DK3157929T3 - Pyrazolforbindelser som modulatorer af fshr og anvendelser deraf - Google Patents
Pyrazolforbindelser som modulatorer af fshr og anvendelser deraf Download PDFInfo
- Publication number
- DK3157929T3 DK3157929T3 DK14896199.8T DK14896199T DK3157929T3 DK 3157929 T3 DK3157929 T3 DK 3157929T3 DK 14896199 T DK14896199 T DK 14896199T DK 3157929 T3 DK3157929 T3 DK 3157929T3
- Authority
- DK
- Denmark
- Prior art keywords
- fshr
- modulators
- pyrazole compounds
- pyrazole
- compounds
- Prior art date
Links
- 102100027627 Follicle-stimulating hormone receptor Human genes 0.000 title 1
- 101000862396 Homo sapiens Follicle-stimulating hormone receptor Proteins 0.000 title 1
- WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical class C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/541—Non-condensed thiazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Reproductive Health (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CN2014/080519 WO2015196335A1 (en) | 2014-06-23 | 2014-06-23 | Pyrazole compounds as modulators of fshr and uses thereof |
| PCT/CN2014/094459 WO2015196759A1 (en) | 2014-06-23 | 2014-12-22 | Pyrazole compounds as modulators of fshr and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3157929T3 true DK3157929T3 (da) | 2024-02-05 |
Family
ID=54936412
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK14896199.8T DK3157929T3 (da) | 2014-06-23 | 2014-12-22 | Pyrazolforbindelser som modulatorer af fshr og anvendelser deraf |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US10208055B2 (enExample) |
| EP (1) | EP3157929B1 (enExample) |
| JP (3) | JP6557331B2 (enExample) |
| KR (1) | KR102416279B1 (enExample) |
| CN (1) | CN106573937B (enExample) |
| AU (3) | AU2014398875B2 (enExample) |
| CA (1) | CA2955415A1 (enExample) |
| DK (1) | DK3157929T3 (enExample) |
| ES (1) | ES2972131T3 (enExample) |
| MX (1) | MX389867B (enExample) |
| RU (1) | RU2752173C2 (enExample) |
| WO (2) | WO2015196335A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015196335A1 (en) | 2014-06-23 | 2015-12-30 | Tocopherx, Inc. | Pyrazole compounds as modulators of fshr and uses thereof |
| CN106977523A (zh) * | 2017-03-30 | 2017-07-25 | 河南师范大学 | 具有苯基并四氢吡咯结构的fshr拮抗剂及其制备方法 |
| CN106866692A (zh) * | 2017-03-30 | 2017-06-20 | 毛阿龙 | 具有苯并1,4‑二氧杂环己二烯酮结构的fshr拮抗剂的制备方法 |
| CN106967076A (zh) * | 2017-03-30 | 2017-07-21 | 河南师范大学 | 一种具有6h‑二苯并吡喃结构化合物及其制备方法 |
| CN111936484A (zh) * | 2017-12-22 | 2020-11-13 | 拉文纳制药公司 | 作为磷脂酰肌醇磷酸激酶抑制剂的色烯并吡啶衍生物 |
| SMT202300212T1 (it) * | 2018-05-03 | 2023-09-06 | Shanghai hengrui pharmaceutical co ltd | Derivati di benzimidazolo come modulatori del recettore gamma orfano correlato al retinoide (rory) e usi farmaceutici di essi |
| TW202112784A (zh) | 2019-06-17 | 2021-04-01 | 美商佩特拉製藥公司 | 作為磷脂酸肌醇磷酸激酶抑制劑之𠳭唏并嘧啶衍生物 |
