JP2013056930A5 - - Google Patents
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- JP2013056930A5 JP2013056930A5 JP2012257150A JP2012257150A JP2013056930A5 JP 2013056930 A5 JP2013056930 A5 JP 2013056930A5 JP 2012257150 A JP2012257150 A JP 2012257150A JP 2012257150 A JP2012257150 A JP 2012257150A JP 2013056930 A5 JP2013056930 A5 JP 2013056930A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- cancer
- substituted
- unsubstituted
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims 36
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 27
- 208000035475 disorder Diseases 0.000 claims 23
- 239000008194 pharmaceutical composition Substances 0.000 claims 23
- 125000000217 alkyl group Chemical group 0.000 claims 21
- 150000003839 salts Chemical class 0.000 claims 16
- RGICCULPCWNRAB-UHFFFAOYSA-N 2-[2-(2-hexoxyethoxy)ethoxy]ethanol Chemical compound CCCCCCOCCOCCOCCO RGICCULPCWNRAB-UHFFFAOYSA-N 0.000 claims 12
- 229910052799 carbon Inorganic materials 0.000 claims 12
- 239000012453 solvate Substances 0.000 claims 12
- 208000014767 Myeloproliferative disease Diseases 0.000 claims 11
- 201000007224 Myeloproliferative neoplasm Diseases 0.000 claims 11
- 125000000623 heterocyclic group Chemical group 0.000 claims 9
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 8
- 125000003118 aryl group Chemical group 0.000 claims 8
- 125000001072 heteroaryl group Chemical group 0.000 claims 8
- 206010028980 Neoplasm Diseases 0.000 claims 7
- 201000011510 cancer Diseases 0.000 claims 7
- 229910052739 hydrogen Inorganic materials 0.000 claims 7
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 6
- 101000997832 Homo sapiens Tyrosine-protein kinase JAK2 Proteins 0.000 claims 6
- 102100033444 Tyrosine-protein kinase JAK2 Human genes 0.000 claims 6
- 208000032839 leukemia Diseases 0.000 claims 6
- 208000032027 Essential Thrombocythemia Diseases 0.000 claims 5
- 206010061218 Inflammation Diseases 0.000 claims 5
- 108091000080 Phosphotransferase Proteins 0.000 claims 5
- 201000004681 Psoriasis Diseases 0.000 claims 5
- 208000036142 Viral infection Diseases 0.000 claims 5
- 208000017733 acquired polycythemia vera Diseases 0.000 claims 5
- 230000004054 inflammatory process Effects 0.000 claims 5
- 229910052757 nitrogen Inorganic materials 0.000 claims 5
- 102000020233 phosphotransferase Human genes 0.000 claims 5
- 208000037244 polycythemia vera Diseases 0.000 claims 5
- 230000009385 viral infection Effects 0.000 claims 5
- 125000004103 aminoalkyl group Chemical group 0.000 claims 4
- 230000033115 angiogenesis Effects 0.000 claims 4
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 208000030533 eye disease Diseases 0.000 claims 4
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 208000003476 primary myelofibrosis Diseases 0.000 claims 4
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 3
- 206010012689 Diabetic retinopathy Diseases 0.000 claims 3
