)
|
1992-02-06 |
1993-08-19 |
Creative Biomolecules, Inc. |
Biosynthetic binding protein for cancer marker
|
|
US6177401B1
(en)
|
1992-11-13 |
2001-01-23 |
Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften |
Use of organic compounds for the inhibition of Flk-1 mediated vasculogenesis and angiogenesis
|
|
US5455258A
(en)
|
1993-01-06 |
1995-10-03 |
Ciba-Geigy Corporation |
Arylsulfonamido-substituted hydroxamic acids
|
|
EP0647450A1
(en)
|
1993-09-09 |
1995-04-12 |
BEHRINGWERKE Aktiengesellschaft |
Improved prodrugs for enzyme mediated activation
|
|
IL112248A0
(en)
|
1994-01-25 |
1995-03-30 |
Warner Lambert Co |
Tricyclic heteroaromatic compounds and pharmaceutical compositions containing them
|
|
US5521173A
(en)
|
1995-01-17 |
1996-05-28 |
American Home Products Corporation |
Tricyclic benzazepine vasopressin antagonists
|
|
US5863949A
(en)
|
1995-03-08 |
1999-01-26 |
Pfizer Inc |
Arylsulfonylamino hydroxamic acid derivatives
|
|
JP3053222B2
(ja)
|
1995-04-20 |
2000-06-19 |
ファイザー・インコーポレーテッド |
Ｍｍｐおよびｔｎｆ抑制剤としてのアリールスルホニルヒドロキサム酸誘導体
|
|
GB9508538D0
(en)
|
1995-04-27 |
1995-06-14 |
Zeneca Ltd |
Quinazoline derivatives
|
|
US5747498A
(en)
|
1996-05-28 |
1998-05-05 |
Pfizer Inc. |
Alkynyl and azido-substituted 4-anilinoquinazolines
|
|
US5880141A
(en)
|
1995-06-07 |
1999-03-09 |
Sugen, Inc. |
Benzylidene-Z-indoline compounds for the treatment of disease
|
|
GB9520822D0
(en)
|
1995-10-11 |
1995-12-13 |
Wellcome Found |
Therapeutically active compounds
|
|
GB9523675D0
(en)
*
|
1995-11-20 |
1996-01-24 |
Celltech Therapeutics Ltd |
Chemical compounds
|
|
GB9624482D0
(en)
|
1995-12-18 |
1997-01-15 |
Zeneca Phaema S A |
Chemical compounds
|
|
ATE225343T1
(de)
|
1995-12-20 |
2002-10-15 |
Hoffmann La Roche |
Matrix-metalloprotease inhibitoren
|
|
AU1618697A
(en)
|
1996-02-06 |
1997-08-28 |
Japan Tobacco Inc. |
Novel compounds and pharmaceutical use thereof
|
|
ES2169355T3
(es)
|
1996-03-05 |
2002-07-01 |
Astrazeneca Ab |
Derivados de 4-anilinoquinazolina.
|
|
JP3195756B2
(ja)
|
1996-07-04 |
2001-08-06 |
公子 吉水 |
潤滑補助体
|
|
EP0818442A3
(en)
|
1996-07-12 |
1998-12-30 |
Pfizer Inc. |
Cyclic sulphone derivatives as inhibitors of metalloproteinases and of the production of tumour necrosis factor
|
|
EA199900021A1
(ru)
|
1996-07-13 |
1999-08-26 |
Глаксо, Груп Лимитед |
Бициклические гетероароматические соединения в качестве ингибиторов протеинтирозинкиназы
|
|
HRP970371A2
(en)
|
1996-07-13 |
1998-08-31 |
Kathryn Jane Smith |
Heterocyclic compounds
|
|
DE69716916T2
(de)
|
1996-07-13 |
2003-07-03 |
Glaxo Group Ltd., Greenford |
Kondensierte heterozyklische verbindungen als protein kinase inhibitoren
|
|
CA2260898C
(en)
|
1996-07-18 |
2002-05-14 |
Pfizer Limited |
Phosphinate based inhibitors of matrix metalloproteases
|
|
PL331895A1
(en)
|
1996-08-23 |
1999-08-16 |
Pfizer |
Arylosulphonylamino derivatives of hydroxamic acid
|
|
ID18494A
(id)
|
1996-10-02 |
1998-04-16 |
Novartis Ag |
Turunan pirazola leburan dan proses pembuatannya
|
|
DZ2376A1
(fr)
|
1996-12-19 |
2002-12-28 |
Smithkline Beecham Plc |
Dérivés de sulfonamides nouveaux procédé pour leurpréparation et compositions pharmaceutiques les c ontenant.
