JP2013056930A5 - - Google Patents
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- JP2013056930A5 JP2013056930A5 JP2012257150A JP2012257150A JP2013056930A5 JP 2013056930 A5 JP2013056930 A5 JP 2013056930A5 JP 2012257150 A JP2012257150 A JP 2012257150A JP 2012257150 A JP2012257150 A JP 2012257150A JP 2013056930 A5 JP2013056930 A5 JP 2013056930A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- cancer
- substituted
- unsubstituted
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims 36
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 27
- 208000035475 disorder Diseases 0.000 claims 23
- 239000008194 pharmaceutical composition Substances 0.000 claims 23
- 125000000217 alkyl group Chemical group 0.000 claims 21
- 150000003839 salts Chemical class 0.000 claims 16
- RGICCULPCWNRAB-UHFFFAOYSA-N 2-[2-(2-hexoxyethoxy)ethoxy]ethanol Chemical compound CCCCCCOCCOCCOCCO RGICCULPCWNRAB-UHFFFAOYSA-N 0.000 claims 12
- 229910052799 carbon Inorganic materials 0.000 claims 12
- 239000012453 solvate Substances 0.000 claims 12
- 208000014767 Myeloproliferative disease Diseases 0.000 claims 11
- 201000007224 Myeloproliferative neoplasm Diseases 0.000 claims 11
- 125000000623 heterocyclic group Chemical group 0.000 claims 9
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 8
- 125000003118 aryl group Chemical group 0.000 claims 8
- 125000001072 heteroaryl group Chemical group 0.000 claims 8
- 206010028980 Neoplasm Diseases 0.000 claims 7
- 201000011510 cancer Diseases 0.000 claims 7
- 229910052739 hydrogen Inorganic materials 0.000 claims 7
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 6
- 101000997832 Homo sapiens Tyrosine-protein kinase JAK2 Proteins 0.000 claims 6
- 102100033444 Tyrosine-protein kinase JAK2 Human genes 0.000 claims 6
- 208000032839 leukemia Diseases 0.000 claims 6
- 208000032027 Essential Thrombocythemia Diseases 0.000 claims 5
- 206010061218 Inflammation Diseases 0.000 claims 5
- 108091000080 Phosphotransferase Proteins 0.000 claims 5
- 201000004681 Psoriasis Diseases 0.000 claims 5
- 208000036142 Viral infection Diseases 0.000 claims 5
- 208000017733 acquired polycythemia vera Diseases 0.000 claims 5
- 230000004054 inflammatory process Effects 0.000 claims 5
- 229910052757 nitrogen Inorganic materials 0.000 claims 5
- 102000020233 phosphotransferase Human genes 0.000 claims 5
- 208000037244 polycythemia vera Diseases 0.000 claims 5
- 230000009385 viral infection Effects 0.000 claims 5
- 125000004103 aminoalkyl group Chemical group 0.000 claims 4
- 230000033115 angiogenesis Effects 0.000 claims 4
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 208000030533 eye disease Diseases 0.000 claims 4
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 208000003476 primary myelofibrosis Diseases 0.000 claims 4
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 3
- 206010012689 Diabetic retinopathy Diseases 0.000 claims 3
- 102000001253 Protein Kinase Human genes 0.000 claims 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 3