- 102000001253 Protein Kinase Human genes 0.000 claims 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 3
- 125000000753 cycloalkyl group Chemical group 0.000 claims 3
- 229910052736 halogen Inorganic materials 0.000 claims 3
- 150000002367 halogens Chemical class 0.000 claims 3
- 201000007914 proliferative diabetic retinopathy Diseases 0.000 claims 3
- 108060006633 protein kinase Proteins 0.000 claims 3
- SNOOUWRIMMFWNE-UHFFFAOYSA-M sodium;6-[(3,4,5-trimethoxybenzoyl)amino]hexanoate Chemical compound [Na+].COC1=CC(C(=O)NCCCCCC([O-])=O)=CC(OC)=C1OC SNOOUWRIMMFWNE-UHFFFAOYSA-M 0.000 claims 3
- 239000000126 substance Substances 0.000 claims 3
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 2
- PKTQHWKZGFKXGT-UHFFFAOYSA-N 3-bromo-n-tert-butylbenzenesulfonamide Chemical compound CC(C)(C)NS(=O)(=O)C1=CC=CC(Br)=C1 PKTQHWKZGFKXGT-UHFFFAOYSA-N 0.000 claims 2
- OTYZNDKWNPQQJP-UHFFFAOYSA-N 4-(2-pyrrolidin-1-ylethoxy)aniline Chemical compound C1=CC(N)=CC=C1OCCN1CCCC1 OTYZNDKWNPQQJP-UHFFFAOYSA-N 0.000 claims 2
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 claims 2
- 206010005003 Bladder cancer Diseases 0.000 claims 2
- 206010005949 Bone cancer Diseases 0.000 claims 2
- 208000018084 Bone neoplasm Diseases 0.000 claims 2
- 208000003174 Brain Neoplasms Diseases 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 2
- 208000026310 Breast neoplasm Diseases 0.000 claims 2
- 206010009944 Colon cancer Diseases 0.000 claims 2
- 206010017993 Gastrointestinal neoplasms Diseases 0.000 claims 2
- 102000042838 JAK family Human genes 0.000 claims 2
- 108091082332 JAK family Proteins 0.000 claims 2
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 2
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 2
- 206010025323 Lymphomas Diseases 0.000 claims 2
- 208000002231 Muscle Neoplasms Diseases 0.000 claims 2
- 206010033128 Ovarian cancer Diseases 0.000 claims 2
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 2
- 206010060862 Prostate cancer Diseases 0.000 claims 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 2
- 206010038389 Renal cancer Diseases 0.000 claims 2
- 208000000453 Skin Neoplasms Diseases 0.000 claims 2
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 125000000304 alkynyl group Chemical group 0.000 claims 2
- 208000029742 colonic neoplasm Diseases 0.000 claims 2
- 239000012043 crude product Substances 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 230000002496 gastric effect Effects 0.000 claims 2
- 125000005842 heteroatom Chemical group 0.000 claims 2
- 150000004677 hydrates Chemical class 0.000 claims 2
- 201000010982 kidney cancer Diseases 0.000 claims 2
- 201000007270 liver cancer Diseases 0.000 claims 2
- 208000014018 liver neoplasm Diseases 0.000 claims 2
- 201000005202 lung cancer Diseases 0.000 claims 2
- 208000020816 lung neoplasm Diseases 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 201000002077 muscle cancer Diseases 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 230000037361 pathway Effects 0.000 claims 2