| CN113754678B (zh) * | 2020-06-02 | 2023-03-10 | 江苏恒瑞医药股份有限公司 | 二氢硫代色烯并吡唑类衍生物、其制备方法及其在医药上的应用 |
| WO2022007924A1 (zh) * | 2020-07-09 | 2022-01-13 | 江苏恒瑞医药股份有限公司 | 氧杂氮杂双环类衍生物、其制备方法及其在医药上的应用 |
| WO2022022630A1 (zh) | 2020-07-29 | 2022-02-03 | 江苏恒瑞医药股份有限公司 | 氧杂氮杂螺环类衍生物、其制备方法及其在医药上的应用 |
| KR20240101561A (ko) | 2021-10-14 | 2024-07-02 | 인사이트 코포레이션 | Kras의 저해제로서의 퀴놀린 화합물 |
| EP4577206A2 (en) * | 2022-08-26 | 2025-07-02 | Celmatix Inc. | Novel modulators of fshr and uses thereof |
| WO2024077006A1 (en) * | 2022-10-05 | 2024-04-11 | Radionetics Oncology, Inc. | Follicle-stimulating hormone receptor (fshr) targeted therapeutics and uses thereof |
| WO2024184461A2 (en) | 2023-03-08 | 2024-09-12 | Ferring B.V. | Small molecule fsh receptor modulators |
| WO2024263803A2 (en) * | 2023-06-21 | 2024-12-26 | Celmatix Inc. | Novel modulators of fshr and uses thereof |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8814586D0 (en) * | 1988-06-20 | 1988-07-27 | Erba Carlo Spa | Tricyclic 3-oxo-propanenitrile derivatives & process for their preparation |
| WO2002009706A1 (en) | 2000-07-27 | 2002-02-07 | Smithkline Beecham Corporation | Agonists of follicle stimulating hormone activity |
| CA2460939C (en) * | 2001-09-19 | 2008-07-29 | Pharmacia Corporation | Substituted pyrazolyl compounds for the treatment of inflammation |
| RU2332412C2 (ru) | 2003-02-07 | 2008-08-27 | Дайити Фармасьютикал Ко., Лтд. | Производные пиразола |
| EP1879898A2 (en) * | 2005-05-12 | 2008-01-23 | Wyeth a Corporation of the State of Delaware | Pyrrolobenzodiazepines and heterocyclic carboxamide derivatives as follicle stimulating hormone receptor (fsh-r) antagonists |
| WO2008035356A2 (en) * | 2006-09-20 | 2008-03-27 | Glenmark Pharmaceuticals Limited | Novel cannabinoid receptor ligands, pharmaceutical compositions containing them, and process for their preparation |
| IT1393930B1 (it) * | 2009-02-25 | 2012-05-17 | Neuroscienze Pharmaness S C A R L | Composti farmaceutici |
| IT1394400B1 (it) * | 2009-02-25 | 2012-06-15 | Neuroscienze Pharmaness S C Ar L | Composizioni farmaceutiche |
| TWI461426B (zh) * | 2009-05-27 | 2014-11-21 | Merck Sharp & Dohme | （二氫）咪唑並異〔５，１－ａ〕喹啉類 |
| MX2012005518A (es) * | 2009-11-13 | 2012-06-19 | Merck Serono Sa | Derivados de pirazol amina triciclica. |
| JP6170043B2 (ja) | 2011-07-01 | 2017-07-26 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ | ジヒドロピラゾール |
| WO2013012848A1 (en) | 2011-07-18 | 2013-01-24 | Merck Patent Gmbh | Benzamides |
| ES2663972T3 (es) | 2012-01-10 | 2018-04-17 | Merck Patent Gmbh | Derivados de benzamida como moduladores de la hormona folículo estimulante |
| KR20140120903A (ko) | 2012-02-08 | 2014-10-14 | 메르크 파텐트 게엠베하 | 여포 자극 호르몬수용체의 아고니스트로서 중수소화 티아졸리디논 유사체 |
| EP3013823B1 (en) | 2013-06-24 | 2017-11-01 | Merck Patent GmbH | Imidazole compounds as modulators of fshr and uses thereof |