|
|
DE69730151T2
(de)
|
1997-01-06 |
2005-08-04 |
Pfizer Inc. |
Cyclische sulfonderivate
|
|
AU721748B2
(en)
|
1997-02-03 |
2000-07-13 |
Pfizer Products Inc. |
Arylsulfonylamino hydroxamic acid derivatives
|
|
CA2279863A1
(en)
|
1997-02-07 |
1998-08-13 |
Pfizer Inc. |
N-hydroxy-beta-sulfonyl-propionamide derivatives and their use as inhibitors of matrix metalloproteinases
|
|
WO1998034918A1
(en)
|
1997-02-11 |
1998-08-13 |
Pfizer Inc. |
Arylsulfonyl hydroxamic acid derivatives
|
|
CA2289102A1
(en)
|
1997-05-07 |
1998-11-12 |
Sugen, Inc. |
2-indolinone derivatives as modulators of protein kinase activity
|
|
JP2002501532A
(ja)
|
1997-05-30 |
2002-01-15 |
メルク エンド カンパニー インコーポレーテッド |
新規血管形成阻害薬
|
|
US5835420A
(en)
|
1997-06-27 |
1998-11-10 |
Aplus Flash Technology, Inc. |
Node-precise voltage regulation for a MOS memory system
|
|
ID23668A
(id)
|
1997-08-08 |
2000-05-11 |
Pfizer Prod Inc |
Turunan asam ariloksiarilsulfonilamino hidroksamat
|
|
ATE368665T1
(de)
|
1997-08-22 |
2007-08-15 |
Astrazeneca Ab |
Oxindolylchinazolinderivate als angiogenesehemmer
|
|
JP2001518470A
(ja)
|
1997-09-26 |
2001-10-16 |
メルク エンド カムパニー インコーポレーテッド |
新規な血管形成阻害剤
|
|
WO1999024440A1
(en)
|
1997-11-11 |
1999-05-20 |
Pfizer Products Inc. |
Thienopyrimidine and thienopyridine derivatives useful as anticancer agents
|
|
GB9725782D0
(en)
|
1997-12-05 |
1998-02-04 |
Pfizer Ltd |
Therapeutic agents
|
|
RS49779B
(sr)
|
1998-01-12 |
2008-06-05 |
Glaxo Group Limited, |
Biciklična heteroaromatična jedinjenja kao inhibitori protein tirozin kinaze
|
|
GB9800575D0
(en)
|
1998-01-12 |
1998-03-11 |
Glaxo Group Ltd |
Heterocyclic compounds
|
|
GB9801690D0
(en)
|
1998-01-27 |
1998-03-25 |
Pfizer Ltd |
Therapeutic agents
|
|
GB2335781A
(en)
|
1998-03-24 |
1999-09-29 |
Soho Soundhouse Limited |
Method of selection of audio samples
|
|
JP4462654B2
(ja)
|
1998-03-26 |
2010-05-12 |
ソニー株式会社 |
映像素材選択装置及び映像素材選択方法
|
|
PA8469401A1
(es)
|
1998-04-10 |
2000-05-24 |
Pfizer Prod Inc |
Derivados biciclicos del acido hidroxamico
|
|
PA8469501A1
(es)
|
1998-04-10 |
2000-09-29 |
Pfizer Prod Inc |
Hidroxamidas del acido (4-arilsulfonilamino)-tetrahidropiran-4-carboxilico
|
|
IL139934A0
(en)
|
1998-05-29 |
2002-02-10 |
Sugen Inc |
Pyrrole substituted 2-indolinone derivatives and pharmaceutical compositions containing the same
|
|
UA60365C2
(uk)
|
1998-06-04 |
2003-10-15 |
Пфайзер Продактс Інк. |
Похідні ізотіазолу, спосіб їх одержання, фармацевтична композиція та спосіб лікування гіперпроліферативного захворювання у ссавця
|
|
DK1004578T3
(da)
|
1998-11-05 |
2004-06-28 |
Pfizer Prod Inc |
5-oxo-pyrrolidin-2-carboxylsyrehydroxamidderivater
|
|
IL143236A0
(en)
|
1998-12-16 |
2002-04-21 |
Warner Lambert Co |
Treatment of arthritis with mek inhibitors
|
|
UA71945C2
(en)
|
1999-01-27 |
2005-01-17 |
Pfizer Prod Inc |
Substituted bicyclic derivatives being used as anticancer agents
|
|
KR20010102073A
(ko)
|
1999-02-11 |
2001-11-15 |
실버스타인 아써 에이. |
항암제로 유용한 헤테로아릴-치환된 퀴놀린-2-온 유도체
|
|
US6511993B1
(en)
|
1999-06-03 |
2003-01-28 |
Kevin Neil Dack |
