JP2013010792A5 - - Google Patents
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- Publication number
- JP2013010792A5 JP2013010792A5 JP2012226367A JP2012226367A JP2013010792A5 JP 2013010792 A5 JP2013010792 A5 JP 2013010792A5 JP 2012226367 A JP2012226367 A JP 2012226367A JP 2012226367 A JP2012226367 A JP 2012226367A JP 2013010792 A5 JP2013010792 A5 JP 2013010792A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- acceptable salt
- compound according
- hydrogen
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims description 42
- 239000000203 mixture Substances 0.000 claims description 3
- 150000003839 salts Chemical class 0.000 claims 38
- 229910052739 hydrogen Inorganic materials 0.000 claims 25
- 239000001257 hydrogen Substances 0.000 claims 25
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 20
- 229910052731 fluorine Inorganic materials 0.000 claims 9
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 claims 8
- 125000001931 aliphatic group Chemical group 0.000 claims 8
- 239000011737 fluorine Substances 0.000 claims 8
- 229910052799 carbon Inorganic materials 0.000 claims 7
- 239000003814 drug Substances 0.000 claims 7
- 229940079593 drug Drugs 0.000 claims 6
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 5
- 229910052736 halogen Inorganic materials 0.000 claims 5
- 150000002367 halogens Chemical class 0.000 claims 5
- 150000002431 hydrogen Chemical class 0.000 claims 5
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 3
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims 3
- -1 COOR' Chemical group 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 239000012472 biological sample Substances 0.000 claims 2
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 208000020084 Bone disease Diseases 0.000 claims 1
- 208000024172 Cardiovascular disease Diseases 0.000 claims 1
- 208000029462 Immunodeficiency disease Diseases 0.000 claims 1
- 108010025020 Nerve Growth Factor Proteins 0.000 claims 1
- 102000007072 Nerve Growth Factors Human genes 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 125000002723 alicyclic group Chemical group 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 229940121363 anti-inflammatory agent Drugs 0.000 claims 1
- 239000002260 anti-inflammatory agent Substances 0.000 claims 1
- 230000001028 anti-proliverative effect Effects 0.000 claims 1
- 239000003443 antiviral agent Substances 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 125000002837 carbocyclic group Chemical group 0.000 claims 1
- 150000001721 carbon Chemical group 0.000 claims 1
- 230000000973 chemotherapeutic effect Effects 0.000 claims 1
- 230000001066 destructive effect Effects 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 208000014951 hematologic disease Diseases 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 239000002955 immunomodulating agent Substances 0.000 claims 1
- 229940121354 immunomodulator Drugs 0.000 claims 1
- 230000002584 immunomodulator Effects 0.000 claims 1
- 229960003444 immunosuppressant agent Drugs 0.000 claims 1
- 230000001861 immunosuppressant effect Effects 0.000 claims 1
- 239000003018 immunosuppressive agent Substances 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 208000019423 liver disease Diseases 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000003900 neurotrophic factor Substances 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 229920006395 saturated elastomer Polymers 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 0 Cc1cnc2[n]cc(C(N=C(*)*)=NC(*)=I)c2c1 Chemical compound Cc1cnc2[n]cc(C(N=C(*)*)=NC(*)=I)c2c1 0.000 description 20
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 description 1
- PSDSIQPUXJCFBK-UHFFFAOYSA-N C(C1C2)C3C11C4C2C3CC1C4 Chemical compound C(C1C2)C3C11C4C2C3CC1C4 PSDSIQPUXJCFBK-UHFFFAOYSA-N 0.000 description 1
- VVRCYUOEOIOIEK-UHFFFAOYSA-O CC(C(N(C)CC(F)(F)F)=O)Nc1nc(C2=C[NH2+]c3ncccc23)ncc1 Chemical compound CC(C(N(C)CC(F)(F)F)=O)Nc1nc(C2=C[NH2+]c3ncccc23)ncc1 VVRCYUOEOIOIEK-UHFFFAOYSA-O 0.000 description 1
- DZDNCAJEJCQSMR-UHFFFAOYSA-N CC(C)(C)C1N(C)CSC1 Chemical compound CC(C)(C)C1N(C)CSC1 DZDNCAJEJCQSMR-UHFFFAOYSA-N 0.000 description 1