| RU2663898C2 (ru) * | 2013-06-24 | 2018-08-13 | Мерк Патент Гмбх | Пиразольные соединения в качестве модуляторов fshr и их применение |
| WO2015196335A1 (en) | 2014-06-23 | 2015-12-30 | Tocopherx, Inc. | Pyrazole compounds as modulators of fshr and uses thereof |
-
2014
- 2014-06-23 WO PCT/CN2014/080519 patent/WO2015196335A1/en not_active Ceased
- 2014-12-22 EP EP14896199.8A patent/EP3157929B1/en active Active
- 2014-12-22 RU RU2017101829A patent/RU2752173C2/ru active
- 2014-12-22 DK DK14896199.8T patent/DK3157929T3/da active
- 2014-12-22 KR KR1020177001959A patent/KR102416279B1/ko not_active Expired - Fee Related
- 2014-12-22 WO PCT/CN2014/094459 patent/WO2015196759A1/en not_active Ceased
- 2014-12-22 ES ES14896199T patent/ES2972131T3/es active Active
- 2014-12-22 AU AU2014398875A patent/AU2014398875B2/en not_active Ceased
- 2014-12-22 CN CN201480081442.1A patent/CN106573937B/zh not_active Expired - Fee Related
- 2014-12-22 JP JP2017519756A patent/JP6557331B2/ja not_active Expired - Fee Related
- 2014-12-22 MX MX2017000182A patent/MX389867B/es unknown
- 2014-12-22 US US15/321,249 patent/US10208055B2/en active Active
- 2014-12-22 CA CA2955415A patent/CA2955415A1/en active Pending
-
2018
- 2018-12-21 US US16/229,119 patent/US10941152B2/en not_active Expired - Fee Related
-
2019
- 2019-07-11 JP JP2019129171A patent/JP2019196375A/ja active Pending
-
2020
- 2020-02-20 AU AU2020201240A patent/AU2020201240A1/en not_active Abandoned
- 2020-11-18 JP JP2020191715A patent/JP2021038245A/ja active Pending
-
2021
- 2021-01-05 US US17/141,621 patent/US20220402929A1/en not_active Abandoned
- 2021-07-09 AU AU2021204814A patent/AU2021204814B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| RU2752173C2 (ru) | 2021-07-23 |
| WO2015196759A1 (en) | 2015-12-30 |
| EP3157929A4 (en) | 2018-03-07 |
| CA2955415A1 (en) | 2015-12-30 |
| AU2021204814A1 (en) | 2021-08-05 |
| US20220402929A1 (en) | 2022-12-22 |
| AU2014398875A1 (en) | 2017-02-02 |
| ES2972131T3 (es) | 2024-06-11 |
| MX389867B (es) | 2025-03-20 |
| KR20170033314A (ko) | 2017-03-24 |
| AU2020201240A1 (en) | 2020-03-12 |
| EP3157929A1 (en) | 2017-04-26 |
| US10208055B2 (en) | 2019-02-19 |
| JP2019196375A (ja) | 2019-11-14 |
| US10941152B2 (en) | 2021-03-09 |
| JP2021038245A (ja) | 2021-03-11 |
| JP2017524733A (ja) | 2017-08-31 |
| KR102416279B1 (ko) | 2022-07-01 |
| CN106573937B (zh) | 2022-02-11 |
| CN106573937A (zh) | 2017-04-19 |
| EP3157929B1 (en) | 2023-12-13 |
| MX2017000182A (es) | 2017-06-30 |
| US20170253605A1 (en) | 2017-09-07 |
| JP6557331B2 (ja) | 2019-08-07 |
| RU2017101829A3 (enExample) | 2018-08-30 |
| RU2017101829A (ru) | 2018-07-27 |
| AU2014398875B2 (en) | 2019-11-21 |
| AU2021204814B2 (en) | 2023-07-20 |
| WO2015196335A1 (en) | 2015-12-30 |
| US20190135823A1 (en) | 2019-05-09 |
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