- 201000000849 skin cancer Diseases 0.000 claims 2
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 2
- 201000005112 urinary bladder cancer Diseases 0.000 claims 2
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 1
- 208000010833 Chronic myeloid leukaemia Diseases 0.000 claims 1
- 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 claims 1
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims 1
- 208000017442 Retinal disease Diseases 0.000 claims 1
- 206010038923 Retinopathy Diseases 0.000 claims 1
- 125000002252 acyl group Chemical group 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 239000002260 anti-inflammatory agent Substances 0.000 claims 1
- 229940121363 anti-inflammatory agent Drugs 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- -1 cyano, nitro, amino Chemical group 0.000 claims 1
- 125000004122 cyclic group Chemical group 0.000 claims 1
- 229940127089 cytotoxic agent Drugs 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 239000002955 immunomodulating agent Substances 0.000 claims 1
- 229940121354 immunomodulator Drugs 0.000 claims 1
- 230000002584 immunomodulator Effects 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 125000005254 oxyacyl group Chemical group 0.000 claims 1
- 230000002062 proliferating effect Effects 0.000 claims 1
- 230000012743 protein tagging Effects 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 125000000547 substituted alkyl group Chemical group 0.000 claims 1
- PXQLVRUNWNTZOS-UHFFFAOYSA-N sulfanyl Chemical class [SH] PXQLVRUNWNTZOS-UHFFFAOYSA-N 0.000 claims 1
- 229940124530 sulfonamide Drugs 0.000 claims 1
- 150000003456 sulfonamides Chemical group 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- KSPFHLWLBKZTOF-UHFFFAOYSA-N CC(C)(C)c1cccc(Nc2nc(Cl)ncc2C)c1 Chemical compound CC(C)(C)c1cccc(Nc2nc(Cl)ncc2C)c1 KSPFHLWLBKZTOF-UHFFFAOYSA-N 0.000 description 1
- XIJQDWHJGDTTCL-UHFFFAOYSA-N CC(CCCC1)N1S(c1cccc(Nc2c(C)cnc(Nc(cc3)ccc3N3CCN(C)CC3)n2)c1)(=O)=O Chemical compound CC(CCCC1)N1S(c1cccc(Nc2c(C)cnc(Nc(cc3)ccc3N3CCN(C)CC3)n2)c1)(=O)=O XIJQDWHJGDTTCL-UHFFFAOYSA-N 0.000 description 1
- RBGUWESBYDZRLM-UHFFFAOYSA-N CC[ClH]c1ncc(C)c(N(C)c(cc2OC)ccc2Cl)n1 Chemical compound CC[ClH]c1ncc(C)c(N(C)c(cc2OC)ccc2Cl)n1 RBGUWESBYDZRLM-UHFFFAOYSA-N 0.000 description 1
- AVOXKMWHDSJKEV-UHFFFAOYSA-N Cc(c(Nc(cc1)ccc1Cl)n1)cnc1Cl Chemical compound Cc(c(Nc(cc1)ccc1Cl)n1)cnc1Cl AVOXKMWHDSJKEV-UHFFFAOYSA-N 0.000 description 1
- PFLCSLXLQSDNBS-UHFFFAOYSA-N Cc(c(Nc(cc1C(F)(F)F)ccc1Cl)n1)cnc1Cl Chemical compound Cc(c(Nc(cc1C(F)(F)F)ccc1Cl)n1)cnc1Cl PFLCSLXLQSDNBS-UHFFFAOYSA-N 0.000 description 1
- VPMZIKZXZUQGRU-UHFFFAOYSA-N Cc(c(Nc(cc1F)ccc1Cl)n1)cnc1Cl Chemical compound Cc(c(Nc(cc1F)ccc1Cl)n1)cnc1Cl VPMZIKZXZUQGRU-UHFFFAOYSA-N 0.000 description 1
- QQVVBQCECZMBDI-UHFFFAOYSA-N Cc(c(Nc1cc(OC)cc(OC)c1)n1)cnc1Cl Chemical compound Cc(c(Nc1cc(OC)cc(OC)c1)n1)cnc1Cl QQVVBQCECZMBDI-UHFFFAOYSA-N 0.000 description 1