- GDHIUXDCYFUUAE-INIZCTEOSA-N CC(C)[C@@H](NCOCNCC(F)(F)F)Nc1ccnc(-c2c[nH]c3ncccc23)n1 Chemical compound CC(C)[C@@H](NCOCNCC(F)(F)F)Nc1ccnc(-c2c[nH]c3ncccc23)n1 GDHIUXDCYFUUAE-INIZCTEOSA-N 0.000 description 1
- QOVARRUAEFTPOJ-UHFFFAOYSA-O CC(CC1C([NH2+]CC(F)(F)F)=O)(CN1c1nc(-c2c[nH]c3ncccc23)ncc1)F Chemical compound CC(CC1C([NH2+]CC(F)(F)F)=O)(CN1c1nc(-c2c[nH]c3ncccc23)ncc1)F QOVARRUAEFTPOJ-UHFFFAOYSA-O 0.000 description 1
- RJCGAHHUKISJIM-UHFFFAOYSA-N CC(CCC1)(C(NCC(CCF)F)=O)N1c1ccnc(-c2c[nH]c3ncccc23)n1 Chemical compound CC(CCC1)(C(NCC(CCF)F)=O)N1c1ccnc(-c2c[nH]c3ncccc23)n1 RJCGAHHUKISJIM-UHFFFAOYSA-N 0.000 description 1
- GGFKQOQFSGPWBG-UHFFFAOYSA-N CC(NCC(F)(F)F)=O Chemical compound CC(NCC(F)(F)F)=O GGFKQOQFSGPWBG-UHFFFAOYSA-N 0.000 description 1
- MKPZDBNKUJHYCK-UHFFFAOYSA-N CC1N(C)CC1 Chemical compound CC1N(C)CC1 MKPZDBNKUJHYCK-UHFFFAOYSA-N 0.000 description 1
- HPFBCTLYLKRWHC-LJQANCHMSA-N CCCN(C[C@H](C(NCC(F)(F)[F]C)=O)Nc1ccnc(-c2c[nH]c3ncccc23)n1)C(C=C(C)C)=O Chemical compound CCCN(C[C@H](C(NCC(F)(F)[F]C)=O)Nc1ccnc(-c2c[nH]c3ncccc23)n1)C(C=C(C)C)=O HPFBCTLYLKRWHC-LJQANCHMSA-N 0.000 description 1
- RAZUSFPITOYAFO-UHFFFAOYSA-N CCN(CCCCC(NCC(F)(F)F)=O)c1nc(-c2cnc3ncccc23)ncc1F Chemical compound CCN(CCCCC(NCC(F)(F)F)=O)c1nc(-c2cnc3ncccc23)ncc1F RAZUSFPITOYAFO-UHFFFAOYSA-N 0.000 description 1
- CQUBJFQPRYBVRL-MRVPVSSYSA-N C[C@H](C(NCC(F)(F)F)=O)Nc1nc(-c2c[nH]c3ncccc23)ncn1 Chemical compound C[C@H](C(NCC(F)(F)F)=O)Nc1nc(-c2c[nH]c3ncccc23)ncn1 CQUBJFQPRYBVRL-MRVPVSSYSA-N 0.000 description 1
- TYGGIVKWEZXSEO-UHFFFAOYSA-O FC(C[NH2+]CC(CSC1)N1c1nc(-c2c[nH]c3ncccc23)ncc1)(F)F Chemical compound FC(C[NH2+]CC(CSC1)N1c1nc(-c2c[nH]c3ncccc23)ncc1)(F)F TYGGIVKWEZXSEO-UHFFFAOYSA-O 0.000 description 1
- KYSLPFWJGHXTEG-UHFFFAOYSA-O Fc1cnc(C2=C[NH2+]c3ncccc23)nc1N1CCNCC1 Chemical compound Fc1cnc(C2=C[NH2+]c3ncccc23)nc1N1CCNCC1 KYSLPFWJGHXTEG-UHFFFAOYSA-O 0.000 description 1
- DKMRYSYNTIZLMX-UHFFFAOYSA-P NC(CC(C1)F)(C([NH2+]CC(F)(F)F)=O)N1c1nc(C2=C[NH2+]c3c2cccn3)ncc1 Chemical compound NC(CC(C1)F)(C([NH2+]CC(F)(F)F)=O)N1c1nc(C2=C[NH2+]c3c2cccn3)ncc1 DKMRYSYNTIZLMX-UHFFFAOYSA-P 0.000 description 1
- PGHMUTCFECJKIO-UHFFFAOYSA-P O=C(C(CSC1)N1c1nc(C2=C[NH2+]c3c2cccn3)ncc1)[NH2+]CC(F)(F)F Chemical compound O=C(C(CSC1)N1c1nc(C2=C[NH2+]c3c2cccn3)ncc1)[NH2+]CC(F)(F)F PGHMUTCFECJKIO-UHFFFAOYSA-P 0.000 description 1
- OLYGQFHFXLFKDY-GFCCVEGCSA-N O=C([C@@H](CC(C1)(F)F)N1c1nc(-c2c[nH]c3ncccc23)ncc1F)NCC(F)(F)F Chemical compound O=C([C@@H](CC(C1)(F)F)N1c1nc(-c2c[nH]c3ncccc23)ncc1F)NCC(F)(F)F OLYGQFHFXLFKDY-GFCCVEGCSA-N 0.000 description 1
- CZCYCVDAGWFZSN-TVQRCGJNSA-N O[C@@H](C[C@@H]1C(NCC(F)(F)F)=O)CN1c1nc(-c2c[nH]c3ncccc23)ncc1F Chemical compound O[C@@H](C[C@@H]1C(NCC(F)(F)F)=O)CN1c1nc(-c2c[nH]c3ncccc23)ncc1F CZCYCVDAGWFZSN-TVQRCGJNSA-N 0.000 description 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US75936706P | 2006-01-17 | 2006-01-17 | |
| US60/759,367 | 2006-01-17 | ||
| US84247106P | 2006-09-06 | 2006-09-06 | |
| US60/842,471 | 2006-09-06 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008551353A Division JP5591471B2 (ja) | 2006-01-17 | 2007-01-17 | ヤヌスキナーゼ阻害剤として有用なアザインドール |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014167160A Division JP2014210823A (ja) | 2006-01-17 | 2014-08-20 | ヤヌスキナーゼ阻害剤として有用なアザインドール |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013010792A JP2013010792A (ja) | 2013-01-17 |
| JP2013010792A5 true JP2013010792A5 (enExample) | 2014-10-02 |
| JP5728454B2 JP5728454B2 (ja) | 2015-06-03 |
Family
ID=38197739
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008551353A Expired - Fee Related JP5591471B2 (ja) | 2006-01-17 | 2007-01-17 | ヤヌスキナーゼ阻害剤として有用なアザインドール |
| JP2012226367A Expired - Fee Related JP5728454B2 (ja) | 2006-01-17 | 2012-10-11 | ヤヌスキナーゼ阻害剤として有用なアザインドール |
| JP2012226368A Ceased JP2013010793A (ja) | 2006-01-17 | 2012-10-11 | ヤヌスキナーゼ阻害剤として有用なアザインドール |
| JP2014167160A Pending JP2014210823A (ja) | 2006-01-17 | 2014-08-20 | ヤヌスキナーゼ阻害剤として有用なアザインドール |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008551353A Expired - Fee Related JP5591471B2 (ja) | 2006-01-17 | 2007-01-17 | ヤヌスキナーゼ阻害剤として有用なアザインドール |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012226368A Ceased JP2013010793A (ja) | 2006-01-17 | 2012-10-11 | ヤヌスキナーゼ阻害剤として有用なアザインドール |