Metalloprotease inhibitors
|
|
CA2277654A1
(en)
*
|
1999-07-19 |
2001-01-19 |
Luxell Technologies Inc. |
Electroluminescent display packaging and method therefor
|
|
EP1081137A1
(en)
|
1999-08-12 |
2001-03-07 |
Pfizer Products Inc. |
Selective inhibitors of aggrecanase in osteoarthritis treatment
|
|
GB9924862D0
(en)
|
1999-10-20 |
1999-12-22 |
Celltech Therapeutics Ltd |
Chemical compounds
|
|
AR034118A1
(es)
|
2000-02-15 |
2004-02-04 |
Sugen Inc |
Compuestos de 2-indolinonas sustituidas con pirroles inhibidoras de proteinquinasas; sus composiciones farmaceuticas e intermediarios de sintesis
|
|
HUP0301117A3
(en)
|
2000-02-17 |
2004-01-28 |
Amgen Inc Thousand Oaks |
Imidazole derivatives kinase inhibitors, their use, process for their preparation and pharmaceutical compositions containing them
|
|
US6440207B1
(en)
|
2000-03-03 |
2002-08-27 |
Bayer Corporation |
Method for preparing organic pigments
|
|
US7163921B1
(en)
|
2000-04-14 |
2007-01-16 |
Nippon Shinyaku Co., Ltd. |
Peptide derivatives and medicinal compositions
|
|
BR0111280A
(pt)
|
2000-06-05 |
2003-06-10 |
Dong A Pharm Co Ltd |
Novos derivados de oxazolidinona e um processo para a preparação dos mesmos
|
|
WO2002006213A2
(en)
|
2000-07-19 |
2002-01-24 |
Warner-Lambert Company |
Oxygenated esters of 4-iodo phenylamino benzhydroxamic acids
|
|
US6995162B2
(en)
|
2001-01-12 |
2006-02-07 |
Amgen Inc. |
Substituted alkylamine derivatives and methods of use
|
|
WO2002094766A1
(en)
|
2001-05-18 |
2002-11-28 |
Nihon Nohyaku Co., Ltd. |
Phthalamide derivative, agricultural or horticultural insecticide, and use thereof
|
|
WO2003003009A1
(en)
|
2001-06-29 |
2003-01-09 |
7Tm Pharma A/S |
Use of metal-ion chelates in validating biological molecules as drug targets in test animal models
|
|
US6939874B2
(en)
*
|
2001-08-22 |
2005-09-06 |
Amgen Inc. |
Substituted pyrimidinyl derivatives and methods of use
|
|
JP5039268B2
(ja)
|
2001-10-26 |
2012-10-03 |
アベンティス・ファーマスーティカルズ・インコーポレイテツド |
ベンゾイミダゾールおよび類縁体および蛋白キナーゼ阻害剤としてのその使用
|
|
US6897208B2
(en)
|
2001-10-26 |
2005-05-24 |
Aventis Pharmaceuticals Inc. |
Benzimidazoles
|
|
WO2003055477A1
(en)
|
2001-12-21 |
2003-07-10 |
7Tm Pharma A/S |
Method for the treatment of mc receptor related disorders with a chelate and/or a chelator
|
|
TWI329105B
(en)
|
2002-02-01 |
2010-08-21 |
Rigel Pharmaceuticals Inc |
2,4-pyrimidinediamine compounds and their uses
|
|
RU2343148C2
(ru)
*
|
2002-02-01 |
2009-01-10 |
Райджел Фармасьютикалз, Инк |
Соединения 2,4-пиримидиндиаминов и их применение
|
|
US7799827B2
(en)
|
2002-03-08 |
2010-09-21 |
Eisai Co., Ltd. |
Macrocyclic compounds useful as pharmaceuticals
|
|
TWI343377B
(en)
|
2002-03-13 |
2011-06-11 |
Array Biopharma Inc |
N3 alkylated benzimidazole derivatives as mek inhibitors
|
|
GB0206215D0
(en)
|
2002-03-15 |
2002-05-01 |
Novartis Ag |
Organic compounds
|
|
GB0206860D0
(en)
|
2002-03-22 |
2002-05-01 |
Glaxo Group Ltd |
Compounds
|
|
ES2307916T3
(es)
|
2002-03-25 |
2008-12-01 |
Nippon Kayaku Kabushiki Kaisha |
Nuevo derivado de alfa-amino-n-(diaminofosfinil)lactama.