- OQJZGYXSRKRKLL-UHFFFAOYSA-N Cc(cn1)c(Nc2ccc3[s]ccc3c2)nc1Cl Chemical compound Cc(cn1)c(Nc2ccc3[s]ccc3c2)nc1Cl OQJZGYXSRKRKLL-UHFFFAOYSA-N 0.000 description 1
- ULUSYRCRCJWMKH-UHFFFAOYSA-N Cc1c(NCc(cc2)c(cc[nH]3)c3c2Cl)nc(Nc(cc2)ccc2N2CCN(C)CC2)nc1 Chemical compound Cc1c(NCc(cc2)c(cc[nH]3)c3c2Cl)nc(Nc(cc2)ccc2N2CCN(C)CC2)nc1 ULUSYRCRCJWMKH-UHFFFAOYSA-N 0.000 description 1
- VRYMNQOAQGCOKO-UHFFFAOYSA-N Cc1c(Nc(cc2)c(cc[nH]3)c3c2Cl)nc(Nc(cc2)ccc2OCCN2CCCC2)nc1 Chemical compound Cc1c(Nc(cc2)c(cc[nH]3)c3c2Cl)nc(Nc(cc2)ccc2OCCN2CCCC2)nc1 VRYMNQOAQGCOKO-UHFFFAOYSA-N 0.000 description 1
- KMTZHIZUSJJWHH-UHFFFAOYSA-N Cc1c(Nc2c(cc[nH]3)c3ccc2)nc(Nc2ccc(CN3CCNCC3)cc2)nc1 Chemical compound Cc1c(Nc2c(cc[nH]3)c3ccc2)nc(Nc2ccc(CN3CCNCC3)cc2)nc1 KMTZHIZUSJJWHH-UHFFFAOYSA-N 0.000 description 1
- JQMLLWAZWNUCKB-UHFFFAOYSA-N Cc1c(Nc2c(cc[nH]3)c3ccc2)nc(Nc2ccc(CN3CCOCC3)cc2)nc1 Chemical compound Cc1c(Nc2c(cc[nH]3)c3ccc2)nc(Nc2ccc(CN3CCOCC3)cc2)nc1 JQMLLWAZWNUCKB-UHFFFAOYSA-N 0.000 description 1
- FYEZWBSZYDCHCA-UHFFFAOYSA-N Cc1cc(C)cc(Nc2nc(Cl)ncc2C)c1 Chemical compound Cc1cc(C)cc(Nc2nc(Cl)ncc2C)c1 FYEZWBSZYDCHCA-UHFFFAOYSA-N 0.000 description 1
- HZYKTMNELNYUID-UHFFFAOYSA-N Cc1cnc(Nc(cc2)ccc2N2CCN(C)CC2)nc1Nc1cc(S(N2CCCC2)(=O)=O)ccc1 Chemical compound Cc1cnc(Nc(cc2)ccc2N2CCN(C)CC2)nc1Nc1cc(S(N2CCCC2)(=O)=O)ccc1 HZYKTMNELNYUID-UHFFFAOYSA-N 0.000 description 1
- GOWPYCGEWFYOCQ-UHFFFAOYSA-N Cc1cnc(Nc(cc2)ccc2N2CCN(C)CC2)nc1Nc1cc(S(NC2CCCC2)(=O)=O)ccc1 Chemical compound Cc1cnc(Nc(cc2)ccc2N2CCN(C)CC2)nc1Nc1cc(S(NC2CCCC2)(=O)=O)ccc1 GOWPYCGEWFYOCQ-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73262905P | 2005-11-01 | 2005-11-01 | |
| US60/732,629 | 2005-11-01 | ||
| US83800306P | 2006-08-15 | 2006-08-15 | |
| US60/838,003 | 2006-08-15 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008538935A Division JP5191391B2 (ja) | 2005-11-01 | 2006-10-26 | キナーゼのビ−アリールメタ−ピリミジン阻害剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013056930A JP2013056930A (ja) | 2013-03-28 |
| JP2013056930A5 true JP2013056930A5 (enExample) | 2013-05-30 |
| JP5814903B2 JP5814903B2 (ja) | 2015-11-17 |
Family
ID=38006192
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008538935A Active JP5191391B2 (ja) | 2005-11-01 | 2006-10-26 | キナーゼのビ−アリールメタ−ピリミジン阻害剤 |
| JP2012257150A Active JP5814903B2 (ja) | 2005-11-01 | 2012-11-26 | キナーゼのビ−アリールメタ−ピリミジン阻害剤 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008538935A Active JP5191391B2 (ja) | 2005-11-01 | 2006-10-26 | キナーゼのビ−アリールメタ−ピリミジン阻害剤 |
Country Status (25)
| Country | Link |
|---|---|
| US (3) | US7528143B2 (enExample) |
| EP (1) | EP1951684B1 (enExample) |
| JP (2) | JP5191391B2 (enExample) |
| KR (2) | KR101467723B1 (enExample) |
| CN (1) | CN103626742B (enExample) |
| AU (1) | AU2006309013B2 (enExample) |
| BR (3) | BR122021011788B1 (enExample) |
| CA (1) | CA2628283C (enExample) |
| CY (2) | CY1118330T1 (enExample) |
| DK (1) | DK1951684T3 (enExample) |
| ES (1) | ES2595636T3 (enExample) |