- 125000000753 cycloalkyl group Chemical group 0.000 claims 3
- 229910052736 halogen Inorganic materials 0.000 claims 3
- 150000002367 halogens Chemical class 0.000 claims 3
- 201000007914 proliferative diabetic retinopathy Diseases 0.000 claims 3
- 108060006633 protein kinase Proteins 0.000 claims 3
- SNOOUWRIMMFWNE-UHFFFAOYSA-M sodium;6-[(3,4,5-trimethoxybenzoyl)amino]hexanoate Chemical compound [Na+].COC1=CC(C(=O)NCCCCCC([O-])=O)=CC(OC)=C1OC SNOOUWRIMMFWNE-UHFFFAOYSA-M 0.000 claims 3
- 239000000126 substance Substances 0.000 claims 3
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 2
- PKTQHWKZGFKXGT-UHFFFAOYSA-N 3-bromo-n-tert-butylbenzenesulfonamide Chemical compound CC(C)(C)NS(=O)(=O)C1=CC=CC(Br)=C1 PKTQHWKZGFKXGT-UHFFFAOYSA-N 0.000 claims 2
- OTYZNDKWNPQQJP-UHFFFAOYSA-N 4-(2-pyrrolidin-1-ylethoxy)aniline Chemical compound C1=CC(N)=CC=C1OCCN1CCCC1 OTYZNDKWNPQQJP-UHFFFAOYSA-N 0.000 claims 2
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 claims 2
- 206010005003 Bladder cancer Diseases 0.000 claims 2
- 206010005949 Bone cancer Diseases 0.000 claims 2
- 208000018084 Bone neoplasm Diseases 0.000 claims 2
- 208000003174 Brain Neoplasms Diseases 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 2
- 208000026310 Breast neoplasm Diseases 0.000 claims 2
- 206010009944 Colon cancer Diseases 0.000 claims 2
- 206010017993 Gastrointestinal neoplasms Diseases 0.000 claims 2
- 102000042838 JAK family Human genes 0.000 claims 2
- 108091082332 JAK family Proteins 0.000 claims 2
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 2
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 2
- 206010025323 Lymphomas Diseases 0.000 claims 2
- 208000002231 Muscle Neoplasms Diseases 0.000 claims 2
- 206010033128 Ovarian cancer Diseases 0.000 claims 2
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 2
- 206010060862 Prostate cancer Diseases 0.000 claims 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 2
- 206010038389 Renal cancer Diseases 0.000 claims 2
- 208000000453 Skin Neoplasms Diseases 0.000 claims 2
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 125000000304 alkynyl group Chemical group 0.000 claims 2
- 208000029742 colonic neoplasm Diseases 0.000 claims 2
- 239000012043 crude product Substances 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 230000002496 gastric effect Effects 0.000 claims 2
- 125000005842 heteroatom Chemical group 0.000 claims 2
- 150000004677 hydrates Chemical class 0.000 claims 2
- 201000010982 kidney cancer Diseases 0.000 claims 2
- 201000007270 liver cancer Diseases 0.000 claims 2
- 208000014018 liver neoplasm Diseases 0.000 claims 2
- 201000005202 lung cancer Diseases 0.000 claims 2
- 208000020816 lung neoplasm Diseases 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 201000002077 muscle cancer Diseases 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 230000037361 pathway Effects 0.000 claims 2
- 201000000849 skin cancer Diseases 0.000 claims 2
