RU2752173C2 - Пиразоловые соединения в качестве модуляторов fshr и пути их применения - Google Patents
Пиразоловые соединения в качестве модуляторов fshr и пути их применения Download PDFInfo
- Publication number
- RU2752173C2 RU2752173C2 RU2017101829A RU2017101829A RU2752173C2 RU 2752173 C2 RU2752173 C2 RU 2752173C2 RU 2017101829 A RU2017101829 A RU 2017101829A RU 2017101829 A RU2017101829 A RU 2017101829A RU 2752173 C2 RU2752173 C2 RU 2752173C2
- Authority
- RU
- Russia
- Prior art keywords
- compound
- methoxy
- methyl
- dihydrochromeno
- nmr
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/541—Non-condensed thiazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Reproductive Health (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CN2014/080519 WO2015196335A1 (en) | 2014-06-23 | 2014-06-23 | Pyrazole compounds as modulators of fshr and uses thereof |
| CNPCT/CN2014/080519 | 2014-06-23 | ||
| PCT/CN2014/094459 WO2015196759A1 (en) | 2014-06-23 | 2014-12-22 | Pyrazole compounds as modulators of fshr and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| RU2017101829A RU2017101829A (ru) | 2018-07-27 |
| RU2017101829A3 RU2017101829A3 (enExample) | 2018-08-30 |
| RU2752173C2 true RU2752173C2 (ru) | 2021-07-23 |
Family
ID=54936412
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2017101829A RU2752173C2 (ru) | 2014-06-23 | 2014-12-22 | Пиразоловые соединения в качестве модуляторов fshr и пути их применения |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US10208055B2 (enExample) |
| EP (1) | EP3157929B1 (enExample) |
| JP (3) | JP6557331B2 (enExample) |
| KR (1) | KR102416279B1 (enExample) |
| CN (1) | CN106573937B (enExample) |
| AU (3) | AU2014398875B2 (enExample) |
| CA (1) | CA2955415A1 (enExample) |
| DK (1) | DK3157929T3 (enExample) |
| ES (1) | ES2972131T3 (enExample) |
| MX (1) | MX389867B (enExample) |
| RU (1) | RU2752173C2 (enExample) |
| WO (2) | WO2015196335A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015196335A1 (en) | 2014-06-23 | 2015-12-30 | Tocopherx, Inc. | Pyrazole compounds as modulators of fshr and uses thereof |
| CN106967076A (zh) * | 2017-03-30 | 2017-07-21 | 河南师范大学 | 一种具有6h‑二苯并吡喃结构化合物及其制备方法 |
| CN106866692A (zh) * | 2017-03-30 | 2017-06-20 | 毛阿龙 | 具有苯并1,4‑二氧杂环己二烯酮结构的fshr拮抗剂的制备方法 |
| CN106977523A (zh) * | 2017-03-30 | 2017-07-25 | 河南师范大学 | 具有苯基并四氢吡咯结构的fshr拮抗剂及其制备方法 |
| AU2018392816B2 (en) * | 2017-12-22 | 2023-04-20 | HiberCell Inc. | Chromenopyridine derivatives as phosphatidylinositol phosphate kinase inhibitors |
| JP7351851B2 (ja) | 2018-05-03 | 2023-09-27 | ジエンス ヘンルイ メデイシンカンパニー リミテッド | レチノイド関連オルファン受容体ガンマ（ＲＯＲγ）のモジュレーターとしてのベンジイミダゾール誘導体およびそれらの医薬品用途 |
| TW202112784A (zh) | 2019-06-17 | 2021-04-01 | 美商佩特拉製藥公司 | 作為磷脂酸肌醇磷酸激酶抑制劑之𠳭唏并嘧啶衍生物 |
| CN113754678B (zh) * | 2020-06-02 | 2023-03-10 | 江苏恒瑞医药股份有限公司 | 二氢硫代色烯并吡唑类衍生物、其制备方法及其在医药上的应用 |
| CN115835863B (zh) * | 2020-07-09 | 2025-08-12 | 江苏恒瑞医药股份有限公司 | 氧杂氮杂双环类衍生物、其制备方法及其在医药上的应用 |
| CA3186193A1 (en) * | 2020-07-29 | 2022-02-03 | Biao Lu | Oxa-azaspiro derivative, and preparation method therefor and pharmaceutical use thereof |