|
|
AR039241A1
(es)
|
2002-04-04 |
2005-02-16 |
Biogen Inc |
Heteroarilos trisustituidos y metodos para su produccion y uso de los mismos
|
|
AU2003231231A1
(en)
*
|
2002-05-06 |
2003-11-11 |
Bayer Pharmaceuticals Corporation |
Pyridinyl amino pyrimidine derivatives useful for treating hyper-proliferative disorders
|
|
AU2003254903B9
(en)
|
2002-08-09 |
2008-08-21 |
Taisho Pharmaceutical Co., Ltd. |
Method for selective preparation of aryl 5-thio-beta-D-aldohexopyranosides
|
|
UA80295C2
(en)
|
2002-09-06 |
2007-09-10 |
Biogen Inc |
Pyrazolopyridines and using the same
|
|
JP4608852B2
(ja)
|
2002-10-15 |
2011-01-12 |
チッソ株式会社 |
液晶性ビニルケトン誘導体およびその重合体
|
|
AU2003287878A1
(en)
|
2002-12-11 |
2004-06-30 |
7Tm Pharma A/S |
Quinoline compounds for use in mch receptor related disorders
|
|
DE602004021472D1
(en)
*
|
2003-02-20 |
2009-07-23 |
Smithkline Beecham Corp |
Pyrimiidinverbindungen
|
|
BRPI0300660B8
(pt)
|
2003-02-28 |
2021-07-27 |
Fapesp Fund De Amparo A Pesquisa Do Estado De Sao Paulo |
método para quantificar liberação mitocondrial de citocromo c e kit para detectar liberação mitocondrial de citocromo c
|
|
GB0319227D0
(en)
*
|
2003-08-15 |
2003-09-17 |
Novartis Ag |
Organic compounds
|
|
GB0305929D0
(en)
|
2003-03-14 |
2003-04-23 |
Novartis Ag |
Organic compounds
|
|
EP1636335B1
(en)
|
2003-05-28 |
2012-07-11 |
Mito Tek, LLC |
Compositions and methods for inhibiting an isoform of human manganese superoxide dismutase
|
|
US20050070554A1
(en)
*
|
2003-08-27 |
2005-03-31 |
Amgen Inc. |
Substituted heterocyclic compounds and methods of use
|
|
BRPI0414544A
(pt)
*
|
2003-09-18 |
2006-11-07 |
Novartis Ag |
2,4-di-(fenilamino) pirimidinas úteis no tratamento de transtornos proliferativos
|
|
WO2005082892A2
(en)
|
2004-02-17 |
2005-09-09 |
Dr. Reddy's Laboratories Ltd. |
Triazole compounds as antibacterial agents and pharmaceutical compositions containing them
|
|
EP1737843B1
(en)
|
2004-04-09 |
2011-02-23 |
Merck Sharp & Dohme Corp. |
Inhibitors of akt activity
|
|
EP1786802A1
(en)
|
2004-08-31 |
2007-05-23 |
Biogen Idec MA, Inc. |
Pyrimidinylimidazoles as tgf-beta inhibitors
|
|
US7786153B2
(en)
|
2005-03-02 |
2010-08-31 |
Abbott Laboratories Inc. |
Compounds that are useful for improving pharmacokinetics
|
|
US20060270694A1
(en)
|
2005-05-03 |
2006-11-30 |
Rigel Pharmaceuticals, Inc. |
JAK kinase inhibitors and their uses
|
|
WO2006124874A2
(en)
|
2005-05-12 |
2006-11-23 |
Kalypsys, Inc. |
Inhibitors of b-raf kinase
|
|
EP2295496A1
(en)
|
2005-06-29 |
2011-03-16 |
Saint-Gobain Abrasives, Inc. |
High performance resin for abrasive products
|
|
US20070032514A1
(en)
|
2005-07-01 |
2007-02-08 |
Zahn Stephan K |
2,4-diamino-pyrimidines as aurora inhibitors
|
|
WO2007014011A2
(en)
|
2005-07-21 |