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 2
- 201000005112 urinary bladder cancer Diseases 0.000 claims 2
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 1
- 208000010833 Chronic myeloid leukaemia Diseases 0.000 claims 1
- 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 claims 1
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims 1
- 208000017442 Retinal disease Diseases 0.000 claims 1
- 206010038923 Retinopathy Diseases 0.000 claims 1
- 125000002252 acyl group Chemical group 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 239000002260 anti-inflammatory agent Substances 0.000 claims 1
- 229940121363 anti-inflammatory agent Drugs 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- -1 cyano, nitro, amino Chemical group 0.000 claims 1
- 125000004122 cyclic group Chemical group 0.000 claims 1
- 229940127089 cytotoxic agent Drugs 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 239000002955 immunomodulating agent Substances 0.000 claims 1
- 229940121354 immunomodulator Drugs 0.000 claims 1
- 230000002584 immunomodulator Effects 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 125000005254 oxyacyl group Chemical group 0.000 claims 1
- 230000002062 proliferating effect Effects 0.000 claims 1
- 230000012743 protein tagging Effects 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 125000000547 substituted alkyl group Chemical group 0.000 claims 1
- PXQLVRUNWNTZOS-UHFFFAOYSA-N sulfanyl Chemical class [SH] PXQLVRUNWNTZOS-UHFFFAOYSA-N 0.000 claims 1
- 229940124530 sulfonamide Drugs 0.000 claims 1
- 150000003456 sulfonamides Chemical group 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- KSPFHLWLBKZTOF-UHFFFAOYSA-N CC(C)(C)c1cccc(Nc2nc(Cl)ncc2C)c1 Chemical compound CC(C)(C)c1cccc(Nc2nc(Cl)ncc2C)c1 KSPFHLWLBKZTOF-UHFFFAOYSA-N 0.000 description 1
- XIJQDWHJGDTTCL-UHFFFAOYSA-N CC(CCCC1)N1S(c1cccc(Nc2c(C)cnc(Nc(cc3)ccc3N3CCN(C)CC3)n2)c1)(=O)=O Chemical compound CC(CCCC1)N1S(c1cccc(Nc2c(C)cnc(Nc(cc3)ccc3N3CCN(C)CC3)n2)c1)(=O)=O XIJQDWHJGDTTCL-UHFFFAOYSA-N 0.000 description 1
- RBGUWESBYDZRLM-UHFFFAOYSA-N CC[ClH]c1ncc(C)c(N(C)c(cc2OC)ccc2Cl)n1 Chemical compound CC[ClH]c1ncc(C)c(N(C)c(cc2OC)ccc2Cl)n1 RBGUWESBYDZRLM-UHFFFAOYSA-N 0.000 description 1
- AVOXKMWHDSJKEV-UHFFFAOYSA-N Cc(c(Nc(cc1)ccc1Cl)n1)cnc1Cl Chemical compound Cc(c(Nc(cc1)ccc1Cl)n1)cnc1Cl AVOXKMWHDSJKEV-UHFFFAOYSA-N 0.000 description 1
- PFLCSLXLQSDNBS-UHFFFAOYSA-N Cc(c(Nc(cc1C(F)(F)F)ccc1Cl)n1)cnc1Cl Chemical compound Cc(c(Nc(cc1C(F)(F)F)ccc1Cl)n1)cnc1Cl PFLCSLXLQSDNBS-UHFFFAOYSA-N 0.000 description 1
- VPMZIKZXZUQGRU-UHFFFAOYSA-N Cc(c(Nc(cc1F)ccc1Cl)n1)cnc1Cl Chemical compound Cc(c(Nc(cc1F)ccc1Cl)n1)cnc1Cl VPMZIKZXZUQGRU-UHFFFAOYSA-N 0.000 description 1
- QQVVBQCECZMBDI-UHFFFAOYSA-N Cc(c(Nc1cc(OC)cc(OC)c1)n1)cnc1Cl Chemical compound Cc(c(Nc1cc(OC)cc(OC)c1)n1)cnc1Cl QQVVBQCECZMBDI-UHFFFAOYSA-N 0.000 description 1
- OQJZGYXSRKRKLL-UHFFFAOYSA-N Cc(cn1)c(Nc2ccc3[s]ccc3c2)nc1Cl Chemical compound Cc(cn1)c(Nc2ccc3[s]ccc3c2)nc1Cl OQJZGYXSRKRKLL-UHFFFAOYSA-N 0.000 description 1