| PE20242113A1 (es) | 2021-10-14 | 2024-10-28 | Incyte Corp | Compuestos de quinolina como inhibidores de kras |
| EP4577206A2 (en) * | 2022-08-26 | 2025-07-02 | Celmatix Inc. | Novel modulators of fshr and uses thereof |
| JP2025535050A (ja) * | 2022-10-05 | 2025-10-22 | ラディオネティクス オンコロジー，インク． | 卵胞刺激ホルモン受容体（ｆｓｈｒ）を標的とした治療薬およびその使用 |
| CN120693335A (zh) | 2023-03-08 | 2025-09-23 | 辉凌公司 | 小分子fsh受体调节剂 |
| WO2024263803A2 (en) * | 2023-06-21 | 2024-12-26 | Celmatix Inc. | Novel modulators of fshr and uses thereof |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003024936A1 (en) * | 2001-09-19 | 2003-03-27 | Pharmacia Corporation | Substituted pyrazolo compounds for the treatment of inflammation |
| WO2008035356A2 (en) * | 2006-09-20 | 2008-03-27 | Glenmark Pharmaceuticals Limited | Novel cannabinoid receptor ligands, pharmaceutical compositions containing them, and process for their preparation |
| RU2332412C2 (ru) * | 2003-02-07 | 2008-08-27 | Дайити Фармасьютикал Ко., Лтд. | Производные пиразола |
| US20100215741A1 (en) * | 2009-02-25 | 2010-08-26 | Neuroscienze Pharmaness S.C. A.R.L. | Pharmaceutical compounds |
| US20100216785A1 (en) * | 2009-02-25 | 2010-08-26 | Neuroscienze Pharmaness S.C. A.R.L. | Pharmaceutical compositions |
| EA201290305A1 (ru) * | 2009-11-13 | 2012-12-28 | Мерк Сероно С.А. | Производные трициклического пиразоламина |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8814586D0 (en) | 1988-06-20 | 1988-07-27 | Erba Carlo Spa | Tricyclic 3-oxo-propanenitrile derivatives & process for their preparation |
| JP2004505051A (ja) | 2000-07-27 | 2004-02-19 | スミスクライン ビーチャム コーポレーション | 卵胞刺激ホルモン活性のアゴニスト |
| EP1879898A2 (en) * | 2005-05-12 | 2008-01-23 | Wyeth a Corporation of the State of Delaware | Pyrrolobenzodiazepines and heterocyclic carboxamide derivatives as follicle stimulating hormone receptor (fsh-r) antagonists |
| TWI461426B (zh) * | 2009-05-27 | 2014-11-21 | Merck Sharp & Dohme | （二氫）咪唑並異〔５，１－ａ〕喹啉類 |
| CN103827091B (zh) | 2011-07-01 | 2016-05-18 | 默克专利有限公司 | 二氢吡唑、其药物组合物及其治疗生育障碍的用途 |
| ES2899000T3 (es) | 2011-07-18 | 2022-03-09 | Merck Patent Gmbh | Benzamidas |
| AU2013208082B2 (en) | 2012-01-10 | 2017-07-20 | Merck Patent Gmbh | Benzamide derivatives as modulators of the follicle stimulating hormone |
| BR112014019351A8 (pt) | 2012-02-08 | 2017-07-11 | Merck Patent Gmbh | Análogos de tiazolidinona deuterados como agonistas para o receptor do hormônio folículo estimulante |
| EP3013832B1 (en) | 2013-06-24 | 2020-11-04 | Merck Patent GmbH | Pyrazole compounds as modulators of fshr and uses thereof |
| ES2657979T3 (es) | 2013-06-24 | 2018-03-07 | Merck Patent Gmbh | Compuestos de imidazol como moduladores de FSHR y sus usos |
| WO2015196335A1 (en) | 2014-06-23 | 2015-12-30 | Tocopherx, Inc. | Pyrazole compounds as modulators of fshr and uses thereof |
-
2014
- 2014-06-23 WO PCT/CN2014/080519 patent/WO2015196335A1/en not_active Ceased
- 2014-12-22 DK DK14896199.8T patent/DK3157929T3/da active
- 2014-12-22 WO PCT/CN2014/094459 patent/WO2015196759A1/en not_active Ceased
- 2014-12-22 US US15/321,249 patent/US10208055B2/en active Active
- 2014-12-22 AU AU2014398875A patent/AU2014398875B2/en not_active Ceased