| JP2014167160A Pending JP2014210823A (ja) | 2006-01-17 | 2014-08-20 | ヤヌスキナーゼ阻害剤として有用なアザインドール |
Country Status (19)
| Country | Link |
|---|---|
| US (6) | US7767816B2 (enExample) |
| EP (3) | EP2537849A3 (enExample) |
| JP (4) | JP5591471B2 (enExample) |
| KR (3) | KR101409727B1 (enExample) |
| CN (3) | CN102532134A (enExample) |
| AR (1) | AR060316A1 (enExample) |
| AU (1) | AU2007207533B8 (enExample) |
| BR (2) | BRPI0706537A2 (enExample) |
| CA (1) | CA2636189A1 (enExample) |
| CL (1) | CL2008002140A1 (enExample) |
| HK (1) | HK1210780A1 (enExample) |
| IL (1) | IL191902A0 (enExample) |
| NO (1) | NO20083501L (enExample) |
| NZ (3) | NZ569899A (enExample) |
| RU (2) | RU2453548C2 (enExample) |
| TW (4) | TW201412738A (enExample) |
| UA (1) | UA95940C2 (enExample) |
| WO (1) | WO2007084557A2 (enExample) |
| ZA (2) | ZA200805053B (enExample) |
Families Citing this family (101)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101676285A (zh) | 2004-03-30 | 2010-03-24 | 沃泰克斯药物股份有限公司 | 用作jak和其它蛋白激酶抑制剂的氮杂吲哚 |
| EP2354139A1 (en) * | 2005-05-20 | 2011-08-10 | Vertex Pharmaceuticals Incorporated | Pyrrolopyridines useful as inhibitors of protein kinase |
| EP2270014A1 (en) | 2005-09-22 | 2011-01-05 | Incyte Corporation | Azepine inhibitors of janus kinases |
| PT2474545T (pt) | 2005-12-13 | 2017-02-14 | Incyte Holdings Corp | Pirrolo[2,3-b]piridinas e pirrolo[2,3-b]pirimidinas substituídas com heteroarilo como inibidores de janus quinase |
| UA95940C2 (uk) * | 2006-01-17 | 2011-09-26 | Вертекс Фармасьютикалс Інкорпорейтед | Азаіндоли як інгібітори кіназ януса |
| KR20090018895A (ko) * | 2006-04-05 | 2009-02-24 | 버텍스 파마슈티칼스 인코포레이티드 | 야누스 키나제의 억제제로서 유용한 데아자푸린 |
| US7754838B2 (en) * | 2006-08-08 | 2010-07-13 | E.I. Du Pont De Nemours And Company | Poly(meth)acrylamides and poly(meth)acrylates containing fluorinated amide |
| CA2673472A1 (en) | 2006-12-21 | 2008-07-03 | Vertex Pharmaceuticals Incorporated | 5-cyan0-4- (pyrrolo) [2, 3b] pyridine-3-yl) -pyrimidine derivatives useful as protein kinase inhibitors |
| WO2008079965A1 (en) | 2006-12-22 | 2008-07-03 | Incyte Corporation | Substituted heterocycles as janus kinase inhibitors |
| CN101778825A (zh) * | 2007-03-22 | 2010-07-14 | 沃泰克斯药物股份有限公司 | 适用作詹纳斯激酶抑制剂的n-杂环类化合物 |
| GEP20125533B (en) | 2007-06-13 | 2012-05-25 | Incyte Corp | Salts of the janus kinase inhibitor (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentyl propanenitrile |
| CL2008001709A1 (es) | 2007-06-13 | 2008-11-03 | Incyte Corp | Compuestos derivados de pirrolo [2,3-b]pirimidina, moduladores de quinasas jak; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como cancer, psoriasis, artritis reumatoide, entre otras. |
| JP2011513483A (ja) * | 2008-03-10 | 2011-04-28 | バーテックス ファーマシューティカルズ インコーポレイテッド | タンパク質キナーゼの阻害剤として有用なピリミジンおよびピリジン |
| EA017218B1 (ru) | 2008-03-11 | 2012-10-30 | Инсайт Корпорейшн | Производные азетидина и циклобутана как ингибиторы jak-киназ |
| MX2011000839A (es) * | 2008-07-23 | 2011-04-05 | Vertex Pharma | Inhibidores de pirazolpiridina cinasa. |
| HRP20192203T1 (hr) | 2009-05-22 | 2020-03-06 | Incyte Holdings Corporation | 3-[4-(7h-pirolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il]oktan- ili heptan-nitril kao jak inhibitori |
| WO2010135650A1 (en) | 2009-05-22 | 2010-11-25 | Incyte Corporation | N-(HETERO)ARYL-PYRROLIDINE DERIVATIVES OF PYRAZOL-4-YL-PYRROLO[2,3-d]PYRIMIDINES AND PYRROL-3-YL-PYRROLO[2,3-d]PYRIMIDINES AS JANUS KINASE INHIBITORS |
| BRPI1011993A2 (pt) | 2009-06-17 | 2021-07-06 | Vertex Pharmaceuticals Incorporated | inibidores de replicação do vírus influenza, seu uso, método de preparação dos mesmos e compositção farmacêutica que os compreende |
| TW201113285A (en) | 2009-09-01 | 2011-04-16 | Incyte Corp | Heterocyclic derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors |
| EP2486041B1 (en) | 2009-10-09 | 2013-08-14 | Incyte Corporation | Hydroxyl, keto, and glucuronide derivatives of 3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentylpropanenitrile |
| DK2516434T3 (en) | 2009-12-23 | 2015-08-31 | Takeda Pharmaceutical | FUSED HETEROAROMATIC PYRROLIDINONS AS SICK INHIBITORS |
| PE20130038A1 (es) | 2010-03-10 | 2013-01-28 | Incyte Corp | Derivados de piperidin-4-il azetidina como inhibidores de jak1 |
| US8481541B2 (en) | 2010-03-22 | 2013-07-09 | Hoffmann-La Roche Inc. | Pyrrolopyrazine kinase inhibitors |
| WO2011137022A1 (en) * | 2010-04-27 | 2011-11-03 | Merck Sharp & Dohme Corp. | Azaindoles as janus kinase inhibitors |
| CA2798970A1 (en) | 2010-05-20 | 2011-11-24 | F. Hoffmann-La Roche Ag | Pyrrolopyrazine derivatives as syk and jak inhibitors |
| RS54824B1 (sr) | 2010-05-21 | 2016-10-31 | Incyte Holdings Corp | Topikalna formulacija za inhibiciju jak-a |
| WO2013149194A1 (en) * | 2012-03-29 | 2013-10-03 | The Trustees Of Columbia University In The City Of New York | Methods for treating hair loss disorders |
| US9198911B2 (en) | 2010-11-02 | 2015-12-01 | The Trustees Of Columbia University In The City Of New York | Methods for treating hair loss disorders |
| WO2012068440A1 (en) | 2010-11-19 | 2012-05-24 | Incyte Corporation | Heterocyclic-substituted pyrrolopyridines and pyrrolopyrimidines as jak inhibitors |
| KR20140019300A (ko) | 2010-11-19 | 2014-02-14 | 인사이트 코포레이션 | Ｊａｋ 억제제로서 사이클로부틸 치환된 피롤로피리딘 및 피롤로피리미딘 유도체 |
| KR20130128435A (ko) | 2010-12-16 | 2013-11-26 | 버텍스 파마슈티칼스 인코포레이티드 | 인플루엔자 바이러스 복제의 억제제 |
| CN103492381A (zh) | 2010-12-16 | 2014-01-01 | 沃泰克斯药物股份有限公司 | 流感病毒复制的抑制剂 |
| KR20130128436A (ko) | 2010-12-16 | 2013-11-26 | 버텍스 파마슈티칼스 인코포레이티드 | 인플루엔자 바이러스 복제의 억제제 |
| DE102011009961A1 (de) * | 2011-02-01 | 2012-08-02 | Merck Patent Gmbh | 7-Azaindolderivate |
| PT2675451E (pt) | 2011-02-18 | 2015-10-16 | Incyte Corp | Terapia de combinação com inibidores mtor/jak |
| JP6277121B2 (ja) | 2011-03-22 | 2018-02-07 | アドヴィナス・セラピューティックス・リミテッド | 置換された縮合三環式化合物、その組成物および医学的応用 |
| JP2014515368A (ja) | 2011-05-26 | 2014-06-30 | 第一三共株式会社 | プロテインキナーゼ阻害剤としての複素環化合物 |
| EA201490042A1 (ru) | 2011-06-20 | 2014-10-30 | Инсайт Корпорейшн | Азетидинил-фенил-, пиридил- или пиразинилкарбоксамидные производные как ингибиторы jak |
| EP2723739B1 (en) | 2011-06-22 | 2016-08-24 | Takeda Pharmaceutical Company Limited | Substituted 6-aza-isoindolin-1-one derivatives |
| PL3141548T3 (pl) | 2011-07-05 | 2020-09-07 | Vertex Pharmaceuticals Incorporated | Sposoby i związki pośrednie do wytwarzania azaindoli |
| UA118010C2 (uk) | 2011-08-01 | 2018-11-12 | Вертекс Фармасьютікалз Інкорпорейтед | Інгібітори реплікації вірусів грипу |
| CA2844507A1 (en) | 2011-08-10 | 2013-02-14 | Novartis Pharma Ag | Jak pi3k/mtor combination therapy |
| TW201313721A (zh) | 2011-08-18 | 2013-04-01 | Incyte Corp | 作為ｊａｋ抑制劑之環己基氮雜環丁烷衍生物 |
| UA111854C2 (uk) | 2011-09-07 | 2016-06-24 | Інсайт Холдінгс Корпорейшн | Способи і проміжні сполуки для отримання інгібіторів jak |
| AU2012336019A1 (en) | 2011-11-07 | 2014-05-29 | Vertex Pharmaceuticals Incorporated | Methods for treating inflammatory diseases and pharmaceutical combinations useful therefor |
| CN107898790B (zh) | 2011-11-30 | 2024-06-21 | 埃默里大学 | 用于治疗或预防逆转录病毒和其它病毒感染的抗病毒jak抑制剂 |
| WO2013117649A1 (en) * | 2012-02-10 | 2013-08-15 | Galapagos Nv | Imidazo [4, 5 -c] pyridine derivatives useful for the treatment of degenerative and inflammatory diseases |
| UY34616A (es) * | 2012-02-10 | 2013-09-30 | Galapagos Nv | Nuevo compuesto útil para el tratamiento de enfermedades degenerativas e inflamatorias. |
| US20130310340A1 (en) | 2012-05-16 | 2013-11-21 | Rigel Pharmaceuticals, Inc. | Method of treating muscular degradation |
| TW201406761A (zh) | 2012-05-18 | 2014-02-16 | Incyte Corp | 做爲ｊａｋ抑制劑之哌啶基環丁基取代之吡咯并吡啶及吡咯并嘧啶衍生物 |
| WO2013184985A1 (en) | 2012-06-08 | 2013-12-12 | Vertex Pharmaceuticals Incorporated | Inhibitors of influenza viruses replication |
| WO2014013014A1 (en) | 2012-07-18 | 2014-01-23 | Fundació Privada Centre De Regulació Genòmica (Crg) | Jak inhibitors for activation of epidermal stem cell populations |
| IN2015DN02008A (enExample) | 2012-09-21 | 2015-08-14 | Advinus Therapeutics Ltd | |