- ULUSYRCRCJWMKH-UHFFFAOYSA-N Cc1c(NCc(cc2)c(cc[nH]3)c3c2Cl)nc(Nc(cc2)ccc2N2CCN(C)CC2)nc1 Chemical compound Cc1c(NCc(cc2)c(cc[nH]3)c3c2Cl)nc(Nc(cc2)ccc2N2CCN(C)CC2)nc1 ULUSYRCRCJWMKH-UHFFFAOYSA-N 0.000 description 1
- VRYMNQOAQGCOKO-UHFFFAOYSA-N Cc1c(Nc(cc2)c(cc[nH]3)c3c2Cl)nc(Nc(cc2)ccc2OCCN2CCCC2)nc1 Chemical compound Cc1c(Nc(cc2)c(cc[nH]3)c3c2Cl)nc(Nc(cc2)ccc2OCCN2CCCC2)nc1 VRYMNQOAQGCOKO-UHFFFAOYSA-N 0.000 description 1
- KMTZHIZUSJJWHH-UHFFFAOYSA-N Cc1c(Nc2c(cc[nH]3)c3ccc2)nc(Nc2ccc(CN3CCNCC3)cc2)nc1 Chemical compound Cc1c(Nc2c(cc[nH]3)c3ccc2)nc(Nc2ccc(CN3CCNCC3)cc2)nc1 KMTZHIZUSJJWHH-UHFFFAOYSA-N 0.000 description 1
- JQMLLWAZWNUCKB-UHFFFAOYSA-N Cc1c(Nc2c(cc[nH]3)c3ccc2)nc(Nc2ccc(CN3CCOCC3)cc2)nc1 Chemical compound Cc1c(Nc2c(cc[nH]3)c3ccc2)nc(Nc2ccc(CN3CCOCC3)cc2)nc1 JQMLLWAZWNUCKB-UHFFFAOYSA-N 0.000 description 1
- FYEZWBSZYDCHCA-UHFFFAOYSA-N Cc1cc(C)cc(Nc2nc(Cl)ncc2C)c1 Chemical compound Cc1cc(C)cc(Nc2nc(Cl)ncc2C)c1 FYEZWBSZYDCHCA-UHFFFAOYSA-N 0.000 description 1
- HZYKTMNELNYUID-UHFFFAOYSA-N Cc1cnc(Nc(cc2)ccc2N2CCN(C)CC2)nc1Nc1cc(S(N2CCCC2)(=O)=O)ccc1 Chemical compound Cc1cnc(Nc(cc2)ccc2N2CCN(C)CC2)nc1Nc1cc(S(N2CCCC2)(=O)=O)ccc1 HZYKTMNELNYUID-UHFFFAOYSA-N 0.000 description 1
- GOWPYCGEWFYOCQ-UHFFFAOYSA-N Cc1cnc(Nc(cc2)ccc2N2CCN(C)CC2)nc1Nc1cc(S(NC2CCCC2)(=O)=O)ccc1 Chemical compound Cc1cnc(Nc(cc2)ccc2N2CCN(C)CC2)nc1Nc1cc(S(NC2CCCC2)(=O)=O)ccc1 GOWPYCGEWFYOCQ-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73262905P | 2005-11-01 | 2005-11-01 | |
| US60/732,629 | 2005-11-01 | ||
| US83800306P | 2006-08-15 | 2006-08-15 | |
| US60/838,003 | 2006-08-15 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008538935A Division JP5191391B2 (ja) | 2005-11-01 | 2006-10-26 | キナーゼのビ−アリールメタ−ピリミジン阻害剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013056930A JP2013056930A (ja) | 2013-03-28 |
| JP2013056930A5 true JP2013056930A5 (enExample) | 2013-05-30 |
| JP5814903B2 JP5814903B2 (ja) | 2015-11-17 |
Family
ID=38006192
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008538935A Active JP5191391B2 (ja) | 2005-11-01 | 2006-10-26 | キナーゼのビ−アリールメタ−ピリミジン阻害剤 |
| JP2012257150A Active JP5814903B2 (ja) | 2005-11-01 | 2012-11-26 | キナーゼのビ−アリールメタ−ピリミジン阻害剤 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008538935A Active JP5191391B2 (ja) | 2005-11-01 | 2006-10-26 | キナーゼのビ−アリールメタ−ピリミジン阻害剤 |
Country Status (27)
| Country | Link |
|---|---|
| US (3) | US7528143B2 (enExample) |
| EP (1) | EP1951684B1 (enExample) |
| JP (2) | JP5191391B2 (enExample) |
| KR (2) | KR101467723B1 (enExample) |
| CN (1) | CN103626742B (enExample) |
| AU (1) | AU2006309013B2 (enExample) |
| BE (1) | BE2021C513I2 (enExample) |
| BR (3) | BR122021011788B1 (enExample) |
| CA (1) | CA2628283C (enExample) |
| CY (2) | CY1118330T1 (enExample) |
| DK (1) | DK1951684T3 (enExample) |
| ES (1) | ES2595636T3 (enExample) |
| FI (1) | FIC20210010I1 (enExample) |
| FR (1) | FR21C1019I2 (enExample) |
| HU (2) | HUE028987T2 (enExample) |
| IL (1) | IL191167A (enExample) |