| FI (1) | FIC20210010I1 (enExample) |
| HU (2) | HUE028987T2 (enExample) |
| IL (1) | IL191167A (enExample) |
| LT (2) | LT1951684T (enExample) |
| MX (2) | MX391408B (enExample) |
| MY (1) | MY167260A (enExample) |
| NL (1) | NL301104I2 (enExample) |
| NO (1) | NO342221B1 (enExample) |
| NZ (2) | NZ592990A (enExample) |
| PL (1) | PL1951684T3 (enExample) |
| PT (1) | PT1951684T (enExample) |
| RU (2) | RU2589878C2 (enExample) |
| TW (1) | TWI444368B (enExample) |
| WO (1) | WO2007053452A1 (enExample) |
Families Citing this family (337)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI329105B (en) | 2002-02-01 | 2010-08-21 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds and their uses |
| JP2006514989A (ja) | 2002-07-29 | 2006-05-18 | ライジェル ファーマシューティカルズ | ２，４−ピリミジンジアミン化合物による自己免疫疾患の治療および予防方法 |
| US20050282814A1 (en) * | 2002-10-03 | 2005-12-22 | Targegen, Inc. | Vasculostatic agents and methods of use thereof |
| WO2004030635A2 (en) * | 2002-10-03 | 2004-04-15 | Targegen, Inc. | Vasculostatic agents and methods of use thereof |
| KR20120062863A (ko) | 2003-07-30 | 2012-06-14 | 리겔 파마슈티칼스, 인크. | 자가면역 질환의 치료 또는 예방에 사용하기 위한 2,4-피리미딘디아민 화합물 |
| EP1809614B1 (en) | 2004-04-08 | 2014-05-07 | TargeGen, Inc. | Benzotriazine inhibitors of kinases |
| PL382308A1 (pl) * | 2004-08-25 | 2007-08-20 | Targegen, Inc. | Związki heterocykliczne i sposoby stosowania |
| DK1856135T3 (da) | 2005-01-19 | 2010-04-12 | Rigel Pharmaceuticals Inc | Prodrugs af 2,4-pyrimidindiamin-forbindelser og deres anvendelser |
| US20060292203A1 (en) * | 2005-06-08 | 2006-12-28 | Targegen, Inc. | Methods and compositions for the treatment of ocular disorders |
| ES2651349T3 (es) | 2005-06-08 | 2018-01-25 | Rigel Pharmaceuticals, Inc. | Composiciones y métodos para la inhibición de la ruta JAK |
| US20070203161A1 (en) | 2006-02-24 | 2007-08-30 | Rigel Pharmaceuticals, Inc. | Compositions and methods for inhibition of the jak pathway |
| US8604042B2 (en) * | 2005-11-01 | 2013-12-10 | Targegen, Inc. | Bi-aryl meta-pyrimidine inhibitors of kinases |
| MX391408B (es) * | 2005-11-01 | 2025-03-21 | Impact Biomedicines Inc | Inhibidores de biaril meta-pirimidina de cinasas. |
| US8133900B2 (en) | 2005-11-01 | 2012-03-13 | Targegen, Inc. | Use of bi-aryl meta-pyrimidine inhibitors of kinases |
| US20070149508A1 (en) * | 2005-11-02 | 2007-06-28 | Targegen, Inc. | Six membered heteroaromatic inhibitors targeting resistant kinase mutations |
| SI1966202T1 (sl) | 2005-12-13 | 2012-01-31 | Incyte Corp | S heteroarilom substituirani pirolo (2,3-b)piridini in pirolo (2,3-b)pirimidini kot zaviralci janus kinaze |
| ES2622493T3 (es) | 2006-02-24 | 2017-07-06 | Rigel Pharmaceuticals, Inc. | Composiciones y métodos para la inhibición de la ruta de JAK |
| WO2007127366A2 (en) * | 2006-04-25 | 2007-11-08 | Targegen, Inc. | Kinase inhibitors and methods of use thereof |
| WO2008008234A1 (en) * | 2006-07-07 | 2008-01-17 | Targegen, Inc. | 2-amino-5-substituted pyrimidine inhibitors |