2007-02-01 |
Ardea Biosciences, Inc. |
N-(arylamino)-sulfonamide inhibitors of mek
|
|
US7528143B2
(en)
|
2005-11-01 |
2009-05-05 |
Targegen, Inc. |
Bi-aryl meta-pyrimidine inhibitors of kinases
|
|
US8133900B2
(en)
|
2005-11-01 |
2012-03-13 |
Targegen, Inc. |
Use of bi-aryl meta-pyrimidine inhibitors of kinases
|
|
ZA200804083B
(en)
*
|
2005-11-01 |
2009-09-30 |
Targegen Inc |
Bi-aryl meta-pyrimidine inhibitors of kinases
|
|
US8604042B2
(en)
|
2005-11-01 |
2013-12-10 |
Targegen, Inc. |
Bi-aryl meta-pyrimidine inhibitors of kinases
|
|
BRPI0621027A2
(pt)
|
2006-01-13 |
2011-11-29 |
Pharmacyclics Inc |
composto, composição farmacêutica
|
|
JO2660B1
(en)
|
2006-01-20 |
2012-06-17 |
نوفارتيس ايه جي |
Pi-3 inhibitors and methods of use
|
|
CN101421250A
(zh)
*
|
2006-01-30 |
2009-04-29 |
埃克塞里艾克西斯公司 |
作为jak-2调节剂的4-芳基-2-氨基-嘧啶或4-芳基-2-氨基烷基-嘧啶及包含它们的药物组合物
|
|
KR20080110998A
(ko)
|
2006-01-30 |
2008-12-22 |
엑셀리시스, 인코포레이티드 |
Ｊａｋ２ 조절자로서 ４아릴２아미노피리미딘 또는 4아릴２아미노알킬피리미딘 및 이들을 포함하는 약제학적 조성물
|
|
JP2009528295A
(ja)
|
2006-02-24 |
2009-08-06 |
ライジェル ファーマシューティカルズ， インコーポレイテッド |
Ｊａｋ経路の阻害のための組成物および方法
|
|
CA2652385A1
(en)
|
2006-06-08 |
2007-12-21 |
Eli Lilly And Company |
Novel mch receptor antagonists
|
|
EP2054392A2
(en)
|
2006-06-15 |
2009-05-06 |
Boehringer Ingelheim International GmbH |
2-anilino-4-(heterocyclic)amino-pyrimidines as inhibitors of protein kinase c-alpha
|
|
PL2526933T3
(pl)
|
2006-09-22 |
2015-08-31 |
Pharmacyclics Llc |
Inhibitory kinazy tyrozynowej Brutona
|
|
ES2555803T3
(es)
|
2006-10-23 |
2016-01-08 |
Cephalon, Inc. |
Fusión de derivados bicíclicos 2,4-diaminopirimidina como utilizar inhibidores ALK y c-Met
|
|
ES2403546T3
(es)
|
2006-11-03 |
2013-05-20 |
Pharmacyclics, Inc. |
Sonda de actividad de la tirosina-cinasa de Bruton y procedimiento de utilización
|
|
TW200902010A
(en)
|
2007-01-26 |
2009-01-16 |
Smithkline Beecham Corp |
Anthranilamide inhibitors of aurora kinase
|
|
ES2702362T3
(es)
|
2007-01-31 |
2019-02-28 |
Ym Biosciences Australia Pty |
Compuestos a base de tiopirimidina y usos de los mismos
|
|
AU2008221278A1
(en)
*
|
2007-03-01 |
2008-09-04 |
Supergen, Inc. |
Pyrimidine-2,4-diamine derivatives and their use as JAK2 kinase inhibitors
|
|
CN101657431A
(zh)
|
2007-03-01 |
2010-02-24 |
休普基因公司 |
嘧啶-2，4-二胺衍生物及其作为jak2激酶抑制剂的用途
|
|
US7947698B2
(en)
*
|
2007-03-23 |
2011-05-24 |
Rigel Pharmaceuticals, Inc. |
Compositions and methods for inhibition of the JAK pathway
|
|
US7834024B2
(en)
|
2007-03-26 |
2010-11-16 |
Rigel Pharmaceuticals, Inc. |
Compositions and methods for inhibition of the JAK pathway
|
|
US20120101113A1
(en)
|
2007-03-28 |
2012-04-26 |
Pharmacyclics, Inc. |
Inhibitors of bruton's tyrosine kinase
|
|
WO2008124085A2
(en)
|
2007-04-03 |
2008-10-16 |
Exelixis, Inc. |