| WO2014074471A1 (en) | 2012-11-06 | 2014-05-15 | Vertex Pharmaceuticals Incorporated | Methods for treating inflammatory diseases and pharmaceutical combinations useful therefor |
| TWI761825B (zh) | 2012-11-15 | 2022-04-21 | 美商英塞特控股公司 | 盧梭利替尼之緩釋性劑型 |
| WO2014089280A1 (en) * | 2012-12-07 | 2014-06-12 | Calitor Sciences, Llc | Alkynyl compounds and methods of use |
| WO2014110259A1 (en) | 2013-01-09 | 2014-07-17 | Vertex Pharmaceuticals Incorporated | Solid forms of a jak inhibitor |
| EP2945623B1 (en) * | 2013-01-15 | 2018-09-05 | Suzhou Kintor Pharmaceuticals, Inc. | Hedgehog pathway signaling inhibitors and therapeutic applications thereof |
| TW201513861A (zh) * | 2013-01-17 | 2015-04-16 | Galapagos Nv | 用於治療退化性及發炎疾病之新穎化合物 |
| TWI841376B (zh) | 2013-03-01 | 2024-05-01 | 美商英塞特控股公司 | 吡唑并嘧啶衍生物治療PI3Kδ相關病症之用途 |
| BR122021015061B1 (pt) | 2013-03-06 | 2022-10-18 | Incyte Holdings Corporation | Processos e intermediários para preparar um inibidor de jak |
| BR112015023878A2 (pt) * | 2013-03-19 | 2017-07-18 | Merck Sharp & Dohme | composto, composição farmacêutica, e, uso de um composto |
| WO2014201332A1 (en) | 2013-06-14 | 2014-12-18 | Vertex Pharmaceuticals Incorporated | Pharmaceutical combinations useful for treating rheumatoid arthritis |
| WO2015021153A1 (en) | 2013-08-07 | 2015-02-12 | Incyte Corporation | Sustained release dosage forms for a jak1 inhibitor |
| EP3036225A1 (en) | 2013-08-22 | 2016-06-29 | Vertex Pharmaceuticals Incorporated | Isotopically enriched azaindoles |
| US9296727B2 (en) | 2013-10-07 | 2016-03-29 | Vertex Pharmaceuticals Incorporated | Methods of regioselective synthesis of 2,4-disubstituted pyrimidines |
| PT3068776T (pt) | 2013-11-13 | 2019-08-26 | Vertex Pharma | Inibidores da replicação de vírus da gripe |
| WO2015073481A1 (en) | 2013-11-13 | 2015-05-21 | Vertex Pharmaceuticals Incorporated | Methods of preparing inhibitors of influenza viruses replication |
| PL3070086T3 (pl) * | 2014-02-04 | 2019-04-30 | Taiho Pharmaceutical Co Ltd | Pochodna azaindolu |
| US9498467B2 (en) | 2014-05-30 | 2016-11-22 | Incyte Corporation | Treatment of chronic neutrophilic leukemia (CNL) and atypical chronic myeloid leukemia (aCML) by inhibitors of JAK1 |
| EP3177609A1 (en) | 2014-08-08 | 2017-06-14 | Janssen Sciences Ireland UC | Indoles for use in influenza virus infection |
| NO2721710T3 (enExample) | 2014-08-21 | 2018-03-31 | ||
| TWI679205B (zh) | 2014-09-02 | 2019-12-11 | 日商日本新藥股份有限公司 | 吡唑并噻唑化合物及醫藥 |
| BR112017009501A2 (pt) * | 2014-11-10 | 2018-02-06 | Glaxosmithkline Ip No 2 Ltd | método para tratar uma infecção por hcv, método para curar uma infecção por hcv, e, composição farmacêutica. |
| JP6460382B2 (ja) * | 2014-11-28 | 2019-01-30 | 株式会社豊田自動織機 | 飽和ヘテロ環含有化合物、並びにこれを用いた二次電池用電極及び二次電池、結着剤、蛍光物質 |
| MA42422A (fr) | 2015-05-13 | 2018-05-23 | Vertex Pharma | Inhibiteurs de la réplication des virus de la grippe |
| EP3294717B1 (en) | 2015-05-13 | 2020-07-29 | Vertex Pharmaceuticals Inc. | Methods of preparing inhibitors of influenza viruses replication |
| TWI712604B (zh) | 2016-03-01 | 2020-12-11 | 日商日本新藥股份有限公司 | 具jak抑制作用之化合物之結晶 |
| WO2017198122A1 (zh) * | 2016-05-19 | 2017-11-23 | 四川大学 | 抗流感小分子化合物及其制备方法和用途 |
| WO2018019222A1 (zh) | 2016-07-26 | 2018-02-01 | 张文燕 | 作为jak抑制剂杂环化合物，该化合物的盐类及其治疗用途 |
| WO2018041989A1 (en) | 2016-09-02 | 2018-03-08 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for diagnosing and treating refractory celiac disease type 2 |
| TWI778052B (zh) | 2017-04-24 | 2022-09-21 | 美商共結晶製藥公司 | 流感病毒複製之抑制劑 |
| AR113922A1 (es) | 2017-12-08 | 2020-07-01 | Incyte Corp | Terapia de combinación de dosis baja para el tratamiento de neoplasias mieloproliferativas |
| WO2019152374A1 (en) | 2018-01-30 | 2019-08-08 | Incyte Corporation | Processes for preparing (1 -(3-fluoro-2-(trifluoromethyl)isonicotinyl)piperidine-4-one) |
| AU2019234574A1 (en) | 2018-03-12 | 2020-09-03 | Abbvie Inc. | Inhibitors of tyrosine kinase 2 mediated signaling |
| PL3773593T3 (pl) | 2018-03-30 | 2024-09-02 | Incyte Corporation | Leczenie ropnego zapalenia gruczołów potowych z zastosowaniem inhibitorów jak |
| WO2020023813A1 (en) | 2018-07-27 | 2020-01-30 | Cocrystal Pharma, Inc. | Pyrrolo[2,3-b]pyridin derivatives as inhibitors of influenza virus replication |
