JP2017524733A5 - - Google Patents
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- Publication number
- JP2017524733A5 JP2017524733A5 JP2017519756A JP2017519756A JP2017524733A5 JP 2017524733 A5 JP2017524733 A5 JP 2017524733A5 JP 2017519756 A JP2017519756 A JP 2017519756A JP 2017519756 A JP2017519756 A JP 2017519756A JP 2017524733 A5 JP2017524733 A5 JP 2017524733A5
- Authority
- JP
- Japan
- Prior art keywords
- nitrogen
- sulfur
- oxygen
- independently selected
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 92
- 150000001875 compounds Chemical class 0.000 claims description 88
- 229910052760 oxygen Inorganic materials 0.000 claims description 80
- 229910052717 sulfur Inorganic materials 0.000 claims description 80
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 64
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 64
- 125000005842 heteroatom Chemical group 0.000 claims description 64
- 229910052757 nitrogen Inorganic materials 0.000 claims description 64
- 239000001301 oxygen Substances 0.000 claims description 64
- 239000011593 sulfur Substances 0.000 claims description 64
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 36
- 125000001931 aliphatic group Chemical group 0.000 claims description 34
- 125000003118 aryl group Chemical group 0.000 claims description 32
- 229920006395 saturated elastomer Polymers 0.000 claims description 28
- 125000000623 heterocyclic group Chemical group 0.000 claims description 27
- 125000004429 atom Chemical group 0.000 claims description 20
- 150000003839 salts Chemical class 0.000 claims description 18
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 9
- 229910052736 halogen Inorganic materials 0.000 claims description 8
- 150000002367 halogens Chemical class 0.000 claims description 8
- 229910052739 hydrogen Inorganic materials 0.000 claims description 8
- 239000001257 hydrogen Substances 0.000 claims description 8
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 8
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 8
- 239000000203 mixture Substances 0.000 claims description 8
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 8
- 102100027627 Follicle-stimulating hormone receptor Human genes 0.000 claims description 7
- 101000862396 Homo sapiens Follicle-stimulating hormone receptor Proteins 0.000 claims description 7
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 7
- 230000001404 mediated effect Effects 0.000 claims description 5
- 125000002837 carbocyclic group Chemical group 0.000 claims description 4
- 125000001072 heteroaryl group Chemical group 0.000 claims description 4
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 4
- -1 pyridyl compound Chemical class 0.000 claims description 4
- 125000001544 thienyl group Chemical group 0.000 claims description 4
- 239000012472 biological sample Substances 0.000 claims description 3
- 230000000069 prophylactic effect Effects 0.000 claims description 3
- 125000004076 pyridyl group Chemical group 0.000 claims description 3
- 230000001225 therapeutic effect Effects 0.000 claims description 3
- 125000004011 3 membered carbocyclic group Chemical group 0.000 claims description 2
- 239000002671 adjuvant Substances 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 230000000694 effects Effects 0.000 claims description 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 2
- 208000021267 infertility disease Diseases 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims description 2
- 125000003107 substituted aryl group Chemical group 0.000 claims description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000035475 disorder Diseases 0.000 description 2
- 102000012673 Follicle Stimulating Hormone Human genes 0.000 description 1