| LT (2) | LT1951684T (enExample) |
| MX (2) | MX391408B (enExample) |
| MY (1) | MY167260A (enExample) |
| NL (1) | NL301104I2 (enExample) |
| NO (1) | NO342221B1 (enExample) |
| NZ (2) | NZ567851A (enExample) |
| PL (1) | PL1951684T3 (enExample) |
| PT (1) | PT1951684T (enExample) |
| RU (2) | RU2589878C2 (enExample) |
| TW (1) | TWI444368B (enExample) |
| WO (1) | WO2007053452A1 (enExample) |
Families Citing this family (346)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI329105B (en) | 2002-02-01 | 2010-08-21 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds and their uses |
| BR0313059B8 (pt) | 2002-07-29 | 2021-07-27 | Rigel Pharmaceuticals | composto, e, composição farmacêutica |
| BR0315053A (pt) * | 2002-10-03 | 2005-08-09 | Targegen Inc | Agentes vasculostáticos , composição, artigo e processo de preparação dos mesmos |
| US20050282814A1 (en) * | 2002-10-03 | 2005-12-22 | Targegen, Inc. | Vasculostatic agents and methods of use thereof |
| CN102358738A (zh) | 2003-07-30 | 2012-02-22 | 里格尔药品股份有限公司 | 2,4-嘧啶二胺化合物及其预防和治疗自体免疫疾病的用途 |
| US7456176B2 (en) * | 2004-04-08 | 2008-11-25 | Targegen, Inc. | Benzotriazine inhibitors of kinases |
| US7652051B2 (en) * | 2004-08-25 | 2010-01-26 | Targegen, Inc. | Heterocyclic compounds and methods of use |
| JP4801096B2 (ja) | 2005-01-19 | 2011-10-26 | ライジェル ファーマシューティカルズ, インコーポレイテッド | 2,4−ピリミジンジアミン化合物のプロドラッグおよびそれらの使用 |
| EP1904457B1 (en) | 2005-06-08 | 2017-09-06 | Rigel Pharmaceuticals, Inc. | Compositions and methods for inhibition of the jak pathway |
| US20070203161A1 (en) * | 2006-02-24 | 2007-08-30 | Rigel Pharmaceuticals, Inc. | Compositions and methods for inhibition of the jak pathway |
| CA2611720A1 (en) * | 2005-06-08 | 2006-12-14 | Targegen, Inc. | Methods and compositions for the treatment of ocular disorders |
| US8604042B2 (en) * | 2005-11-01 | 2013-12-10 | Targegen, Inc. | Bi-aryl meta-pyrimidine inhibitors of kinases |
| US8133900B2 (en) | 2005-11-01 | 2012-03-13 | Targegen, Inc. | Use of bi-aryl meta-pyrimidine inhibitors of kinases |
| US7528143B2 (en) * | 2005-11-01 | 2009-05-05 | Targegen, Inc. | Bi-aryl meta-pyrimidine inhibitors of kinases |
| US20070161645A1 (en) * | 2005-11-02 | 2007-07-12 | Targegen, Inc. | Thiazole inhibitors targeting resistant kinase mutations |
| CN103214484B (zh) | 2005-12-13 | 2016-07-06 | 因塞特控股公司 | 作为两面神激酶抑制剂的杂芳基取代的吡咯并[2,3-b]吡啶和吡咯并[2,3-b]嘧啶 |
| JP2009528295A (ja) | 2006-02-24 | 2009-08-06 | ライジェル ファーマシューティカルズ, インコーポレイテッド | Jak経路の阻害のための組成物および方法 |
| WO2007127366A2 (en) * | 2006-04-25 | 2007-11-08 | Targegen, Inc. | Kinase inhibitors and methods of use thereof |
| US8030487B2 (en) * | 2006-07-07 | 2011-10-04 | Targegen, Inc. | 2-amino—5-substituted pyrimidine inhibitors |
| ES2555803T3 (es) | 2006-10-23 | 2016-01-08 | Cephalon, Inc. | Fusión de derivados bicíclicos 2,4-diaminopirimidina como utilizar inhibidores ALK y c-Met |
| MX2009006454A (es) | 2006-12-22 | 2009-06-26 | Hoffmann La Roche | Derivados de espiro-piperidina. |