| EP3887355A1 (en) | 2018-11-26 | 2021-10-06 | Cocrystal Pharma, Inc. | Inhibitors of influenza virus replication |
| BR112021018168B1 (pt) | 2019-03-21 | 2023-11-28 | Onxeo | Composição farmacêutica, combinação e kit compreendendo uma molécula dbait e um inibidor de quinase para o tratamento de câncer |
| WO2020201362A2 (en) | 2019-04-02 | 2020-10-08 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods of predicting and preventing cancer in patients having premalignant lesions |
| EP3955920A1 (en) | 2019-04-16 | 2022-02-23 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Use of jak inhibitors for the treatment of painful conditions involving nav1.7 channels |
| KR102133595B1 (ko) | 2019-05-31 | 2020-07-13 | 에이치케이이노엔 주식회사 | 단백질 키나제 억제제로서의 헤테로고리 화합물 |
| KR102112336B1 (ko) | 2019-08-12 | 2020-05-18 | 에이치케이이노엔 주식회사 | 단백질 키나제 억제제로서의 헤테로고리 화합물 |
| EP4041241A4 (en) | 2019-09-27 | 2023-09-06 | Disc Medicine, Inc. | METHODS OF TREATING MYELOFIBROSIS AND ASSOCIATED CONDITIONS |
| US20220401436A1 (en) | 2019-11-08 | 2022-12-22 | INSERM (Institute National de la Santé et de la Recherche Médicale) | Methods for the treatment of cancers that have acquired resistance to kinase inhibitors |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
| US20230151034A1 (en) | 2020-03-17 | 2023-05-18 | Cocrystal Pharma, Inc. | Peptidomimetic n5-methyl-n2-(nonanoyl-l-leucyl)-l-glutaminate derivatives, triazaspiro[4.14]nonadecane derivatives and similar compounds as inhibitors of norovirus and coronavirus replication |
| KR20230012539A (ko) | 2020-05-13 | 2023-01-26 | 디스크 메디슨, 인크. | 골수섬유증을 치료하기 위한 항-헤모주벨린 (hjv) 항체 |
| US11833155B2 (en) | 2020-06-03 | 2023-12-05 | Incyte Corporation | Combination therapy for treatment of myeloproliferative neoplasms |
| EP4526469A1 (en) | 2022-05-16 | 2025-03-26 | Institut National de la Santé et de la Recherche Médicale | Methods for assessing the exhaustion of hematopoietic stems cells induced by chronic inflammation |
| KR20250170567A (ko) * | 2023-04-17 | 2025-12-05 | 아벨로스테라퓨틱스 주식회사 | 치환된 아세틸렌 화합물 유도체 및 이의 약제학적 용도 |
Family Cites Families (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT85662B (pt) | 1986-09-10 | 1990-06-29 | Sandoz Sa | Processo para a preparacao de derivados de aza-indol e de indolizina e de composicoes farmaceuticas que os contem |
| US5304121A (en) | 1990-12-28 | 1994-04-19 | Boston Scientific Corporation | Drug delivery system making use of a hydrogel polymer coating |
| FR2687402B1 (fr) | 1992-02-14 | 1995-06-30 | Lipha | Nouveaux azaindoles, procedes de preparation et medicaments les contenant. |
| US5994341A (en) | 1993-07-19 | 1999-11-30 | Angiogenesis Technologies, Inc. | Anti-angiogenic Compositions and methods for the treatment of arthritis |
| US6075037A (en) | 1994-06-09 | 2000-06-13 | Smithkline Beecham Corporation | Endothelin receptor antagonists |
| US6099562A (en) | 1996-06-13 | 2000-08-08 | Schneider (Usa) Inc. | Drug coating with topcoat |
| GB9721437D0 (en) | 1997-10-10 | 1997-12-10 | Glaxo Group Ltd | Heteroaromatic compounds and their use in medicine |
| FR2784375B1 (fr) * | 1998-10-12 | 2000-11-24 | Adir | Nouveaux derives cycliques a chaine cycloalkylenique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| US6265403B1 (en) | 1999-01-20 | 2001-07-24 | Merck & Co., Inc. | Angiogenesis inhibitors |
| US20030153560A1 (en) | 1999-04-23 | 2003-08-14 | Salituro Francesco G. | Inhibitors of c-Jun N-terminal kinases (JNK) |
| DE60027431T2 (de) | 1999-07-02 | 2007-07-12 | Stuart A. Rancho Santa Fe Lipton | Verwendung von p38 MAPK Inhibitoren in der Behandlung von Augenkrankheiten |
| JP2003519143A (ja) | 1999-12-28 | 2003-06-17 | ファーマコピーア，インコーポレーティッド | ピリミジン及びトリアジン系キナーゼ阻害剤 |
| CA2400447C (en) | 2000-02-17 | 2008-04-22 | Amgen Inc. | Kinase inhibitors |
| DE60128709T2 (de) | 2000-09-15 | 2007-12-27 | Vertex Pharmaceuticals Inc., Cambridge | Triazol-verbindungen als protein-kinase-inhibitoren |
| JP4343534B2 (ja) | 2001-03-02 | 2009-10-14 | ゲーペーツェー バイオテック アクチェンゲゼルシャフト | ３ハイブリッド・アッセイ・システム |