- 108010079345 Follicle Stimulating Hormone Proteins 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 230000036755 cellular response Effects 0.000 description 1
- 229940028334 follicle stimulating hormone Drugs 0.000 description 1
- 239000013610 patient sample Substances 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CN2014/080519 WO2015196335A1 (en) | 2014-06-23 | 2014-06-23 | Pyrazole compounds as modulators of fshr and uses thereof |
| CNPCT/CN2014/080519 | 2014-06-23 | ||
| PCT/CN2014/094459 WO2015196759A1 (en) | 2014-06-23 | 2014-12-22 | Pyrazole compounds as modulators of fshr and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019129171A Division JP2019196375A (ja) | 2014-06-23 | 2019-07-11 | Ｆｓｈｒのモジュレータとしてのピラゾール化合物およびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017524733A JP2017524733A (ja) | 2017-08-31 |
| JP2017524733A5 true JP2017524733A5 (enExample) | 2018-01-18 |
| JP6557331B2 JP6557331B2 (ja) | 2019-08-07 |
Family
ID=54936412
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017519756A Active JP6557331B2 (ja) | 2014-06-23 | 2014-12-22 | Ｆｓｈｒのモジュレータとしてのピラゾール化合物およびその使用 |
| JP2019129171A Pending JP2019196375A (ja) | 2014-06-23 | 2019-07-11 | Ｆｓｈｒのモジュレータとしてのピラゾール化合物およびその使用 |
| JP2020191715A Pending JP2021038245A (ja) | 2014-06-23 | 2020-11-18 | Ｆｓｈｒのモジュレータとしてのピラゾール化合物およびその使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019129171A Pending JP2019196375A (ja) | 2014-06-23 | 2019-07-11 | Ｆｓｈｒのモジュレータとしてのピラゾール化合物およびその使用 |
| JP2020191715A Pending JP2021038245A (ja) | 2014-06-23 | 2020-11-18 | Ｆｓｈｒのモジュレータとしてのピラゾール化合物およびその使用 |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US10208055B2 (enExample) |
| EP (1) | EP3157929B1 (enExample) |
| JP (3) | JP6557331B2 (enExample) |
| KR (1) | KR102416279B1 (enExample) |
| CN (1) | CN106573937B (enExample) |
| AU (3) | AU2014398875B2 (enExample) |
| CA (1) | CA2955415A1 (enExample) |
| DK (1) | DK3157929T3 (enExample) |
| ES (1) | ES2972131T3 (enExample) |
| MX (1) | MX389867B (enExample) |
| RU (1) | RU2752173C2 (enExample) |
| WO (2) | WO2015196335A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015196335A1 (en) | 2014-06-23 | 2015-12-30 | Tocopherx, Inc. | Pyrazole compounds as modulators of fshr and uses thereof |
| CN106866692A (zh) * | 2017-03-30 | 2017-06-20 | 毛阿龙 | 具有苯并1,4‑二氧杂环己二烯酮结构的fshr拮抗剂的制备方法 |
| CN106967076A (zh) * | 2017-03-30 | 2017-07-21 | 河南师范大学 | 一种具有6h‑二苯并吡喃结构化合物及其制备方法 |
| CN106977523A (zh) * | 2017-03-30 | 2017-07-25 | 河南师范大学 | 具有苯基并四氢吡咯结构的fshr拮抗剂及其制备方法 |
| RU2020124136A (ru) * | 2017-12-22 | 2022-01-25 | Хиберселл, Инк. | Производные хроменопиридина в качестве ингибиторов фосфатидилинозитолфосфаткиназы |
| MY208400A (en) | 2018-05-03 | 2025-05-07 | Shanghai hengrui pharmaceutical co ltd | Benzimidazole derivatives as modulators of retinoid-related orphan receptor gamma (ror) and pharmaceutical uses thereof |
| TW202112784A (zh) | 2019-06-17 | 2021-04-01 | 美商佩特拉製藥公司 | 作為磷脂酸肌醇磷酸激酶抑制劑之𠳭唏并嘧啶衍生物 |
| CN113754678B (zh) * | 2020-06-02 | 2023-03-10 | 江苏恒瑞医药股份有限公司 | 二氢硫代色烯并吡唑类衍生物、其制备方法及其在医药上的应用 |
| CN115835863B (zh) * | 2020-07-09 | 2025-08-12 | 江苏恒瑞医药股份有限公司 | 氧杂氮杂双环类衍生物、其制备方法及其在医药上的应用 |
| US20230234962A1 (en) | 2020-07-29 | 2023-07-27 | Jiangsu Hengrui Pharmaceuticals Co., Ltd. | Oxa-azaspiro derivative, and preparation method therefor and pharmaceutical use thereof |
| IL312114A (en) | 2021-10-14 | 2024-06-01 | Incyte Corp | Quinoline compounds as Kras inhibitors |
| EP4577206A2 (en) * | 2022-08-26 | 2025-07-02 | Celmatix Inc. | Novel modulators of fshr and uses thereof |
| WO2024077006A1 (en) * | 2022-10-05 | 2024-04-11 | Radionetics Oncology, Inc. | Follicle-stimulating hormone receptor (fshr) targeted therapeutics and uses thereof |
| EP4676591A2 (en) | 2023-03-08 | 2026-01-14 | Ferring B.V. | Small molecule fsh receptor modulators |