| TW200840581A (en) * | 2007-02-28 | 2008-10-16 | Astrazeneca Ab | Novel pyrimidine derivatives |
| AU2008221278A1 (en) * | 2007-03-01 | 2008-09-04 | Supergen, Inc. | Pyrimidine-2,4-diamine derivatives and their use as JAK2 kinase inhibitors |
| US7947698B2 (en) | 2007-03-23 | 2011-05-24 | Rigel Pharmaceuticals, Inc. | Compositions and methods for inhibition of the JAK pathway |
| HUE029236T2 (en) | 2007-06-13 | 2017-02-28 | Incyte Holdings Corp | (R) -3- (4- (7H-Pyrrolo [2,3-d] pyrimidin-4-yl) -1H-pyrazol-1-yl) -3-cyclopentylpropanenitrile Crystalline salts of Janus kinase inhibitor |
| WO2009010789A2 (en) * | 2007-07-16 | 2009-01-22 | Astrazeneca Ab | Pyrimidine derivatives 934 |
| CN101903357A (zh) | 2007-07-17 | 2010-12-01 | 里格尔药品股份有限公司 | 作为pkc抑制剂的环状胺取代的嘧啶二胺 |
| WO2009032668A2 (en) | 2007-08-28 | 2009-03-12 | Irm Llc | 2 -biphenylamino-4 -aminopyrimidine derivatives as kinase inhibitors |
| EP2217716A4 (en) * | 2007-11-09 | 2011-02-09 | Salk Inst For Biological Studi | USE OF TAM RECEPTOR INHIBITORS AS ANTIMICROBIAL AGENTS |
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| KR101244517B1 (ko) | 2008-01-11 | 2013-03-18 | 에프. 호프만-라 로슈 아게 | 아밀로이드 베타에 대한 조절제 |
| HRP20170050T1 (hr) * | 2008-02-22 | 2017-03-10 | Rigel Pharmaceuticals, Inc. | Uporaba 2,4-pirimidindiamina za liječenje ateroskleroze |
| AU2009216851B2 (en) | 2008-02-22 | 2013-11-07 | F. Hoffmann-La Roche Ag | Modulators for amyloid beta |
| EP2286224A4 (en) * | 2008-05-05 | 2012-04-25 | Univ Winthrop Hospital | METHOD FOR IMPROVING THE CARDIOVASCULAR RISK PROFILE OF COX-INHIBITORS |
| EP2300013B2 (en) | 2008-05-21 | 2024-11-13 | Takeda Pharmaceutical Company Limited | Phosphorous derivatives as kinase inhibitors |
| US9273077B2 (en) | 2008-05-21 | 2016-03-01 | Ariad Pharmaceuticals, Inc. | Phosphorus derivatives as kinase inhibitors |
| UY31929A (es) | 2008-06-25 | 2010-01-05 | Irm Llc | Compuestos y composiciones como inhibidores de cinasa |
| NZ603525A (en) | 2008-06-27 | 2015-02-27 | Celgene Avilomics Res Inc | Pyrimidine based compound and uses thereof |
| US11351168B1 (en) | 2008-06-27 | 2022-06-07 | Celgene Car Llc | 2,4-disubstituted pyrimidines useful as kinase inhibitors |
| US8338439B2 (en) | 2008-06-27 | 2012-12-25 | Celgene Avilomics Research, Inc. | 2,4-disubstituted pyrimidines useful as kinase inhibitors |
| WO2010011349A2 (en) * | 2008-07-25 | 2010-01-28 | Supergen, Inc. | Pyrimidine-2,4-diamine jak2 kinase inhibiting anti-inflammation use |
| RU2011108563A (ru) * | 2008-08-05 | 2012-09-10 | Таргеджен, Инк. (US) | Способы лечения талассемии |
| CL2009001884A1 (es) * | 2008-10-02 | 2010-05-14 | Incyte Holdings Corp | Uso de 3-ciclopentil-3-[4-(7h-pirrolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il)propanonitrilo, inhibidor de janus quinasa, y uso de una composición que lo comprende para el tratamiento del ojo seco. |
| WO2010040661A1 (en) | 2008-10-09 | 2010-04-15 | F. Hoffmann-La Roche Ag | Modulators for amyloid beta |
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