| US7081454B2 (en) | 2001-03-28 | 2006-07-25 | Bristol-Myers Squibb Co. | Tyrosine kinase inhibitors |
| US6825190B2 (en) | 2001-06-15 | 2004-11-30 | Vertex Pharmaceuticals Incorporated | Protein kinase inhibitors and uses thereof |
| GB0115109D0 (en) | 2001-06-21 | 2001-08-15 | Aventis Pharma Ltd | Chemical compounds |
| US20040236110A1 (en) | 2001-09-26 | 2004-11-25 | Ladouceur Gaetan H | Substituted 3-pyridyl indoles and indazoles as c17,20 lyase inhibitors |
| TW200306819A (en) | 2002-01-25 | 2003-12-01 | Vertex Pharma | Indazole compounds useful as protein kinase inhibitors |
| EP1506189A1 (en) | 2002-04-26 | 2005-02-16 | Vertex Pharmaceuticals Incorporated | Pyrrole derivatives as inhibitors of erk2 and uses thereof |
| ATE308544T1 (de) | 2002-04-26 | 2005-11-15 | Pfizer Prod Inc | N-substituiete heteroaryloxy-aryl-spiro- pyrimidine-2,4,6-trion metalloproteinase inhibitoren |
| KR20050004214A (ko) | 2002-05-31 | 2005-01-12 | 에자이 가부시키가이샤 | 피라졸 화합물 및 이것을 포함하여 이루어지는 의약 조성물 |
| UA78999C2 (en) | 2002-06-04 | 2007-05-10 | Wyeth Corp | 1-(aminoalkyl)-3-sulfonylazaindoles as ligands of 5-hydroxytryptamine-6 |
| ZA200501124B (en) | 2002-08-02 | 2006-10-25 | Vertex Pharma | Pyrazole compositions useful as inhibitors of GSK-3 |
| SE0202463D0 (sv) | 2002-08-14 | 2002-08-14 | Astrazeneca Ab | Novel compounds |
| US7262200B2 (en) | 2002-10-25 | 2007-08-28 | Vertex Pharmaceuticals Incorporated | Indazolinone compositions useful as kinase inhibitors |
| US7432375B2 (en) | 2003-03-06 | 2008-10-07 | Eisai R & D Management Co., Ltd. | JNK inhibitors |
| US7381825B2 (en) | 2003-03-17 | 2008-06-03 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| GB0308466D0 (en) | 2003-04-11 | 2003-05-21 | Novartis Ag | Organic compounds |
| AR045595A1 (es) | 2003-09-04 | 2005-11-02 | Vertex Pharma | Composiciones utiles como inhibidores de proteinas quinasas |
| WO2005044181A2 (en) | 2003-09-09 | 2005-05-19 | Temple University-Of The Commonwealth System Of Higher Education | Protection of tissues and cells from cytotoxic effects of ionizing radiation by abl inhibitors |
| CN1897950A (zh) | 2003-10-14 | 2007-01-17 | 惠氏公司 | 稠合芳基和杂芳基衍生物及其使用方法 |
| PT1696920E (pt) | 2003-12-19 | 2015-01-14 | Plexxikon Inc | Compostos e métodos para o desenvolvimento de moduladores de ret |
| CN101676285A (zh) | 2004-03-30 | 2010-03-24 | 沃泰克斯药物股份有限公司 | 用作jak和其它蛋白激酶抑制剂的氮杂吲哚 |
| MXPA06011328A (es) | 2004-04-02 | 2006-12-15 | Vertex Pharma | Azaindoles utiles como inhibidotes de roca y otras proteinas cinasas. |
| AU2005265017A1 (en) | 2004-06-17 | 2006-01-26 | Plexxikon, Inc. | Azaindoles modulating c-kit activity and uses therefor |
| US20060122213A1 (en) | 2004-06-30 | 2006-06-08 | Francoise Pierard | Azaindoles useful as inhibitors of protein kinases |
| JP2008508303A (ja) | 2004-07-27 | 2008-03-21 | エスジーエックス ファーマシューティカルズ、インコーポレイテッド | ピロロ−ピリジンキナーゼモジュレーター |
| GB0420719D0 (en) | 2004-09-17 | 2004-10-20 | Addex Pharmaceuticals Sa | Novel allosteric modulators |
| WO2006038001A1 (en) | 2004-10-06 | 2006-04-13 | Celltech R & D Limited | Aminopyrimidine derivatives as jnk inhibitors |
| US7855205B2 (en) | 2004-10-29 | 2010-12-21 | Janssen Pharmaceutica Nv | Pyrimidinyl substituted fused-pyrrolyl compounds useful in treating kinase disorders |
| EP1814882A1 (en) | 2004-11-22 | 2007-08-08 | Vertex Pharmaceuticals Incorporated | Pyrrolopyrazines and pyrazolopyrazines useful as inhibitors of protein kinases |
| JP2008524233A (ja) | 2004-12-16 | 2008-07-10 | バーテックス ファーマシューティカルズ インコーポレイテッド | 炎症性疾患、増殖性疾患および免疫介在性疾患の治療のためのｔｅｃファミリータンパク質キナーゼのインヒビターとして有用なピリド−２−オン |
| ZA200707342B (en) | 2005-02-03 | 2009-03-25 | Vertex Pharma | Pyrrolopyrimidines useful as inhibitors of protein kinase |
| PL1896470T3 (pl) | 2005-05-16 | 2011-03-31 | Irm Llc | Pochodne pirolopirydynowe jako inhibitory kinazy białkowej |
| EP2354139A1 (en) | 2005-05-20 | 2011-08-10 | Vertex Pharmaceuticals Incorporated | Pyrrolopyridines useful as inhibitors of protein kinase |
| EP2395004B1 (en) | 2005-06-22 | 2016-01-20 | Plexxikon Inc. | Pyrrolo [2,3-b]pyridine derivatives as protein kinase inhibitors |
| ZA200802685B (en) | 2005-09-30 | 2009-10-28 | Vertex Pharma | Deazapurines useful as inhibitors of janus kinases |