Methods of using combinations of mek and jak-2 inhibitors
|
|
CA2682733A1
(en)
|
2007-04-13 |
2008-10-23 |
Supergen, Inc. |
Axl kinase inhibitors
|
|
WO2008137605A1
(en)
|
2007-05-04 |
2008-11-13 |
Irm Llc |
Pyrimidine derivatives and compositions as c-kit and pdgfr kinase inhibitors
|
|
WO2009010794A1
(en)
|
2007-07-19 |
2009-01-22 |
Astrazeneca Ab |
2,4-diamino-pyrimidine derivatives
|
|
AU2008298948B2
(en)
|
2007-09-12 |
2014-09-04 |
F. Hoffmann-La Roche Ag |
Combinations of phosphoinositide 3-kinase inhibitor compounds and chemotherapeutic agents, and methods of use
|
|
EP2214675B1
(en)
|
2007-10-25 |
2013-11-20 |
Genentech, Inc. |
Process for making thienopyrimidine compounds
|
|
WO2009080638A2
(en)
*
|
2007-12-20 |
2009-07-02 |
Cellzome Limited |
Sulfamides as zap-70 inhibitors
|
|
EP2300013B2
(en)
*
|
2008-05-21 |
2024-11-13 |
Takeda Pharmaceutical Company Limited |
Phosphorous derivatives as kinase inhibitors
|
|
EP2331526A2
(en)
*
|
2008-06-25 |
2011-06-15 |
Irm Llc |
Pyrimidine derivatives as kinase inhibitors
|
|
US8338439B2
(en)
|
2008-06-27 |
2012-12-25 |
Celgene Avilomics Research, Inc. |
2,4-disubstituted pyrimidines useful as kinase inhibitors
|
|
NZ603525A
(en)
|
2008-06-27 |
2015-02-27 |
Celgene Avilomics Res Inc |
Pyrimidine based compound and uses thereof
|
|
CA2730930C
(en)
|
2008-07-16 |
2015-01-13 |
Pharmacyclics, Inc. |
Inhibitors of bruton's tyrosine kinase for the treatment of solid tumors
|
|
CA2730749A1
(fr)
|
2008-07-18 |
2010-01-21 |
Sanofi-Aventis |
Nouveaux derives imidazo[1,2-a]pyridine, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation notamment commeinhibiteurs de met
|
|
WO2010011349A2
(en)
|
2008-07-25 |
2010-01-28 |
Supergen, Inc. |
Pyrimidine-2,4-diamine jak2 kinase inhibiting anti-inflammation use
|
|
RU2011108563A
(ru)
|
2008-08-05 |
2012-09-10 |
Таргеджен, Инк. (US) |
Способы лечения талассемии
|
|
PL2389372T3
(pl)
|
2009-01-23 |
2016-02-29 |
Rigel Pharmaceuticals Inc |
Kompozycje i sposoby hamowania szlaku JAK
|
|
JP2012517426A
(ja)
|
2009-02-09 |
2012-08-02 |
アステックス ファーマシューティカルズ インコーポレイテッド |
ピロロピリミジニルａｘｌキナーゼ阻害剤
|
|
US20120040955A1
(en)
|
2009-04-14 |
2012-02-16 |
Richard John Harrison |
Fluoro substituted pyrimidine compounds as jak3 inhibitors
|
|
RU2595718C2
(ru)
|
2009-09-09 |
2016-08-27 |
Селджен Авиломикс Рисерч,Инк. |
Ингибиторы pi3-киназы и их применение
|
|
US9556426B2
(en)
|
2009-09-16 |
2017-01-31 |
Celgene Avilomics Research, Inc. |
Protein kinase conjugates and inhibitors
|
|
CN102791697A
(zh)
|
2009-10-12 |
2012-11-21 |
瑞科西有限公司 |
作为TBKL和/或IKKε抑制剂的氨基-嘧啶化合物
|
|
US7741330B1
(en)
|
2009-10-12 |
2010-06-22 |
Pharmacyclics, Inc. |
Pyrazolo-pyrimidine inhibitors of Bruton's tyrosine kinase
|
|
CN102791690B
(zh)
|