- 2014-12-22 EP EP14896199.8A patent/EP3157929B1/en active Active
- 2014-12-22 KR KR1020177001959A patent/KR102416279B1/ko active Active
- 2014-12-22 MX MX2017000182A patent/MX389867B/es unknown
- 2014-12-22 ES ES14896199T patent/ES2972131T3/es active Active
- 2014-12-22 CN CN201480081442.1A patent/CN106573937B/zh not_active Expired - Fee Related
- 2014-12-22 JP JP2017519756A patent/JP6557331B2/ja active Active
- 2014-12-22 CA CA2955415A patent/CA2955415A1/en active Pending
- 2014-12-22 RU RU2017101829A patent/RU2752173C2/ru active
-
2018
- 2018-12-21 US US16/229,119 patent/US10941152B2/en not_active Expired - Fee Related
-
2019
- 2019-07-11 JP JP2019129171A patent/JP2019196375A/ja active Pending
-
2020
- 2020-02-20 AU AU2020201240A patent/AU2020201240A1/en not_active Abandoned
- 2020-11-18 JP JP2020191715A patent/JP2021038245A/ja active Pending
-
2021
- 2021-01-05 US US17/141,621 patent/US20220402929A1/en not_active Abandoned
- 2021-07-09 AU AU2021204814A patent/AU2021204814B2/en not_active Ceased
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003024936A1 (en) * | 2001-09-19 | 2003-03-27 | Pharmacia Corporation | Substituted pyrazolo compounds for the treatment of inflammation |
| RU2332412C2 (ru) * | 2003-02-07 | 2008-08-27 | Дайити Фармасьютикал Ко., Лтд. | Производные пиразола |
| WO2008035356A2 (en) * | 2006-09-20 | 2008-03-27 | Glenmark Pharmaceuticals Limited | Novel cannabinoid receptor ligands, pharmaceutical compositions containing them, and process for their preparation |
| US20100215741A1 (en) * | 2009-02-25 | 2010-08-26 | Neuroscienze Pharmaness S.C. A.R.L. | Pharmaceutical compounds |
| US20100216785A1 (en) * | 2009-02-25 | 2010-08-26 | Neuroscienze Pharmaness S.C. A.R.L. | Pharmaceutical compositions |
| EA201290305A1 (ru) * | 2009-11-13 | 2012-12-28 | Мерк Сероно С.А. | Производные трициклического пиразоламина |
Also Published As
| Publication number | Publication date |
|---|---|
| DK3157929T3 (da) | 2024-02-05 |
| RU2017101829A (ru) | 2018-07-27 |
| CA2955415A1 (en) | 2015-12-30 |
| RU2017101829A3 (enExample) | 2018-08-30 |
| JP2019196375A (ja) | 2019-11-14 |
| EP3157929A1 (en) | 2017-04-26 |
| WO2015196759A1 (en) | 2015-12-30 |
| WO2015196335A1 (en) | 2015-12-30 |
| KR20170033314A (ko) | 2017-03-24 |
| US20190135823A1 (en) | 2019-05-09 |
| EP3157929B1 (en) | 2023-12-13 |
| ES2972131T3 (es) | 2024-06-11 |
| JP6557331B2 (ja) | 2019-08-07 |
| EP3157929A4 (en) | 2018-03-07 |
| AU2014398875A1 (en) | 2017-02-02 |
| US20170253605A1 (en) | 2017-09-07 |
| US20220402929A1 (en) | 2022-12-22 |
| JP2021038245A (ja) | 2021-03-11 |
| MX389867B (es) | 2025-03-20 |
| AU2021204814B2 (en) | 2023-07-20 |
| JP2017524733A (ja) | 2017-08-31 |
| CN106573937A (zh) | 2017-04-19 |
| AU2020201240A1 (en) | 2020-03-12 |
| US10941152B2 (en) | 2021-03-09 |
| CN106573937B (zh) | 2022-02-11 |
| US10208055B2 (en) | 2019-02-19 |
| AU2014398875B2 (en) | 2019-11-21 |
| AU2021204814A1 (en) | 2021-08-05 |
| KR102416279B1 (ko) | 2022-07-01 |
| MX2017000182A (es) | 2017-06-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| HZ9A | Changing address for correspondence with an applicant |