| EP2222647B1 (en) | 2006-10-23 | 2015-08-05 | Cephalon, Inc. | Fused bicyclic derivatives of 2,4-diaminopyrimidine as alk and c-met inhibitors |
| BRPI0721138A2 (pt) | 2006-12-22 | 2014-04-01 | Hoffmann La Roche | Derivados de espiro-piperidina |
| TW200840581A (en) * | 2007-02-28 | 2008-10-16 | Astrazeneca Ab | Novel pyrimidine derivatives |
| EP2121634A1 (en) * | 2007-03-01 | 2009-11-25 | SuperGen, Inc. | Pyrimidine-2,4-diamine derivatives and their use as jak2 kinase inhibitors |
| WO2008118822A1 (en) * | 2007-03-23 | 2008-10-02 | Rigel Pharmaceuticals, Inc. | Compositions and methods for inhibition of the jak pathway |
| EP2173752B2 (en) | 2007-06-13 | 2022-07-13 | Incyte Holdings Corporation | Salts of the janus kinase inhibitor (r)-3-(4-(7h-pyrrolo(2,3-d)pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentylpropanenitrile |
| CA2693880A1 (en) * | 2007-07-16 | 2009-01-22 | Astrazeneca Ab | Pyrimidine derivatives 934 |
| NZ582485A (en) | 2007-07-17 | 2012-05-25 | Rigel Pharmaceuticals Inc | Cyclic amine substituted pyrimidinediamines as pkc inhibitors |
| EP2190826A2 (en) | 2007-08-28 | 2010-06-02 | Irm Llc | 2-biphenylamino-4-aminopyrimidine derivatives as kinase inhibitors |
| JP2011514881A (ja) | 2007-11-09 | 2011-05-12 | ザ ソルク インスティテュート フォー バイオロジカル スタディーズ | 免疫増強剤としてのｔａｍ受容体阻害剤の使用および免疫抑制剤としてのｔａｍ活性化剤の使用 |
| US20100310563A1 (en) * | 2007-11-30 | 2010-12-09 | Bumm Thomas G P | Methods for treating induced cellular proliferative disorders |
| RU2010132728A (ru) | 2008-01-11 | 2012-02-20 | Ф.Хоффманн-Ля Рош Аг (Ch) | Модуляторы бета-амилоида |
| CA2713716A1 (en) | 2008-02-22 | 2009-08-27 | F. Hoffmann-La Roche Ag | Modulators for amyloid beta |
| CA2715962C (en) | 2008-02-22 | 2017-03-07 | Rigel Pharmaceuticals, Inc. | Use of 2,4-pyrimidinediamines for the treatment of atherosclerosis |
| JP2011519926A (ja) * | 2008-05-05 | 2011-07-14 | ウィンスロップ−ユニバーシティー ホスピタル | Ｃｏｘ阻害薬の心血管系リスク因子の改善方法 |
| US9273077B2 (en) | 2008-05-21 | 2016-03-01 | Ariad Pharmaceuticals, Inc. | Phosphorus derivatives as kinase inhibitors |
| KR101860057B1 (ko) | 2008-05-21 | 2018-05-21 | 어리어드 파마슈티칼스, 인코포레이티드 | 키나아제 억제제로서 포스포러스 유도체 |
| UY31929A (es) | 2008-06-25 | 2010-01-05 | Irm Llc | Compuestos y composiciones como inhibidores de cinasa |
| US11351168B1 (en) | 2008-06-27 | 2022-06-07 | Celgene Car Llc | 2,4-disubstituted pyrimidines useful as kinase inhibitors |
| EP2361248B1 (en) | 2008-06-27 | 2018-09-19 | Celgene CAR LLC | Heteroaryl compounds and uses thereof |
| US8338439B2 (en) | 2008-06-27 | 2012-12-25 | Celgene Avilomics Research, Inc. | 2,4-disubstituted pyrimidines useful as kinase inhibitors |
| US20100029675A1 (en) * | 2008-07-25 | 2010-02-04 | Hwang Soo-In | Pyrimidine-2, 4-diamine JAK2 Kinase inhibiting anti-inflammation use |
| WO2010017122A2 (en) * | 2008-08-05 | 2010-02-11 | Targegen Inc. | Methods of treating thalassemia |
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