2010-01-29 |
2015-12-02 |
大塚制药株式会社 |
作为抗癌药的二取代吡啶衍生物
|
|
WO2011106168A1
(en)
|
2010-02-24 |
2011-09-01 |
Dcam Pharma Inc |
Purine compounds for treating autoimmune and demyelinating diseases
|
|
WO2011121223A1
(fr)
|
2010-03-30 |
2011-10-06 |
Sanofi-Aventis |
Derives de 6-(alkyl- ou cycloalkyl-triazolopyridazine-sulfanyl) benzothiazoles: preparation, application comme medicaments et utilisation comme inhibiteurs de met
|
|
NZ772688A
(en)
|
2010-06-03 |
2022-09-30 |
Pharmacyclics Llc |
The use of inhibitors of bruton’s tyrosine kinase (btk)
|
|
CA2794731C
(en)
|
2010-06-18 |
2019-03-19 |
Genentech, Inc. |
Anti-axl antibodies and methods of use
|
|
US9249124B2
(en)
|
2011-03-30 |
2016-02-02 |
H. Lee Moffitt Cancer Center And Research Institute, Inc. |
Aurora kinase inhibitors and methods of making and using thereof
|
|
EP3628665B1
(en)
|
2011-04-01 |
2022-11-02 |
University of Utah Research Foundation |
Substituted n-phenylpyrimidin-2-amine analogs as inhibitors of the axl kinase
|
|
US8703767B2
(en)
|
2011-04-01 |
2014-04-22 |
University Of Utah Research Foundation |
Substituted N-(3-(pyrimidin-4-yl)phenyl)acrylamide analogs as tyrosine receptor kinase BTK inhibitors
|
|
JP6001060B2
(ja)
|
2011-06-06 |
2016-10-05 |
ユニバーシティ オブ アイオワ リサーチ ファウンデーション |
筋萎縮を阻害するための方法
|
|
EA201490265A1
(ru)
|
2011-07-13 |
2014-12-30 |
Фармасайкликс, Инк. |
Ингибиторы тирозинкиназы брутона
|
|
CN110801454A
(zh)
|
2011-10-19 |
2020-02-18 |
药品循环有限责任公司 |
布鲁顿酪氨酸激酶(btk)抑制剂的用途
|
|
CN103087077B
(zh)
|
2011-11-03 |
2016-05-18 |
上海希迈医药科技有限公司 |
噻吩并嘧啶和呋喃并嘧啶类衍生物、其制备方法及其在医药上的应用
|
|
US8377946B1
(en)
|
2011-12-30 |
2013-02-19 |
Pharmacyclics, Inc. |
Pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine compounds as kinase inhibitors
|
|
US8501724B1
(en)
|
2012-01-31 |
2013-08-06 |
Pharmacyclics, Inc. |
Purinone compounds as kinase inhibitors
|
|
WO2013173518A1
(en)
|
2012-05-16 |
2013-11-21 |
Pharmacyclics, Inc. |
Inhibitors of bruton's tyrosine kinase
|
|
WO2013184572A1
(en)
|
2012-06-04 |
2013-12-12 |
Pharmacyclics, Inc. |
Crystalline forms of a bruton's tyrosine kinase inhibitor
|
|
AU2013293087B2
(en)
|
2012-07-24 |
2017-08-31 |
Pharmacyclics Llc |
Mutations associated with resistance to inhibitors of Bruton's tyrosine kinase (BTK)
|
|
US8703981B2
(en)
|
2012-08-03 |
2014-04-22 |
Xerox Corporation |
Lignosulfonate compounds for solid ink applications
|
|
ES2733576T3
(es)
|
2012-08-06 |
2019-12-02 |
Acea Therapeutics Inc |
Nuevos compuestos de pirrolopirimidina como inhibidores de proteína cinasas
|
|
KR101446742B1
(ko)
|
2012-08-10 |
2014-10-01 |
한국화학연구원 |
Ｎ2,ｎ4-비스(4-(피페라진-1-일)페닐)피리미딘-2,4-디아민 유도체 또는 이의 약학적으로 허용가능한 염 및 이를 유효성분으로 함유하는 암의 예방 또는 치료용 약학적 조성물
|
|
CN104812756A
(zh)
|
2012-09-26 |
2015-07-29 |
曼凯德公司 |
多激酶通路抑制剂
|
|