| WO2024263803A2 (en) * | 2023-06-21 | 2024-12-26 | Celmatix Inc. | Novel modulators of fshr and uses thereof |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8814586D0 (en) * | 1988-06-20 | 1988-07-27 | Erba Carlo Spa | Tricyclic 3-oxo-propanenitrile derivatives & process for their preparation |
| EP1307193A1 (en) | 2000-07-27 | 2003-05-07 | Affymax Research Institute | Agonists of follicle stimulating hormone activity |
| ES2286275T3 (es) * | 2001-09-19 | 2007-12-01 | Pharmacia Corporation | Compuestos de pirazolo sustituidos para el tratamiento de la inflamacion. |
| DE602004028800D1 (en) * | 2003-02-07 | 2010-10-07 | Daiichi Sankyo Co Ltd | Pyrazolderivat |
| CA2607882A1 (en) * | 2005-05-12 | 2006-11-23 | Wyeth | Pyrrolobenzodiazepines and heterocyclic carboxamide derivatives as follicle stimulating hormone receptor (fsh-r) antagonists |
| WO2008035356A2 (en) * | 2006-09-20 | 2008-03-27 | Glenmark Pharmaceuticals Limited | Novel cannabinoid receptor ligands, pharmaceutical compositions containing them, and process for their preparation |
| IT1394400B1 (it) * | 2009-02-25 | 2012-06-15 | Neuroscienze Pharmaness S C Ar L | Composizioni farmaceutiche |
| IT1393930B1 (it) * | 2009-02-25 | 2012-05-17 | Neuroscienze Pharmaness S C A R L | Composti farmaceutici |
| TWI461426B (zh) * | 2009-05-27 | 2014-11-21 | Merck Sharp & Dohme | （二氫）咪唑並異〔５，１－ａ〕喹啉類 |
| MX2012005518A (es) * | 2009-11-13 | 2012-06-19 | Merck Serono Sa | Derivados de pirazol amina triciclica. |
| AU2012279416B2 (en) | 2011-07-01 | 2017-04-06 | Merck Patent Gmbh | Dihydropyrazoles, pharmaceutical compositions thereof and their use for the treatment of fertility disorders |
| CA2834199C (en) | 2011-07-18 | 2020-01-07 | Merck Patent Gmbh | Benzamides as allosteric modulators of the fsh receptor |
| CA2860808A1 (en) | 2012-01-10 | 2013-07-18 | Henry Yu | Benzamide derivatives as modulators of the follicle stimulating hormone |
| ES2672326T3 (es) | 2012-02-08 | 2018-06-13 | Merck Patent Gmbh | Analogos de tiazolidinona deuterados como agonistas para el receptor de la hormona folículo estimulante |
| CA2912921C (en) | 2013-06-24 | 2021-05-18 | Merck Patent Gmbh | Pyrazole compounds as modulators of fshr and uses thereof |
| WO2014209978A1 (en) | 2013-06-24 | 2014-12-31 | Merck Patent Gmbh | Imidazole compounds as modulators of fshr and uses thereof |
| WO2015196335A1 (en) | 2014-06-23 | 2015-12-30 | Tocopherx, Inc. | Pyrazole compounds as modulators of fshr and uses thereof |
-
2014
- 2014-06-23 WO PCT/CN2014/080519 patent/WO2015196335A1/en not_active Ceased
- 2014-12-22 RU RU2017101829A patent/RU2752173C2/ru active
- 2014-12-22 WO PCT/CN2014/094459 patent/WO2015196759A1/en not_active Ceased
- 2014-12-22 AU AU2014398875A patent/AU2014398875B2/en not_active Ceased
- 2014-12-22 EP EP14896199.8A patent/EP3157929B1/en active Active
- 2014-12-22 ES ES14896199T patent/ES2972131T3/es active Active
- 2014-12-22 US US15/321,249 patent/US10208055B2/en active Active
- 2014-12-22 JP JP2017519756A patent/JP6557331B2/ja active Active
- 2014-12-22 CN CN201480081442.1A patent/CN106573937B/zh not_active Expired - Fee Related
- 2014-12-22 CA CA2955415A patent/CA2955415A1/en active Pending
- 2014-12-22 DK DK14896199.8T patent/DK3157929T3/da active
- 2014-12-22 MX MX2017000182A patent/MX389867B/es unknown
- 2014-12-22 KR KR1020177001959A patent/KR102416279B1/ko active Active
-
2018
- 2018-12-21 US US16/229,119 patent/US10941152B2/en not_active Expired - Fee Related
-
2019
- 2019-07-11 JP JP2019129171A patent/JP2019196375A/ja active Pending
-
2020
- 2020-02-20 AU AU2020201240A patent/AU2020201240A1/en not_active Abandoned
- 2020-11-18 JP JP2020191715A patent/JP2021038245A/ja active Pending
-
2021
- 2021-01-05 US US17/141,621 patent/US20220402929A1/en not_active Abandoned
- 2021-07-09 AU AU2021204814A patent/AU2021204814B2/en not_active Ceased
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