| UA95940C2 (uk) * | 2006-01-17 | 2011-09-26 | Вертекс Фармасьютикалс Інкорпорейтед | Азаіндоли як інгібітори кіназ януса |
| CA2641254A1 (en) | 2006-02-14 | 2007-08-23 | Vertex Pharmaceuticals Incorporated | Pyrrolo(3,2-c) pyridines useful as inhibitors of protein kinases |
| KR20090018895A (ko) | 2006-04-05 | 2009-02-24 | 버텍스 파마슈티칼스 인코포레이티드 | 야누스 키나제의 억제제로서 유용한 데아자푸린 |
| ATE497961T1 (de) | 2006-12-14 | 2011-02-15 | Vertex Pharma | Als proteinkinaseinhibitoren geeignete verbindungen |
| EP2145887B1 (en) | 2007-04-05 | 2016-04-27 | Alla Chem, LLC. | Substituted 2,3,4,5-tetrahydro-1h-pyrido[4,3-b]indoles, methods for the production and use thereof |
| CN101903384A (zh) | 2007-11-02 | 2010-12-01 | 沃泰克斯药物股份有限公司 | 作为蛋白激酶Cθ抑制剂的[1H-吡唑并[3,4-B]吡啶-4-基]-苯基或-吡啶-2-基衍生物 |
| JP2011513483A (ja) | 2008-03-10 | 2011-04-28 | バーテックス ファーマシューティカルズ インコーポレイテッド | タンパク質キナーゼの阻害剤として有用なピリミジンおよびピリジン |
| AU2012336019A1 (en) | 2011-11-07 | 2014-05-29 | Vertex Pharmaceuticals Incorporated | Methods for treating inflammatory diseases and pharmaceutical combinations useful therefor |
-
2007
- 2007-01-17 UA UAA200810409A patent/UA95940C2/uk unknown
- 2007-01-17 NZ NZ569899A patent/NZ569899A/en not_active IP Right Cessation
- 2007-01-17 CA CA 2636189 patent/CA2636189A1/en not_active Abandoned
- 2007-01-17 KR KR1020087017472A patent/KR101409727B1/ko not_active Expired - Fee Related
- 2007-01-17 RU RU2008133613/04A patent/RU2453548C2/ru not_active IP Right Cessation
- 2007-01-17 AU AU2007207533A patent/AU2007207533B8/en not_active Ceased
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- 2007-01-17 KR KR1020137005929A patent/KR20130041313A/ko not_active Withdrawn
- 2007-01-17 TW TW102147300A patent/TW201412738A/zh unknown
- 2007-01-17 EP EP20120176813 patent/EP2537849A3/en not_active Withdrawn
- 2007-01-17 CN CN2011104033161A patent/CN102532134A/zh active Pending
- 2007-01-17 EP EP07718337.4A patent/EP1973911B1/en active Active
- 2007-01-17 NZ NZ59296807A patent/NZ592968A/xx not_active IP Right Cessation
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- 2007-01-17 EP EP20120176810 patent/EP2559694A3/en not_active Withdrawn
- 2007-01-17 AR ARP070100199 patent/AR060316A1/es unknown
- 2007-01-17 WO PCT/US2007/001225 patent/WO2007084557A2/en not_active Ceased
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- 2007-01-17 TW TW101137037A patent/TWI424999B/zh not_active IP Right Cessation
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- 2007-01-17 BR BRPI0722364-1A patent/BRPI0722364A2/pt not_active IP Right Cessation
-
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- 2008-06-10 ZA ZA2008/05053A patent/ZA200805053B/en unknown
- 2008-07-21 CL CL2008002140A patent/CL2008002140A1/es unknown
- 2008-08-13 NO NO20083501A patent/NO20083501L/no not_active Application Discontinuation
-
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- 2009-04-30 HK HK15111605.7A patent/HK1210780A1/xx unknown
- 2009-06-12 ZA ZA2009/04147A patent/ZA200904147B/en unknown
-
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- 2010-05-07 US US12/775,885 patent/US8163917B2/en not_active Expired - Fee Related
-
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- 2011-12-14 RU RU2011151085/02A patent/RU2011151085A/ru not_active Application Discontinuation
-
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- 2012-03-01 US US13/409,702 patent/US8450489B2/en not_active Expired - Fee Related
- 2012-10-11 JP JP2012226367A patent/JP5728454B2/ja not_active Expired - Fee Related
- 2012-10-11 JP JP2012226368A patent/JP2013010793A/ja not_active Ceased
-
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- 2013-04-25 US US13/870,173 patent/US8822681B2/en not_active Expired - Fee Related
-
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- 2014-07-24 US US14/339,514 patent/US9120790B2/en not_active Expired - Fee Related
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-
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- 2015-07-29 US US14/812,158 patent/US20160008359A1/en not_active Abandoned
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