SG11201503842PA
(en)
|
2012-11-15 |
2015-06-29 |
Pharmacyclics Inc |
Pyrrolopyrimidine compounds as kinase inhibitors
|
|
US9561228B2
(en)
|
2013-02-08 |
2017-02-07 |
Celgene Avilomics Research, Inc. |
ERK inhibitors and uses thereof
|
|
US10322125B2
(en)
|
2013-02-22 |
2019-06-18 |
Emory University |
TGF-beta enhancing compositions for cartilage repair and methods related thereto
|
|
US9708326B2
(en)
|
2013-02-25 |
2017-07-18 |
Pharmacyclics Llc |
Inhibitors of bruton's tyrosine kinase
|
|
US20160115167A1
(en)
|
2013-03-04 |
2016-04-28 |
The Brigham And Women's Hospital, Inc. |
Bmp inhibitors and methods of use thereof
|
|
JP6433974B2
(ja)
|
2013-03-14 |
2018-12-05 |
トレロ ファーマシューティカルズ， インコーポレイテッド |
Ｊａｋ２およびａｌｋ２阻害剤およびその使用方法
|
|
EP2968341A4
(en)
|
2013-03-14 |
2016-11-23 |
Pharmacyclics Llc |
COMBINATIONS OF BURTON TYROSINE KINASE INHIBITORS AND CYP3A4 INHIBITORS
|
|
US9745319B2
(en)
|
2013-03-15 |
2017-08-29 |
Araxes Pharma Llc |
Irreversible covalent inhibitors of the GTPase K-Ras G12C
|
|
TW201524952A
(zh)
|
2013-03-15 |
2015-07-01 |
Araxes Pharma Llc |
Ｋｒａｓ ｇ１２ｃ之共價抑制劑
|
|
AU2014251028A1
(en)
|
2013-04-08 |
2015-11-05 |
Janssen Pharmaceutica Nv |
Ibrutinib combination therapy
|
|
US9637487B2
(en)
|
2013-07-02 |
2017-05-02 |
Pharmacyclics Llc |
Purinone compounds as kinase inhibitors
|
|
CA2925124A1
(en)
|
2013-09-30 |
2015-04-02 |
Pharmacyclics Llc |
Inhibitors of bruton's tyrosine kinase
|
|
JP6559123B2
(ja)
|
2013-10-10 |
2019-08-14 |
アラクセス ファーマ エルエルシー |
Ｋｒａｓｇ１２ｃの阻害剤
|
|
JP6525236B2
(ja)
|
2014-09-01 |
2019-06-05 |
能美防災株式会社 |
減光式煙検知器
|
|
WO2016105529A1
(en)
|
2014-12-23 |
2016-06-30 |
Cephalon, Inc. |
Methods for preparing fused bicyclic 2, 4-diaminopyrimidine derivatives
|
|
WO2016146651A1
(en)
|
2015-03-16 |
2016-09-22 |
Oncodesign Sa |
Macrocyclic activin-like receptor kinase inhibitors
|
|
CA2982664A1
(en)
|
2015-04-16 |
2016-10-20 |
Merck Patent Gmbh |
3-(1h-benzimidazol-2-yl)-1h-pyridin-2-one derivatives
|
|
PL3298021T3
(pl)
|
2015-05-18 |
2019-11-29 |
Tolero Pharmaceuticals Inc |
Proleki alvocidibu o zwiększonej biodostępności
|
|
FI3442977T3
(fi)
|
2016-04-15 |
2023-09-26 |
Blueprint Medicines Corp |
Aktiviinireseptorin kaltaisen kinaasin estäjät
|
|
WO2018124001A1
(ja)
|
2016-12-27 |
2018-07-05 |
国立研究開発法人理化学研究所 |
Ｂｍｐシグナル阻害化合物
|
|
AR112027A1
(es)
|
2017-06-15 |
2019-09-11 |
Biocryst Pharm Inc |
Inhibidores de alk 2 quinasa que contienen imidazol
|
|
BR112020020246A8
(pt)
|
2018-04-05 |
2022-10-18 |
Sumitomo Dainippon Pharma Oncology Inc |
Inibidores de cinase axl e uso dos mesmos
|
|
WO2020023910A1
(en)
|
2018-07-26 |
2020-01-30 |
Tolero Pharmaceuticals, Inc. |
Methods for treating diseases associated with abnormal acvr1 expression and acvr1 inhibitors for use in the same
|